ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.

Page 1 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=1' data-page='1' class='cut-thumb lazyload' alt='Page 1: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/1.jpg' width='140' height='200' /> Page 2 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=2' data-page='2' class='cut-thumb lazyload' alt='Page 2: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/2.jpg' width='140' height='200' /> Page 3 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=3' data-page='3' class='cut-thumb lazyload' alt='Page 3: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/3.jpg' width='140' height='200' /> Page 4 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=4' data-page='4' class='cut-thumb lazyload' alt='Page 4: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/4.jpg' width='140' height='200' /> ER CK5/6

Page 5 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=5' data-page='5' class='cut-thumb lazyload' alt='Page 5: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/5.jpg' width='140' height='200' /> Flat epithelial atypia

Columnar cell lesions: A spectrum: columnar cell change, columnar cell

hyperplasia, flat epithelial atypiaFEA has mild cytologic atypia (similar to

ADH,DCIS) but without architectural atypia. May be more than one cell layer thick.

Cytology: enlarged nuclei, rounding, crowding, loss of polarity, visible nucleoli, few mitoses.

Page 6 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=6' data-page='6' class='cut-thumb lazyload' alt='Page 6: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/6.jpg' width='140' height='200' /> IHC in FEA

Not helpful CCC, CCH, FEA, ADH, low grade DCIS all have the

same immunophenotype ER+, PgR+, HER2 -, E-Cadherin+, LMWK+, HMWK-.

Page 7 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=7' data-page='7' class='cut-thumb lazyload' alt='Page 7: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/7.jpg' width='140' height='200' /> Page 8 <img data-url='document/erck56-flat-epithelial-atypia-columnar-cell-lesions-a-spectrum-columnar-cell-change-columnar-cell-hyperplasia-flat-epithelial-atypia-fea-has.html?page=8' data-page='8' class='cut-thumb lazyload' alt='Page 8: ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.' loading='lazy' src='data:image/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVR42mNk+P+/HgAFhAJ/wlseKgAAAABJRU5ErkJggg==' data-src='https://reader035.cupdf.com/reader035/viewer/2022081502/551b3ce8550346dd1a8b5488/html5/thumbnails/8.jpg' width='140' height='200' />