Formative Assessment (29/06/2012)Top of
FormPage:1234(Next)Question 1 Marks: 1 An organism isolated from
the sputum of patient X, when stained with an acid-fast stain
appeared to be pink, thin, and beaded when observed under the
microscope. The MOST likely organism isChoose one answer. a.
Salmonella typhi
b. Escherichia coli
c. Treponema pallidum
d. Mycobacterium tuberculosis
e. Corynebacterium diptheriae
Question 2 Marks: 1 Which ONE of the following statements is
TRUE regarding the ovary and its function?Choose one answer. a. It
is located on the anterior aspect of broad ligament
b. Graafian follicles are situated in its medulla.
c. During ovulation, the oocyte separates along with theca
interna.
d. The oocyte has undergone two mitotic divisions before
ovulation.
e. Corpus luteum becomes dysfunctional 14 days after
ovulation.
Question 3 Marks: 1 A childhood viral infection which can result
in paralysis is preventable by vaccination. The causal agent is
transmitted primarily by the faecal-oral route. Which ONE of the
following is the MOST appropriate vaccine to prevent this
infection?Choose one answer. a. Bacillus Calmette -Guerin (BCG)
vaccine
b. Diphtheria, Pertussis and Tetanus (DPT) vaccine
c. Hepatitis B vaccine
d. Measles, Mumps and Rubella (MMR) vaccine
e. Oral polio vaccine (OPV /Sabin vaccine)
Question 4 Marks: 1 A study is performed to analyse the
characteristics of malignant neoplasms in biopsy specimens. Which
ONE of the following microscopic findings MOST likely indicates
that the neoplasm is malignant?Choose one answer. a.
Pleomorphism
b. Atypia
c. Metastasis
d. Increased Nuclear/ cytoplasmic (N/C) ratio
e. Necrosis
Question 5 Marks: 1 A 2-year-old child suffered from weakness of
the legs as a residual effect of poliomyelitis. Which ONE of the
following viruses is the MOST likely causal agent?Choose one
answer. a. Enveloped, complex, RNA virus
b. Enveloped, icosahedral, RNA virus
c. Naked, complex, RNA virus
d. Naked, icosahedral, RNA virus
e. Enveloped, helical, RNA virus
Question 6 Marks: 1 Body temperature can be increased by drugs
or chemicals that inhibit theChoose one answer. a. secretion of
thyroid hormones
b. the action of noradrenaline on blood vessels
c. binding of acetylcholine to muscarinic receptors.
d. formation of prostaglandins in the hypothalamus.
e. act of shivering.
Question 7 Marks: 1 Which ONE of the following characteristics
is TRUE about the mature cyst of Entamoeba histolytica?Choose one
answer. a. The cytoplasm is retracted from the cyst wall creating a
clear zone.
b. It has a distinct hyaline knob at the anterior end.
c. It is pear shaped with one nucleus.
d. It is elliptical with kidney shaped macronucleus.
e. It has 4 nuclei with evenly distributed peripheral nuclear
chromatin.
Question 8 Marks: 1 Antibiotic resistance is developed in
shigellae through the transfer of small fractions of DNA from the
donor to the recipient bacterial cell. Which ONE of the following
processes is MOST likely to be responsible?Choose one answer. a.
Conjugation
b. Mutation
c. Transduction
d. Transformation
e. Relocation
Question 9 Marks: 1 A housewife wanted to serve dinner to her
family. She decided that she wanted to finish some of the leftover
food in the refrigerator and remembered that she had some pickled
vegetables (acar) that she made three weeks ago. She took out the
acar and noticed that there was a bluish-black growth on top of the
acar. Which ONE of the following microorganisms is MOST likely to
be the growthcontaminating the acar?Choose one answer. a. Candida
albicans
b. Tinea species
c. Aspergillus species
d. Group A streptococci
e. Staphylococcus species
Question 10 Marks: 1 Which ONE of the following chemicals may be
both a disinfectant and a sterilant?Choose one answer. a.
Formaldehyde
b. Ethanol
c. Chlorhexidine
d. Iodine
e. Phenols
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Formative Assessment (29/06/2012)Top of
FormPage:(Previous)1234(Next)Question 11 Marks: 1 Which ONE of the
following changes would occur to the ovaries of a 23 -year -old
woman who has undergone hypophysectomy (removal of pituitary
glands)?Choose one answer. a. Hypersecretion of oestrogen
b. Hypersecretion of progesterone
c. Development of ovarian resistance against gonadotrophin
d. Reduction of the number of ovarian follicles.
e. Gonadal atrophy
Question 12 Marks: 1 A 32-year-old man presented with symptoms
of gastric ulcer. Gastric biopsy tissue cultured on enriched media
yielded Gram-negative, spiral-shaped bacteria. What is the MOST
likely causal agent of this patients illness?Choose one answer. a.
Campylobacter fetus
b. Helicobacter pylori
c. Spirillum minus
d. Vibrio cholerae
e. Yersinia enterocolitica
Question 13 Marks: 1 Oral antacids can bind to some drugs given
orally at the same time, thus preventing their absorption. This is
an example of aChoose one answer. a. pharmacodynamic drug
interaction.
b. drug with a narrow toxic therapeutic ratio.
c. drug causing enzyme inhibition.
d. pharmacokinetic drug interaction.
e. drug causing pharmacological antagonism.
Question 14 Marks: 1 Which ONE of the following statements is
TRUE regarding the germinal epithelium of the seminiferous
tubule?Choose one answer. a. It is a simple epithelium.
b. It has no basal lamina.
c. It is divided into two compartments by the processes of
Leydig cells (interstitial cells).
d. Late spermatids are in its basal compartment.
e. Secondary spermatocytes are in its adluminal compartment.
Question 15 Marks: 1 Which ONE of the following is responsible
for the formation of mesoderm?Choose one answer. a. Hypoblast
b. Notochord
c. Primitive streak
d. Trophoblast
e. Placenta
Question 16 Marks: 1 Aplasia of which ONE of the following
organs is incompatible with life?Choose one answer. a. Kidney
b. Lung
c. Adrenal
d. Pituitary
e. Testis
Question 17 Marks: 1 A young man is practicing for an important
upcoming sports event in the noon-day sun, and does not realize
that it was very hot. He noticed that he did not pass urine for
many hours after that. Which ONE of the following events had taken
place in his body?Choose one answer. a. There is fall in plasma
osmolality.
b. The extracellular fluid volume rises.
c. Anti-diuretic hormone (ADH) is released from the anterior
pituitary.
d. ADH is acting on the proximal convoluted tubules of the
kidney.
e. The membrane of the collecting ducts becomes permeable to
water.
Question 18 Marks: 1
These organisms are described as Gram positive bacteria with a
Chinese letter like formation. Which ONE of the following diseases
is MOST likely to be caused by these organisms?Choose one answer.
a. Cholera
b. Diptheria
c. Typhoid
d. Syphilis
e. Tuberculosis
Question 19 Marks: 1 The blood tends to pool at the lower limbs
and causes oedema in the passengers of a long flight. Which ONE of
the following factors would be increased to cause the oedema?Choose
one answer. a. Intravascular hydrostatic pressure
b. Interstitial fluid hydrostatic pressure
c. Intravascular oncotic pressure
d. Interstitial fluid oncotic pressure
e. Vascular permeability
Question 20 Marks: 1 Which ONE of the following characteristic
features is TRUE regarding Plasmodium malariae?Choose one answer.
a. The gametocyte is crescent shaped.
b. The infected red blood cell is larger than the normal
RBC.
c. The infected RBC is fimbriated and oval shaped.
d. The trophozoite stage is band-shaped.
e. The hypnozoites are found in the liver.
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Formative Assessment (29/06/2012)Top of
FormPage:(Previous)1234(Next)Question 21 Marks: 1 Which ONE of the
following is a metabolic effect of cortisol?Choose one answer. a.
Increased protein synthesis in extrahepatic tissues
b. Increased glycogenolysis in the liver
c. Increased gluconeogenesis in the liver
d. Increased triglyceride synthesis in the liver
e. Increased uptake of glucose by skeletal muscles
Question 22 Marks: 1 A 6-year-old child has attained the full
stature of an adult and the brain scan shows a tumour in the
pituitary. Which ONE of the following hormones is MOST likely to
have a direct effect on the bone?Choose one answer. a. Growth
hormone releasing hormone(GHRH)
b. Growth hormone(GH)
c. Insulin-like growth factor 1 (IGF-1)
d. Insulin
e. Platelet derived growth factor(PDGF)
Question 23 Marks: 1 Which ONE of the following statements is
TRUE regarding drugs having antagonistic actions?Choose one answer.
a. Competitive antagonists bind to a site different from the
agonist site.
b. Non-competitive antagonists are likely to bind covalently
with the receptor.
c. Competitive antagonists are not useful as drugs.
d. Non-competitive antagonists primarily affect the potency of
drug.
e. Inverse agonists do not have intrinsic activity.
Question 24 Marks: 1 Which ONE of the following conditions is
MOST likely to show rudimentary organs which are smaller than the
normal organ and lacking the full complement of cells?Choose one
answer. a. Hyperplasia
b. Neoplasia
c. Metaplasia
d. Hypoplasia
e. Dysplasia
Question 25 Marks: 1 A 50-year-old patient developed sepsis in
his superficial skin incision after a thoracic operation. The
causal organisms were Gram-positive and were from an endogenous
source. Which ONE of the following is the MOST likely cause of his
wound sepsis?Choose one answer. a. Bacteroides fragilis
b. Clostridium perfringens
c. Escherichia coli
d. Peptostreptococcus
e. Staphylococcus aureus
Question 26 Marks: 1 Which ONE of the following is the
predominant form of thyroid hormones found in the blood
circulation?Choose one answer. a. Thyroxine (T4)
b. Triiodothyronine (T3)
c. Monoiodothyronine (MIT)
d. Diiodothyronine (DIT)
e. Reverse T3
Question 27 Marks: 1 Transport of drugs across cell membranes is
reduced byChoose one answer. a. a high lipid solubility.
b. being unionized at environmental pH.
c. a passive diffusion process.
d. the P- Glycoprotein pump.
e. a small molecular size.
Question 28 Marks: 1 A study showed that the mean systolic blood
pressure of a group of students before sitting an examination was
raised. What could be the MOST likely factor that causes the rise
in the systolic blood pressure?Choose one answer. a. Increased
urination
b. Increased vasodilation
c. Increased breathing rate
d. Increased heart rate
e. Increased water intake
Question 29 Marks: 1 The strongest ligament which is responsible
for the maintenance of the uterus in its normal position within the
pelvic cavity is theChoose one answer. a. broad ligament.
b. round ligament.
c. uterosacral ligament.
d. transverse cervical ligament.
e. ovarian ligament.
Question 30 Marks: 1 One of the mechanisms by which bacteria
acquire drug resistance is through the development of an altered
metabolic pathway. Which ONE of the following drugs is this
mechanism of resistance MOST relevant?Choose one answer. a.
Chloramphenicol
b. Erythromycin
c. Penicillin
d. Sulphonamides
e. Tetracyclines
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Formative Assessment (29/06/2012)Top of
FormPage:(Previous)1234Question 31 Marks: 1 Cell X releases hormone
Y as it is synthesized. Stimulation on cell X causes a gradual rise
in plasma concentrations of hormone Y over a few days. Based on the
observation, what can you conclude about the nature of hormone
Y?Choose one answer. a. Protein
b. Polypeptide
c. Amine
d. Fatty acid derivative
e. Steroid
Question 32 Marks: 1 In bronchial asthma, relaxation of
bronchiolar smooth muscle can be achieved by a drug that
activates/stimulates theChoose one answer. a. alpha-1 adrenergic
receptor.
b. beta-1 adrenergic receptor.
c. beta-2 adrenergic receptor.
d. nicotinic cholinergic receptor.
e. muscarinic cholinergic receptor.
Question 33 Marks: 1 An increase in libido in both sexes is
contributed byChoose one answer. a. testosterone
b. dehydroepiandrosterone
c. progesterone
d. oestrogen
e. oxytocin
Question 34 Marks: 1 During the fight-or-flight reaction,
sympathetic stimulation results in widespread effects. Some of
these effects are mediated through alpha and some through beta
receptor stimulation. Which ONE of the following is an alpha
adrenergic effect?Choose one answer. a. Bronchoconstriction
b. Contraction of circular muscles of the iris
c. Vasoconstriction of blood vessels supplying the viscera
d. Increase in heart rate
e. Contraction of the radial muscles of gastro-intestinal
sphincters
Question 35 Marks: 1 Hepatic microsomal drug metabolizing
enzymes can be inhibited by Choose one answer. a. smoking
b. drinking grape fruit juice.
c. chronic alcoholism.
d. using herbs like St. Johns wort.
e. eating charbroiled (barbecued) meat.
Question 36 Marks: 1 A 45-year-old patient developed sepsis
after bowel surgery. The causal organisms which were isolated under
strict anaerobic culture were Gram-negative bacteria. What is the
MOST likely organism for the patients sepsis?Choose one answer. a.
Bacteroides fragilis
b. Clostridium perfringens
c. Escherichia coli
d. Pseudomonas aeruginosa
e. Peptostreptococcus
Question 37 Marks: 1 A 25-year-old HIV positive patient
presented to the family physician with recurring painful vesicular
lesions on the lips. The causal agent was an enveloped DNA virus.
Which ONE of the following is the MOST likely cause of the
vesicular lesions?Choose one answer. a. Adenovirus
b. Coxsackie virus
c. Herpes simplex virus
d. Papilloma virus
e. Kaposi sarcoma virus
Question 38 Marks: 1 Which ONE of the following is MOST likely a
physiological function of mediators formed by the cyclooxygenase
pathway of arachidonic acid?Choose one answer. 2 a. vasodilatation
by thromboxane (TxA2).
b. platelet aggregation by prostacyclin (PGI2).
c. increased gastric acid secretion.
d. reduction of intraocular pressure.
e. reduction of renal blood flow.
Question 39 Marks: 1 At which ONE of the following circumstances
the meiotic II division of the oocyte will be completed?Choose one
answer. a. Cleavage
b. Fertilization
c. Gastrulation
d. Implantation
e. Ovulation
Question 40 Marks: 1
The following bacteria were isolated from a patient suffering
from syphilis. These bacteria cannot be gram stained. Which ONE of
the following organisms cause this condition?Choose one answer. a.
Treponema pallidum
b. Mycobacterium tuberculosis
c. Salmonella typhi
d. Chlamydia trachomatis
e. Rickettsia prowazeki
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Formative Assessment (29/06/2012)Review of attempt 1Started
onFriday, 29 June 2012, 02:43 PM
Completed onFriday, 29 June 2012, 03:35 PM
Time taken52 mins 21 secs
Grade30 out of a maximum of 40 (75%)
Question 1 Marks: 1 An organism isolated from the sputum of
patient X, when stained with an acid-fast stain appeared to be
pink, thin, and beaded when observed under the microscope. The MOST
likely organism isChoose one answer. a. Salmonella typhi
b. Escherichia coli
c. Treponema pallidum
d. Mycobacterium tuberculosis Mycobacterium tuberculosis is
stained using the acid fast stain. Under the microscope it appears
pink, beaded and thin.
e. Corynebacterium diptheriae
CorrectMarks for this submission: 1/1.Question 2 Marks: 1 Which
ONE of the following statements is TRUE regarding the ovary and its
function?Choose one answer. a. It is located on the anterior aspect
of broad ligament
b. Graafian follicles are situated in its medulla.
c. During ovulation, the oocyte separates along with theca
interna.
d. The oocyte has undergone two mitotic divisions before
ovulation.
e. Corpus luteum becomes dysfunctional 14 days after ovulation.
The corpus luteum continues to secrete progesterone which produces
changes in the uterine wall for implantation. If fertilization does
not happen, it withers away 14 days after ovulation. This causes
reduction in progesterone level causing initiation of menstrual
bleeding.
CorrectMarks for this submission: 1/1.Question 3 Marks: 1 A
childhood viral infection which can result in paralysis is
preventable by vaccination. The causal agent is transmitted
primarily by the faecal-oral route. Which ONE of the following is
the MOST appropriate vaccine to prevent this infection?Choose one
answer. a. Bacillus Calmette -Guerin (BCG) vaccine
b. Diphtheria, Pertussis and Tetanus (DPT) vaccine
c. Hepatitis B vaccine
d. Measles, Mumps and Rubella (MMR) vaccine
e. Oral polio vaccine (OPV /Sabin vaccine) The vaccines listed
above form part of the childhood immunization programme. BCG and
DPT vaccines prevent bacterial infections. Hepatitis B, MMR, and
OPV vaccines prevent viral infections. Polio is transmitted
primarily by the faecal-oral route. The Oral polio vaccine (OPV) is
the appropriate vaccine to prevent this infection.
CorrectMarks for this submission: 1/1.Question 4 Marks: 1 A
study is performed to analyse the characteristics of malignant
neoplasms in biopsy specimens. Which ONE of the following
microscopic findings MOST likely indicates that the neoplasm is
malignant?Choose one answer. a. Pleomorphism
b. Atypia
c. Metastasis The ability of a neoplasm to metastasize is the
most important indicator of malignancy. The neoplasms initially
invade and later metastasize or spread to other places.
d. Increased Nuclear/ cytoplasmic (N/C) ratio
e. Necrosis
CorrectMarks for this submission: 1/1.Question 5 Marks: 1 A
2-year-old child suffered from weakness of the legs as a residual
effect of poliomyelitis. Which ONE of the following viruses is the
MOST likely causal agent?Choose one answer. a. Enveloped, complex,
RNA virus
b. Enveloped, icosahedral, RNA virus
c. Naked, complex, RNA virus
d. Naked, icosahedral, RNA virus Poliomyelitis is caused by
poliovirus types 1, 2 and 3 which belong to the picornaviridae
family which comprises naked, icosahedral, RNA viruses.
e. Enveloped, helical, RNA virus
CorrectMarks for this submission: 1/1.Question 6 Marks: 1 Body
temperature can be increased by drugs or chemicals that inhibit
theChoose one answer. a. secretion of thyroid hormones
b. the action of noradrenaline on blood vessels
c. binding of acetylcholine to muscarinic receptors.
Acetylcholine released by postganglionic sympathetic nerve endings
binds to muscarinic receptors in glands (including the sweat
glands) causing an increase in secretion. Inhibition of this
binding will reduce sweat secretion and subsequently the
evaporative heat loss. Decreased heat loss can raise the body
temperature, particularly if the person is already feverish.
d. formation of prostaglandins in the hypothalamus.
e. act of shivering.
CorrectMarks for this submission: 1/1.Question 7 Marks: 1 Which
ONE of the following characteristics is TRUE about the mature cyst
of Entamoeba histolytica?Choose one answer. a. The cytoplasm is
retracted from the cyst wall creating a clear zone. This morphology
is only seen in a mature cyst of Giardia lamblia.
b. It has a distinct hyaline knob at the anterior end.
c. It is pear shaped with one nucleus.
d. It is elliptical with kidney shaped macronucleus.
e. It has 4 nuclei with evenly distributed peripheral nuclear
chromatin.
IncorrectMarks for this submission: 0/1.Question 8 Marks: 1
Antibiotic resistance is developed in shigellae through the
transfer of small fractions of DNA from the donor to the recipient
bacterial cell. Which ONE of the following processes is MOST likely
to be responsible?Choose one answer. a. Conjugation
b. Mutation
c. Transduction Lysogenic conversion /transduction is mediated
by a bacteriophage.
d. Transformation
e. Relocation
IncorrectMarks for this submission: 0/1.Question 9 Marks: 1 A
housewife wanted to serve dinner to her family. She decided that
she wanted to finish some of the leftover food in the refrigerator
and remembered that she had some pickled vegetables (acar) that she
made three weeks ago. She took out the acar and noticed that there
was a bluish-black growth on top of the acar. Which ONE of the
following microorganisms is MOST likely to be the
growthcontaminating the acar?Choose one answer. a. Candida
albicans
b. Tinea species
c. Aspergillus species Aspergillus species are highly aerobic
and are found in almost all oxygen-rich environments, where they
commonly grow as molds on the surface of a substrate, as a result
of the high oxygen tension. Commonly, fungi grow on carbon-rich
substrates such as monosaccharides (such as glucose) and
polysaccharides (such as amylose). Aspergillus species are common
contaminants of starchy foods (such as bread and potatoes), and
grow in or on many plants and trees.
d. Group A streptococci
e. Staphylococcus species
CorrectMarks for this submission: 1/1.Question 10 Marks: 1 Which
ONE of the following chemicals may be both a disinfectant and a
sterilant?Choose one answer. a. Formaldehyde
b. Ethanol All the other options act as disinfectants only.
c. Chlorhexidine
d. Iodine
e. Phenols
IncorrectMarks for this submission: 0/1.Question 11 Marks: 1
Which ONE of the following changes would occur to the ovaries of a
23 -year -old woman who has undergone hypophysectomy (removal of
pituitary glands)?Choose one answer. a. Hypersecretion of
oestrogen
b. Hypersecretion of progesterone
c. Development of ovarian resistance against gonadotrophin
d. Reduction of the number of ovarian follicles.
e. Gonadal atrophy The gonadotrophin secretion will be absent if
the pituitary glands are removed. The gonads will regress if there
is no stimulation from the gonadotrophins chronically
(hypogonadodism).
CorrectMarks for this submission: 1/1.Question 12 Marks: 1 A
32-year-old man presented with symptoms of gastric ulcer. Gastric
biopsy tissue cultured on enriched media yielded Gram-negative,
spiral-shaped bacteria. What is the MOST likely causal agent of
this patients illness?Choose one answer. a. Campylobacter fetus
b. Helicobacter pylori The organisms stated are Gram-negative
bacteria. Helicobacter pylori is documented to be associated with
gastritis and gastric ulcer.
c. Spirillum minus
d. Vibrio cholerae
e. Yersinia enterocolitica
CorrectMarks for this submission: 1/1.Question 13 Marks: 1 Oral
antacids can bind to some drugs given orally at the same time, thus
preventing their absorption. This is an example of aChoose one
answer. a. pharmacodynamic drug interaction.
b. drug with a narrow toxic therapeutic ratio.
c. drug causing enzyme inhibition.
d. pharmacokinetic drug interaction. Pharmacokinetic
interactions between drugs can occur during absorption,
distribution, metabolism or excretion of drugs (ADME). This is an
example of an interaction during drug absorption.
e. drug causing pharmacological antagonism.
CorrectMarks for this submission: 1/1.Question 14 Marks: 1 Which
ONE of the following statements is TRUE regarding the germinal
epithelium of the seminiferous tubule?xChoose one answer. a. It is
a simple epithelium.
b. It has no basal lamina.
c. It is divided into two compartments by the processes of
Leydig cells (interstitial cells).
d. Late spermatids are in its basal compartment.
e. Secondary spermatocytes are in its adluminal compartment.
Secondary spermatocytes have haploid number of chromosomes. Thus
they are considered as foreign. Therefore they are located in the
adluminal compartment of the germinal epithelium and prevented from
coming into contact with antibody forming cells by the blood-
testes barrier
CorrectMarks for this submission: 1/1.Question 15 Marks: 1 Which
ONE of the following is responsible for the formation of
mesoderm?Choose one answer. a. Hypoblast
b. Notochord
c. Primitive streak Primitive streak appears on the midline of
the caudal half of the epiblast surface of the bilaminar germ disc.
Cells of the epiblast migrate in the direction of primitive streak
and on reaching the primitive streak the cells detach themselves
from the epiblast and invaginate between the epiblast and hypoblast
layer thus forming the mesoderm.
d. Trophoblast
e. Placenta
CorrectMarks for this submission: 1/1.Question 16 Marks: 1
Aplasia of which ONE of the following organs is incompatible with
life?Choose one answer. a. Kidney
b. Lung
c. Adrenal
d. Pituitary Aplasia or Agenesis is failure of development of
tissue or organ, which is a developmental abnormality that
presumably develops early in intra uterine life. Aplastic organs
are either totally absent or represented by small mass of fibrous
or fatty tissue containing a few rudimentary cells. In unpaired
organs like aplasia of aorta or pituitary, it is incompatible with
life.
e. Testis
CorrectMarks for this submission: 1/1.Question 17 Marks: 1 A
young man is practicing for an important upcoming sports event in
the noon-day sun, and does not realize that it was very hot. He
noticed that he did not pass urine for many hours after that. Which
ONE of the following events had taken place in his body?Choose one
answer. a. There is fall in plasma osmolality.
b. The extracellular fluid volume rises.
c. Anti-diuretic hormone (ADH) is released from the anterior
pituitary.
d. ADH is acting on the proximal convoluted tubules of the
kidney.
e. The membrane of the collecting ducts becomes permeable to
water. Antidiuretic hormone (ADH) binds to receptors on cells in
the collecting ducts of the kidney and promotes reabsorption of
water back into the circulation. In the absence of antidiuretic
hormone, the collecting ducts are virtually impermeable to water,
and it flows out as urine. Antidiuretic hormone stimulates water
reabsorption by stimulating insertion of "water channels" or
aquaporins into the membranes of kidney tubules. These channels
transport solute-free water through tubular cells and back into
blood, leading to a decrease in plasma osmolarity and an increase
osmolarity of urine.
CorrectMarks for this submission: 1/1.Question 18 Marks: 1
These organisms are described as Gram positive bacteria with a
Chinese letter like formation. Which ONE of the following diseases
is MOST likely to be caused by these organisms?Choose one answer.
a. Cholera
b. Diptheria Corynebacterium diphtheriae are the causative
agents of diphtheria. They are often described as having Chinese
letter- like formation.
c. Typhoid
d. Syphilis
e. Tuberculosis
CorrectMarks for this submission: 1/1.Question 19 Marks: 1 The
blood tends to pool at the lower limbs and causes oedema in the
passengers of a long flight. Which ONE of the following factors
would be increased to cause the oedema?Choose one answer. a.
Intravascular hydrostatic pressure When the blood pools at the vein
of the lower limbs due to muscle inactivity, the capillary pressure
which is equivalent to intravascular hydrostatic pressure will be
increased. This will promote fluid filtration and oedema.
b. Interstitial fluid hydrostatic pressure
c. Intravascular oncotic pressure
d. Interstitial fluid oncotic pressure
e. Vascular permeability
CorrectMarks for this submission: 1/1.Question 20 Marks: 1 Which
ONE of the following characteristic features is TRUE regarding
Plasmodium malariae?Choose one answer. a. The gametocyte is
crescent shaped.
b. The infected red blood cell is larger than the normal
RBC.
c. The infected RBC is fimbriated and oval shaped. The infected
RBC is fimbriated and oval shaped. This morphological feature is
seen only in Plasmodium ovale.
d. The trophozoite stage is band-shaped.
e. The hypnozoites are found in the liver.
IncorrectMarks for this submission: 0/1.Question 21 Marks: 1
Which ONE of the following is a metabolic effect of cortisol?Choose
one answer. a. Increased protein synthesis in extrahepatic
tissues
b. Increased glycogenolysis in the liver
c. Increased gluconeogenesis in the liver Cortisol is produced
by the adrenal gland in the zona fasciculata, the second of three
layers comprising the adrenal cortex. This release is controlled by
the hypothalamus, a part of the brain. It stimulates
gluconeogenesis (formation, in the liver, of glucose from certain
amino acids, glycerol, lactate and/or propionate)
d. Increased triglyceride synthesis in the liver
e. Increased uptake of glucose by skeletal muscles
CorrectMarks for this submission: 1/1.Question 22 Marks: 1 A
6-year-old child has attained the full stature of an adult and the
brain scan shows a tumour in the pituitary. Which ONE of the
following hormones is MOST likely to have a direct effect on the
bone?Choose one answer. a. Growth hormone releasing
hormone(GHRH)
b. Growth hormone(GH) GH would definitely have an effect on bone
but such effect is mediated by IGF -1.
c. Insulin-like growth factor 1 (IGF-1)
d. Insulin
e. Platelet derived growth factor(PDGF)
IncorrectMarks for this submission: 0/1.Question 23 Marks: 1
Which ONE of the following statements is TRUE regarding drugs
having antagonistic actions?Choose one answer. a. Competitive
antagonists bind to a site different from the agonist site.
b. Non-competitive antagonists are likely to bind covalently
with the receptor. Non-competitive antagonist can bind covalently
(irreversibly) to the same site as the agonist or to a different
site. Hence, increasing the concentration of the agonist cannot
overcome the blockade.
c. Competitive antagonists are not useful as drugs.
d. Non-competitive antagonists primarily affect the potency of
drug.
e. Inverse agonists do not have intrinsic activity.
CorrectMarks for this submission: 1/1.Question 24 Marks: 1 Which
ONE of the following conditions is MOST likely to show rudimentary
organs which are smaller than the normal organ and lacking the full
complement of cells?Choose one answer. a. Hyperplasia
b. Neoplasia
c. Metaplasia
d. Hypoplasia Hypoplasia is failure of organ to attain full
size. This is a less severe abnormality than aplasia. There are
rudimentary organs, smaller than normal that lack the full
complement of cells, so the function may be reduced. Usually
affects the same paired & unpaired organs as aplasia.
e. Dysplasia
CorrectMarks for this submission: 1/1.Question 25 Marks: 1 A
50-year-old patient developed sepsis in his superficial skin
incision after a thoracic operation. The causal organisms were
Gram-positive and were from an endogenous source. Which ONE of the
following is the MOST likely cause of his wound sepsis?Choose one
answer. a. Bacteroides fragilis
b. Clostridium perfringens
c. Escherichia coli
d. Peptostreptococcus Clostridium and Peptostreptococcus are
strict anaerobes and thus are unlikely in a superficial skin
wound.
e. Staphylococcus aureus
IncorrectMarks for this submission: 0/1.Question 26 Marks: 1
Which ONE of the following is the predominant form of thyroid
hormones found in the blood circulation?Choose one answer. a.
Thyroxine (T4) T4 is the major form of thyroid hormones
secreted
b. Triiodothyronine (T3)
c. Monoiodothyronine (MIT)
d. Diiodothyronine (DIT)
e. Reverse T3
CorrectMarks for this submission: 1/1.Question 27 Marks: 1
Transport of drugs across cell membranes is reduced byChoose one
answer. a. a high lipid solubility.
b. being unionized at environmental pH.
c. a passive diffusion process.
d. the P- Glycoprotein pump. P glycoprotein is the efflux pump,
situated at GI mucosa, biliary tree, blood brain barrier and renal
tubules. This pump transports drugs back to the original site and
reduces absorption.
e. a small molecular size.
CorrectMarks for this submission: 1/1.Question 28 Marks: 1 A
study showed that the mean systolic blood pressure of a group of
students before sitting an examination was raised. What could be
the MOST likely factor that causes the rise in the systolic blood
pressure?Choose one answer. a. Increased urination
b. Increased vasodilation
c. Increased breathing rate
d. Increased heart rate The sympathetic outflow to the heart
will be increased in an anticipatory period. This would raise the
heart rate and subsequently the blood pressure.
e. Increased water intake
CorrectMarks for this submission: 1/1.Question 29 Marks: 1 The
strongest ligament which is responsible for the maintenance of the
uterus in its normal position within the pelvic cavity is theChoose
one answer. a. broad ligament. Broad ligament is a peritoneal fold
covering the uterus and the fallopian tubes.
b. round ligament.
c. uterosacral ligament.
d. transverse cervical ligament.
e. ovarian ligament.
IncorrectMarks for this submission: 0/1.Question 30 Marks: 1 One
of the mechanisms by which bacteria acquire drug resistance is
through the development of an altered metabolic pathway. Which ONE
of the following drugs is this mechanism of resistance MOST
relevant?Choose one answer. a. Chloramphenicol
b. Erythromycin
c. Penicillin
d. Sulphonamides The sulphonamides develop resistance by
altering the metabolic pathway.
e. Tetracyclines
CorrectMarks for this submission: 1/1.Question 31 Marks: 1 Cell
X releases hormone Y as it is synthesized. Stimulation on cell X
causes a gradual rise in plasma concentrations of hormone Y over a
few days. Based on the observation, what can you conclude about the
nature of hormone Y?Choose one answer. a. Protein
b. Polypeptide
c. Amine
d. Fatty acid derivative
e. Steroid The steroid hormone is not stored in cells and is
usually released once synthesized and therefore the increase in the
hormonal levels may take days to happen. e.g. oestrogen.
CorrectMarks for this submission: 1/1.Question 32 Marks: 1 In
bronchial asthma, relaxation of bronchiolar smooth muscle can be
achieved by a drug that activates/stimulates theChoose one answer.
a. alpha-1 adrenergic receptor.
b. beta-1 adrenergic receptor.
c. beta-2 adrenergic receptor. beta-2 adrenergic receptors are
abundant in the bronchiolar smooth muscle. Activation/stimulation
of the beta-2 receptor leads to activation of adenylate cyclase,
increasing formation of cAMP and relaxation of smooth muscle.
d. nicotinic cholinergic receptor.
e. muscarinic cholinergic receptor.
CorrectMarks for this submission: 1/1.Question 33 Marks: 1 An
increase in libido in both sexes is contributed byChoose one
answer. a. testosterone Testosterone is secreted in large amounts
by the testes only in males. Therefore it is mainly responsible an
increase in libido in males but not in females.
b. dehydroepiandrosterone
c. progesterone
d. oestrogen
e. oxytocin
IncorrectMarks for this submission: 0/1.Question 34 Marks: 1
During the fight-or-flight reaction, sympathetic stimulation
results in widespread effects. Some of these effects are mediated
through alpha and some through beta receptor stimulation. Which ONE
of the following is an alpha adrenergic effect?Choose one answer.
a. Bronchoconstriction Sympathetic stimulation causes
bronchodilation.
b. Contraction of circular muscles of the iris
c. Vasoconstriction of blood vessels supplying the viscera
d. Increase in heart rate
e. Contraction of the radial muscles of gastro-intestinal
sphincters
IncorrectMarks for this submission: 0/1.Question 35 Marks: 1
Hepatic microsomal drug metabolizing enzymes can be inhibited by
Choose one answer. a. smoking
b. drinking grape fruit juice. Grape fruit juice inhibits
CYP3A4, which is the major microsomal enzyme responsible for
metabolism of drugs. When drugs are prescribed to patients who were
taking grapefruit juice, the drug metabolism is inhibited leading
to higher plasma concentration and toxicity.
c. chronic alcoholism.
d. using herbs like St. Johns wort.
e. eating charbroiled (barbecued) meat.
CorrectMarks for this submission: 1/1.Question 36 Marks: 1 A
45-year-old patient developed sepsis after bowel surgery. The
causal organisms which were isolated under strict anaerobic culture
were Gram-negative bacteria. What is the MOST likely organism for
the patients sepsis?Choose one answer. a. Bacteroides fragilis The
organisms stated are commensals of the intestinal tract and thus
can constitute a source of infection. Bacteroides is gram negative
and a strict anaerobe.
b. Clostridium perfringens
c. Escherichia coli
d. Pseudomonas aeruginosa
e. Peptostreptococcus
CorrectMarks for this submission: 1/1.Question 37 Marks: 1 A
25-year-old HIV positive patient presented to the family physician
with recurring painful vesicular lesions on the lips. The causal
agent was an enveloped DNA virus. Which ONE of the following is the
MOST likely cause of the vesicular lesions?Choose one answer. a.
Adenovirus
b. Coxsackie virus
c. Herpes simplex virus The viruses listed are DNA viruses
except Coxsackie virus, and can cause opportunistic infection in a
patient who is HIV positive with possible immunosuppression. Herpes
simplex virus presents with vesicular lesions on the lips known as
cold sores.
d. Papilloma virus
e. Kaposi sarcoma virus
CorrectMarks for this submission: 1/1.Question 38 Marks: 1 Which
ONE of the following is MOST likely a physiological function of
mediators formed by the cyclooxygenase pathway of arachidonic
acid?Choose one answer. a. vasodilatation by thromboxane (TxA2).
Thromboxane (TxA2) is a potent vasoconstrictor. Prostacyclin causes
vasodilatation.
b. platelet aggregation by prostacyclin (PGI2).
c. increased gastric acid secretion.
d. reduction of intraocular pressure.
e. reduction of renal blood flow.
IncorrectMarks for this submission: 0/1.Question 39 Marks: 1 At
which ONE of the following circumstances the meiotic II division of
the oocyte will be completed?Choose one answer. a. Cleavage
b. Fertilization Fertilization results in the completion of
meiotic II division. Meiosis is a process of cell division which
results in the division of diploid parental cell into haploid
progeny. Meiosis I is followed by meiosis II. Cell division
following meiosis I is asymmetrical, resulting in the production of
small polar body and an oocyte that retain its large size. The
oocyte then enters into meiosis II without having reformed a
nucleus or decondensed its chromosome. Most vertebrate oocytes are
arrested in metaphase II, where they remain until
fertilization.
c. Gastrulation
d. Implantation
e. Ovulation
CorrectMarks for this submission: 1/1.Question 40 Marks: 1
The following bacteria were isolated from a patient suffering
from syphilis. These bacteria cannot be gram stained. Which ONE of
the following organisms cause this condition?Choose one answer. a.
Treponema pallidum Treponema pallidum is the aetiological agent of
syphilis.
b. Mycobacterium tuberculosis
c. Salmonella typhi
d. Chlamydia trachomatis
e. Rickettsia prowazeki
CorrectMarks for this submission: 1/1.