Framingham Heart Study The Pre-Clinical Stage of Alzheimer’s The Pre-Clinical Stage of Alzheimer’s Disease: A 30-year Prospective Study of Disease: A 30-year Prospective Study of the Framingham Cohort the Framingham Cohort Rhoda Au, Ph.D. Rhoda Au, Ph.D. March 6, 2010 March 6, 2010
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Framingham Heart Study
The Pre-Clinical Stage of Alzheimer’s The Pre-Clinical Stage of Alzheimer’s Disease: A 30-year Prospective Study of Disease: A 30-year Prospective Study of
Present data from 3 different Present data from 3 different points of longitudinal follow-uppoints of longitudinal follow-up
Revisit the concept of “pre-Revisit the concept of “pre-clinical”clinical”
Examine the idea of age-specific Examine the idea of age-specific definitions of “pre-clinical” and definitions of “pre-clinical” and impact on measurement toolsimpact on measurement tools
Framingham Heart StudyFramingham Heart Study Longitudinal Community-Based Family StudyLongitudinal Community-Based Family Study
Gen 1 Original cohort
Gen 2 Offspring cohort
19482010
1971 2007
Gen 3 cohort
2002 2010
OvervieOvervieww
Core Exam
Anthropometry (ht, wt, girth)
Blood Pressure (resting)
Urinalysis
Lifestyle/Habits (drinking, smoking, work,
sociodemographic)
Medical History (dr.visits, hopitalization, illness, health
status, medication)
MD Physical Exam
Chemistries (lipids, cholesterol, triglycerides,
glucose, TSH, apoprotein)
Echocardiography
Electrocardiogram
Holter Monitor
Pulmonary Function
Twins
Sleep
Cardiac MRI
Hearing
Hypergen
Stroke (PSIP)
MRI, Cognition & Genetics
Bone StudyAncillary Studies
Carotid Doppler
Cognition (MMSE) Psychosocial (self-report, CES-D, Type A)
Physical Activity/Fitness (ADL, walk/jog, falls)
Alcohol Use and Abuse Epidemiology of Dementia
Framingham Heart StudyFramingham Heart Study Dementia Study – Prevalence: Gen 1 Original Dementia Study – Prevalence: Gen 1 Original cohortcohort
WMS Visual Reproductions – IRWMS Visual Reproductions – IR WMS Paired Associates -IRWMS Paired Associates -IR Controlled Word Association Test (COWAT)Controlled Word Association Test (COWAT) WAIS SimilaritiesWAIS Similarities WAIS Digit SpanWAIS Digit Span
Linn et al., 1995Linn et al., 1995
13 years follow-up13 years follow-up– 65+ years old65+ years old