Pachymetric changes during corneal collagen cross- linking and effect of hydroxipropylmethylcellulos e on corneal thickness Faik Oruçoğlu (Orucov) Kudret Eye Hospital / Istanbul
Jan 27, 2016
Pachymetric changes during corneal collagen cross-linking and
effect of hydroxipropylmethylcellulose on
corneal thickness
Faik Oruçoğlu(Orucov)
Kudret Eye Hospital / Istanbul
Purpose
To evaluate central corneal pachymetric changes during corneal collagen cross-linking (CXL) and effect of hydroxipropylmethylcellulose (HPMC) drops.
Hydroxipropylmethylcellulose
Hypromellose• Hydrophylic• pH: 7,2-7,9• Osmolarity 240-300 mOsm
Spoerl E,.Safety of UVA-riboflavin cross-linking of the cornea. Cornea 2007;26:385–9
Ophthalmology 2009; 116(12) 2336-9
Methods
Grup 1. (N=18). • Epithelial abrasion (9mm)• 0.1 % Riboflavin drops in dextrane every 3 minutes for 30 minutes. • UVA 3mw/cm2 at 365nm for 30 min
Grup 2. (N=21). • Epithelial abrasion (9mm)• 0.1 % Riboflavin drops in dextrane every 3 minutes and
hydroxipropylmethylcellulose (HPMC) every 5 minutes for 30 minutes. • UVA 3mw/cm2 at 365nm for 30 min
Two groups were formed in patients with keratoconus undergoing cross-linking ;
Central corneal thicknesses were measured by ultrasound pachimetry
– before epithelial abrasion, – after epithelial abrasion and – 30 minutes after beginning riboflavin installation
Before epithelial abrasion After epithelial abrasion P
Grup 1 457.2 + 62.6 395±54,9 <0,001
Grup 2 449.7 + 62.6 389,4±44,2 0,009
After epithelial abrasion 30 minutes after riboflavin installation
P
Grup 1 395±54,9 360±44,4 <0,001
Grup 2 389,4±44,2 374,4±38,1 0,08
450
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Group 1
Group 2
After epithelial abrasion 30 minutes after riboflavin
Conclusion Decrease of corneal thickness continues with
epithelial peeling. This decrease in corneal thickness is significantly reduced by continuing the procedure with the addition of HPMC.
Rb+Dextran H2O Rb+Dextran H2OHPMC
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