Fungal Colonic Mass : Basidiobolus

FUNGAL MASS : Rt. Iiac

Fossa

Case presentation

Dept.Histopathology

KFUCH, KSA

Clinical details

•18 YRS FEMALE

•YEMENI

•RT.ILIAC FOSSA MASS

•? LYMPHOMA

•?FUNGAL INFECTION

FROZEN STUDY

•1 st SAMPLE : INFLAMMATORY

•2nd SAMPLE : MASS OF BOGGY SOFT

TISSUE & FAT

•6cmX4cms

•FROZEN DIAGNOSIS :

•NECROTIZING FUNGAL

INFLAMMATION

SPLENDORE HOEPPLI MATERIAL

DIAGNOSIS

FUNGAL INFLAMMATORY MASS :

Zygomycosisspecies Of -? Sub

** Fungal cultures are recommended for identification of exact type.

Fungal infection

•>100,000 fungal species

•Only 150 are pathogenic for humans

• -: FACTORS AFFECTING

•1)Virulence of agent

• 2) Route of infection

• 3)Dose of the agent

•4) Immunological status of host.

Broad Categories

•1. Superficial fungus

•2.Cutaneous&sub-cutaneous

•3.Systemic mycoses

•4.Infections that resemble Mycosis

Terminology

•Filament that forms the thallus or body of most : HYPHA

fungi.

•like filament produced -Short hyphal: PSEUDOHYPHAby the sucessive buds – of a yeast that elongate and fail to

separate.

•: having craoss walls.SEPATE

•’’ : HOEPPLI Material-SPLENDORE‘‘Eosinophilic substance ,surrounding some fungi, represents a

localized antigen antibody reaction in hypersensitizesd host.

Lab Diagnosis of Fungal infection

• Fungal Culture & Morphology. 1

•KOH preparation,Microscopy

• :.Immunohistology2

•DFA(direct fluorescent antibody),

•Immunohistochemical method,

•Molecular tests- DNA/RNA based(PCR).

•.Serological:3

• Latex agglutination,Complement fixation,ELISA

•.Blood Antigens:4

• Galactomannan,Glucan

Angioinvasive Fungi

•.Zygomycosi(mucormycosis)

•Aspergillus spc’s

•Systemic Phycomycetes

•Occasionally Candida albicans

SPLENDORE HOEPPLI material”“

•SC PHYCOMYCOSIS (Basidiobolus sp’s)

•SUBMUCOUS PHYCOMYCOSIS : (Entomotphthora coronata)

•ASPERGILLUS

•

•SPOROTHRIX

,6, No:39, Vol:2001Reference: Jr.Clinical microbiology, June

.GIT Basidiobolus Rt.Iliac fossa massDr Z.U.Khan, Kuwait :

Thank

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