Feline post-traumatic ocular sarcoma Anya C. Hawthorn, MS, DVM* D. Phillip Sponenberg, DVM, PhD
Jan 11, 2016
Feline post-traumatic ocular sarcoma
Anya C. Hawthorn, MS, DVM*D. Phillip Sponenberg, DVM, PhD
Acknowledgements
• Histology:– Luther Vest– Barbara Wheeler– Jill Songer
• Sub-gross photography– Jerry Baber
Signalment and History
• 17 year old FS DSH• Respiratory distress• Mucopurulent nasal discharge• Missing upper canine •“Lost” right eye 8 years ago• Unresponsive to antibiotics
Gross Findings
PAS
Feline post-traumatic ocular sarcoma
• associated with a past history of traumatic lens rupture
• believed to arise from lens epithelium or ciliary body • develop 1 to 10 years after the initial injury• locally invasive, may metastasize, and carry a poor
prognosis• Vimentin positive, cytokeratin negative, and
frequently produces PAS positive material similar to lens capsule
References• 1. Zeiss, CJ, E.M. Johnson. R.R. Dubiezig. 2003. Feline
Intraocular Tumors May Arise from Transformation of Lens Epithelium. Veterinary Pathology. 40:355-362.
• 2. Meuten, D.J. 2002. Tumors in domestic Animals, 4th Ed. Iowa State Press, Ames, Iowa.
• 3. Grahn, B.H., R.L. Peiffer, C.L. Cullen, D.M. Heins. 2006. Classification of feline intraocular neoplasms based on morphology, histochemical staining, and immunohistochemical labeling. Veterinary Ophthalmology. 9, 6:395-403.
• 4. F. Jelinek. 2003. Postinflammatory sarcoma in cats. Experimental and Toxicologic Pathology. 55: 167-172.
Questions
• Relation to feline post-vaccine sarcomas?
• What about the feline chronic inflammatory response is oncogenic?