EXCEMED Blended Educ ation Ovarian stimulation strategies ......ONLINE PREPARATORY TUTORIALS March 2018 The live component of the Learning Journey begins with a 30-minute roundtable

EXCEMED Blended EducationOvarian stimulation strategies: maximizing efficiency in ART

Rio de Janeiro, Brazil6-7 April 2018

Dear Participants,

On behalf of EXCEMED, it is my pleasure to welcome you to the live intervention element of yourLearning Journey, Ovarian stimulation strategies: maximizing efficiency in ART.

This face-to-face learning experience consists of two plenary sessions: in one, experts will explorehot topics in ART and the other will be a hosted discussion involving you - the delegate. We lookforward to your participation.

The learning continues after the live intervention.

Visit your Learning Journey page after the face-to-face meeting to access the in-depth interactivetutorials. Review key messages from the meeting with a video from your faculty members andassess your skills with the interactive clinical case study exploring the POSEIDON criteria.

We also welcome your presence in the private Facebook group which is accessible through yourpersonal Journey Page. Network with colleagues and discuss what you learned here in Rio.Complete the entire journey – including the assessment surveys – and get access to a Diplomasigned by the faculty as well as the final Outcomes & Feedback Report. We look forward to seeing you in person and online!

Yours sincerely,

Chloé XilinasSenior Programme ManagerEXCEMED

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CME ProviderEXCEMED is a non profit foundation dedicated, since the last four decades, to the development ofhigh-quality medical education programmes all over the world.

EXCEMED adheres to the guidelines and standards of the European Accreditation Council forContinuing Medical Education (EACCME®) which states that continuing medical education must bebalanced, independent, objective and scientifically rigorous.

EXCEMED - Excellence in Medical EducationSenior Programme Manager: Chloé XilinasT +39 06 420413 505 - F +39 06 420413 [email protected]

Medical Advisor: Sesh Kamal SunkaraQueen's HospitalEssex, UK

EXCEMED adheres to the principles of the Good CME Practice group (gCMEp).

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OverviewSuccess rates following IVF treatment have increased significantly since its early days, largely as aresult of the introduction and use of ovarian stimulation. Controlled ovarian stimulation (COS) nowplays a major role in optimising IVF outcomes by facilitating control of different aspects of theprocess and increasing the number of oocytes available. COS aims to achieve maximal success withminimal side effects. Progress in and understanding of ovarian physiology, as well as new advancesin ovarian stimulation strategies have made it possible for healthcare professionals to achieve theoptimal outcomes for patients.

An EXCEMED Learning JourneyThe EXCEMED blended education approach reinforces concepts from different angles using diverseformats which reinforce the learning experience. A multistep approach is used, encompassing web-based and live activities. All activities – in-person and online – involves the full interactivity oflearners. At three stages throughout the process, you will be asked to give your feedback on thelearning experience through the 3 surveys. The aim of this learner-centred programme is toenhance clinical practice by exploring the ideal outcomes desired by patients, embryologists, andclinicians following ART, with individualized approaches toward attaining these goalsAfter completing your Learning Journey with EXCEMED, you will receive a Diploma signed by thefaculty members and a final Outcomes and Feedback Report.

Learning objectivesBy attending this programme, you will be able to: • Interpret how laboratory and clinical outcomes define success in ART• Apply the different strategies available to increase the availability of oocytes• Tailor the best protocol for patients undergoing ART by selecting the most appropriatetreatment for individual patients

Target audienceThis programme is designed for clinicians and biologists working in assisted reproductive medicine,who want to acquire up-to date information for improving their current practice.

ChairRobert FischerFertility Centre HamburgHamburg, Germany

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Ovarian stimulation strategies: maximizing efficiency in ART

ONLINEPREPARATORYTUTORIALSMarch 2018

LIVEINTERVENTION

6-7 April 2018

ONLINEIN-DEPTHTUTORIALS

May 2018

4

ONLINEPREPARATORYTUTORIALSMarch 2018

LIVEINTERVENTION

6-7 April 2018

ONLINEIN-DEPTHTUTORIALS

May 2018

PREPARATORY LECTUREAn introductory lecture by Sandro C. Esteves, which highlights the key points of the POSEIDONconcept. This first tutorial prepares you for the live intervention lecture on POSEIDON in Riode Janeiro, and will enable you to: • Grasp the latest scientific advances in the field of impaired response to ovarian stimulation• Understand the new low prognosis concept and its application in clinical practice• Individualize and manage women with expected or unexpected low ovarian response toART according to the POSEIDON classification

LIBRARYThe second tutorial augments the content of the live intervention and gives you the informationyou need to be fully engaged with the live intervention. You are also able to share your researchand publications with the rest of the community using the library platform, and submit anyquestions you have to the faculty ahead of the meeting, which will be answered during the liveintervention panel discussion.

Features of the interactive library: – Literature corner: summarises the key points and related publications for each of the lecturesbeing presented during the live intervention in Rio de Janeiro.

– Publications exchange: contains a section for learners to share their research and publicationsrelated to the educational activity topics.

– Question time: is a chance for leaners to ask questions anonymously – the faculty will answerthem during the live intervention.

The second tutorial helps you to:• Find the latest information on protocols and techniques and keep up-to-date with advances inART procedures

• Share best practices with colleagues and therefore improve patient management• Access information from the leading experts in the field

ONLINE PREPARATORY TUTORIALSMarch 2018

The live component of the Learning Journey begins with a 30-minute roundtable discussion,allowing you and experts to engage with one another prior to the plenary sessions.Faculty members presents their scientific material using a combination of lectures, paneldiscussions and case studies.You are notified via email when the video lectures, slide kits and a scientific highlights publicationfrom the live intervention is available online.

VenueThis live educational course takes place at the:Windsor Convention & Expo CenterR. Martinho de Mesquita, 129Barra da Tijuca, Rio de Janeiro - RJ, 20031-204Brazil

LanguageThe official language of the live intervention is English. Simultaneous translation from English toSpanish and Portuguese and viceversa is provided.

For any logistic inquiry, please contact: Meridiano Congress InternationalProject Manager: Giorgia Di EgidioT +39 06 88595 209 - F +39 06 88595 [email protected]

LIVE INTERVENTION6-7 April 2018

ONLINEPREPARATORYTUTORIALSMarch 2018

LIVEINTERVENTION

6-7 April 2018

ONLINEIN-DEPTHTUTORIALS

May 2018

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Continuing medical educationEXCEMED (www.excemed.org) is accredited by the European Accreditation Council forContinuing Medical Education (EACCME®) to provide the following CME activity for medicalspecialists. The EACCME® is an institution of the European Union of Medical Specialists (UEMS),www.uems.net

The CME course “Ovarian stimulation strategies: maximizing efficiency in ART” held on 6-7 April2018 in Rio de Janeiro, Brazil, is designated for a maximum of 5 (five) hours of European CMEcredits (ECMEC). Each medical specialist should claim only those credits that he/she actuallyspent in the educational activity. EACCME® credits are recognized by the American MedicalAssociation (AMA) towards the Physician's Recognition Award (PRA). To convert EACCME® creditto AMA PRA category 1 credit, please contact the AMA.

FACULTY

Carlo AlviggiFederico II University of NaplesNaples, Italy

Sandro C. EstevesANDROFERTAndrology & Human Reproduction Clinicand University of Campinas (UNICAMP)Campinas, Brazil

Robert FischerFertility Centre HamburgHamburg, Germany

Fernando NeuspillerGeneral IVI Buenos AiresIVI Buenos AiresBuenos Aires, Argentina

Matheus RoqueORIGENCenter for Reproductive MedicineRio de Janeiro, Brazil

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PROGRAMME

Friday, 6 April 2018

From 12.00 Lunch and registration

13.30 Round tableC. Alviggi (Italy), S.C. Esteves (Brazil), R. Fischer (Germany), F. Neuspiller (Argentina) and M. Roque (Brazil)

14.00 Opening and introductionR. Fischer (Germany)

14.10 L1: How should we measure success in ART? S.C. Esteves (Brazil)

14.35 Question timeS.C. Esteves (Brazil)

14.45 L2: Optimising IVF outcomes through increased number of oocytesF. Neuspiller (Argentina)

15.10 Question timeF. Neuspiller (Argentina)

15.20 L3: Choosing the most appropriate gonadotropin for your patients: Exploring the pros and cons of recombinant vs urinary FSH, and the role of LHC. Alviggi (Italy)

15.45 Question timeC. Alviggi (Italy)

15.55 Coffee break

Session I

Legend: : Round table L : Lecture : Question time : Panel discussion : Case study

16.15 L4: Ovarian response groups: Suboptimal response and the POSEIDON concept C. Alviggi (Italy)

16.40 Question timeC. Alviggi (Italy)

16.50 Panel discussion

17.20 Interactive case study sessionC. Alviggi (Italy)

18.00 End of the first day

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Saturday, 7 April 2018

09.00 L5: Is there a place for mild stimulation and modified natural cycle in iCOS?M. Roque (Brazil)

09.25 Question timeM. Roque (Brazil)

09.35 L6: New challenges in COS what are the best options for luteal phase support infresh cycles? S.C. Esteves (Brazil)

10.00 Question timeS.C. Esteves (Brazil)

10.10 L7: Frozen embryo strategies: Are we ready for a freeze all approach? M. Roque (Brazil)

10.35 Question timeM. Roque (Brazil)

10.45 Coffee break

11.05 L8: Choices in endometrial preparation for frozen embryo transfer cycles: Natural cycle or hormone replacement therapy?F. Neuspiller (Argentina)

11.30 Question timeF. Neuspiller (Argentina)

11.40 Panel discussion

12.10 Two interactive case studies sessionM. Roque (Brazil) - F. Neuspiller (Argentina)

13.10 Concluding remarksR. Fischer (Germany)

13.20 End of the live intervention

13.30 Closing lunch

Session II

FACULTY DISCLOSURESEXCEMED adheres to guidelines of the European Accreditation Council for Continuing MedicalEducation (EACCME®) and all other professional organizations, as applicable, which state thatprogrammes awarding continuing education credits must be balanced, independent, objective andscientifically rigorous. Investigative and other uses for pharmaceutical agents, medical devices andother products (other than those uses indicated in approved product labeling/package insert for theproduct) may be presented in the programme (which may reflect clinical experience, theprofessional literature or other clinical sources known to the presenter). We ask all presenters toprovide participants with information about relationships with pharmaceutical or medicalequipment companies that may have relevance to their lectures. This policy is not intended toexclude faculty who have relationships with such companies; it is only intended to informparticipants of any potential conflicts so that participants may form their own judgements, based onfull disclosure of the facts. Further, all opinions and recommendations presented during theprogramme and all programme-related materials neither imply an endorsement nor arecommendation on the part of EXCEMED. All presentations represent solely the independent viewsof the presenters/authors.

The following faculty provided information regarding significant commercial relationships and/ordiscussions of investigational or non-EMEA/FDA approved (off-label) uses of drugs:

Carlo Alviggi Declared receipt of honoraria or consultation fees from Merck

Sandro C. Esteves Declared receipt of honoraria or consultation fees from Merck, Lilly andBesins

Robert Fischer Declared no potential conflict of interest

Fernando Neuspiller Declared no potential conflict of interest

Matheus Roque Declared receipt of honoraria or consultation fees from Merck

All EXCEMED programmes are organized solely to promote the exchange and dissemination of scientific andmedical information. No forms of promotional activities are permitted. There may be presentations discussinginvestigational uses of various products. These views are the responsibility of the named speakers, and do notrepresent an endorsement or recommendation on the part of EXCEMED. This independent programme ismade possible thanks to educational grants received from: Ferty School, MVZ Fertility Center Hamburg, Istitutodi Ricerche Genetiche, Merck KGaA Darmstadt Germany and San Raffaele Hospital Milan.

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ONLINEPREPARATORYTUTORIALSMarch 2018

LIVEINTERVENTION

6-7 April 2018

ONLINEIN-DEPTHTUTORIALS

May 2018

ONLINE IN-DEPTH TUTORIALMay 2018

Continue your Learning Journey after the live intervention!

INTERACTIVE CLINICAL CASEOnline post event tutorials helps you delve deeper into content and test yourself with an interactiveclinical case study exploring the POSEIDON criteria. The third tutorial helps you to:• Understand why testicular sperm may lead to better ART outcomes than ejaculated sperm, andwhen sperm DNA fragmentation (SDF) is indicated

• Determine which genetic evaluations are available for “low prognosis” patients and when to usethem

• Grasp how to use the ART Online Calculator to estimate the number of oocytes needed to obtainat least one euploid blastocyst

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