ESTIMATION OF ORGAN DOSES OF PATIENT UNDERGOING HEPATIC CHEMOEMBOLIZATION PROCEDURES William Jaramillo, Richard Kramer, Helen Khoury, Vinicius Saito and Gustavo Andrade Department of Nuclear Energy - Federal University of Pernambuco Recife, Brazil X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
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ESTIMATION OF ORGAN DOSES OF PATIENT UNDERGOING … · 2015. 5. 13. · F 45 68 159 184 21.7 113.4 1.439 1.122 F 75 49 158 180 11.7 73.5 0.906 0.858 F 45 65 165 137 36 162.7 1.439
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ESTIMATION OF ORGAN DOSES OF PATIENT UNDERGOING
HEPATIC CHEMOEMBOLIZATION PROCEDURES
William Jaramillo, Richard Kramer, Helen Khoury, Vinicius Saito
and Gustavo Andrade
Department of Nuclear Energy - Federal University of Pernambuco
Recife, Brazil
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Introduction
Hepatic chemoembolization
Previous studies
(maximum skin dose) Few organ doses studies?
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Organ doses conversion coefficients in IR
… if patient size is neglected when choosing DCC, the organ and effective dose
will be underestimated to an underweight patient and will be overestimated to an
overweight patient, with errors as large as 113% for certain projections.
Therefore, the use of phantoms with different body masses and/or heights for
the Monte Carlo calculations would certainly improve the organ and tissue
absorbed dose assessments for populations such as patients
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Objective
The aim of this study is to evaluate the organ and tissue absorbed doses as
well as radiation risks of patients undergoing hepatic chemoembolization
procedures performed in two hospitals in the city of Recife-Brazil.
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
• Patients
50 hepatic chemoembolization procedures were investigated for 48
patients diagnosed with hepatocellular carcinoma which have been treated
in two hospitals in Recife Brazil.
Hospital A Hospital B
Methodology
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Methodology
• Data collection
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Methodology
• Calibration of KAP meters
𝑓 =𝐾𝑎 ∗ 𝐴𝑟𝑒𝑎
𝐾𝐴𝑃
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Conversion coefficients estimation
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Risk conversion coefficients assessment
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Results and discussion
Anthropometric data of the patients
Mean values of irradiation and dose parameters per hospital and gender for all
patients
X Congreso Regional Latinoamericano de Protección y seguridad Radiológica IRPA
Conversion coefficients
HVL (mmAl)
Organ dose (mGy/Gy*cm2) 5,487 6,307 7,78 8,42 8,97
ADRENALS 1,141 1,113 1,407 1,283 1,398
BLADDER WALL 0,009 0,013 0,023 0,019 0,026
BRAIN *** *** 0,001 *** ***
ORAL MUCOSA 0,011 0,008 0,017 0,011 0,014
COLON WALL 0,194 0,19 0,27 0,237 0,263
BREASTS,glandular 0,148 0,118 0,195 0,153 0,178
KIDNEYS 1,398 1,298 1,615 1,481 1,555
LIVER 0,659 0,628 0,862 0,755 0,835
LUNGS 0,476 0,412 0,593 0,472 0,505
OESOPHAGUS 0,276 0,25 0,405 0,322 0,38
OVARIES *** *** 0,04 0,038 0,041
PANCREAS 0,544 0,521 0,748 0,656 0,745
SMALL INTESTINE WALL 0,238 0,237 0,345 0,295 0,333
SKIN ENTRANCE 7,2cm X 7,2cm 2,897 3,138 3,108 3,251 3,254