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“Forget Antibodies. Use Aptamers!
10

“Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Dec 19, 2015

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Patrick Allison
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Page 1: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

“Forget Antibodies. Use Aptamers!”

Page 2: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Opportunity for Employer Savings

Smoking employee costs the Employer an additional ~$3,000/year

40 Million employees work for large self-insured Companies

Page 3: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Opportunity for Life Insurance

Quick Facts for Smoking Individuals:

Life Insurance Premium Increase= 50-65%

Life Insurance Policies = 10 Million annually (USA)

Page 4: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

The Problem of Testing for Tobacco Use

Tobacco Use

Nicotine Products

$2Results in minutes

Page 5: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Only anabasine detection available in the market: LC-MS

COST of Assay= ~$100Time = 1 day before Results

Trained Technician & Equipment needed

Anabasine is a definitive marker for Tobacco Use.

Nicotine products are negative for Anabasine.

Page 6: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Apta-basine™Test Strip (Y/N)

The Solution:

Quantify

Short-term Vision

Long-term Vision

Page 7: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Caffeine Theophylline

Apta-beacon™ (GQ-EXPAR)Demonstration Kit (Theophylline/Caffeine)

Selectivity:Distinguish just a few Atoms!

Current PlatformTest Strip

(Lateral Flow Platform)

ReconfigureColorimetric

Page 8: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.
Page 9: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Apta-basine™ Licensing Strategy

Apta-basine™Test Strip (Y/N)

$2/test X 50 million individuals =$100M Market

Page 10: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

“Forget Antibodies. Use Aptamers!”