This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Ca2+ channel
Neurotransmitters
PiccoloBassoon
Actin
Actin
Synapticvesicle
Early endosome
ClathrinCa2+
Rab3
APC
PRA1
RIM
Eph
rinA
Eph
A
Eph
rinB
Eph
B
LAR
Net
rinG
NGL
Neu
rexi
nN
euro
ligin
LRR
TM
nCad
herin
SNAP25 SNAP25
Syntaxin SyntaxinSySMUNC18
MUNC13
SyntaxinS
NMUSynaptobrevin
Syn
deca
n
SSyntaxinSynaptobrevin
nCad
herin
CN
RC
N R
Syn
Cam
Syn
Cam
CASK
VelisMINT
PRA1
mGluR
ACh R
Kainate R
nnel
AMPA RNMDA R
Axonalguidance
Actinreorganization
Spinogenesis Synapse development,function, and plasticity
Glutamate: mGlu AMN082 dihydrochloride mGlu7 agonist >99% ab120011L-AP4 Selective group III mGlu agonist >99% ab120002(R,S)-CHPG Selective mGlu5 agonist >98% ab120039Cinnabarinic acid Endogenous mGlu4 selective agonist >98% ab120506(S)-3,5-DHPG Selective group I mGlu agonist >99% ab120007LY 341495 Potent, selective group II antagonist. Group III antagonist at higher concentrations >98% ab120199LY 367385 mGlu1a antagonist >99% ab120067(S)-MCPG Group I / II mGlu antagonist >98% ab120059mGlu Agonists Kit A collection of 7 agonists and modulators for a range of mGlu receptor subtypes - ab120321
RuBi-Glutamate: A novel light-sensitive,caged ligand (ab120408)
• Activated by visible wavelengths of light• No need for harmful UV light or expensive quartz optics• Fast uncaging speeds - single photochemical step
Releases glutamate after one- or two- photon excitation.Can be used at low concentrations. Enablesphotoactivation of neuronal dendrites and circuits.Other caged compounds include RuBi-GABA (ab120409),RuBi-nicotine (ab120450) and RuBi-AP (ab120410)
Fluorescent false neurotransmitter - highlyefficient optical tracer of dopamine (ab120331)
Fluorecsent false neurotransmitter (FFN) acts as asubstrate for the synaptic vesicle monoamine transporter.
• Resolution seen at individual synaptic level• Concentration required does not interfere with
normal synaptic function• Compatible with GFP-based tags and other