FABRICATION OF METAL MICRONEEDLE BASED ON LASER ABLATION USING TWISTED LIGHT WITH SPIN SCPY491 Undergraduate Physics Seminar 21 September 2021 st Natwadee Sarapong 6105161, 4 year undergraduate student, Department of Physics, Faculty of Science, Mahidol University th Faculty of Science https://www.chula.ac.th/en/news/12824/
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FABRICATION OF METAL MICRONEEDLE BASED ON LASER ABLATION USING TWISTED LIGHT WITH SPINSCPY491 Undergraduate Physics Seminar 21 September 2021st
Natwadee Sarapong 6105161, 4 year undergraduate student, Department of Physics, Faculty of Science, Mahidol University
th
Faculty of Science
https://www.chula.ac.th/en/news/12824/
Introduction
Methodology
Results and Discussion
Conclusion
OUTLINES- What is microneedle - Laser ablation
- Twisted light with spin - Experimental Set Up
2
Microneedles are the technique of transdermal drug delivery which are ;
- pain free
- no damaging blood vessels
- higher weights of drug
- drug delivery with differing features
Suh H, et al., 2014
INTRODUCTION
3
WHAT IS MICRONEEDLE ?
INTRODUCTION
4
There are several type of microneedles ; solid removable, dissolving, holow, hydrogel-forming and coated microneedles
Rzhevskiy, A.S., et al., 2018
Laser ablation is a promising top-down process for material precessing by irradiating it with laser beam.
INTRODUCTION
5
LASER ABLATION
For example:
- Microdrilling - Cutting - Scribing
- Metals - Dielectric materials - Semiconductors
into
INTRODUCTION
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LASER ABLATION
- Energy is first transferred to the electron system, and then to the lattice system.
- Its temperature increases phase transition occurs from solid state to liquid, gaseous, and plasma states
- Phase transition occurs from solid state to plasma states
Preparation of nanoparticles by laser in solution https://en.wikipedia.org/wiki/Laser_ablation
INTRODUCTION
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LASER ABLATION At high laser flux, the material is typically converted to a plasma.
- pulsed laser
- continuous wave laser with high intensity
Wavelength of laser is approximately 200nm
HIGH COST
Types of laser that can contribute the ablation :
Preparation of nanoparticles by laser in solution https://en.wikipedia.org/wiki/Laser_ablation
The surface processed using twisted light caused less debris in comparison with one using untwisted annular nanosecond pulses.
Hongkun Huang, Jiancheng Lai, Jian Lu, and Zhenhua Li , "Pulsed laser ablation of bulk target and particle products in liquid for nanomaterial fabrication", AIP Advances 9, 015307 (2019) https://doi.org/10.1063/1.5082695