ATR 2511 VPFRLTH NMVNGMGP MGTEGLFRRACEV TMRLMRDQR EPLMSVLKTFLHDPLVEWSKPVK 2570 ATM 2906 VPFRLTR DIVDGMG ITGVEGVFRRCCEK TMEVMRNSQ ETLLTIVEVLLY DPLFDWTMNPL 2965 DNA-PKcs 3959 MPFRLTRQFINLML PMKETGL MYSIMVHA LRAFRSDPGL LTNT MDVFVKEPSFDWKNFEQ 4018 mTOR 2375 IPFRLTR MLTNAMEV TGLDGN YRITCHTV MEVLREHK DSVMA VLEAFVY DPLLNWRLMDT 2424 ATR 2571 GH----------SKAPLNE TG EVVN------------------------------- EKAK 2589 ATM 2966 KALYLQQRP--EDETELHP TLNAD D--------------------QECKRNLSDIDQSFN 3003 DNA-PKcs 4019 KMLKKGGSWIQEINVA EKNWYPRQKICYAKRKLAG -----ANPAVITCDELLLGHEKAPA 4073 mTOR 2435 NTKGNKRSRTRTDSYSAGQ SV EILDGVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALN 2494 ATR 2590 T HVLDIEQ RLQGVI KTRNRVTGLP LSIEG HVHYLI QEATDENL LCQMYLGWTPYM 2644 ATM 3004 KVAERVL MRLQEKL KG--VEEGTV LSVG GQVNLLI QQAIDPK NLSRLFP GWKAWV 3056 DNA-PKcs 4074 F RDYVAV ARGSKDHNI RAQEPESG LSEE TQVKCLM DQATDPNI LGRTWE GWEPWM 4128 mTOR 2495 KKAIQII NRVRDKL TGRDFSHDDT LDVPT QVELLI KQATSHE NLCQCYIGWCPFW 2549 A B * H. sapiens 204 T KLQTS--ERAN K LAAPSVSH VSPR KNPSVV IK PEAC S-PQF GKT SFPT KESFSANMS LP 259 B. taurus 201 T KLQSS--ERAN K LAVPTVSH VSPR KSPSVV IK PEAC S-PQF GKP SFPT KESFSANKS LP 257 M. musculus 204 T KSQSN--GRTN K PAAPSVSH VSPR KGSSVV LK SEAC S-PHV GKT TFPT KESFSANTP LF 259 R. norvegicus 204 T KLQSN--ERTN K LTIPSVSQ VSPR KGSSVV VK SEAC S-PHV GKT TFPT KESFSANTP LF 259 X. laevis 233 T KLQNC--ERSN R TSVP---V VSPK KSPSKG LK SEAC SSPLP GRS SFPT KESFCSDMN LR 287 D. rerio 171 T QAQSDREKELS R KVQSLQSE LHFK EAEMNE MR GKLQ SVERG GKQ SG-T PARQAVKSP LS 229 H. sapiens 260 HPCQTESGYKPLVGREDSK --PHSLRGDSIKQ---EEAQKSFVDSWRQRSNTQ GSILINL 315 B. taurus 258 QPCQTEPAYKSPMSREVAENKVHSLGGGPIKQ ---EEPQKSLLDSWR --SNNQ GSILINL 312 M. musculus 260 HPCQTEAGHRFLVGQEVSDNKNHSLGGSLMKQ ---DVQQRILADGWMQRKDAQ GSILINL 317 R. norvegicus 260 HPCQTEAGHKFLVGQEVSDNKAHVGG -NLLKQ---DVQQKILTDSWVQRKNTQ GSILINL 316 X. laevis 288 TPPLISAQIGPRTPVISKEPEALPMSSKTFSS ----------- FFYAQRKNSQ GSLLLNA 336 D. rerio 230 RTFMTKENFSAEISKRTSPVKPGPSSDNAALSRCLLPEEQRSQQCIASDLQKE GCVLLKL 289 H. sapiens 316 LLKQPLIPGSS LS LCHLLS SSS ESPAGTPLQPP 348 B. taurus 313 LLKQPLIPGSP LG LCHLLS SCP EAPAGTQFQLP 345 M. musculus 318 LLKQPLVPGSS LG LCHLLS SCP EVPTGTLLQPP 350 R. norvegicus 317 LLKQPLVPGSS LG LCHLLS SGA EVPTGPILQPA 349 X. laevis 337 LMQQPICPG-SLG LCNLLS SSTESLPGSPGRNA 369 D. rerio 290 LLQQPLDP-SVLG LCHLLS ISP DALPNMLTQHG 322 Figure S1. Sequence alignments of ATRIP and ATR TopBP1 interacting regions. A) Alignment of the minimal TopBP1 interacting region of human ATRIP and ATRIP homologs of the indicated species. The solid line indicates the position of the ATRIP-top mutation. B) Alignment of the C-terminus of human PIKK family members. The solid line denotes the C-terminal end of the phosphoinositide 3-kinase-related kinase domain. The dotted line overlies the highly conserved FATC (FRAP, ATM, TRRAP C-terminal) domain. The PIKK Regulatory Domain (PRD) is between the kinase domain and the FATC domain. The ATR PRD and the ATM PRD are predicted to contain an -helix 30 amino acids long. The asterisk denotes the location of ATR lysine 2589.
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Figure S1. Sequence alignments of ATRIP and ATR TopBP1 ...genesdev.cshlp.org/content/suppl/2008/05/21/22.11.1478.DC1/... · mtor 2375 ipfrltr mltnamev tgldgn yritchtv mevlrehk dsvma
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