Exercise right heart catheterization before and after pulmonary … · 2018. 7. 26. · Exercise Right Heart Catheterization Before and After Pulmonary Endarterectomy in Patients
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Early View
Original article
Exercise right heart catheterization before and
after pulmonary endarterectomy in patients with
chronic thromboembolic disease
Stefan Guth, Christoph B. Wiedenroth, Andreas Rieth, Manuel J. Richter, Ekkehard Gruenig, Hossein
Ardeshir Ghofrani, Matthias Arlt, Christoph Liebetrau, Diethard Prüfer, Andreas Rolf, Christian W.
Hamm, Eckhard Mayer
Please cite this article as: Guth S, Wiedenroth CB, Rieth A, et al. Exercise right heart
catheterization before and after pulmonary endarterectomy in patients with chronic
thromboembolic disease. Eur Respir J 2018; in press (https://doi.org/10.1183/13993003.00458-
2018).
This manuscript has recently been accepted for publication in the European Respiratory Journal. It is
published here in its accepted form prior to copyediting and typesetting by our production team. After
these production processes are complete and the authors have approved the resulting proofs, the article
PhD), Andreas Rolf5,6 (MD, PhD), Christian W. Hamm5,6 (MD, PhD) and Eckhard
Mayer1 (MD, PhD)
1 Department of Thoracic Surgery, Kerckhoff Heart and Lung Center, Bad Nauheim,
Germany 2 Department of Pulmonology, Kerckhoff Heart and Lung Center, Bad Nauheim,
Germany 3 Thorax Clinic, University Hospital Heidelberg, Heidelberg, Germany 4 Department of Anesthesiology, Kerckhoff Heart and Lung Center, Bad Nauheim,
Germany 5 Department of Cardiology, Kerckhoff Heart and Lung Center, Bad Nauheim,
Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-
Main, Frankfurt am Main, Germany
6 Department of Internal Medicine I, Division of Cardiology and Angiology, Justus
equivalent for carbon dioxide at the anaerobic threshold; O2 pulse, oxygen pulse; *Significant
difference (P <0.05)
;
Figure Legends
Figure 1:
Flowchart of patient selection.
Figure 2:
Mean pulmonary arterial pressure (MPAP) – cardiac output (CO) relationship of 12 patients
with exercise right heart catheterization before (red) and one year after (green) pulmonary
endarterectomy. The values of the individual slopes are depicted in the table. The black line
shows the mean slope of healthy volunteers by Kovacs et al. [39].
Figure 3:
Mean values +/- standard deviation and individual changes in A) TPR during exercise and in
B) slopes of the MPAP/CO relationship of 12 patients with exercise right heart catheterization
before (red) and one year after (green) pulmonary endarterectomy.
The dotted line depicts 3.0 WU, which is the upper limit of normal proposed by Naeije et
al.[15]
Figure 4:
Changes in World Health Organisation functional class (WHO-FC) before and one year after
surgery. A) Scattered dot plot of the distribution of WHO FC with mean and standard
deviation before and after surgery; B) Individual changes in WHO FC before and after
surgery showing the number of subjects.
Figure 5:
Pulmonary endarterectomy specimen of a patient with CTED.
References
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