Fibroblast growth factor signals as potential molecular targets in synovial sarcoma. Tatsuya Ishibe, Tomitaka Nakayama, Takeshi Okamoto, Tomoki Aoyama, Koichi Nishijo, Satoshi Nagayama, Takashi Nakamura, and Junya Toguchida Department of Orthopaedic Surgery and Surgery, Institute for Frontier Medical Sciences, Kyoto University, Japan
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Fibroblast growth factor signals as potential molecular targets in synovial sarcoma.
Fibroblast growth factor signals as potential molecular targets in synovial sarcoma. Tatsuya Ishibe, Tomitaka Nakayama, Takeshi Okamoto, Tomoki Aoyama, Koichi Nishijo, Satoshi Nagayama, Takashi Nakamura, and Junya Toguchida Department of Orthopaedic Surgery and Surgery, - PowerPoint PPT Presentation
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Gene expression profiling of 47 soft tissue sarcomas
by cDNA microarray (23,040 genes)
Identified 26 genes as up-regulated genes
commonly in synovial sarcomas,
including Fibroblast Growth Factor 18 gene
FGF
polypeptide growth factors, a large family with 22 members which share 120 amino acids.
FGF receptor (FGFR)
FGF binds one of five subtypes of FGFR, inducing the tyrosine kinase activity, and transmit the signal by sequential phosphorylation of down-stream kinases. Function
cell growth, angiogenesis, differentiation, etc.
Association with tumor
FGF3, 4, 5: originally reported by transforming activity FGF8: prostate and breast cancer
Fibroblast Growth Factor (FGF)
FGFR
FGF
Auto-phosphorylation
Signal transduction
ObjectivesObjectives
To investigate the role of FGF signal in synovial sarcoma (SS),
and to evaluate the therapeutic effect of FGFR inhibitors.