Factors Affecting Drug Activity Chapter 11 Start Quiz.

Factors Affecting Drug Activity

Chapter 11

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Which is NOT a variable that can alter blood concentration–time profiles?

Age

Gender

Body weight

Race

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Yes No(Hint: see page 314 of The Pharmacy

Technician 5E)

Why does the presence of disease alter the disposition and effect of some drugs in

some people?The disease can disrupt the drugs’ absorption, distribution, metabolism, and/or excretion.

A hepatic disease allows for more absorption to the kidneys.

A renal disease disrupts excretion of perspiration.

Thyroid disease affects the blood flow, causing a change in heart rhythm.

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Yes No(Hint: see pages 316-317 of The Pharmacy

Technician 5E)

The ability of a substance to cause renal toxicity is called

Hepatotoxicity

Nephrotoxicity

Teratogenicity

None of the above

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Yes No(Hint: see page 318-319 of The Pharmacy

Technician 5E)

Drug-drug interactions are commonly called

Additive, synergistic, or potentiation

Additive, alchemistic, or potentiation

Additive, atravistic, or potentiation

Additive, albinistic, or potentiation

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Yes No(Hint: see page 322 of The Pharmacy Technician

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Some drugs are capable of increasing the concentration of

metabolizing enzymes in the liver. This process is called

Enzyme inhibition

Enzyme displacement

Enzyme induction

Enzyme filtration

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Additive effects occur when

Two drugs with similar pharmacological actions result in an effect equal to the sum of the individual effects.

Two drugs with similar pharmacological actions produce greater effects than the sum of individual effects.

One drug with no inherent activity increases the activity of another drug, which produces an effect.

None of the above

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An antidote to a particular drug is given to

Block or reduce its anticoagulation effects

Block or increase its toxic effects

Block or reduce its toxic effects

Block or increase its anticoagulation effects

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Yes No(Hint: see page 323 of The Pharmacy Technician

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The physical presence of food in the gastrointestinal tract can

alter absorption by

Improving the solubility of increasing bile secretion

Altering gastric emptying

Altering liver blood flow

Altering intestinal motility

All of the above

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Yes No(Hint: see page 324 of The Pharmacy

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Which statement is NOT true about metabolism?

High protein diets are associated with accelerated metabolism.

High carbohydrate diets appear to decrease metabolism.

The substitution of fat calories for carbohydrate seems not to affect drug metabolism rates.

Generally, mildly or moderately undernourished adults have slower metabolism of drugs.

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Yes No(Hint: see page 325 of The Pharmacy

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Which statement is true about reactions of foods with certain

drugs?

MAO inhibitors may produce severe hypotension and intercranial ischemia.

Certain cruciferous vegetables decrease the metabolism of a few drugs.

A patient ingesting foods containing vitamin K while taking an anticoagulant would not receive the full therapeutic effect from warfarin.

All of the above

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Yes No(Hint: see page 325 of The Pharmacy

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