Folic acid

Folic acid - +

T

T

C

Supplementary figure-1

m-CN-AGOH

RBDRaf -GFP

LimE-RFP

Supplementary figure-2

RBDRaf -GFP

LimE-RFP

p-CF3O-AGOH BzDMAOH

Folic acid - + - +

cT T c

T T

RBDRaf -GFP

LimE-RFP

p-iPr-AGOH AFOH

Tc c T

TTP-CF3 O-PGOH

Folic acid - + - +

m-CF3 O-PGOH

T

T

c

p-CF3O-PGOH

Folic acid - + - +

T

T

cRBDRaf -GFP

LimE-RFP

c T

RBDRaf -GFP

LimE-RFP

p-tBu-AGOH p-CF3S-PGOH

cT c T

TT

Folic acid - + - +

LimE-RFP

RBDRaf -GFP

Tc

T

p-PhO-AGOHFolic acid - +