BASF Corporation Fungicide Update IR 4 Food Use Workshop IR-4 Food Use Workshop Cleveland, OH Sept. 16, 2009 Ted Bardinelli
BASF CorporationFungicide Update
IR 4 Food Use WorkshopIR-4 Food Use WorkshopCleveland, OH
Sept. 16, 2009
Ted Bardinelli
MetrafenoneMetrafenone(BAS 560F)( )
A New Powdery Mildew Fungicide from BASFFungicide from BASF
Metrafenone is not registered by the US EPA and is not available for sale. This presentation is for informational purposes only and is notintended to promote the sale of the product. Any sale of this product after registration is obtained shall be solely on the basis of the EPA-approved product label, and any claims regarding product safety and efficacy shall be addressed solely by the label.app o ed p oduct abe , a d a y c a s ega d g p oduct sa ety a d e cacy s a be add essed so e y by t e abe
Metrafenone FungicideCh i l Ch t i tiChemical Characteristics
Totally unique chemistry and mode of actionTotally unique chemistry and mode of action
Benzophenone chemical class
N k i tNo known cross-resistance
FRAC MoA Group U8
Biochemical site of action is not known
Actin disruption has been proposed.
Actins are structural proteins critical to cell division and function.
Favorable Toxicity and Environmental Profile
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MetrafenoneProposed Directions for Use on GrapesProposed Directions for Use on Grapes
Use Rate InformationUse Rate Information10.3 -15.4 fl oz/A rate range (224 – 337 g ai/ha)
Spray intervals of 14-21 days
Maximum of 6 applications per season
No more than 2 consecutive applications
Restricted-entry interval (REI) = 12 hoursRestricted entry interval (REI) 12 hours
Application TimingApply preventively for best performance
Any time after bud break to 14 day PHI
Adjuvants
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Performance may be improved by adding non-phytotoxic adjuvants
– e.g. organo-silicone adjuvants commonly used in grapes
Metrafenone FungicideP d t I t d tiProduct Introduction
Anticipated registration with EPA and California in June of 2010Anticipated registration with EPA and California in June of 2010 for use in grapes.
Proposed commercial name will be VivandoTMProposed commercial name will be VivandoTM.
300 g ai/L SC formulation.
Label will be for powdery mildew (Uncinula necator) only.
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Initium®Initium®
(BAS 650F)
An innovative fungicidegof a new chemical class
for the control offor the control of oomycetes
Initium is not registered by the US EPA and is not available for sale. This presentation is for informational purposes only and is notintended to promote the sale of the product. Any sale of this product after registration is obtained shall be solely on the basis of the EPA-approved product label, and any claims regarding product safety and efficacy shall be addressed solely by the label.app o ed p oduct abe , a d a y c a s ega d g p oduct sa ety a d e cacy s a be add essed so e y by t e abe
Reliable & highly active against oomycete diseases
Initium® – The key benefitsReliable & highly active against oomycete diseases with excellent selectivity
Innovative complex III inhibitor of a new chemical classInnovative complex III inhibitor of a new chemical class and a new tool in resistance management
Very favorable regulatory profileVery favorable regulatory profile
Premium preventive action
Excellent grape cluster efficacy
W ld id i t ti d i t t l
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World-wide registrations and import tolerances
Reliable & highly active against oomycete diseases with excellent selectivity
Proposed uses of Initium®
Application rates
200 – 300 g/ha in combination with other fungicides of a different mode of action
SSpray interval 7 - 14 days
F iFungi controlled Downy mildew & late blight diseases
Grapes potatoes tomatoes & otherCrops
Grapes, potatoes, tomatoes & other Solanaceae,
cucurbits, leafy & fruiting vegetables,bulb vegetables brassicas hops ornamentals
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bulb vegetables, brassicas, hops, ornamentals
Spectrum of activity
Reliable & highly active against oomycete diseases with excellent selectivity
p y
P t t Ph t hth i f tPotatoes Phytophthora infestansTomatoes Phytophthora infestansGrapes Plasmopara viticolaGrapes Plasmopara viticolaVegetables Peronospora spp.Vegetables Phytophthora spp.Vegetables Phytophthora spp.Cucurbits Pseudoperonospora cubensisLettuce Bremia lactucaeHops Pseudoperonospora humuliOrnamentals Phytophthora spp.
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Innovative complex III inhibitor of a new chemical class and a new tool in resistance management
A new choice in resistance managementInitium® displays no cross resistance to fungicide classes ofInitium® displays no cross-resistance to fungicide classes of
phenylamides (e.g. metalaxyl)
Q i hibit ( t bil i )Qo inhibitors (e.g. strobilurins)
carboxylic acid amides (e.g. dimethomorph)
benzimidazoles, SDH inhibitors, triazoles and imidazoles
As a pro-active measure Initium will be marketed only as ready mixes inAs a pro active measure, Initium will be marketed only as ready mixes incombination with other fungicidal active ingredients of a different mode of action.The partners will complement the activity spectrum and deliver built-in resistancemanagement for Initium and vice versa.
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– a new tool for resistance management
Innovative complex III inhibitor of a new chemical class and a new tool in resistance management
New proprietary chemical class: pyrimidylamines
The mode of action of Initium® – summaryNew proprietary chemical class: pyrimidylamines
Initium inhibits respiration at complex III
Exact binding site at complex III is not yet known
No cross-resistance to important oomycete fungicide classes detected,
including complex III Qo inhibitors
Cross-resistance to QiI fungicides cyazofamid and amisulbrom cannot
be excluded
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be excluded
is the innovative complex III inhibitor of a new chemical class
World-wide registrations and import tolerances
Initium® registration
A II I iti i t ti d i b itt d f i i EAnnex II Initium registration dossier submitted for review in Europe
in September 2008.
MRL dossier submitted as an application for EU MRLs for all European
uses developed up to now.
World-wide registration campaign for Initium products in progress.
First registration expected in 2010.
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is on track for world-wide registration