FISHERIES RESEARCH BOARD OF CANADA Translation Series No. 2669 Biological studies on the nutritional value of edib_le,fats. Part III. Influènce of selected.fats on the morphological changes in various organs by Swiatoslaw Ziemlanski, Teresa Opuszynska, and Stefan Krus original title: Badania biologiczne wartosci zywieniowej tluszczow jadalnych. Czesc-III. Wplyw wybranych tluszczow na zmiany morfologiczne roznych narzadow From: Roczniki Panstwowego Zakladu Hygieny (Annals of the State Hygiene Institute), (6) . 685-694, 1972. Translated by the Translation Bureau.(^.MJK) Multilingual Services Division Departme nt of the Secretary of State of ,Canada Department of-the Environment. Fisheries Research Board of Canada Halifax Laboratorÿ' Halifax, N. •S . 197.3 16 pages typescript
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FISHERIES RESEARCH BOARD OF CANADA
Translation Series No. 2669
Biological studies on the nutritional value of edib_le,fats.Part III. Influènce of selected.fats on themorphological changes in various organs
by Swiatoslaw Ziemlanski, Teresa Opuszynska,and Stefan Krus
original title: Badania biologiczne wartosci zywieniowej
tluszczow jadalnych. Czesc-III. Wplyw wybranych
tluszczow na zmiany morfologiczne roznych narzadow
From: Roczniki Panstwowego Zakladu Hygieny (Annals of the
State Hygiene Institute), (6) . 685-694, 1972.
Translated by the Translation Bureau.(^.MJK)Multilingual Services Division
Departme nt of the Secretary of State of ,Canada
Department of-the Environment.Fisheries Research Board of Canada
Halifax Laboratorÿ'
Halifax, N. •S .
197.3
16 pages typescript
•
DEPAR.TMENT OF THE SECRETARY OF STATE
TRANSLATION BUREAU
SE/7RETARIAT
BUREAU DES TRADUCTIONS
MULTILINGUAL SERVICES DIVISION DES SERVICES
INTO — EN TRANSLATED FROb.1 — TRADUCTION DE
Polish English
DATE OF PUBLICATION DATE DE PUBLICATION
PAGE NUMBERS IN ORIGINAL NUMÉROS DES PAGES DANS
L'ORI GINAL
685-694 YEAR
ANNÉE
1972
ISSUE NO. NUMÉRO
6
NUMBER OF TYPED PAGES NOMBRE DE PAGES
DACTYLOGRAPHIÉES
16
VOLUME
PUBLISHER — ÉDITEUR
State Hygiene Institute
PLACE OF PUBLICATION LIEU DE PUBLICATION
Warsaw
PERSON REQUESTING DEMANDÉ PAR Dr. R.G.Ackman., Halifax Laboratory . \
Halifax, Nova Scotia. YOUR NUMBER VOTRE DOSSIER N 0
DATE OF REQUEST DATE DE LA DEMANDE —19../. 06.1_973
CANADA
DIVISION MULTILINGUES
AUTHOR AUTEUR
Swiatoslaw Ziemlanski, Teresa Opuszynska, Stefan Krus TITLE IN ENGLISH — TITRE ANGLAIS
Biological Studies on the nutritional value of edible fats. Part III. Influence of selected fats on the morphological changes in various organs.
TITLE IN FOREIGN LANGUAGE (TRANSLITERATE FOREIGN CHARACTERS) TITRE EN LANGUE ÉTRANGÉRE (TRANSCRIRE EN CARACTERES ROMAINS)
Badania biologiczne wartosci zywieniowej tluszczow jadalnych. Czesc III. Wplyw wybranych tluszczow na zmiany morfologiczne roznych narzadow.
REFERENCE IN FOREIGN LANGUAGE (NAME OF BOOK OR PUBLICATION) IN FULL. TRANSLITERATE FOREIGN CHARACTERS.
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Roczniki Panstwowego Zakladu Hygieny
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Annals of the State Hygiene Institute
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BRANCH OR DIVISION Fisheries Services Office of TRANSLATOR (INITIALS) Men( DIRECTION OU DIVISION TRADUCTEUR (INITIALES)
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DEPARTMENT. OF THE SECRETARY OF STATE
TRANSLATION BUREAU SECRÉTARIAT D'ÉTAT
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BUREAU NO. LANGUAGE TRANSLATOR (INITIALS) N ° DU BUREAU LANGUE TRADUCTEUR (INITIALES)
143913 Polish MJK 'JUL .2 3 1973
Roczniki Panstwowego Zakladu Hygieny ga l 1972, Nr.6. pp. 685-69+ (Annals of the State Hygiene Institute)
Swiatoslaw 2iemlanski, Teresa Opuszynska, Stefan Krus
Btolongal studies on the nutritional value of edible fats. Part III. Influence of selected fats on the mornhologi_n_e
chanm§ in various gnarans.
From the Institute of physiology and biochemIstry of nutrition in Warsaw. Manager: Assist. Prof. S. Ziemlanskl M.D.
From the DeDartment of pathological anatomy of the Institute of Biostrucure, Academy of Medicine in Warsaw. Manager e Assist , Prof. St. Krus MD.
Authors , English abstract
•
0 In 300 Wistar rats in long-term experiments (7 and 12 months) the effects ofe,, ;
MB, MC and MD) of different composition were studied (Table I). The conteiit .c*
' of erucic acid in these margarines ranged from 18% (MA) to 33 010 (MB), in liquid'
rapeseed oil it was 47.6% and in „oma" fat it was 37.1%. The animais received À.
ad libitum experimental diets containing 15% by weight of one of these fats. One
group of rats was kept on granulated laboratory choi.v „Bacutil" containing only
7% kcal of fat. Gross and histological examinations of the liver, kidneys, spleen, adrenals,
testicles, pancreas, myocardium and small intestine i.vere carried out. The degree
of fatty degeneration of these organs i.vas studied, staining specimens with oil red
0, fat red 7B, and sudan III. The degree of fatty degeneration of the liver was
determined using Thaler's staging system. No pathological changes were found
• in the organs examined, with the exception of the heart. In the myocardium of
;
animais receiving liquid or hardened rapeseed oil and experimental margarines with higher contents of erucic acid in diet focal infiltrations with histiocytes and fibrosis were found. These changes increased in intensity after 12 months of the
experiment (Table IV), e.g. in the group receiving liquid rapessed oil after 7 months
; on diet in 8 of 9 rats (88.9%) cardiac changes were found, and after 12 months ,
changes developed in 17 of 19 (89.5%) rats in this group Such changes are an evidence of microfocal myocardial necrosis. •
• •.•••2 305-200-10-31 *Translatorts note: the number in the right margin is the
page number of the original text.
0 A . e 0
t;•4; _ , rapeseed oil — liquid as well as hardened (orna) and experimental 'margarines (Mig',
Fig.2. Heart muscle. Dark sections of the fibers in the uppertop of the picture are proof of necrosis or necrobiosis ofthe muscle. Histiocytes are accumulated in the vicinity.H.E. magn. 300 x.
Fig.3. Granuloma composed of histiocytes among muscle fibres.H. E. magn. 300x.
Fig.4. Fibrosis of the heart muscle (centre of picture),remains of histiocyte infiltration (centre of pictureon left). H.E. magn. 30Gx.
The histopathological picture becomes somewhat
intensified after 12 months of administering experimental
margarines or rape seed oil. The greatest intensification of
the changes ( 89.5%) was noted in the group of animals obtaining
rape seec' oil. These data are illustrated in Table IV.
In the control group, i.e. the breed;ng group,
pathological changes were not observed after experiments
0 0 0 0 . 1 4
-
lasting 7 and 12 months.
In the group of animals obtaining butter, 2 cases
of occurrence of small granulomas for 14 rats examined (i.e.
were established after 7 months, and 2 cases for 24
rats (i.e. 8.3%) after 12 months.
In many animais of all the groups studied,
occurrence of changes in the mucous membrane of the intestine
was noted; these consisted in shortening and widening of the
infiltration of acid-absorbing lymphocytes and
granulocytes in the stroma of the villi, and fibrosis of the
villi. These changes became intensified after 12 months of
experiments. This problem requires further investigation, in 692
order to clarify whether the changes found in rats occur with
age, or whether the quantity and quality of the fat and the
kind of diet have a direct influence on the occurrence of this
kind of disorders.
Discussion of the results
It follows from the macroscopic and micro-
scopic anatomo-pathological examinations of various organs of
rats, to which experimental margarines of various composition
as well as liquid and solidified rape seed oil /7ere administered
in the diet, that the most substantial deviations from the
normal conditions were established in the heart muscle. There
is a strict relationship between the occurrence of morphological
changes in this organ and the content of erucic acid in the diet. *Translator's note: page 693 - Russian abstract - omitted.
English abstract - see first page of translation.
.15
- .11
The occurrence in the heart muscle of focal
necrotic changes should be connected with the impossibility
of a regular metabolic conversion of the erucic acid.
Investigations of many authors (3,6,10,11,12,17,18) and our
own (unpublished data) indicate the occurrence of fatty
degeneration of the heart and accumulation of erucic acid
in this organ. These changes appear in the first place in
young animals. It is worth noting that Beare-Rogers (18)
achieved fatty degeneration of the heart muscle in young
animals also after application of larger quantities of fish
fat, the so called herring oilj in the diet. This fat is
characteristic by its large content of monounsaturated
long-chain fatty acids. However the fatty degeneration of
the heart never reaches as high intensity as after administering
rape seed oil in the diet.
The appearance in the heart muscle of micro-
focal granulomas, similar to those which occur after applic-
ation of rape seed oil in the diet, was determined by us in
our investigations after administering to the animals in the
diet a major quantity of the theobroma oil-like fat used in
some countries as a substitute for cocoa butter in the
manufacture of chocolate products.
One can conclude hence that microfocal necrotic
changes of the heart muscle may occur as a result of inferior
metabolic conversion of certain fats and oils. The mechanism
of these changes is the subject of further investigations.
Olszewska Buclzenska-Topoloieslca J.: Badania biologiczne wartogci iywienio- wej tluszczôw jadalnych. CzOé I. Roczniki PZI-1, 22, 4, 1972. — 2. zierniafiski e., Bullzak,-Jachyniczyk. B•, Kucharczyk B., Rusiecka M., Opuszyziska T., Budzwisk- -Topolowska J.: Badania biologiczne 1.vartoci iywieniowej tluszczôw jadalnych.
• CzeU II. Roczniki PZFI, 22, 5, 1972. — 3. Bear J., Jensen B.: J. Nutr., 1947, 03, 339 • — 4. Thornasson H. J.: J. Nutr., 1955, 56, 455. — 5. Thornasson H. J.: J. Nutr., 1955, 56, 455. -- 6. Roine P., Uksila E., Teif "M., Rapo/a J.: Z. Ernahr. Wiss., 1960, .1, 118. — 7. Thornasson H. J., Gottenbos J., van Pijpen P. L., Vies R. 0.: Zesz. Probl. Post. N. RoIn., 1970, z. 91, 381. — 8. Rocquelin G., Cluzan Zcsz. Probl. Post. N. RoIn., 1970, z. 91, 403. — 9. .Ttocqzâire G., Chtzan R.: Ann. Biol. Anim. Bioch. Biophys., 1968, 8, 395. — 10. ex/el/a/if A. M. M.;. Vles R. 0.: Nutr. and IVIetabol., 1970, 12, 285.
11. Abdellatif A. M. M., Vies R. 0.: Nutr. and Metabol., 1970, 12, 305. — 12. Abdellatif A. M. M., Vies R. 0.: Nutr. and Nletabol., 1971, 13, 65. — 13.. Zion/b-e/a Zesz. Probl. Polst. N. Roln., 1970, z. 91, 420. — 14. Ziemlediski Opuszyi-ska T., Rusieeka M.: Zesz. Probl. Post. N. Roln., 1970, z. 91, 425. — 15. Nikonorunz
. M., FIomrowski S.: Roczn. Wojsk. Inst. Hig. Epid., 1965, 4, 39. — 16. Honirowski S.: J. Nutr. Dietet., 1969, 6, 22. — 17. Walker B. L., Zall S. P., Slinger S. J., Bayley H. S.: Pr‘ocedings International Rapeseed Conference Ste. Adéle, Quebec, Canada- September 20-23, 1970, str. 377. — 18. Beare-Rogers J. L.i Procedings International Repeseed Conference. Ste. Adéle, Quebec Canada, September 20-23, 1970, str. 450. — 19. Thaler II.: Gastroenterologia, suppl. 1961, 95, 2-16.
• 14.V.1972 r.
Warszawa, ul. Powsitiska 63.
Translated items:
Ziemlanski et al. Biological studies of the nutritional value
of edible fats Part I. Annals of the State Hygiene Institute 22, 4, 1972.
2. Ziemlanski et al. Biological studies of the nutritional
value of edible fats. Part II. Annals of the State Uygiene Institute 22, 5, 1972.