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Furin is a direct transcription target of Notch1
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Notch1 auto-activation via transcriptional regulation of Furin, which sustains Notch1 signaling by 1
processing Notch1-activating proteases ADAM10 and MT1-MMP* 2
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Hong Qiu, Xiaoying Tang, Jun Ma, Khvaramze Shaverdashvili, Keman Zhang, Barbara Bedogni 4
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Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106 6
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*Running title: furin is a direct transcription target of Notch1 8
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To whom correspondence should be addressed: Barbara Bedogni, Dept. Of Biochemistry, Case Western 10
Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH 44106, USA; Tel: 216-368-7602; 11
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This work was supported by a grant from the Harry Lloyd Charitable Trust and by a grant from the 559