exploitation of miRNA by exploitation of miRNA by phylogeny tree phylogeny tree construction construction Presentation: Shaojun Tang* Shizhao Zhou** *Genetics Institute, College of Medicine, University of Florida **Computer information and science engineering, University of Florida Mentor: Tamer Kahveci
16
Embed
Evolutionary exploitation of miRNA by phylogeny tree construction
Evolutionary exploitation of miRNA by phylogeny tree construction. Presentation: Shaojun Tang* Shizhao Zhou** *Genetics Institute, College of Medicine, University of Florida **Computer information and science engineering, University of Florida Mentor: Tamer Kahveci . Outline . - PowerPoint PPT Presentation
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Evolutionary exploitation of Evolutionary exploitation of miRNA by phylogeny tree miRNA by phylogeny tree constructionconstruction
Presentation: Shaojun Tang* Shizhao Zhou**
*Genetics Institute, College of Medicine, University of Florida**Computer information and science engineering, University of Florida
Mentor: Tamer Kahveci
Outline Outline Part I: What and why miRNA ?
Part II: Gene regulation governed by transcription binding and miRNA targeting.
Part III: Phylogeny tree construction of miRNA from different organism.
Part IV: Multiply sequence alignment analysis to identify evolutionary conserved miRNAs.
Part I: What and why Part I: What and why miRNA.miRNA.What is miRNA. Ribonucleic acid(RNA) molecules of about 21–23 nucleotides long, which regulation gene expression.
Function of miRNA
1: Mature miRNA molecules are partially complementary to one or more message RNA (mRNA) molecules, which down-regulate gene expression
2: miRNA regulation of gene expression are
associated with many disease and even cancer.
Current research of miRNA 1: more than 700 miRNAs are identified in
humans
2: miRNA regulation of gene transcription is important, but poorly understood and addressed.
3: miRNA can be a powerful tool in helping solve many disease or cancer in human.
Part II Gene regulation Part II Gene regulation governed by transcription governed by transcription factor and miRNAfactor and miRNA Transcription factor (sequence-specific DNA binding factor)
Specific factors such as protein, that binds to particular DNA sequence and thereby controls the gene transcription from DNA to RNA.
Results of a Single group 1): Forward construction 3 tables from Edit(0, 1, 1) : (0, 1 3) :
Percentage 2): Backward construction 3 tables from Edit(0, 1, 1) : (0, 1 3) :
Percentage
ConclusionConclusion1: The association of transcription factor binding site and miRNA targets given the pathway can provide useful information for research related to pathways.
2: The UPGMA construction of phylogeny tree may provide useful information for clustering evolutionary conserved genes in any given organism,.
3: while our two methods of miRNA pairwise construction among organism may shield light on future research in miRNA evolution, regulation and function.