Light exercise central blood pressure: A correlate of left ventricular mass that is simpler than 24 hour ambulatory blood pressure monitoring SB. Thomas * , RL. Leano * , JK Brown * , DT. Gilroy * , JL. Hare * , TH. Marwick * , JE. Sharman *† . Cardiovascular Imaging Research Group, * The University of Queensland,
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Light exercise central blood pressure:A correlate of left ventricular mass that is simpler than 24 hour ambulatory blood pressure monitoring
SB. Thomas *, RL. Leano *, JK Brown *, DT. Gilroy *, JL. Hare *, TH. Marwick *, JE. Sharman *†.Cardiovascular Imaging Research Group, *The University of Queensland, Department of Medicine and †School of Human Movement Studies, Brisbane, AUSTRALIA.
Blood pressure measurement and CV Risk
• Hypertension is a leading risk factor for CVD1 & mortality2 - related to increases in left ventricular (LV) mass3.
• 24 hour ambulatory blood pressure monitoring (24ABPM) – Current gold standard for BP control as is strongest correlate for LV mass (r = 0.3)4.
1 Vasan R. N Engl J Med. (2001); 345:1291-97 2 Lewington S. Lancet (2002); 260: 1903-13 3Simone G. JACC 1995. 25(5): 1056-62 4 Mancia G. Circulation. 1997;95(6):1464-70.
Central Blood pressure and CV Risk
• Central BP – BP at the ascending aorta predicts CVD and mortality 1-4
1 London, G. (2001) 2 Pini, R. JACC (2008); 51(25):2432-39 3 Williams, B. Circ (2006); 113:1213-25 4 Safar, M. (2002); Hypertension; 39:735-38 5 Munir S. Hypertension. 2008;51(1):112-118.
• BP Monitoring during ADL = Gold Standard• Large differences between central and upper
arm SBP occur during light exercise similar to that of daily life1.
…This raises the possibility that light exercise central BP may provide more accurate estimations of BP control compared with the current gold standard
1 Sharman J. J Hypertens. 2007;25(6):1249-54.
Study Aims
1. To determine the association between light exercise central SBP (and radial P2 as a measure that is analogous to central SBP) with LV mass
2. To compare the strength of the associations between light exercise central SBP and 24 ABPM SBP with LV mass
Hypotheses
1. Central SBP and radial P2 during light exercise will be stronger correlates of LV mass compared to 24 ABPM SBP (the current “gold standard”).
2. Central SBP and radial P2 will predict LV mass independent of 24 ABPM SBP