Enzymes م ي ا ز ن ا3a. Without references, identify basic facts and principles about blood chemistry enzymes with a minimum of 70% accuracy. (1) Introduction to Enzymes (2) Enzymatic Reactions (3) Creatine kinase (CK) (4) Alanine aminotransferase (ALT) (5) Lactate dehydrogenase (LDH) 3a ، ذخا م ت يد و جو م ذون . بردو م را در ي س سا ا ق ي ا ق ح اي ي م ي ك هاي م ي ا ز ناعذ ا و ق ري غ ص ا ت ق د ا بن و ج70 % (1 م ي ا ز ن ا ف ي ر غ ت(2 م ي ا ز ن ا ل هاي م ع ل س ا ك ع(3 ار ي ي ك ن ي ي ي را ك(4 راس ي ف ت زا ن و ن ي م ا ن ي ي ل ا(5 اس ن ج ذرو هاب ي د ات ي ك ل
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Enzymes انزايم 3a.Without references, identify basic facts and principles about blood chemistry enzymes with a minimum of 70% accuracy. (1) Introduction.
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Enzymes انزايم
3a. Without references, identify basic facts and principles about blood chemistry
AST is found in practically every tissue in the body with particularly high concentrations in the liver and cardiac tissue, intermediate in skeletal muscle and kidney, and low in most other tissues
AST مقدار به اما ميشود پيدا بدن نسج هر دربه و ميشود دريافت قلبي و كبدي نسج در زياد
و كليوي و اسكليتي عضالت در اوسط مقداردارد وجود بدن انساج تمام در كم مقدار به
Clinical Significanceكلينيكي اهميت
• AST has several isoenzymes; the origin of each isoenzyme has not been established
• AST is most often used in conjunction CK, LDH, and ALT to confirm a diagnosis of liver or cardiac disease
•AST هر منبه اما است ايزميراز نوع چندين داراياست نشده ثابت كدام
•AST “ با همراه استفاده ALTو , CK, LDHاكثرا موردنمايد تشخيص را قلبي و كبدي امراض تا ميگيرد قرار
Amylaseاميالز
• Amylase functions to break down complex carbohydrate molecules
• The majority of amylase is formed in the pancreas and also found in significant amounts to be secreted by the salivary glands
• Amylase is useful in diagnosis of acute pancreatitis كاربوهايدريت • ماليكول كامپليكس شكستاندن اميالز وظيفه
است قابل • مقدار به و شده ساخته پانقراس در اميالز زياد مقدار
ميشود افراز لعابيه غداوات در مالحظهاستفاده • مورد پانقراص حاد التهاب تشخيص براي اميالز
ALKP is found in high concentrations in bone tissue and intestines; it is found in lower concentrations in the liver and placental tissues
ALKP امعا و استخوان نسج در زياد مقدار بهشده انساج ;يافت و كبد در كم مقدار به و
ميشود پيدا پالسنتا
Clinical Significance
كلينكي اهميت• Aid in diagnosis of bone disorders• Often included in the battery of hepatic test• ALKP has several isoenzymes that can be separated to determine
affected body areas such as the liver and bone• Electrophoresis is the preferred method of isoenzyme separation
ميكند • كمك استخوان تشوشات تشخيص درميگردد“ • كبدي هاي تست شامل اكثرا• ALKP هاي افت و شود جدا كه ميتواند و است ايزوميراز چندين داراي
دهد نشان را استخوان و كبد مثل بدن مختلفه هاي قسمتميشود • داده ترجع ايزوانزايم تجزيه در الكتروفوروسيس ميتود
قلبی های مارکر
Definition of an myocardial infarction Definition of an myocardial infarction (MI)(MI)
(MI) (MI) قلبي احتشاي قلبي تعريف احتشاي تعريف
Death of part of the heart muscle due to its sudden Death of part of the heart muscle due to its sudden loss of blood supplyloss of blood supply
Electrical instability causes ventricular fibrillationElectrical instability causes ventricular fibrillation بوجود خون جريان كاهش اثر از كه قلب از هاي قسمت بوجود مرگ خون جريان كاهش اثر از كه قلب از هاي قسمت مرگ
ميايد ميايد ميگردد بطيني فبريليشن باعث برقي سيستم در ثباتي ميگردد بي بطيني فبريليشن باعث برقي سيستم در ثباتي بي
Risk factors and symptomsRisk factors and symptomsعاليم فكتوفكتو و خطر هاي عاليم ر و خطر هاي ر
Cardiac markers-the new Cardiac markers-the new standardstandard
جديد – استندرد قلبي هاي جديد – ماركر استندرد قلبي هاي ماركر MyoglobinMyoglobin
OxygenOxygen binding binding proteinprotein
CK-MBCK-MB Isoenzyme specific Isoenzyme specific
for cardiac musclefor cardiac muscle Troponin-ITroponin-I
Protein released Protein released from cardiac muscle from cardiac muscle fiber released during fiber released during a MIa MI
EnzymesEnzymesها ها انزايم انزايم
3a.3a. Without references, identify Without references, identify basic facts basic facts and and principles about blood principles about blood chemistry chemistry analytes with analytes with a minimum of 70%a minimum of 70%
accuracy.accuracy.
)1( Introduction to Enzymes )1( Introduction to Enzymes
3a.3a. Without references, Without references, identify basic facts identify basic facts and and principles about blood principles about blood chemistry chemistry analytes with analytes with a minimum of 70% a minimum of 70% accuracy.accuracy.