Ethical issues related to animal use in biomedical research Diarsvitri W 1 , Triakoso N 2 , Ashrin MN 1 , Trisyani N 1 1 Research Ethics Committee, Hang Tuah University, Surabaya. 2 Research Ethics Committee, Faculty of Veterinary Medicine, Airlangga University, Surabaya, Indonesia. 13 th FERCAP, 18-19 November 2013, Bali, Indonesia
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Ethical issues related to animal use in biomedical researchfercap-sidcer.org/newsletter/2013/12/PPT/20 Wienta Diarsvitri-PPT.pdf · E thical issues related to animal use in biomedical
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1 Research Ethics Committee, Hang Tuah University, Surabaya. 2 Research Ethics Committee, Faculty of Veterinary Medicine,
Airlangga University, Surabaya, Indonesia.
13th FERCAP, 18-19 November 2013, Bali, Indonesia
BACKGROUND
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CANNOT
CONSENT
KILLED
LIMITED
FREEDOM
ETHICAL ISSUES
DISTRESS &
PAINFUL
INTERVENTIO
N
NO BENEFIT
FROM
PARTICIPA-
TION
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Festing & Wilkinson, 2007
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Animal welfare is very important
Resource-limited setting:
A long-term goal: complete
replacement of using animals
Mandatory goal: reduce the
number of animals used and
advancing refinement.
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Refinement
to alleviate or minimize the pain,
distress and other adverse
effects suffered by the animals
involved or enhance animal
well-being.
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OBJECTIVE
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As of January 2013, Hang Tuah University has required its students to apply the research ethics.
The objectives of this study to evaluate issues related to the use of
animals in the undergraduates’ biomedical research proposals
how the Research Ethics Committee advances the refinement of animal use in their researches.
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METHODS
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All undergraduate biomedical
research proposals involving
experimental animals in the
period of January to June 2013
(32 proposals) were evaluated
descriptively
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Ethical review
Contribution to knowledge
Objectives: realistic, original, timely?
Design: Choice & number of animals used
Experimental design refinement
Competence of staff
Appropriate facilities
Communication of results Diarsvitri et al.
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RESULTS
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Experimental animal used in all
32 proposals: Rattus norvegicus
Wistar strain.
10 proposals (31,3%): calculation
of sample size has been
corrected to conform with the
reduce principle.
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30 proposals (93,8%) were:
derived from 14 herbal medicine &
marine product researches: S.
polycysticum, M. charantia, M.
oleifera, red yeast rice, A. antiquata
shell powder.
used to treat chronic degenerative
diseases (dyslipidemia), increase
antioxidant and wound healing.
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2 proposals (6,2%) were:
derived from one hyperbaric
research.
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19 proposals (59,4%): needed a
change of
experimental design (pretest
posttest to posttest only control
group design)
better care of the animals
approriate pain management
better euthanasia procedure.
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CONCLUSION
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Consideration of practical and ethical aspects of laboratory animal use should be included in undergraduate biomedical courses.
A need to improve appreciation and commitment to advancement of refinement principle.
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REFERENCES
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Festing, S., Wilkinson, R. 2007. The ethics of animal research. Talking point on the use of animals in scientific research. EMBO Reports 8(6): 526-30.
Gilbert, S., Kaebnick, G.E., Murray, T.H (eds). 2012. Animal research ethics. Evolving views and practices. A Hasting Center Special Report.
McGill University Animal Care Committee. 2009. The laboratory mouse. Handling and restraint.
Olsson, IAS., Robinson, P., Sandoe, P. 2010. Ethics of animal research. In: Hau, J., Schapiro, SJ (eds). 2010. Handbook of laboratory animal science. Vol. 1. 3rd ed. Essentials principles and practices.
Pitts, M., Bayne, K. (eds). 2002. Institutional animal care and use committee guidebook. 2nd ed. Office of Laboratory Animal Welfare. National Institutes of Health.