Managing compliance with environmental chemistry and toxicology regulations in the highly regulated areas of Research, Development and Manufacturing is a major undertaking. Failure of an organization to adequately manage this process can lead to environmental mishaps, severely damaging the company’s brand, damaging the environment and costing millions in fines. Environmental Chemistry and Toxicology Environmental chemists must be able to accurately model and predict what a facility is contributing to the environment, the environmental toxicity risks of that output, and the optimum set of actions for mitigating or managing those risks. To effectively manage regulatory compliance, an organization must be able to leverage data and analysis from multiple sources to ensure that standards are met consistently and effectively across manufacturing sites, an endeavor complicated by requirements that can frequently change and vary from one jurisdiction to another. Many R&D manufacturing companies’ regulatory compliance processes are often hindered by: Reliance upon a series of manual, error-prone tasks that disjointedly incorporate multiple disparate data sources and analytical tools Loss of productivity from the lack of an efficient automated method to carry out the necessary multiple repetitive tasks that inherently require in-depth scientific knowledge Results that are not well-documented or repeatable, prohibiting the organization from capturing the critical knowledge and decision-making practices accumulated over time The Accelrys Environmental Chemistry and Toxicology Solution The Accelrys ECT(Environmental Chemistry and Toxicology) Solution is a customizable “scientifically-aware” platform to streamline monitoring, analysis, and reporting of chemical by-products for the purposes of regulatory compliance. This scientifically-aware solution inherently allows for QSAR analysis, chemical similarity searching and other read-across techniques to maximize the value of all data. The scientific platform can easily be configured to automatically predict biodegradation products, physical properties, ADME and Toxicology properties and many other descriptors. The solution can also be configured to automatically compare any of these properties to codified business rules specific for each facility. These, and many other capabilities can automatically be presented on interactive dashboards or on REACH, MSDS or other formal documentation. • • • Real Results in the Real World One of the top five pharmaceutical companies in the world recently deployed a new toolset for managing its EHS(Environmental Health & Safety) requirements. Although its track record was good, the company did not have enterprise-wide, repeatable, documented processes for managing all the data related to its manufacturing processes. Working side-by-side with the company’s environmental chemists, Accelrys consultants were able to capture their existing (though mostly informal) EHS processes and deploy a dashboard system tailored to support those processes and integrate existing tool sets and data sources. The pharmaceutical company now has the capacity to integrate multiple datasets into reliable and trusted information. Its processes are systematized; its policy and regulatory changes can be rapidly incorporated into the automated business processes and rolled out to dozens of manufacturing plants simultaneously.