Gait Disorders- Assessment and Intervention “Don’t walk behind me, I may not lead. Don’t walk ahead of me, I may not follow. Walk next to me & be my friend.” Albert Camus Ali AL-Memar Consultant Neurologist- St Georges Hospital , London UK One Day Essential | Neurology Friday 25 January 2019
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Gait Disorders- Assessment and Intervention
“Don’t walk behind me, I may not lead. Don’t walk ahead of me, I may not follow.Walk next to me & be my friend.”
Albert Camus
Ali AL-MemarConsultant Neurologist- St Georges Hospital , London UK
One Day Essential | Neurology
Friday 25 January 2019
Road Map
• Road Map
• Normal Gait
• Epidemiology of Gait disorders
• Classification of Gait disorders
• Abnormal Gait Pattern /pattern recognition
• Clinical assessment of Gait
• Clinical Evaluation & Interventions
Road Map
Normal Gait
Gait
Series of rhythmical , alternating movements of trunk & limbs resulting in forward progression of the COG
Human Gait depends on complex interplay of major parts of :
1- the Nervous system
2-Musckloskeletal system
3- cardiorespiratory systemThere are (4) major criteria essential to walking: • Equilibrium:
The ability to assume an upright posture and maintain balance.• Locomotion:
The ability to initiate and maintain rhythmic stepping• Musculoskeletal Integrity:
Normal bone, joint, and muscle function • Neurological Control:
Must receive and send messages telling the body how and when to move.(visual, vestibular, auditory, sensory-motor input)
Normal Gait
Gait Cycle
Center of Gravity (COG) COG
• Center of Gravity (CG):
• midway between the hips
• Few cm in front of S2
• Least energy consumption if CG travels in straight line
• The Location of the COG changes constantly with every position of the body and limbs
Gait Cycle
Gait Cycle
Begins when reference foot contacts the ground,
Ends with subsequent floor contact by the same foot
Step length
Right step Length = Left step Length (Normal Gait)
Stride Length
Double the step length
Walking base
Side-to-side distance between the line of the two feet
Gait Cycle
Gait Cycle
• The gait cycle is divided into the stance and swing phase.
• The stance phase constitutes approximately 60 % of the gait cycle and is subdivided into initial contact (heel strike), loading response, mid-stance, terminal stance and pre-swing.
• Both feet are on the ground at the beginning and end of the stance phase.
• Each of these two double support periods lasts for approximately 10–12 % of the gait cycle.
• The swing phase takes up about 40 % of the gait cycle and is subdivided into initial swing (toe-off), mid-swing (tibia vertical) and terminal swing, terminated by the heel striking the ground
Gait Cycle
Gait Cycle
• To start walking, one leg is raised and directed forward by flexing the hips and knee.
• Activation of the supporting contralateral leg and trunk muscles moves the body’s centre of gravity over the weight-bearing leg and forward.
• The heel of the swinging leg is then placed on the ground.
• The body weight is gradually shifted to the sole and then onwards to the toes.
• During mid-stance, the opposite leg is lifted and moves forward until the heel strikes the ground.
• Meanwhile, the body is held upright, the shoulders and pelvis remain relatively level and each arm swings in the direction opposite to that of its ipsilateral leg.
Gait Cycle
Measures of Gait
Measures of gait include :
1- walking speed
2- cadence (number of steps per unit of time)
3-walking base width (measured from midpoint to midpoint of both heels),
4-step length (measured from the point of foot contact to the point of contralateral foot contact)
5- stride length (linear distance covered by one gait cycle).
The preferred walking speed in healthy adults up to the age of 59 years is approximately 1.4 m/s.
The average cadence in young adults was reported to range between 115 and 120 steps/min.
Average stride lengths in healthy adults range between 150 and 170 cm.
Ageing is associated with a decline in gait speed and step length whereas cadence remains relatively stable.
Elderly patients prefer a 40 % wider step width than young persons (average step width in elderly women approximately 8 cm and in elderly men 10 cm) .
Measures of Gait
Basic Neuroanatomy
• Power-Motor System
• 1-CST (UMN)
• 2- Anterior horn cells and MPN (LMN)
• Speed-Basal Ganglia
• Coordination- Cerebellum
• Sensory-• 1-Sensory Cortex,
• 2-Spinal connections (STT,Post Column)
• 3- sensory peripheral nerves
Role of cognition
• Frontal executive functions, visuospatial perception and attention all contribute to walking safely. Cognitive impairment will have a negative effect on all aspects of gait performance.
• Psychological factors also influence gait. For instance, depression is associated with slower gait and anxiety may lead to an overly cautious gait.
• The role of cognition for gait is revealed in the multitask paradigm where persons are asked to perform mental tasks while walking. Elderly persons who walk while talking have a significantly higher risk of falling .
• Further investigations have shown that patients with dementia walk slowly but in relation to their motor and cognitive deficits, they actually walk too fast leading to an increased risk of falling .
• These multiple interactions demonstrate that improving cognitive functioning may have an essential role in the rehabilitation of gait disorders.
Role of cognition
Epidemiology of gait disorders
• in 488 persons: between the ages of 60 and 97 years one third of this population had a gait disorder, with a marked increase in prevalence with age.
• Between the ages of 60 and 69 years, the prevalence was 10 % and in those over 80 years it was >60 % .
• In two thirds of those affected by any gait disorder, the cause was neurological and in approximately one half, the cause was non-neurological, indicating that there was a considerable overlap of patients affected by neurological as well as by non-neurological gait disorders.
• Among the neurological causes :
• Sensory ataxia (18 %) parkinsonian (16 %) gait disorders were the most common
• Frontal (8 %), followed by cerebellar ataxic gait disorders, spastic, vestibular and dyskinetic gait disorders.
• In approximately one third of the patients the gait disorder was due to more than one neurological cause, making a precise classification difficult
Epidemiology of gait disorders
Epidemiology of gait disorders
• In elderly persons, pre-existing difficulties with walking and balance are more commonly the cause of falls than acute disturbances, such as syncope, seizures or stroke.
• Approximately 10–15 % of these falls lead to serious injuries, such as traumatic brain injury or hip fractures.
• It has been estimated that inadvertent injuries are the fifth most common cause of death in elderly persons .
• Factors that might precipitate falls in the home include loose carpets on wooden floors.
• Polypharmacy is regarded as an important risk factor for falls in the elderly; however, newer studies suggest that polypharmacy only poses a risk if it includes medications that increase the risk for falls, such as sedatives, antidepressants and benzodiazepines
Epidemiology of gait disorders
Risk factors for falls
Female gender, low body weight, age >80 years
Number of falls in previous year/month
Use of sedatives, particularly with long half-life
Limited physical activity
Difficulties rising from sitting position
Reduced muscle strength in the lower limbs
Impaired balance Standing
Walking
Turning
Impaired postural reflexes
Impaired vision
Impaired cognitive functions, depression, anxiety
Risk factors for falls
Phenomenological classification of gait disorders (modified from Ružička and Jankovic )
Gait disorder Characteristics
Hemispastic gait Unilateral extension and circumduction
Paraspastic gait Bilateral extension and adduction, stiff
Ataxic gait Broad base, lack of coordination
Sensory ataxic gait Cautious, worsening without visual input
• Signs: when underlying disease can not be identified
• Causes: May present early manifestation of subclinical ds.
• Psychogenic
• Description: Bizarre, Non physiologic gait
• Signs: Absence of neurological signs
• Causes: Factitious, Somatotisation
Gait Patterns
Fear of falling: Possible contributors Older Age, female gender, poor social support, H/O falls, depression and poor lower limb function
Lower personal mastery and poor dynamic balance are associated with fear of falling
Lack of social support, depressive symptoms, H/O multiple falls and presence of ≥ 2 chronic conditions are associated with fear-induced activity restriction
Fear of falling may not always precipitate activity restriction , half of those who report fear of falling do not restrict activities
Gait Patterns
Clinical Evaluation
• History
• Acute and Chronic Medical problems
• Complete Review of Systems (ROS)
• Falls History (Previous Falls, Injury resulted, circumstances )
• Nature of Difficulty with Walking (e.g. Pain, imbalance)
• Surgical History
• Usual Activity, mobility status, and level of function
• Medication review
• New medication or dosing review
• Number and type of medications
Clinical Evaluation
Clinical Evaluation
• Presence of environmental Hazards
• Clutter , Electrical Cords
• Lack of grab bars near bathtub & toilets
• Low chairs , Poor Lighting
• Slippery Surfaces ,Throw /rugs
• Physical Examination
• Vitals
• (Wt. Ht. Orthostatic BP & Pulse)
• Affective/cognitive
• (Delirium, Dementia, Depression, Fear of Falling)
• (Pt arise from a chair, without using arms, walk 3 meter, turn, return to the chair and sit down. They allowed to use their usual walking aids.)
• Score < 10 sec normal
• Score > 14 Sec Abnormal
• Score > 20 Sec Severe gait impairment
Evaluation : Gait & Balance Performance
Evaluation :Gait & Balance Performance
4. Single leg stance test
• Best balance measure for any individual
• If one can stay on one leg for >10 sec, usually no significant balance problems
Evaluation : Gait & Balance Performance
Complex tests of stance and gait
• Tandem stance
• Tandem gait
• Romberg’s test (standing with eyes closed and narrow base)
• Walking backwards
• Walking fast
• Walking slowly (in a deliberate manner)
• Running Turning quickly
• Turning on the spot
• Unterberger’s test (walking on the spot with eyes closed)
• Standing and walking on heels
• Standing and walking on toes
• Hopping on one foot
• Dual task manoeuvre (walking while talking or carrying objects)
Complex tests of stance and gait
Balance Scale
• Dynamic Gait Index
• Developed to quantify gait dysfunction in older adults during level surface walking as well as more complex functional tasks.
• Dual task demands relevant to falls risk in elderly
• Applicable to assessing balance in other groups of patients including those with vestibular disorders, multiple sclerosis, head injury, and Parkinson’s
• Scores of 19 or less out of 24 indicate increased risk of falling in older adults (Shumway-Cook 1997)
• Berg Balance Scale
• Measure of static and dynamic balance in movements common in everyday life on 14-item scale (56 points)
• Useful for evaluating multiple falls risk in community living older adults
• No longer recommends a dichotomous 45 point cut-off
• Likelihood of multiple falls increases as score decreases
• Reliable test of balance in elderly in residential care – change of 8 points required to reveal genuine change
in function
• Discriminates persons with Parkinson’s disease who fall vs. those who do not fall
• Cut-off score of 44/56 recommended by Landers, 2008
Balance Scale
Limitations of Balance Scales and Screening Tools
• Screening for falls may increase fear of falling
• Falls are multifactorial, no scale captures all aspects
• Scales and balance screening tools have not been well tested in a wide range of populations/settings
• Uncertainty regarding predictive scores
• Scales test different aspects of balance, sensitivity for prediction and examination may be best with multiple tests
Limitations of Balance Scales and Screening Tools
Intervention
• Interventions may impact important Functional outcomes, including Reduction in
• Falls
• Fear of falling
• Overall limitation in mobility
• Gait Disorder secondary to Medical Conditions
• (Arthritis, Vitamin B12, Thyroid Problems, Arrhythmias, Depression etc.) respond well to Medical Therapies.
• Adjustment in Medication improves gait disorder-Parkinson disease
• Surgery may improve Gait
• Cervical spondylotic myelopathy
• Lumbar spinal stenosis
• Normal pressure hydrocephalus
• Arthritis of hip or knee
• Improving Sensory Input
• Visual Correction
• Hearing Aids
Intervention
Intervention :General measures to prevent falls and fall-related injuries
Check entire list of medication :
Avoid sedatives, particularly with long half-life
Avoid (classical) neuroleptics and tricyclic antidepressants
Check the indications for and dose of atypical neurolepticsAnxiolytic and antidepressant therapy , Behavioural therapy for anxiety, depression and dementia
Increase physical activity , Muscle training , Balance training
Therapy of orthostatic hypotension
Treatment for osteoporosis
Adequate footwear
Protective devices such as hip protectors
Remove risks at home and adjust personal environment
Electronic warning systems
Intervention :General measures to prevent falls and fall-related injuries
Intervention
EXERCISE INTERVENTION & PHYSICAL THERAPY
• Target strengths
• Balance training
• Functional exercises
• Flexibility
Evidence supports HOME ENVIRONMENT ASSESSMENT prevent falls & related injuries
Exercise intervention can improve the dysfunction and reduce the likelihood of falls and their complications :
• Many studies show benefits of muscle strength with gait parameters in older adults and the use of exercise to improve measures of balance and reduce incidence of falls
• Increases of 5-15% in ambulatory function after 8-12 weeks of a walking and endurance program
• Balance training improved force-plate balance parameters by 20-50%
• Tai chi improved balance (postural sway) by 32% and fall risk by 49% (OR 0.51, 95% CI 0.36-0.73)
• Aerobic conditioning improved balance by 20% in adults over age 70
• Use of a multidimensional exercise program that incorporates balance training and strengthening should improve postural stability and reduce fall risk
Intervention
Exercise Recommendations
1- Balance7 x/week, dynamic exercises focused on mobility, static exercise focused on single leg stand, 4-10 different exercises
2- Muscle Performance• 3 x/week, 8 to 10 exercises
• Frailty - > 3 x/week, at least 20 minutes, 11-13 Borg Scale
• Flexibility• 7 x/week, 3-5 reps each major muscle group, 10-30 s. hold
• Dance Therapy for PD
Exercise Recommendations
Assistive Devices : Canes
STANDARD CANE
• Indications:
• Mild ataxia (sensory, vestibular, or visual)
• Mild arthritis
• Advantages:
• Inexpensive
• Adjustable
• Improves balance
• Disadvantages:
• Umbrella handle cause carpal tunnel syndrome
• Not for weight bearing
Assistive Devices : Canes
OFFSET CANE
• Indication:
• Moderate arthritis
• Advantages:
• Inexpensive
• Intermittent weight bearing
• Shotgun handle put less pressure on palm
• Disadvantages:
• Commonly used incorrectly
Assistive Devices
QUADRIPOD
• Indications:
• Hemiparesis
• Advantages:
• Increased base of support
• bear large weight
• Stands freely on its own
• Disadvantages:
• Slightly heavier
• Awkward to use correctly with all four points on ground simultaneously
Assistive Devices : CRUTCHES
AXILLARY CRUTCHES
• Indication:
• Lower extremity fracture
• Advantages:
• Inexpensive
• Completely redistribute weight off of lower extremities
• Permits 80-100 % weight-bearing support
• Disadvantages:
• Difficult to learn to use
• Requires energy & strength
• Risk of nerve or artery compression
Assistive Devices : CRUTCHESFOREARM CRUTCHES:
• Indication:
• Paraparesis
• Advantages:
• Frees hands without having to drop crutch
• Less cumbersome to use, particularly on stairs
• No Axillary compression
• Disadvantages:
• Permits only occasional weight bearing
Assistive Devices : WALKERS
STANDARD WALKER
• Indications:
• Severe myopathy
• severe neuropathy
• Cerebellar ataxia
• Advantages:
• Most stable walker
• Folds easily
• Disadvantages:
• Slower
• Needs to be lifted up with each step
• Less natural gait
Assistive Devices : Walkers
FRONT-WHEELED WALKER
• Indications:
• Severe myopathy
• Severe neuropathy
• Paraparesis
• Parkinsonism
• Advantages:
• Maintains normal gait pattern
• No need to be lifted up with each step
• Disadvantages:
• Large turning arc
• Less stable
Assistive Devices : WALKERS
ROLLATOR
• Indications:
• Moderate arthritis
• Claudication
• Lung disease, CHF
• Advantages:
• Easy to propel
• Highly movable
• Small turning arc
• Has seat & basket
• Disadvantages:
• Not for weight bearing
• Less stable
• Does not fold easily
Non-Actuator
Devices
Functional
Electrical
Stimulation
Robotics
Virtual RealitySensor
Technology
New Technologies:
Changing Brains
Neurotechnology The Artificial Brain?
First pacemakers were introduced in the early 1960s
3 million people worldwide use them
1st cochlear implants developed in the late 1970s~ 225,000 fitted worldwide
Amazing? New?
Neuromodulation works by using electrical stimulation to improve control of an existing part of the nervous system. Examples include spinal cord stimulation systems used for chronic pain management that block pain signals to the brain and gastric stimulation systems, which are used to block the signals of hunger.
Deep brain stimulation (DBS) and
Spinal Cord Stimulation
Transcranial magnetic stimulation
(TMS)
Vagal nerve stimulation
There are three different types of neuromodulation
Neurology 2019
Deep brain stimulation (DBS)This involves the placement of an electrode inside the brain with a wire running down the neck connected to a battery pack or pulse generator under the skin in the chest or abdomen.Currently used to treat Parkinson's disease, epilepsy, stroke and severe obsessive compulsive disorders.Research is underway into its use to treat obesity, Tourette's syndrome, anorexia, addictions.
Neurology 2019
When a strong, rapid current is passed through a stimulating coil (top), a rapidly changing magnetic
field is produced, which induces current into the brain
Bolognini N , and Ro T J. Neurosci. 2010;30:9647-9650
Transcranial magnetic stimulation (TMS)This involves the application of a magnetic field to induce electrical currents into the brain. It is a non-invasive procedure.Currently used in several countries to treat depression, or to enhance cognitive functions such as attention, understanding, perception.Future applications may include treatment for severe migraines.There is significant interest in the development of TMS to enhance mood and cognitive skills such as problem-solving and memory.
TCMS requires hospital visits 5 x 40 min visits each week for up to six weeks
As a result of this ion flow, action potentials are triggered in neurons that are within the induced current field, along with a subsequent period of deactivation, presumably through prolonged IPSPs. Because normal ongoing brain activity is disrupted by this induced current, TMS provides a way for investigators to produce a transient and reversible period of brain disruption or “virtual lesion.” Thus, unlike other experimental techniques [e.g., functional magnetic resonance imaging (fMRI), electroencephalography (EEG)/event-related potentials (ERPs)], TMS can assess whether a given brain area is necessary for a given function rather than simply correlated with it.
Neurology 2019
Brain-machine interfaces (BMIs)devices that detect intent—typically intended movement—frombrain activity, and translate it into an output action, such ascontrol of a cursor on a screen or a robotic arm.1) acquiring a neural signal that can be consciously controlled; 2) analyzing that signal to identify an intended motor output; and 3) executing the intended action
Neurology 2019
Neural Prostheses and Neural Rehabilitation is used in conjunction with a planned training program to replace or improve function of an impaired nervous system or to provide a better, more controllable prosthesis following loss of a limb.
Neurology 2019
Retinal ImplantsRetinal Implants
Jennifer French US Sailing Paralympic Silver MedalistWhile snowboarding in 1998, French suffered a severe spinal cord injury that left her a quadriplegic.The following year she received implants that allowed her to stand and, ultimately, walk down the aisle at her wedding. She is the first woman to receive an implanted neural prosthetic device allowing her to use paralyzed lower limbs.
Claire Lomas & ReWalk
Claire Lomas is an event rider who was paralysed from the chest down following an injury. Using the ReWalk bionic suit, she completed the London Marathon in 17 days.
The ReWalk exoskeleton suit uses motorized legs that power knee and hip movement and is controlled by on-board computers and motion sensors, restoring self-initiated walking without needing tethers or switches to begin stepping.
ReWalk controls movement using subtle changes in centre of gravity, mimics natural gait and provides functional walking speed. A forward tilt of the upper body is sensed by the system, which triggers the first step. Repeated body shifting generates a sequence of steps, which allows natural and efficient walking.
The ReWalk also sits, stands, allows turning and has the ability to climb and descend stairs. Using crutches for support, the user can walk and speak eye-to-eye with others on city streets and also navigate slopes and uneven terrain.
Claire Lomas & ReWalk
Neuro Pharmaceuticals is an emerging field of therapy, applied through the use of devices combined with pharmaceuticals, particularly for cognition and emotional treatments. Examples include pumps for baclofen to treat spasticity or morphine for chronic pain.
Intrathecal pump delivers medication to spinal fluid. There is no feedback loop.
Neurology 2019
Summary• Bipedal gait is a fundamental function that determines human life beyond early infancy almost as much as speech,
higher cognitive abilities and use of complex tools.
• As the prevalence of gait disorders increases with age, the number of people affected will substantially increase in the coming decades due to the expected demographic changes.
• Gait disorders lead to a loss of personal freedom and to reduced quality of life.
• Gait impairments are also precursors of falls and therefore of potentially severe injuries in elderly persons.
• The causes of gait disorders include neurological, orthopaedic, medical and psychiatric conditions and multifactorial aetiology becomes more common with advancing age, making classification and management more complex.
• Any gait disorder should be thoroughly investigated in order to improve patient mobility and independence, to prevent falls and to detect the underlying causes as early as possible.
• Thorough clinical observation of gait, careful history taking focussed on gait and falls and physical, neurological and orthopaedic examinations are basic steps in the categorization of gait disorders and serve as a guide for ancillary investigations and therapeutic interventions.
Summary
Summary• Prevention and treatment of iatrogenic, especially medication-induced, gait disorders are
important measures to reduce the burden of falls in the geriatric population.
• Several gait disorders are amenable to specific treatment. Levodopa is the drug of choice for the treatment of the gait disorder of PD and in some other parkinsonian syndromes.
• In normal pressure hydrocephalus, cervical spondylotic myelopathy, lumbar spinal stenosis and hip or knee osteoarthritis, surgical treatment should be considered.
• Patients with gait disorders not amenable to specific treatment (e. g. many neuromuscular conditions, frontal gait disorders) may benefit from multimodal rehabilitation, gait training, use of assistive devices and fall prevention measures.
• Commonly used exercise interventions such as muscle strength, power and resistance training as well as coordination training can improve habitual and maximum gait speed in elderly subjects .
• These exercise programs can be individualized according to the type of gait impairment, the therapist’s experience and patient’s preferences.
Summary
Conclusions
• Comprehensive evaluation with targeted interventions reduce falls by 30-40%
• Gait Disorder evaluation the most effective strategy for falls prevention
• Emerging evidence supports a cognitive component to measuring falls and treating fall risks.
• Encourage exercise to improve muscle strength and balance
• Consider assistive devices and use OT for home safety assessments
• Screen for fear of falling and counsel to improve mobility
• Neurotechnology is future technology that improves or repairs nervous system function or facilitates understanding of the nervous system.
Conclusions
Graphic representation of the step sequence in classical gait disorders
Graphic representation of the step sequence in classical gait disorders