Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted Imaging Lakshman Gollapalli
Dec 21, 2015
Evaluation of CN iron in Huntington’s Disease using Susceptibility Weighted
Imaging
Lakshman Gollapalli
Huntington’s Disease (HD)
• Huntington’s disease is a dominantly inherited degenerative disease of the CNS
• The pathological features include atrophy of the CN, chorea and neuronal loss
• Changes in caudate volume have been documented in MRI studies
Susceptibility Weighted Imaging (SWI)
• SWI exploits the magnetic susceptibility effects generated by local field inhomogeneities
• Signals from tissues with different susceptibilities compared to their neighboring tissue will become out of phase
• New type of contrast
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PHASE PLOT