Esco Service Guide...• North American facilities in Pennsylvania and Ohio Sales, service, logistics for US & Canada. • Other Esco locations in Bahrain, China, India, Malaysia,

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Decontamination and Maintenance • Validation and Certification Parts Replacement • Aftermarket Support • Training and Workshops

Esco Service Guide

Esco Service Guide

Guide to Esco Products and Services

Table of Contents:

Corporate Profile ............................................................................ 3

Products and Application ................................................................ 4

Global Network .............................................................................. 4

Decontamination and Maintenance ................................................ 5

Parts Replacement .......................................................................... 5

Validation and Certification ............................................................ 5

Descriptions of Esco Validation and Certification Services ................ 6

IQ/OQ Documentation .................................................................... 6

Aftermarket Support ...................................................................... 7

Training and Workshop .................................................................. 7

Biological Safety Cabinets ............................................................... 8

Compounding Pharmacy Equipment .............................................. 9

Ductless Fume Hoods ................................................................... 10

Special Purpose Cabinets .............................................................. 11

Laboratory Fume Hoods ............................................................... 12

Lab Animal Research Products ...................................................... 13

Laminar Flow Clean Benches ........................................................ 14

Powder Weighing Balance Enclosures ........................................... 15

Esco Service Guide

2

• A leader in the development of controlled environment,

laboratory and cleanroom equipment solutions.

• A world leader in biological safety cabinets.

• Headquartered in Singapore.

• North American facilities in Pennsylvania and Ohio

Sales, service, logistics for US & Canada.

• Other Esco locations in Bahrain, China, India, Malaysia,

Netherlands, UK.

• Group total of more than 500 employees.

• Distributors in more than 100 countries.

• Products independently tested to international standards.

• Large R&D investments, world leading technologies.

• State-of-the-art production, vertically integrated, 300,000

sq. ft. floor space.

• Worldwide service.

Welcome to Esco

Pictured: Esco Micro Pte. Ltd. is headquartered in Singapore, a modern city state located in Southeast Asia with a population of more than 4 million. From Singapore, Esco manages operations throughout the world.

Esco’s Vision is to provide enabling technologies for scientific discoveries to make human lives

healthier and safer.

Pictured: Esco provides service worldwide via a network of highly trained factory direct and independent service representatives."

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Esco Service Guide

Global Network

Products and Application

Esco Controlled Environment Equipment Solutions

Laboratory Equipment

Biosafety and Laminar Flow

•ClassIITypeA2BiologicalSafety

Cabinets

•ClassIITypeB2BiologicalSafety

Cabinets

•ClassIIIBiologicalSafetyCabinets

•HorizontalLaminarFlowCleanBenches

•InVitroFertilizationWorkstations

•LaboratoryAnimalResearchWorkstations

•PCRCabinets

•VerticalLaminarFlowCleanBenches

Fume Hoods

•DuctlessFumeHoods

•ExhaustBlowers

•FumeHoodAirflowMonitors

•FumeScrubbers

•LaboratoryFumeHoods

Incubators and Ovens

•CO2Incubators

•ForcedConvectionLaboratoryIncubators

•ForcedConvectionLaboratoryOvens

•LowTemperatureBODIncubators

•NaturalConvectionLaboratoryIncubators

•RemoteMonitoring,DataLogging,

andProgrammingSoftware

Life Science

•PCRThermalCyclers

Not Available in North America

Cold Chain Storage

•UltraLowTemperatureFreezers

Cleanroom Equipment•AirShowers

•GarmentStorageCabinets

•PassBoxes

•SoftCapsuleCleanrooms

•StraddleUnits

•TransferHatches

Pharmaceutical Equipment•CytotoxicSafetyCabinets

•DownflowBooths

•PharmacyIsolators

•PowderWeighingBalanceEnclosures

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Proper operation of Esco products usually requires periodic maintenance and/or decontamination in accordance with common Standard Operating Procedures and recognized laboratory safety protocols.

Decontamination is a process that reduces contaminants to acceptable levels in biological safety cabinets to eliminate their disease causing capabilities. Decontamination/fumigation using formaldehyde, hydrogen peroxide or other agents should only be carried out by trained personnel with proper knowledge and equipment.

Every Esco cabinet is manufactured as a commercial grade product and Esco provides replacements for consumable elements as well as any components that might fail while the product is in service.

Every Esco product is shipped with a Statement of Part Numbers for Replaceable Parts. From time to time, Esco may use components from different sources or change them after design improvements. The serial number of a product, usually located on an identification tag on its upper front side, may be used to query an on-line database to retrieve accurate part numbers.

In order to maintain consistent and safe operating conditions for any equipment, regular performance tests must be conducted. Esco’s Validation and Certification Services can ensure that all Esco equipment is providing sufficient containment in the equipment’s work areas and a pleasant working environment for its operators.

Qualified from the Start

Esco is committed to manufacture products compliant with international standards for performance, safety and energy efficiency for its worldwide market. We are equally committed to manufacturing processes, administrative documentation, and product certification testing compliant with applicable certifications, GLP (good laboratory practices) and cGMP (current good manufacturing practices). This is critical to our business model and to our relationships with customers, distributors and certifying agencies.

Support after the Sale

Esco’s customers subject its products to IQ/OQ validation or similar Standard Operating Procedures (SOPs), many of which Esco itself uses during the design and manufacture of its products. Some of the tests and procedures require calibrated equipment and certified operators. Although many customers perform these SOPs in house, others choose to outsource them to supplement their capabilities, control time lines, and obtain independent verification of results.

Esco provides its customers with IQ/OQ documentation for its products and offers a broad range of validation, certification and maintenance services to support their needs. Regular attention to equipment performance will ensure optimal performance and early detection and correction of potential problems, thus increasing utilization and product yields.

Validation and Certification Services Staff

Esco is a firm with trained field service engineers, specializing in the testing and certification of:

• BiologicalSafetyCabinets• AnimalContainmentWorkstations• HospitalPharmacyWorkstations• LaminarFlowCleanBenches• ApplicationSpecificCabinets• DuctlessFumeHoods• FumeHoods(Ducted)

Thoroughly trained, experienced and competent engineers perform clean room and associated clean air device certification in accordance with NEBB procedural standards, IEST (Institute of Environmental Sciences) Recommended Practices, ISO 14664.1, the NSF 49 Standard for Biosafety Cabinets, EN12469 European Norm Standard for Microbiological Safety Cabinets, and others. We also offer customized certification audits and evaluation programs for clean rooms and associated clean air devices.

Decontamination and Maintenance

Parts Replacement

Validation and Certification

5

Esco Service Guide

Service Description

Airflow Balancing Adjust cabinet internal flow control devices to produce desired air flow.

ULPA / HEPA Filter Integrity Determine the integrity of down flow and exhaust filters by measuring penetration of a test aerosol.

ULPA / HEPA Filter Replacement Replace compromised filters or those at the end of their service life.

Inflow / Face Velocity Determine the velocity profile of air entering a cabinet through its work access opening via measurement and calculation.

Laminar Flow Velocity Determine the velocity profile of air moving within a cabinet work space using a thermal anemometer.

Particle Count Verify work zone air cleanliness in accordance with ISO 14644.1 classification criteria by particle counting.

Airflow Visualization Qualitatively evaluate airflow into work access area by visualizing smoke patterns.

Airflow Alarm Calibration Adjust the alarm set point of the airflow measurement system.

Blower / Fan Replacement Remove and replace a defective blower or fan assembly.

Electrical Troubleshooting Examine electrical devices, wiring connections and adjustments in a cabinet to diagnose and correct improper operation.

Electrical Safety Inspect grounding system and measure leakage currents in a cabinet electrical system to ensure equipment safety.

GFCI Performance Test Ground Fault Circuit Interrupter outlets, when installed, to ensure proper operation and protection.

Pressurization Measure pressure differentials from ambient in cabinet work space and/or pass-through to evaluate adequacy.

Enclosure Integrity Assess the integrity of the surfaces, seams and joint of a cabinet.

Product Ingress / Egress Measure particle counts during material transfer procedures into/out of glove boxes/isolators to verify acceptable values.

Recovery Time Measure the time interval after simulated major contamination for a cabinet work zone to return to acceptable cleanliness.

Glove Breach Verify the integrity of a glove and its attachment system to an isolator/glove box by measuring inward airflow at an open glove port.

Decontamination Biologically sterilize a cabinet using formalin vapor or hydrogen peroxide.

Noise Measure the corrected A-weighted sound level pressure produced by the fan(s).

Light Measure the lighting intensity at the work surface in a cabinet.

Vibration Measure vibration level of the work surface to prevent damage to sensitive processes and to ensure operator comfort.

UV Intensity Measure the effectiveness of the ultraviolet lamp, when installed, for surface germicidal decontamination.

Site Installation Assessment Verify proper installation of cabinet pursuant to recommended practices regarding location, external connections, etc.

KI Discus Containment Determine the containment integrity of a cabinet by measurement of potassium iodide droplet leakage.

SF6 Chemical Containment Determine the containment integrity of a cabinet by measurement of sulfur hexafluoride gas leakage.

Carbon Filter Retention Measure the adsorption capacity of a carbon filter to assess performance.

Carbon Filter Replacement Remove and replace compromised carbon filters or those at the end of their service life.

Aerosol Induction (Sash Seal) Inspect for leakage of the sash seal of a cabinet using an aerosol.

Temperature Calibration Sensor adjustment, temperature fluctuation, temperature uniformity and temperature recovery test.

CO2 Calibration Sensor adjustment, CO2 fluctuation and CO2 recovery test.

O2 Calibration Sensor adjustment, O2 fluctuation and O2 recovery test.

Humidity Calibration Sensor adjustment, humidity fluctuation and humidity recovery test.

Heater Replacement Remove and replace a defective heater assembly.

Pump Replacement Remove and replace a defective pump.

Piping Replacement Remove and replace compromised piping.

Compressor Replacement Remove and replace a defective compressor.

Thermostat Replacement Remove and replace the hard wired safety thermostat.

Pre-Filter Replacement Remove and replace compromised pre-filters filters or those at the end of their service life.

Lamp Replacement Remove and replace defective or underperforming cabinet fluorescent and/or ultraviolet lamp bulbs.

General Cleaning and Maintenance Thoroughly inspect, clean surfaces of, and make performance adjustments on a cabinet.

Esco and/or our officers are members of the following professional organizations:

• ControlledEnvironmentTestingAssociation(CETA)• ScientificEquipment&FurnitureAssociation(SEFA)• InstituteofEnvironmentalSciencesandTechnology(IEST)• LaboratoryProductsAssociation(LPA)• AmericanBiologicalSafetyAssociation(ABSA)• NSFInternational

We also offer these services through a network of certified subsidiary companies and international distributors and partners.

Descriptions of Esco Validation and Certification Services

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Esco offers in-warranty and post-warranty support for all products.

Extended Warranty

Extensions of Esco's standard warranty against defects in materials and workmanship are available. Extended warranties fix the capital cost of ownership of the product over its entire service life by eliminating the risk of failure due to latent defects.

Technical Support Subscription

Esco provides technical support via email and telephone, including troubleshooting performance issues, answering questions about product operation and maintenance, and assisting with certification.

Preventive Maintenance Agreements

Periodic preventive maintenance assures that Esco products provide desired performance. Preventive maintenance contracts are customer specified and may include periodic filter changing, decontamination, interior cleaning, and replacement of the UV lamp or other functions.

Replacement Manuals

All Esco products are shipped with comprehensive installation and operation documentation. While Esco Service Manuals include information for field-level maintenance, electrical component replacement and calibration.

Sentinel Software Upgrades

The Sentinel suite of microprocessor-based controllers operates on software developed for maximum performance and data management. New software releases are offered as required, and available for download via the Internet.

Esco offers training for users of its equipment on the procedures in its User and Service Manuals.

Operational training includes product placement, electrical connection, connection to facility air handling system, adjustment of leveling feet and locking of casters, use of Sentinel Software and pressure measurement instrumentation, cleaning, decontamination and changing filters.

Maintenance training includes the procedures used by our personnel and described above. You can assure that your personnel are prepared to deploy and use your Esco products.

Certification training is similar in scope to the training described above, and includes hands on demonstration of the skills being taught. The use of certified personnel facilitates assessing utilization, productivity and risks of complicated or sensitive protocols. Those who complete Esco Certification Workshops will receive a certificate of attendance.

Aftermarket Support

Training and Workshop

A certified process ensures that qualified equipment is used pursuant to validated Standard Operating Procedures (SOPs). Those SOPs that are applicable to equipment and instruments are classified as follows:

Installation Qualification (IQ) documents that the specified equipment was received and properly installed in a suitable environment. IQ is also required for used equipment installation, equipment moved within a facility or connected to modified systems at the facility or subject to a changed SOP. IQ can be performed by the customer or Esco.

Operational Qualification (OQ) documents that the equipment still meets its specifications after installation in the customer’s facility. OQ can be performed by the customer or Esco, and must be performed at least annually for every piece of equipment.

Esco provides our customers instructions for IQ and OQ of our products. Esco also can perform these services directly on behalf of its customers or arrange them through independent approved local certifiers. The availability may vary from country to country and region to region. Also, Esco can train customer employees to perform IQ/OQ as described in the Aftermarket Support section later in this document.

IQ/OQ Documentation

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Esco Service Guide

Esco Biological Safety Cabinets represent more than 20 locally, regionally and internationally-r e c o g n i z e d c e r t i f i c a t i o n s . These accreditations testify to the enhanced performance of Esco products in biological and microbiological applications.

Product lines:•Class II, Type A2 Biological Safety Cabinets.

•Class II, Type B2 Biological Safety Cabinets.

•Class III Biological Safety Cabinets.

• Formalin Vaporizers.

•Options and Accessories.

TheSafetySolutionforLifeScienceLaboratories

Biological Safety Cabinets

Pictured: Esco Biological Safety Cabinets

Testing/Maintenance ServiceBiological Safety Cabinets

Class I Cabinets Class II Cabinets Class III Cabinets

Airflow Balancing Standard Standard Standard

ULPA / HEPA Filter Integrity Standard Standard Standard

ULPA / HEPA Filter Replacement If Required If Required If Required

Inflow / Face Velocity Standard Standard

Laminar Flow Velocity Standard Standard

Particle Count Optional Optional

Airflow Visualization Standard Standard

Airflow Alarm Calibration If Required If Required If Required

Blower / Fan Replacement If Required If Required If Required

Electrical Troubleshooting If Required If Required If Required

Electrical Safety Optional Optional Optional

GFCI Performance Optional Optional Optional

Pressurization Standard

Enclosure Integrity Optional Optional Optional

Product Ingress / Egress Optional

Recovery Time Optional

Glove Breach Optional

Decontamination If Required If Required If Required

Noise Optional Optional Optional

Light Optional Optional Optional

Vibration Optional Optional Optional

UV Intensity Optional Optional Optional

Site Installation Assessment Optional Optional Optional

KI Discus Containment Optional Optional Optional

Aerosol Induction (Sash Seal) Optional Optional

Pre-Filter Replacement If Required If Required

Lamp Replacement If Required If Required If Required

General Cleaning and Maintenance If Required If Required If Required

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* Esco is a member of the NSF49 Joint Comittee that maintains the NSF49 standard* Esco participated in drafting the SFDA YY-0569 standard

Esco compounding pharmacy equipment includes a complete range of barrier isolators, NSF listed biological safety cabinets and clean benches.

Product lines:•Cytotoxic Safety Cabinets.

•Compounding Aseptic Isolators.

•Compounding Aseptic Containment Isolators

(Recirculating).

ThePremiumSolutionforSterileDrugCompounding

Compounding Pharmacy Equipment

Testing/Maintenance ServiceHospital Pharmacy Workstations

Hospital Pharmacy Isolators Cytotoxic Safety Cabinets

Airflow Balancing Standard Standard

ULPA / HEPA Filter Integrity Standard Standard

ULPA / HEPA Filter Replacement If Required If Required

Inflow / Face Velocity Standard


Particle Count Standard Standard

Airflow Visualization Standard

Airflow Alarm Calibration If Required If Required

Blower / Fan Replacement If Required If Required

Electrical Troubleshooting If Required If Required

Electrical Safety Optional Optional

GFCI Performance Optional Optional

Pressurization Standard

Enclosure Integrity Standard Optional

Product Ingress / Egress Optional


Glove Breach Optional

Decontamination If Required If Required

Noise Optional Optional

Light Optional Optional

Vibration Optional Optional

Site Installation Assessment Optional Optional

KI Discus Containment Optional

Aerosol Induction (Sash Seal) Optional

Pre-Filter Replacement If Required

Lamp Replacement If Required If Required

General Cleaning and Maintenance If Required If Required

Pictured: Esco Compounding Pharmacy Equipment

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Esco Service Guide

10

Esco ductless and laboratory fume hoods serve to control exposure to toxic, offensive or flammable vapors, gases and aerosols.

Product lines:•General Purpose Benchtop Hoods.

•Acid Digestion Hoods.

• Perchloric Acid Hoods.

• Radioisotope Hoods.

• Floor Mounted Hoods.

•High Performance, Low Flow Hoods.

• Educational Hoods.

• Polypropylene Hoods.

•Chemical Fume Scrubbers.

• Exhaust Blowers.

• DuctlessFumeHoods.

LaminarTopographyandPerfectProtectionPerimeter

Fume Hoods

Testing/Maintenance Service D Ductless Fume Hoods Laboratory Fume Hoods

Inflow / Face Velocity Standard Standard

Airflow Visualization Standard Standard

Airflow Alarm Calibration If Required If Required

Blower / Fan Replacement If Required

Electrical Troubleshooting If Required If Required

Electrical Safety Optional Optional

GFCI Performance Optional Optional

Noise Optional Optional

Light Optional Optional

Vibration Optional Optional

Site Installation Assessment Optional

SF6 Chemical Containment Optional

Carbon Filter Retention Optional

Carbon Filter Replacement Optional


Lamp Replacement If Required If Required

General Cleaning and Maintenance If Required If Required

Pictured: Esco Laboratory Fume Hoods

Testing/Maintenance ServiceSpecial Purpose Cabinets

IVF RHL PCR

Airflow Balancing Standard Standard Standard

ULPA / HEPA Filter Integrity Standard Standard Standard

ULPA / HEPA Filter Replacement If Required If Required If Required



Particle Count Standard Standard

Airflow Visualization Optional Optional Optional

Airflow Alarm Calibration If Required If Required If Required

Blower / Fan Replacement If Required If Required If Required

Electrical Troubleshooting If Required If Required If Required

Electrical Safety Optional Optional Optional

GFCI Performance Optional Optional Optional

Noise Optional Optional Optional

Light Optional Optional Optional

Vibration Optional Optional Optional

UV Intensity Standard

Aerosol Induction (Sash Seal) Optional Optional

Pre-Filter Replacement If Required If Required If Required

Lamp Replacement If Required If Required If Required

General Cleaning and Maintenance If Required If Required If Required

Esco special purpose cabinets are designed for a specific applications that cannot be handled by any other equipment.

Product lines:• In Vitro Fertilization Workstations.

• Reverse Horizontal Laminar Flow Cabinets.

• PCRWorkstations.

EscoIn VitroFertilizationWorkstations

Special Purpose Cabinets

Pictured: Esco Special Purpose Cabinets

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Esco Service Guide

12

Esco is the world leader in premium laminar flow cabinets for the global life sciences market.

Product lines:•Horizontal Laminar Flow Clean Benches.

•Vertical Laminar Flow Clean Benches.

TheLeadingSolutionforResearchLaboratories

Laminar Flow Clean Benches

Testing/Maintenance Service Laminar Flow

Airflow Balancing Standard

ULPA / HEPA Filter Integrity Standard

ULPA / HEPA Filter Replacement If Required



Airflow Alarm Calibration If Required


Electrical Troubleshooting If Required

Electrical Safety Optional

GFCI Performance Optional

Enclosure Integrity Optional


Decontamination If Required

Noise Optional

Light Optional

Vibration Optional

UV Intensity Optional

Site Installation Assessment Optional

Aerosol Induction (Sash Seal) Optional


Lamp Replacement If Required

General Cleaning and Maintenance If Required

Pictured: Esco Laminar Flow Clean Benches

Testing/Maintenance Service Animal Containment Workstations





Particle Count Optional

Airflow Visualization Optional






Decontamination If Required

Noise Optional

Light Optional

Vibration Optional


Carbon Filter Retention Optional

Carbon Filter Replacement Optional




Animal research, cage changing and bedding disposal procedures are now simpler, safer and more productive with the Esco range of VIVA® Lab Animal Research Products.

Product lines:•Universal Access Animal Containment

Workstations.

•Dual Access Animal Containment

Workstations.

• Bedding Disposal Workstations.

EscoSolutionforAnimalResearchLaboratories

Lab Animal Research Products

Pictured: Esco Lab Animal Research Products

13

Esco Service Guide

Laboratory operations involving weighing, mixing and dispensing hazardous or nuisance powders can now be performed safely and economically with the Esco Powdermax 1 Powder Weighing Balance Enclosure.

Product lines:• Powder Weighing Balance Enclosures.

Powder Weighing Balance Enclosures

Pictured: Esco PW1 Product

14

Testing/Maintenance Service Powder Weighing Balance Enclosures











Noise Optional

Light Optional

Vibration Optional





Testing/Maintenance Service Oven IncubatorsCO2

IncubatorsFreezers


Blower / Fan Replacement If Required If Required* If Required If Required

Electrical Troubleshooting If Required If Required If Required If Required

Electrical Safety Optional Optional Optional Optional

Enclosure Integrity Standard Standard Standard Standard

Noise Optional

UV Intensity Optional** Optional

Temperature Calibration Standard Standard Standard Standard

CO2 Calibration Optional

O2 Calibration Optional

Humidity Calibration Optional

Heater Replacement If Required If Required If Required

Pump Replacement If Required

Piping Replacement If Required** If Required

Compressor Replacement If Required** If Required

Thermostat Replacement If Required If Required***

Lamp Replacement If Required** If Required

General Cleaning and Maintenance If Required If Required If Required If Required

Esco thermostatics products are able to provide precisely controlled environment for all your laboratory needs.

Product lines:•Ultra Low Temperature Freezers.

•CO2 Incubators.

• Forced Convection Laboratory Ovens.

• Forced Convection Laboratory Incubators.

•Natural Convection Laboratory Incubators.

• Low Temperature BOD Incubators.

EscoReliableSolutionforPCRProcess

Thermostatics Products

15

Notes: * Not applicable to Natural Convection Laboratory Incubators (INA)** Only applicable to Low Temperature BOD Incubators (IFC)*** Only applicable to Forced Convection Laboratory Incubators (IFA)

Pictured: Esco Thermostatics Product

PT Esco Bintan IndonesiaCert. No: 651333/1

Esco Micro Pte Ltd Cert. No: 651333

LIVE SUPPORTescoglobal.com

LIVE SUPPORTescoglobal.com

EscoTechnologies,Inc.•2940TurnpikeDrive,Units15-16•Hatboro,PA19040,USAToll-FreeUSAandCanada877-479-3726•Tel215-441-9661•Fax215-441-9660us.escoglobal.com•[email protected]

EscoMicroPte.Ltd.•21ChangiSouthStreet1•Singapore486777Tel+6565420833•Fax+6565426920•[email protected]

Esco Global Offices | Beijing, China | Breukelen, The Netherlands | Guangzhou, China | Kuala Lumpur, MalaysiaManama, Bahrain | Marietta, OH, USA | Mumbai, India | Philadelphia, PA, USA | Salisbury, UK | Shanghai, China | Singapore

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Esco Service Guide...• North American facilities in Pennsylvania and Ohio Sales, service, logistics for US & Canada. • Other Esco locations in Bahrain, China, India, Malaysia,

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