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Some Basic Neuroanatomy
The Central Nervous SystemFigure 3.3: Central Nervous System Development
• Brain develops from a fluid-filled, tubular structure• Upper tube develops
into• Forebrain• Midbrain• Hindbrain• At 3 weeks: all equal in
• Mental representation of the world; working memory & temporal memory (order of events in time)
• Forming goals, anticipating consequences
• Considering options; applying knowledge & past emotions &
consequences to making choices/decisions
• Choosing & initiating goal-directed behaviors
• Self-monitoring your responses
• Correcting/adapting behavior in response to feedback or changes in context; inhibiting responses
• Attention & persistence towards goal despite distraction
• Prefrontal lobotomy cut the connections between this executive area and the rest of the brain/spinal cord
• https://www.youtube.com/watch?v=ftDGcCbkeH4
The Case of Phineas Gage
• Phineas had been a responsible, mild mannered, church-going family man before his accident.
• After afterwards he not only lost executive functions but his behavior & emotions were disinhibited.
MRI Reconstructions of Damage
• Phineas as well as many modern day frontal patients are also likely to lose their social sensitivity to others (lack of tact, empathy, conscience, caring about others)
A “Processing Unit” Within the Cortex is a Column of Cells
The Forebrain – Cortex. Figure 3.8: Lobes and Cortical Areas
20Garrett: Brain & Behavior 4e
The Brain is Like a Tootsie Pop
Some forebrain areas are
hidden beneath the cortex
See 235-236
The Basal Ganglia Motor System (see 361)
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Hypothalamus• Plays a role in lots of different basic behaviors/motivations
necessary for survival of individual & survival of the species
• The “four F’s”• Feeding
• Fighting (aggression & rage)
• Fleeing (fear behaviors)
• Mating : )
• But also primitive parenting behaviors, temperature regulation, hormone regulation, biorhythms & sleep, mood/emotions
The Hypothalamus
Means “beneath the thalamus”
The Brainstem Areas Again
The Thalamusworks closely with regions of cortex
• Best known for partially processing all incoming sensations except smell before passing input on to cortex
• Also has some motor, memory and emotional functions.
In Front of Hypothalamus is the“Basal Forebrain”
• Nucleus basalis activates cortex for consciousness and cognitive/memory function.
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Another component of the basal forebrain is the nucleus accumbens, a hub of our pleasure/reward pathway CSF is continually produced in all ventricles the heads towards the hindbrain to
exit thru the 4th ventricle roof to circulate around the outer surface of cord and
brain. It is finally reabsorbed into bloodstream at the center top of the brain
Ventricles Filled With CSF
Enlarged VentriclesDue to Hydrocephalus https://www.youtube.com/watch?v=WU
• The brain stem, especially its core, is the most primitive portion of our brain, relatively unchanged from the time that dinosaurs roamed the earth. Most reptile behavior is reflexive response to stimuli.
A Sadder Example• Anencephaly – forebrain fails to develop.
Baby has a flattened, open skull. Baby shows basic reflexive behaviors (can nurse, grasp, etc.) but with only hindbrain & midbrain structures intact, survival is brief (hours-days).
• An example of such reflexive behaviors in a normal infant
https://www.youtube.com/watch?v=lw-psbNU5XA go to :45
• Brain areas with lots of neuron cell bodies/dendrites look darker (“gray matter”) & function like information processors – receiving & combining input
• Areas with lots of myelinated axons appear lighter (“white matter”) & function like cables connecting regions
• A group of neuron cell bodies = “nucleus” (in CNS) or “ganglion” (in PNS)
• A bundle of axons = “tract” or “pathway” (in CNS) or “nerve” (in PNS)
• The CNS has a continuous fluid filled canal (or “ventricle” system throughout its length.
Afferent
Efferent
Spinal Reflexes Are Triggered Before Brain Experiences Sensation CNS is Protected by:
• Bone
• Meninges
• Layer of cerebrospinal fluid (CSF)
• Blood-brain Barrier
• But these protections have their limits!
The Meninges completely
enclose the CNS and help
protect it.
Dura
Arachnoid
Pia
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“-itis” = inflammationMeningitis= inflammation of meninges