FIXED DRUG ERUPTION DUE TO COMMON COLD MEDICATION CONFIRMED BY ORAL PROVOCATION TEST KEPANITERAAN KLINIK FAKULTAS KEDOKTERAN UNIVERSITAS TRISAKTI SMF ILMU KESEHATAN KULIT DAN PENYAKIT KELAMIN RUMKITAL Dr. MINTOHARDJO Made Ayu Intan Winayati Oka 030.09.1
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
FIXED DRUG ERUPTION DUE TO COMMON COLD MEDICATION
CONFIRMED BY ORAL PROVOCATION TEST
KEPANITERAAN KLINIK FAKULTAS KEDOKTERAN UNIVERSITAS TRISAKTISMF ILMU KESEHATAN KULIT DAN PENYAKIT KELAMIN
RUMKITAL Dr. MINTOHARDJO
Made Ayu Intan Winayati Oka 030.09.140
INTRODUCTION
22
1. Gendermalik SB, Galeckas KJ: Fixed drug eruptions: A case report and review of the literature. Cutis 2009,84:215-2192. Farshner J, Ericson K, Werner S: Treatment of the common cold in children and adults. Am Fam Physician 2012, 86: 153-159
• The most common reaction to oral sympathomimetics is non pigmenting fixed exanthema
• Medication induced fixed drug eruption has been confirmed by oral provocative test
7
3. Ozkaya E, Sevunc M, Asien E. Pseudoephedrine may cause pigmenting fixed drug eruption. Dermatitis 2011, 22:e7-94. Aberer W, Bircher A, Romano A, Blanca M, Campi P, Fernandez J (et al). Drug provocation testing in the diagnosis of drug hypersensitivity reaction: General considerations. Allergy 2003, 58: 854-863
• In Indonesia Pseudoephedrine as common cold medication usually sold in combination with other substances
• Diagnosis -> quite hard• Patients had a history of recurrent signs and
symptoms of FDE.• Time of taking the medication until symptoms
occur become increasingly fast and symptoms are also more intense.
8
• FDE characteristically recurs in the same site each time the drug is administered.
• Intraepidermal CD8+ T cells resident in the FDE lesions have a major contributory role in the development of localized tissue damage.
• Treatment includes stopping the offending drug with topical steroid and oral antihistamines.
9
5. Shiohara T. Fixed drug eruption: pathogenesis and diagnosis test. Curr Opin Allergy Clin Immunol 2009. 9: 316-3216. Dubey AK, Prabhu S, Shankar PR. Subish P, Prabhu MM, Mishra P. Dermatological adverse drug reactions due to systemic medications- a review of literature. Journal of Pakistan Association of Dermatologists 2006; 16: 28-38