Ferran Sanz – GRIB Research Programme on Biomedical Informatics (GRIB)
Dec 19, 2015
Ferran Sanz – GRIB
What is the GRIB?
• GRIB is a research programme of both Universitat Pompeu Fabra (UPF) and IMIM.
• IMIM is the research institute ofHospital del Mar (PSM)and it is academically affiliated to the UPF.
• GRIB is located in the Biomedical Research Park of Barcelona (PRBB).
• GRIB is also the Biomedical Informatics node of the Spanish Institute of Bioinformatics (INB).
TICs and computational approaches are mandatory tools for managing and exploiting the immense amounts of data that are currently generated in the biomedical research (experimental, clinical, epidemiological).
Mission:
To invent, develop and apply computational methods that, through an intensive use of and information technologies, allow a better understanding and prediction of biological phenomena, giving especial emphasis to those related to the human diseases and their treatment.
GRIB Mission
Ferran Sanz – GRIB
GRIB themes and organisation
GRIB is organised in six thematicin silico labs:
Computational Genomics: Computational analysis of genomic sequences and information. PIs: M. Albà, E. Eyras, N. Lopez-Bigas & R. Castelo.Structural Bioinformatics:Analysis and modelling of protein structures and interactions. PI: B. Oliva.Computational Biochemistry and Biophysics:Modelling and simulation of biophysical and biochemical phenomena at molecular and systemic scales. IPs: J. Villà-Freixa and G. de Fabritiis.Chemogenomics: Computational annotation and analysis of massive molecular DBs vs. protein families showing therapeutic interest. IP: J. Mestres.Computer-Assisted Drug Design:Molecular modelling and multivariate statistical analysis in the drug R&D. IPs: M. Pastor, J. Selent & I. Zamora (part time)Integrative Biomedical Informatics:Integrative knowledge management in biomedical research. IP: F. Sanz.+Management office.Manager: C. Donlo
Ferran Sanz – GRIB
The GRIB team
The GRIB staff is a multidisciplinary team of +70 professionals (+20PhDs), which includes:
• biologists,• pharmacists,• chemists,• physicians,• computer scientists,• mathematicians• research management staff
Ferran Sanz – GRIB
GRIB publications in SCI journals 2005-2009
27 29 27
3834
0
5
10
15
20
25
30
35
40
2005 2006 2007 2008 2009
Total no. of the period: 155
GRIB research outcomes
* Without including Complex System Lab. publications
Ferran Sanz – GRIB
GRIB research outcomes
Quartil distribution of the journals of GRIB publications(SCI classification)
2005 - 2009
22
3126
11 0
11
2326
0
5
10
15
20
25
30
35
40
2005 2006 2007 2008 2009
Q1 Q2 Q3 Q4
• Average IF of the journals of GIB publications (2005-09): 5.33
• No. of citations of papers published in 2005-07: 1668
Ferran Sanz – GRIB
• GRIB develops open source and proprietary software that is internationally recognised.
• GRIB research has generated two spin-off:
• Pharmatools
• Chemotargets
GRIB research outcomes
Integrative knowledge management in pharmacovigilance
• Literature mining
• in silicosimulation
• Pathway analysis
• Genetic polymorphisms
30M EHRs from 4 EU countries !
www.alert-project.org
Possible drug – AE relationship to be assessed
Biological
pathways
Genetic variants (SNPs)
Drug Adverse event
Similardrugs-ligands
Drugmetabolit
es
Involved proteins
Workflows for chemo- & bio-informatics signal substantiation
Ferran Sanz – GRIB
GRIB’s strategic priority
• The GRIB aims to enhance its biomedical focus, putting the emphasis in the clinical application of the bioinformatics and knowledge management approaches that it develops.
• In particular, we are currently developing a strategic collaboration with Hospital del Mar (PSM)on the research exploitation of its clinical information system (IMASIS).