1 Epigenetics – a New Perspective for Improving Forensic Science Hwan Young Lee, Ph.D. Department of Forensic Medicine Yonsei University College of Medicine Forensic cases -- matching suspect with evidence Paternity testing -- identifying father Current Forensic DNA Typing Paternity testing identifying father Involves generation of DNA profiles usually with the same genetic markers and then MATCHING TO REFERENCE SAMPLE
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Epigenetics – a New Perspective for Imppgroving Forensic Scienceforensic.yonsei.ac.kr/presentation/82.pdf · 2012-05-31 · 1 Epigenetics – a New Perspective for Imppgroving Forensic
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Epigenetics – a New Perspective for Improving Forensic Sciencep g
Hwan Young Lee, Ph.D.Department of Forensic MedicineYonsei University College of Medicine
Forensic cases -- matching suspect with evidence
Paternity testing -- identifying father
Current Forensic DNA Typing
Paternity testing identifying father
Involves generation of DNA profiles usually with the same genetic
markers and then MATCHING TO REFERENCE SAMPLE
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Challenges in Crime Scene Investigation
Technical challenges in forensic STR profiling
Degraded DNA Degraded DNA
Low amount of DNA
Increasing discrimination power
Familiar searching….
Important challenges remain for the use of genetic and Important challenges remain for the use of genetic and
epigenetic approaches in forensic investigations
Kayser M and de Kniff P, Nat Rev Genet (2011)
Future of Crime Scene Investigation
The ability to infer biogeographic ancestry and external
visible characteristics from DNA
Eye (IrisPlex), hair and skin color
Freckles
Stature
Hair morphology
Male baldness, etc.
http://meglikestodraw.tumblr.com/Kayser M and de Kniff P, Nat Rev Genet (2011)
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Body fluid identification can provide information linking
sample donors with actual criminal acts
Future of Crime Scene Investigation
Detailed reconstruction of crime events by determining
the time of sample donation and sample age
Kayser M and de Kniff P, Nat Rev Genet (2011)
Body fluids founds on the bedSex offender’s trial
Genetics and Epigenetics
Epi (on top of or in addition to) + Genetics
Epigenetics is the study of heritable changes in gene
expression or cellular phenotype caused by mechanisms