Friday, 18 September Chapter 11 The Endocrine System • Classes of hormones • The adrenal gland • Fates of hormones • RAA system • ------------------------------- • Hypothalamus-Pituitary System • Hormone interactions • Control of hormone secretion • Categories of endocrine disorders
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Friday, 18 September Chapter 11 The Endocrine System Classes of hormones The adrenal gland Fates of hormones RAA system -------------------------------
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Friday, 18 SeptemberChapter 11 The Endocrine System
• Classes of hormones• The adrenal gland• Fates of hormones• RAA system• -------------------------------• Hypothalamus-Pituitary System• Hormone interactions• Control of hormone secretion• Categories of endocrine disorders
Knowing chemical classes is important because chemical class is related to 1)How hormones are synthesized and2)How hormones are stored before secretion3)How hormones are transported in blood and 4)Where receptors are located on target cells and5)The duration of the effect on the target cells.
Fig. 11.01
Catecholaminessoluble in plasma
ThyroidHormones Not soluble in plasma, bound & free
Target cells have intracellular receptors,Commonly changes is gene expression
Timecourse?
Mostly Bound & Some Free
Thyroid hormones: special synthesis and storage
Questions so far?
Know Table 11-2 p 323
• Hormone class
• Major form in plasma
• Location of receptors
• Signal transduction mechanisms
• Rate of excretion / metabolism
Fig. 11.05
Adrenal Gland
Part of Sympathetic Nervous System
Adrenal Medullary Hormones• Adrenal medulla is modified sympathetic ganglion• Catecholamines: EPI (80-85%), NE (15-20%)• Short half-life in plasma (soluble)• Receptors on surface of target cells (adrenergic) • Effects response to stress• Effects generally prepare for “Fight or Flight”