FORMULASI DAN UJI STABILITAS FISIK SEDIAAN EMULSI MINYAK BIJI JINTEN HITAM (Nigella sativa Linn.) Kurniawan Pambudi Laboratorium Teknologi Farmasi Fakultas Farmasi Universitas Indonesia, Depok, 16424 ABSTRACT The black seeds cumin oil known to have efficacy as medicinal herbs having peculiar odor and taste. Hence preparation made emulsify oils black seeds cumin type O/W. This study aims to cover odor and taste and knowing stability emulsion preparation of black cumin esktract (nigella sativa linn) with emulgator span 80 and tween concentration with variations 20%, 50% and 70% of the oil of cumin black seeds in preparation. Evaluation volume discontinuous, conducted include viscosity, size of particles, the physical stability pH levels and determination. The evaluation of emulsion with concentration emulgator 70% having good stability. This formula could prove the odor and taste of black seeds cumin oil. Keyword : emulsion, cumin seed oil, Nigella sativa Linn, physical stability , hedonic test. ABSTRAK Minyak biji jinten hitam yang dikenal memiliki khasiat sebagai obat herbal mempunyai bau dan rasa yang khas. Oleh karena itu dibuat sediaan emulsi minyak biji jinten hitam tipe O/W. Penelitian ini bertujuan untuk menutupi bau dan rasa serta mengetahui stabilitas sediaan emulsi yang baik dari esktraksi Jinten hitam (Nigella sativa Linn) dengan emulgator Span 80 dan Tween 80 dengan variasi konsentrasi 20%,50% dan 70 % dari jumlah minyak biji jinten hitam dalam sediaan. Evaluasi yang dilakukan meliputi volume sedimentasi, viskositas, ukuran partikel, uji stabilitas fisik, pH, dan penetapan kadar. Dari hasil pengujian, emulsi dengan konsentrasi emulgator 70% memiliki stabilitas yang baik. Formula emulsi tersebut telah dapat memperbaiki aroma dan rasa minyak biji jinten hitam, tetapi belum untuk penampilannya. Kata kunci : emulsi, minyak biji jinten hitam, Nigella sativa Linn, stabilitas fisik, O/W,ujikesukaan Formulasi dan uji ..., Kurniawan Pambudi, FMIPA UI, 2013
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FORMULASI DAN UJI STABILITAS FISIK
SEDIAAN EMULSI MINYAK BIJI JINTEN HITAM
(Nigella sativa Linn.)
Kurniawan Pambudi
Laboratorium Teknologi Farmasi Fakultas Farmasi
Universitas Indonesia, Depok, 16424
ABSTRACT
The black seeds cumin oil known to have efficacy as medicinal herbs having peculiar odor
and taste. Hence preparation made emulsify oils black seeds cumin type O/W. This study
aims to cover odor and taste and knowing stability emulsion preparation of black cumin
esktract (nigella sativa linn) with emulgator span 80 and tween concentration with variations
20%, 50% and 70% of the oil of cumin black seeds in preparation. Evaluation volume
discontinuous, conducted include viscosity, size of particles, the physical stability pH levels
and determination. The evaluation of emulsion with concentration emulgator 70% having
good stability. This formula could prove the odor and taste of black seeds cumin oil.
Badarinath, A., Rao, K.M.,Chetty, C.M., Ramkanth, S.,Rajan, T., & Gnnaprakash, K.(2010). A Review on In-vitroAntioxidant Methods:Comparisions, Correlation, andConsiderations. InternationalJournal of PharmTech ResearchVol. 2, No. 2, 1276-1285.
Formulasi dan uji ..., Kurniawan Pambudi, FMIPA UI, 2013
Bagchi, K., & Puri, S. (1998). FreeRadicals and Antioxidants inHealth and Disease. Eastern
Mediterranean Health JournalVolume 4 Issue 2, 350-360.
Bhatt, P., & S. Madhav, S. (2011). ADetailed Review onNanoemulsion Drug DeliverySystem. International Journalof Pharmaceutical Sciencesand Research Vol 2, 2482-2489.
Burits, M., & Bucar, F. (2000).Antioxidant Activity of Nigellasativa Essential Oil.Phytotherapy Research 14, 323-328.
Departemen Kesehatan RepublikIndonesia. (1979a). MateriaMedika IndonesiaJilid III.Jakarta: Departemen KesehatanRepublik Indonesia, 112-117.
Departemen Kesehatan RepublikIndonesia. (1979b).Vademenkum Bahan Obat Alam.Jakarta: Departemen KesehatanRepublik Indonesia, 99-100.
Departemen Kesehatan RepublikIndonesia. (1995). FarmakopeIndonesia Edisi IV. Jakarta:Direktorat Jenderal PengawasanObat dan Makanan RepublikIndonesia
Djajadisastra, J. (2004). CosmeticStability. Departemen FarmasiFakultas Matematika & IlmuPengetahuan Alam UniversitasIndonesia. Depok: SeminarSetengah Hari HIKI.
Hydrocolloids 25, 1327-1336.El-Beshbishy, H. A., Mohamadin, A.
M., & Abdel-Naim, A. B.(2009). In Vitro Evaluation ofthe Antioxidant Activities ofGrape Seed (Vitis vinifera)Extract, Blackseed (Nigellasativa) Extract, and Curcumin.Journal of Taibah UniversityMedical Science 4(1), 23-35.
El-Tahir, K. E.-D., & Bakeet, D.M. (2006). The Black SeedNigella sativa Linnaeus - AMine for Multi Cures: A Pleafor Urgent Clinical Evaluationof Its Volatile Oil. J T U MedSc1, 1-19.
Fanun, M. (2010). Colloids in DrugDelivery. Florida: CRC Press.
Fletcher, J. (2012). Making theConnection - Particle Size, SizeDistribution, and Rheology.CHEMIE.DE InformationService GmbH.
Harmita. (2006). Buku Ajar AnalisisFisikokimia. Depok: DepartemenFarmasiFMIPA UI, 16-39.
Haq, A., Abdullatif, M., Lobo, P. I.,Khabar, K. S., Sheth, K. V., &Al-Sedairy, S.T. (1995).Nigellasativa: Effect on HumanLymphocytes andPolymorphonuclear LeukocytePhagocytic Activity.Immunopharmacology30, 147-155.
Hutapea, J.R. (1994). InventarisTanaman Obat Indonesia(III). Jakarta: DepartemenKesehatan RI Badan Penelitian& Pengembangan Kesehatan.
Kelmann, R. G., Kuminek, G.,Teixeira, H. F., & Koester, L.S. (2007).CarbamazepineParenteral NanoemulsionsPrepared by SpontaneousEmulsification Prosess.International Journal ofPharmaceutics 342, 231-
Formulasi dan uji ..., Kurniawan Pambudi, FMIPA UI, 2013
239.
Koocheki, A., & Kadkhodaee, R.(2011). Effect of Alyssumhomolocarpum Seed Gum,Tween 80, and NaCl onDroplets Characteristics, FlowProperties, and PhysicalStability of UltrasonicallyPrepared Corn Oil-in-WaterEmulsions. Food Hydrocolloids25, 1149-1157
Kress, H. (2011).http://www.henriettesherbal.com/files/images/photos/p09/nigella-sativa-3.jpg
Lide, D. R. & Haynes, W. M. (2010).CRC Handbook of Chemistry andPhysics 90th edition. Florida :CRC Press Lockwood, B.(2007). Nutraceuticals SecondEdition. Illinois: PharmaceuticalPress
Martin, A., J., & Cammarata, A.(1983). Farmasi Fisik Jilid IIedisi ketiga terjemahan. dariPhysical Pharmacy oleh Joshita.Jakarta: UI Press, 1154,1077- 1096.
Marxen, K., Vanselow, K. H.,Lippemeier, S., Hintze, R.,Ruser, A., & Hansen, U.-P.(2007). Determination ofDPPH Radical OxidationCaused by Methanolic Extractsof Some Microalgal Speciesby Linear Regression Analysisof SpectrophotometricMeasurements. Sensors 7, 2080-2095.
Mason, T. G., Wilking, J. N., Meleson,K., Chang, C. B., & Graves, S.M. (2006). Nanoemulsions:Formation, Structure, andPhysical Properties. Journal ofPhysics: Condensed Matter 18,635-666.
Meyer, L. H. (1976). FoodChemistry. Michigan: VanNostrand Reinhold Company.
Molyneux, P. (2004). The Use of theStable Free RadicalDiphenylpicrylhydrazyl (DPPH)for Estimating AntioxidantActivity. Songklanakarin J.Sci. Technol. 26(2), 211-219.
Myers, R. L. (2004). The IC50 Ratingfor Antioxidant Effectiveness.eBytes Issue8 CNC copyright, 1-3.
Nickavar, B., Mojab, F., Javidnia,K., & Amoli, M. A. (2003).Chemical Composition of theFixed and Volatile Oils ofNigella sativa L. from Iran. Z.Naturforsch 58c, 629-631.
Pantone. (2011). Pantone Calibrated.Pantone Inc. www.grafiport.com
Piao, J.& Adachi, S. (2006). Stabilityof O/W Emulsions PreparedUsing Various MonoacylsugarAlcohols as an Emulsifier.Innovative Food Science andEmerging Technologies 7, 211–216.
Powers, S. K., Deruisseau, K. C.,Quindry, J., & Hamilton, K. L.(2004). Dietary Antioxidants andExercise. Journal of SportsSciences, 81-94.
Ramadan, M. F. (2007).Nutritional Value,FunctionalProperties and NutraceuticalApplications of Black Cumin(Nigella sativa L.): anOverview. International Journalof Food Science and Technology42, 1208-1218.
Ramadan, M. F., Kroh, L. W., &Morsel, J.-T. (2003). RadicalScavenging Activity of BlackCumin (Nigella sativa L.),Coriander (Coriandrum sativumL.), and Niger (Guizotiaabyssinica Cass.) Crude SeedOils and Oil Fractions. Journalof Agricultural and FoodChemistry 51 (24), 6961–6969.
Rao, J. & McClements, D.J. (2011).
Formulasi dan uji ..., Kurniawan Pambudi, FMIPA UI, 2013
Formation of Flavor OilMicroemulsions, Nanoemulsionsand Emulsions: Influence ofComposition and PreparationMethod. Journal of Agriculturaland Food Chemistry 59, 5026–5035.
Rieger, M.M. (1994). Emulsi. Dalam :Lachman. L., H.A. Lieberman,& J.L. Kanig. Teori dan PraktekFarmasi Industri I. Terjemahan:Siti Suyatmi. UI Press. Jakarta :1029-1081.
Salager, J. R., Marquez, L., Mira,I., Perez, M., Ramirez, M.,Tyrode, E., Zambrano, N.,Choplin, L. (2001).Emulsification EfficiencyRelated to The Combination ofMechanical Energy Input andSystem Formulation andComposition Variables.International Symposium onMixing in Industrial Processes,280-284.
Salager, J. L., Andérez, J. M.,Briceño, M. I., de Sánchez, M.P., & de Gouveia,M.R.(2002).Emulsification YieldRelated to Formulation andComposition Variables as Wellas Stirring Energy. Rev. Téc.Ing. Univ. Zulia v.25 n.3Maracaibo dic., 1-16.
Salim, N., Basri, M., Rahman, M. B.,Abdullah, D. K., Basri, H., &Salleh, A. B. (2011). PhaseBehaviour, Formation andCharacterization of Palm-BasedEsters NanoemulsionFormulation containingIbuprofen. J NanomedicNanotechnol Vol 2 Issue 4, 1-5.
Sarma, A. D., Mallick, A. R., &Ghosh, A. K. (2010). FreeRadicals and Their Role inDifferent Clinical Conditions:An Overview. InternationalJournal of Pharma Sciences andResearch Vol.1(3), 185-192.
Shakeel, F., Baboota, S., Ahuja, A.,Ali, J., Aqil, M., & Shafiq, S.(2007). Nanoemulsions asVehicles for TransdermalDelivery of Aceclofenac. AAPSPharmSciTech, 191-199.
Silva, H. D., Cerqueira, M. A., Souza,B. W., Ribeiro, C., Avides, M.C., Quintas, M. A., Coimbra,J.S.R., Carneiro-da-cunha, M.W., Vicente, A.A. (2011).Nanoemulsions of b-CaroteneUsing a High-energyEmulsification– evaporationTechnique. Journal of FoodEngineering 102, 130–135.
Sultan, M. T., Butt, M. S., Anjum,F. M., Jamil, A., Akhtar, S., &Nasir, M. (2009). NutritionalProfile of Indigenous Cultivarof Black Cumin Seeds andAntioxidant Potential.Pak. J.Bot., 41(3), 1321-1330.
Talegaonkar, S., Azeem, A., Ahmad,F.J., Khar, R.K., Pathan, S.A. &Khan, Z.I. (2008).Microemulsions: A NovelApproach to Enhanced DrugDelivery. Recent Patents onDrug Delivery & Formulation,238-257.
Tubesha, Z., Iqbal, S., & Ismail, M.(2011). Effects of HydrolysisConditions on Recovery ofAntioxidants from MethanolicExtracts of Nigella SativaSeeds. Journal of MedicinalPlants Research Vol. 5(22),5393-5399.
Formulasi dan uji ..., Kurniawan Pambudi, FMIPA UI, 2013
Voight, R. (1995). Buku PelajaranTeknologi Farmasi Edisi 5.Yogyakarta: Gadjah MadaUniversity Press.
Wahyuni, S. (2009). Peluang Budidayadan Manfaat Jintan Hitam(Nigella sativa). Warta Penelitiandan Pengembangan TanamanIndustri Volume 15 No 1,23-25.
Widyaningsih, N. N., & Latifah, M.(2008). Pengaruh KeadaanSosial Ekonomi, Gaya Hidup,Status Gizi, dan Tingkat Stresterhadap Tekanan Darah. JurnalGizi dan Pangan 3 (1), 1-6.
Zaoui, A., Cherrah, Y., Mahassini,N., Alaoui, K., Amarouch, H.,& Hassar, M. (2002a). Acuteand Chronic Toxicity ofNigella sativa Fixed Oil.Phytomedicine 9, 69-74.
Zaoui, A., Cherrah, Y., Mahassini, N.,Alaoui, K., Amarouch, H., &Hassar, M. (2002b). Effects ofNigella sativa Fixed Oil onBlood Homeostasis in Rat.Journal of Ethnopharmacology79, 23-26.
Formulasi dan uji ..., Kurniawan Pambudi, FMIPA UI, 2013