ERP ERP Old/New Old/New Effects During Auditory and Visual Word Recognition Memory Effects During Auditory and Visual Word Recognition Memory Tasks: Tasks: Findings for Healthy Adults and Depressed Patients Findings for Healthy Adults and Depressed Patients Jürgen Kayser Jürgen Kayser , Craig Tenke, Regan Fong, Jonathan Stewart, Frederic Quitkin, Gerard , Craig Tenke, Regan Fong, Jonathan Stewart, Frederic Quitkin, Gerard Bruder Bruder Department of Biopsychology Department of Biopsychology New York State Psychiatric New York State Psychiatric Institute Institute 42 42 nd nd Annual Meeting of the Society for Psychophysiological Research (SPR), October 2-6, 2002, Annual Meeting of the Society for Psychophysiological Research (SPR), October 2-6, 2002, Washington, DC, USA Washington, DC, USA Columbia University College of Physicians and Surgeons Psychophysiologic Psychophysiologic al Laboratory al Laboratory
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ERP Old/New Effects During Auditory and Visual Word Recognition Memory Tasks:
Psychophysiological Laboratory. 42 nd Annual Meeting of the Society for Psychophysiological Research (SPR), October 2-6, 2002, Washington, DC, USA. ERP Old/New Effects During Auditory and Visual Word Recognition Memory Tasks: Findings for Healthy Adults and Depressed Patients. - PowerPoint PPT Presentation
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ERP ERP Old/NewOld/New Effects During Auditory and Visual Word Recognition Memory Tasks: Effects During Auditory and Visual Word Recognition Memory Tasks:Findings for Healthy Adults and Depressed PatientsFindings for Healthy Adults and Depressed Patients
Jürgen KayserJürgen Kayser, Craig Tenke, Regan Fong, Jonathan Stewart, Frederic Quitkin, Gerard Bruder, Craig Tenke, Regan Fong, Jonathan Stewart, Frederic Quitkin, Gerard Bruder
Department of BiopsychologyDepartment of BiopsychologyNew York State Psychiatric InstituteNew York State Psychiatric Institute
4242ndnd Annual Meeting of the Society for Psychophysiological Research (SPR), October 2-6, 2002, Annual Meeting of the Society for Psychophysiological Research (SPR), October 2-6, 2002, Washington, DC, USAWashington, DC, USA
Columbia University College of Physicians and Surgeons
Temporal resolution of ERPs allows to study memory-retrieval processes in ‘real time’
Background
Typical finding during explicit memory tasks (i.e., judging items as being old or new)
Old/New EffectOld/New Effect
Friedman 2000, Biol. Psychol., 54:175-206.msms
• begins at 300 – 400 ms
• lasts 300 – 500 ms
• mostly posterior
• overlaps at least two distinct ERP components
ERP correlate of ERP correlate of conscious recollectionconscious recollection
P600
N2
• scalp distribution ERP old/new effect differs from N400/N2 and P600/P3b topographies
• words, pictures, faces, etc.
Price 2000, J. Anat., 197:335-359.
Background (cont.)
Few ERP studies of recognition memory in the auditory modality (although similar ERP old/new effects were observed for spoken words or environmental sounds)
Behavioral and neurological evidence suggests that visual and auditory short-term memory processes are distinct and involve separate neural pathways
ERPs should reflect time course and anatomy ERPs should reflect time course and anatomy of these separate processing streams of of these separate processing streams of
10-20 System EEG Montage10-20 System EEG Montage (Nose Reference) (Nose Reference)
ElectroCapElectroCap(30-channel)(30-channel)
LeftMastoid
RightMastoid
Nose
Kayser et al., in press, Cogn. Brain Res.
Healthy AdultsHealthy Adults((NN = 16) = 16)
Study 1: ERP WaveformsStudy 1: ERP Waveforms
Visual ERPs were normalized within this modality by vector scaling across time, electrodes, condition and lag following the procedure suggested by McCarthy and Wood (1985).
Kayser et al., in press, Cogn. Brain Res.
Study 1: ERP WaveformsStudy 1: ERP Waveforms
Healthy AdultsHealthy Adults((NN = 16) = 16)
Auditory ERPs were normalized within this modality by vector scaling across time, electrodes, condition and lag following the procedure suggested by McCarthy and Wood (1985).
Kayser et al., in press, Cogn. Brain Res.
Study 1: ERP Difference WaveformsStudy 1: ERP Difference Waveforms
Healthy AdultsHealthy Adults((NN = 16) = 16)
ERPs were normalized within each modality by vector scaling across time, electrodes, condition and lag following the procedure suggested by McCarthy and Wood (1985).
ControlsControls(n=16)(n=16)
PatientsPatients(n=30)(n=30)
Time interval: 0 – 1,600 msTime interval: 0 – 1,600 ms
ERPs were normalized within each modality by vector scaling across time, electrodes, condition and lag following the procedure suggested by McCarthy and Wood (1985).
Study 2: Re-referenced ERP WaveformsStudy 2: Re-referenced ERP Waveforms
Linked Linked MastoidsMastoids(TP9/10)(TP9/10)
NoseNose
Linked Linked MastoidsMastoids(TP9/10)(TP9/10)
ERPs were normalized within each modality by vector scaling across time, electrodes, condition and lag following the procedure suggested by McCarthy and Wood (1985).
Conclusions
The expected old/new effect was observed in both modalities:• comparable time course (maximal between 500-600 ms)• a more anterior scalp topography for visual items
common cognitive process (i.e., memory retrieval) associated with common cognitive process (i.e., memory retrieval) associated with separable neural generators in each modalityseparable neural generators in each modality
The posterior old/new effect was markedly reduced in depressed patients for both modalities, but particularly for auditory presentations, despite
Modality-specific ERP components and condition-effects are severely affected by a recording reference placed over regions where these components are prominent
In healthy adults, visual/auditory word recognition memory tasks repeatedly showed:• distinct ERP components• discrete topographies
reflecting anatomy of visual/auditory pathways
However, the old/new effect overlapped ERP components (N2, P3) having distinct• scalp topographies• peak latencies for each modality, suggesting a functionally separable process
• systematic changes of referencessystematic changes of references• reference-free CSD measuresreference-free CSD measures
to dissociate neural generators and their genuine to dissociate neural generators and their genuine contributions to ERP old/new effectscontributions to ERP old/new effects
New York State Psychiatric InstituteNew York State Psychiatric Institute
Department of BiopsychologyDepartment of Biopsychology
http://psychophysiology.cpmc.columbia.edu
Jürgen KayserJürgen KayserCraig TenkeCraig TenkeRegan FongRegan FongGerard BruderGerard Bruder