FaceBase

FaceBaseDeveloping 3D Craniofacial Morphometry

Data and Tools to Transform Dysmorphology

http://www.easy-dna.com/printed-dna-art.html

Richard A. Spritz, MDOphir Klein, MD, PhD

Benedikt Hallgrimsson, PhD

Overview

• What is FaceBase?

• Previous Work

• Purpose

• Our Goals

• How to Participate – 3D Photos

• What will happen to the data we collect?

What is FaceBase?A group of research teams around the country studying facial

development and facial characteristics.

www.facebase.org

Previous Work FaceBase1

• We studied genetic data and facial shape in Tanzanian children

• We showed that 3D photos could distinguish altered facial development from normal

Diagnostic Methods can be Improved

• Not sufficiently objective - Syndrome descriptions sometimes unclear

• Measurement Error- Manual measures are not very

accurate or precise

• Limited Technology-Some 2D and 3D photos-Imprecise landmarking

Our Goals

• Library of 3D Facial Scans

• Diagnostic Aid for Physicians and Scientists

• “Quantitative Science”

1. Dense Surface Modeling

2. Geometric Morphometrics• Automated facial

landmarking

• Combine these analytical tools

• Apply to Clinical Practice!

Storage, William. Augustus Once And For All

Spritz et al

How Does it Work?

• Sign up for an appointment

• Sign consent forms:- I will go over the consent form with you

- HIPAA, Patient Bill of Rights

-Medical Information Form

• Includes consent for “data-sharing”; De-identified photos and data to be deposited in NIH FaceBase “Hub” database. May be shared to qualified researchers approved by NIH “Data Access Committee”.

What will I need to do?

1. 4 Face views will be collected

2. Tie hair back

3. Sit still just like for a normal picture

4. About 10-20 minutes total

5. Each participant will be given an anonymous study number to preserve confidentiality

3D Photos: How to Participate

1. We will take your 3D photo

2. We will analyze the 3D image

3. We will place anatomic landmarks on the 3D image

4. We will analyze the 3D images of patients with a specific known syndrome to define features characteristic of each syndrome

5. We will develop methods to distinguish among different syndromes

What will happen tomy Photo and

Data?

Key Points• FaseBase2 is a research study, and is part of a

larger international project

• We aim to improve how we diagnose genetic syndromes that include atypical facial development

• We need participants to take 3D Photos

• Let me know if you are interested and sign up for an appointment!

Thank you!

Are there any questions?

Study Contact Information:Name Phone Email/ Address

Richard A. Spritz, MDAnschutz Medical CampusUniversity of Colorado, Denver

TEL 303-724-3108FAX 303-724-3100

[email protected]

12800 E. 19th Ave., Rm. 3100, MS8300Aurora, CO 80045 USA

Ophir Klein, MD PhDSchool of DentistryUniversity of California, San Francisco

TEL 415-476-4719FAX 415-476-9513

[email protected]

513 Parnassus AvenueBox 0442San Francisco, CA 94143-0442

Benedikt Hallgrimsson, PhDDepartment of Cell Biology and AnatomyUniversity of Calgary

TEL 403-220-3060FAX 403-283-5666

[email protected]

Rm G503, Health Sciences Centre, 3330 Hospital Drive, NW Calgary, AB T2N 4N1

Elizabeth Beals, BSStudy CoordinatorUniversity of California, San Francisco

TEL 415-476-2985CEL 925-285-5722

[email protected]