Tonsillectomy: A Tonsillectomy: A Review of Methods Review of Methods and Adjunctive and Adjunctive Therapy in 2005 Therapy in 2005 David Kluge, MD David Kluge, MD Division of Division of Otolaryngology- Otolaryngology- Head and Neck Head and Neck Surgery Surgery November 3, November 3, 2005 2005
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Tonsillectomy: A Review Tonsillectomy: A Review of Methods and Adjunctive of Methods and Adjunctive
Therapy in 2005Therapy in 2005
David Kluge, MDDavid Kluge, MD
Division of Division of Otolaryngology-Head Otolaryngology-Head and Neck Surgeryand Neck Surgery
November 3, November 3, 20052005
ObjectivesObjectives
Examine the various methods of tonsillectomy.
Assess the role and mechanism of action of post-operative antibiotics in tonsillectomy.
Examine the role of peri-operative steroids in tonsillectomy as currently accepted in the literature.
Doctor, I want the Doctor, I want the newest, best newest, best and most pain-freeand most pain-free
tonsillectomy for my child or I tonsillectomy for my child or I will go somewhere else…will go somewhere else…
What is “new”?What is “new”? The newer methods of tonsillectomy The newer methods of tonsillectomy
Certain methods are associated Certain methods are associated with less post-operative painwith less post-operative pain
But are these methods also But are these methods also associated with increased associated with increased bleeding or other risks?bleeding or other risks?
OverviewOverview Review of methodsReview of methods
Review of adjunctive therapiesReview of adjunctive therapies
ConclusionConclusion
DisclaimerDisclaimer
The information presented is a brief overview The information presented is a brief overview of the vast information available on methods of the vast information available on methods and adjunctive therapies for tonsillectomy and adjunctive therapies for tonsillectomy
My conclusions are based on the overall My conclusions are based on the overall consensus of the most recent studies available consensus of the most recent studies available
New information is being published weekly in New information is being published weekly in this area this area
Please review the bibliography for more Please review the bibliography for more informationinformation
Cold KnifeCold Knife Involves a combination of Involves a combination of
sharp and blunt dissection sharp and blunt dissection +/- snare to complete the +/- snare to complete the inferior amputationinferior amputation
Guillotine method-now out Guillotine method-now out of favor-but studies show of favor-but studies show very low post tonsillar very low post tonsillar hemmhorage rates as well hemmhorage rates as well as low post operative pain as low post operative pain levelslevels
evidence to indicate evidence to indicate less post-operative less post-operative painpain
Conflicting evidence Conflicting evidence for post tonsillectomy for post tonsillectomy hemorrhage (PTH) but hemorrhage (PTH) but probably less common probably less common than electrocauterythan electrocautery
to indicate more intra-to indicate more intra-operative blood lossoperative blood loss
Variable data on PTH, if it Variable data on PTH, if it does occur it will occur does occur it will occur earlier than cautery and is earlier than cautery and is not usually as severenot usually as severe
Will cause bacteremia, Will cause bacteremia, unlike other methods unlike other methods
Usually takes longer than Usually takes longer than cautery especially if cautery especially if bleeding occursbleeding occurs
Cold Knife-ConclusionsCold Knife-Conclusions
Still the “Gold Standard”Still the “Gold Standard” Trade high intraoperative Trade high intraoperative
blood loss for less post-blood loss for less post-operative painoperative pain
InexpensiveInexpensive
A great method for A great method for most children and most children and adults. Low pain, adults. Low pain, hospital costs and PTH hospital costs and PTH ratesrates
Electrocautery: Monopolar and Electrocautery: Monopolar and BipolarBipolar
Monopolar cautery is Monopolar cautery is currently the most common currently the most common method of tonsillectomy in method of tonsillectomy in the United Statesthe United States
Bipolar cautery has received Bipolar cautery has received more attention in the last few more attention in the last few years and is commonly used years and is commonly used internationallyinternationally
Suction cautery has also Suction cautery has also been described but is not been described but is not extensively usedextensively used
Electrocautery: Monopolar and Electrocautery: Monopolar and BipolarBipolar
Electrocautery is Electrocautery is based on tissue based on tissue dessication to dessication to achieve dissection achieve dissection and hemostasisand hemostasis
There is very high There is very high local energy transfer local energy transfer that heats tissue to that heats tissue to high temperatureshigh temperatures
Electrocautery PrinciplesElectrocautery Principles The post-operative pain The post-operative pain
associated with cautery is associated with cautery is attributed to the spread of attributed to the spread of thermal injurythermal injury
The “newer” methods of The “newer” methods of tonsillectomy attempt to tonsillectomy attempt to minimize this ‘colateral minimize this ‘colateral damage’damage’
Using cut or blend instead Using cut or blend instead of coag may decrease of coag may decrease post-operative pain (good post-operative pain (good study needed here)study needed here)
Electrocautery: Monopolar and Electrocautery: Monopolar and Bipolar-AdvantagesBipolar-Advantages
May have a higher May have a higher PTH rate than cold PTH rate than cold knifeknife
SMOKE!SMOKE! Possibility for Possibility for
endotracheal tube endotracheal tube firefire
Electrocautery: Monopolar and Electrocautery: Monopolar and Bipolar-A Word about BipolarBipolar-A Word about Bipolar
Seems to offer lower Seems to offer lower post-operative pain post-operative pain levels with the same levels with the same PTH rate as PTH rate as monopolar cauterymonopolar cautery
Minimal increase in Minimal increase in operative time over operative time over monopolarmonopolar
Electrocautery: Monopolar and Electrocautery: Monopolar and Bipolar-A Word about SmokeBipolar-A Word about Smoke
Not usually an issue in Not usually an issue in tonsillectomy as it is tonsillectomy as it is suctioned by the suctioned by the surgical assistantsurgical assistant
However it should be However it should be treated like laser smoke treated like laser smoke and aggressively and aggressively removed from all removed from all surgical fields especially surgical fields especially those known to contain those known to contain virus or cancer cellsvirus or cancer cells
No SmokingNo Smoking
NIOSH (the National Institute of Occupational NIOSH (the National Institute of Occupational Safety and Health) and the CDC (Center for Safety and Health) and the CDC (Center for Disease Control) have studied electrosurgical Disease Control) have studied electrosurgical smoke at length. They state:smoke at length. They state: ““Research studies have confirmed that this smoke Research studies have confirmed that this smoke
plume can contain toxic gases and vapors such as plume can contain toxic gases and vapors such as benzene, hydrogen cyanide, and formaldehyde, benzene, hydrogen cyanide, and formaldehyde, bioaerosols, dead and live cellular material (including bioaerosols, dead and live cellular material (including blood fragments), and viruses.”blood fragments), and viruses.”
Electrocautery: Monopolar and Electrocautery: Monopolar and Bipolar-ConclusionsBipolar-Conclusions
Low intraoperative Low intraoperative blood lossblood loss
Possibly higher PTH Possibly higher PTH rates than cold kniferates than cold knife
Highest painHighest pain
A good method for A good method for immediate immediate hemostasis and hemostasis and speed but at the cost speed but at the cost of higher painof higher pain
energy to ionize NaCl in a energy to ionize NaCl in a saline medium, then the energy saline medium, then the energy of these ions (plasma) is used of these ions (plasma) is used to break molecular tissue bondsto break molecular tissue bonds
May also be used for direct May also be used for direct hemostasishemostasis
RF energy is supposed to stay RF energy is supposed to stay in the irrigation to minimize in the irrigation to minimize collateral heatingcollateral heating
Temperatue is not supposed to Temperatue is not supposed to exceed 70 C (cautery is exceed 70 C (cautery is routinely 200-400 C)routinely 200-400 C)
Stoker et al, Otolaryngol Head Neck Surg 204; 130: 666-75
Coblation-Post Op PainCoblation-Post Op Pain
Stoker et al, Otolaryngol Head Neck Surg 204; 130: 666-75
Coblation-DisadvantagesCoblation-Disadvantages Very high cost compared to Very high cost compared to
electrocautery or cold knife electrocautery or cold knife ($150-200/piece)($150-200/piece)
Current studies are highly Current studies are highly variable, but rates of PTH seem variable, but rates of PTH seem to be equivalent to to be equivalent to electrocautery or may even be electrocautery or may even be higherhigher
Operative times up to twice as Operative times up to twice as long than electrocauterylong than electrocautery
Aggressive marketing Aggressive marketing campaign targeted to lay publiccampaign targeted to lay public
Coblation-ConclusionsCoblation-Conclusions Still a new and relatively Still a new and relatively
untested methoduntested method High level of conflicting High level of conflicting
data especially on rate of data especially on rate of PTHPTH
Very expensiveVery expensive
An expensive alternative An expensive alternative to cold knife for pain to cold knife for pain with higher PTH rateswith higher PTH rates
Harmonic ScalpelHarmonic Scalpel
Blade vibrates at 55,500 Blade vibrates at 55,500 hertzhertz
This vibration is in the RF This vibration is in the RF range and causes proteins to range and causes proteins to denature and form a denature and form a coagulum which seals small coagulum which seals small vessels and divides tissuevessels and divides tissue
Larger vessels can be sealed Larger vessels can be sealed by continuous contact and by continuous contact and secondary heatingsecondary heating
Harmonic ScalpelHarmonic Scalpel
Recurrent theme in Recurrent theme in post operative pain is post operative pain is spread of thermal spread of thermal injuryinjury
Coblation, harmonic Coblation, harmonic scalpel and thermal scalpel and thermal welding were welding were designed to minimize designed to minimize this spreadthis spread
Higher cost with longer Higher cost with longer operating timesoperating times
PTH rates about the same as PTH rates about the same as electrocauteryelectrocautery
Less post operative painLess post operative pain
Probably a better choice Probably a better choice than coblation among the than coblation among the ‘new’ methods based on ‘new’ methods based on a lower PTH ratea lower PTH rate
Thermal WeldingThermal Welding Variation of bipolar cautery and Variation of bipolar cautery and
bipolar scissorsbipolar scissors Feedback system to automatically Feedback system to automatically
control ‘seal cycle’control ‘seal cycle’ Minimizes thermal spreadMinimizes thermal spread Rated for up to 7 mm vessels at Rated for up to 7 mm vessels at
3x normal SBP3x normal SBP ‘‘Melts’ collagen and elastin to Melts’ collagen and elastin to
form a coagulum similar to form a coagulum similar to plasma and harmonic scalpelplasma and harmonic scalpel
Does not rely of proximal Does not rely of proximal thrombus like standard thrombus like standard electrocauteryelectrocautery
Also used for neck surgery and Also used for neck surgery and thyroid surgerythyroid surgery
May eventually replace standard May eventually replace standard bipolarbipolar
AdvantagesAdvantages Less post operative painLess post operative pain Probably lower PTH rateProbably lower PTH rate
DisadvantagesDisadvantages Opportunity for tonsillar regrowthOpportunity for tonsillar regrowth Still serves as a nidus for infectionStill serves as a nidus for infection May require formal tonsillectomy in futureMay require formal tonsillectomy in future
Intracapsular MethodsIntracapsular Methods
Powered microdebriderPowered microdebrider
CoblationCoblation
Bipolar ScissorsBipolar Scissors
LaserLaser
MicrodebriderMicrodebrider
Same instrument as used in adenoidectomiesSame instrument as used in adenoidectomies
Requires cauterization for hemostasisRequires cauterization for hemostasis
older technologyolder technology By far, the quickest By far, the quickest
method of intracapsular method of intracapsular tonsillotomytonsillotomy
Also used for Also used for tonsillectomy:tonsillectomy: Post operative pain for total Post operative pain for total
tonsillectomy is actually tonsillectomy is actually similar to cold knife in at similar to cold knife in at least two studiesleast two studies
PTH rates similar to PTH rates similar to monopolar cauterymonopolar cautery
LaserLaser
Used for debridement of Used for debridement of hypertrophied tonsils hypertrophied tonsils
Several laser types usedSeveral laser types used Typically leaves 10-Typically leaves 10-
25% of tonsil tissue 25% of tonsil tissue behindbehind
Associated with lower Associated with lower post-operative pain than post-operative pain than electrocauteryelectrocautery
Best Among Intracapsular Best Among Intracapsular TechniquesTechniques
Pain level amongst all techniques are likely to Pain level amongst all techniques are likely to be similar as none penetrate the capsulebe similar as none penetrate the capsule
Bipolar scissors seem to offer great immediate Bipolar scissors seem to offer great immediate hemostasis and quick operative timeshemostasis and quick operative times
Coblation is slower and more expensiveCoblation is slower and more expensive Microdebrider requires cautery for hemostasisMicrodebrider requires cautery for hemostasis Laser is probably a good technique, however Laser is probably a good technique, however
dissection may be more difficult to controldissection may be more difficult to control
Best Among Intracapsular Best Among Intracapsular TechniquesTechniques
Overall, the bipolar scissors are probably Overall, the bipolar scissors are probably the best method when taking operative the best method when taking operative time and cost into account; assuming the time and cost into account; assuming the rate of PTH and post operative pain levels rate of PTH and post operative pain levels are the same.are the same.
Doctor, I want the Doctor, I want the newest, best newest, best and most pain-freeand most pain-free
tonsillectomy for my child or I tonsillectomy for my child or I will go somewhere else…will go somewhere else…
Which is ‘Best’ choice now?Which is ‘Best’ choice now?
It DependsIt Depends What is important?What is important?
PTH ratesPTH rates Post operative painPost operative pain Intraoperative bleedingIntraoperative bleeding Operative timeOperative time CostCost Possible tonsillar regrowthPossible tonsillar regrowth Chance for bacteremiaChance for bacteremia
Adjunctive TherapyAdjunctive Therapy
Basic catagoriesBasic catagories Perioperative steroidsPerioperative steroids Operative hemostasis (bismuth/afrin)Operative hemostasis (bismuth/afrin) Post operative antibioticsPost operative antibiotics Local AnestheticLocal Anesthetic Post operative pain controlPost operative pain control
Perioperative SteroidsPerioperative Steroids Numerous studies over Numerous studies over
decades have repeatedly decades have repeatedly shown no adverse effects shown no adverse effects with one dose of with one dose of perioperative steroids.perioperative steroids.
Multiple studies have also Multiple studies have also shown reduction in post shown reduction in post operative pain levels and 24 operative pain levels and 24 hr emesis rateshr emesis rates
Study dosages range from Study dosages range from 0.1-1.0 mg/kg up to a total 0.1-1.0 mg/kg up to a total dose of 50 mgdose of 50 mg
Emesis ReductionEmesis Reduction
Steward et al, Laryngoscope 111: October 2001
Return of DietReturn of Diet
Steward et al, Laryngoscope 111: October 2001
Cochrane Database of Systematic Cochrane Database of Systematic Reviews. 4, 2005Reviews. 4, 2005
The evidence suggests that a single intravenous dose The evidence suggests that a single intravenous dose of dexamethasone is an effective, relatively safe and of dexamethasone is an effective, relatively safe and inexpensive treatment for reducing morbidity from inexpensive treatment for reducing morbidity from pediatric tonsillectomy. No adverse events pediatric tonsillectomy. No adverse events attributable to dexamethasone were reported in these attributable to dexamethasone were reported in these trials. Additionally, in our 10-year experience of trials. Additionally, in our 10-year experience of routine use of a single intravenous dose of routine use of a single intravenous dose of dexamethasone during pediatric tonsillectomy, there dexamethasone during pediatric tonsillectomy, there have been no attributable, adverse events. Lastly, we have been no attributable, adverse events. Lastly, we found no reports in the literature of complications found no reports in the literature of complications from use of a single intravenous dose of from use of a single intravenous dose of corticosteroid during pediatric tonsillectomy. corticosteroid during pediatric tonsillectomy.
Bismuth/AfrinBismuth/Afrin
Bismuth is an activator of factor XII Bismuth is an activator of factor XII (Hageman Factor) in vitro(Hageman Factor) in vitro
Studies are mixed and most do not separate the Studies are mixed and most do not separate the Afrin effect from the bismuthAfrin effect from the bismuth
Hemostatic effect (if any) maybe due entirely Hemostatic effect (if any) maybe due entirely to the Afrin and not bismuthto the Afrin and not bismuth
Bismuth aspiration has been associated with Bismuth aspiration has been associated with post operative morbidity including deathpost operative morbidity including death
Bismuth/AfrinBismuth/Afrin
Overall, there is no consensus in the literature Overall, there is no consensus in the literature as to the effectivenessas to the effectiveness
The combination may be harmful if aspiratedThe combination may be harmful if aspirated Prudent, not routine, usage is probably Prudent, not routine, usage is probably
justifiablejustifiable Afrin soaked sponges may work just as well (a Afrin soaked sponges may work just as well (a
straightforward study idea)straightforward study idea)
Post Operative AntibioticsPost Operative Antibiotics
Now generally accepted in the literature Now generally accepted in the literature as routineas routine
Some disagreement on type and durationSome disagreement on type and duration Most studies recommend a 5-7 day Most studies recommend a 5-7 day
course of narrow spectum (amoxicillin) course of narrow spectum (amoxicillin) antibioticsantibiotics
Thought to decrease post operative pain Thought to decrease post operative pain and post operative healing time by and post operative healing time by decreasing the bacterial oral floradecreasing the bacterial oral flora
Local AnestheticsLocal Anesthetics
Three major catagoriesThree major catagories
Pre-surgical injectionPre-surgical injection
Post-surgical injectionPost-surgical injection
Topical administration post operativelyTopical administration post operatively
Cochrane Database of Systematic Cochrane Database of Systematic Reviews. 4, 2005 Reviews. 4, 2005
There is no evidence that the use of There is no evidence that the use of perioperative local anaesthetic in patients perioperative local anaesthetic in patients undergoing tonsillectomy improves post-undergoing tonsillectomy improves post-operative pain control. The trials identified operative pain control. The trials identified were of small size and several involved the were of small size and several involved the perioperative co-administration of intravenous perioperative co-administration of intravenous opiates which may have masked any beneficial opiates which may have masked any beneficial effect of the local anaesthetic. Further effect of the local anaesthetic. Further randomised controlled trials are necessary. randomised controlled trials are necessary.
Post Operative Pain ControlPost Operative Pain Control
Children are routinely given Tylenol #3Children are routinely given Tylenol #3 The literature is mixed but it is a generally The literature is mixed but it is a generally
accepted practiceaccepted practice Codeine can cause constipation, vomiting, and sedationCodeine can cause constipation, vomiting, and sedation
NSAIDS are controversialNSAIDS are controversial Ibuprofen, ketorolac and ketoprofen are the most Ibuprofen, ketorolac and ketoprofen are the most
commonly usedcommonly used Some studies used the NSAIDS in the immediate Some studies used the NSAIDS in the immediate
perioperative periodperioperative period
Cochrane Database of Systematic Cochrane Database of Systematic Reviews. 3, 2004Reviews. 3, 2004
Nonsteroidal anti-inflammatory drugs (NSAIDs) are Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to relieve pain immediately after an operation. used to relieve pain immediately after an operation. Because these drugs can interfere with blood clotting Because these drugs can interfere with blood clotting there has been concern that these drugs will increase there has been concern that these drugs will increase bleeding in children having their tonsils out. This bleeding in children having their tonsils out. This could be a problem because children have relatively could be a problem because children have relatively small breathing airways and lower blood volume small breathing airways and lower blood volume compared to adults. The present review found that, compared to adults. The present review found that, with present evidence, NSAIDs did not significantly with present evidence, NSAIDs did not significantly increase the need to treat bleeding. There was less increase the need to treat bleeding. There was less nausea and vomiting when NSAIDs were used as part nausea and vomiting when NSAIDs were used as part of the analgesic regime, compared to when NSAIDs of the analgesic regime, compared to when NSAIDs were not used. were not used.
SteroidsSteroids Fully supported for 1 mg/kg up to 25-50 mgFully supported for 1 mg/kg up to 25-50 mg
Bismuth/AfrinBismuth/Afrin Good evidence for Afrin but very weak evidence Good evidence for Afrin but very weak evidence
for bismuth-recommend Afrin only packsfor bismuth-recommend Afrin only packs AntibioticsAntibiotics
Fully supported. Type and duration controversial-Fully supported. Type and duration controversial-recommend 5-7 days of limited spectrum abxrecommend 5-7 days of limited spectrum abx
Local AnestheticsLocal Anesthetics Mixed data-Physician’s choiceMixed data-Physician’s choice
Post Operative Pain ControlPost Operative Pain Control Plain Tylenol may be sufficient in young pts. Plain Tylenol may be sufficient in young pts.
NSAIDS are shown to be safe and effective and NSAIDS are shown to be safe and effective and reduce narcotic complications without increasing reduce narcotic complications without increasing bleeding. bleeding.
Overall ConclusionsOverall Conclusions
METHOD: Varies on what the physician METHOD: Varies on what the physician considers important. However, for rates of considers important. However, for rates of post operative pain and PTH cold knife is post operative pain and PTH cold knife is clearly superiorclearly superior
OverviewOverviewPainPain PTHPTH EBLEBL CostCost OR TimeOR Time
Selected BibliographySelected Bibliography Bent, J.,April, M., Ward, R., Sorin, A., Reilly, B., Weiss, G. Bent, J.,April, M., Ward, R., Sorin, A., Reilly, B., Weiss, G.
Ambulatory Powered Intracapsular Tonsillectomy and Ambulatory Powered Intracapsular Tonsillectomy and Adenoidectomy in Children Younger Than 3 Years. Arch Adenoidectomy in Children Younger Than 3 Years. Arch Otolaryngol Head Neck Surg. 2004; 130: 1197-1200.Otolaryngol Head Neck Surg. 2004; 130: 1197-1200.
Cardwell M., Siviter G., Smith A. Non-Steroidal Anti-Cardwell M., Siviter G., Smith A. Non-Steroidal Anti-Inflammatory Drugs and Perioperative Bleeding in Paediatric Inflammatory Drugs and Perioperative Bleeding in Paediatric Tonsillectomy. (Cochrane Review). In: The Cochrane Library, Tonsillectomy. (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Issue 3, 2004.
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Chan, K., Friedman, N., Allen, G., Yaremchuk, K., Wirtschafter, Chan, K., Friedman, N., Allen, G., Yaremchuk, K., Wirtschafter, A., Bikhazi, N., Bernstein, J., Kelley, P., Lee, K. Randomized, A., Bikhazi, N., Bernstein, J., Kelley, P., Lee, K. Randomized, Controlled, Multisite Study of Intracapsular Tonsillectomy Using Controlled, Multisite Study of Intracapsular Tonsillectomy Using Low-Temperature Plasma Excision. Arch Otolaryngol Head Neck Low-Temperature Plasma Excision. Arch Otolaryngol Head Neck Surg. 2004; 130: 1303-1307.Surg. 2004; 130: 1303-1307.
Selected BibliographySelected Bibliography Conley, S., Ellison, M. Avoidance of Primary Post-Conley, S., Ellison, M. Avoidance of Primary Post-
tonsillectomy Hemorrhage in a Teaching Program. Arch tonsillectomy Hemorrhage in a Teaching Program. Arch Otolaryngol Head Neck Surg. 1999; 125: 330-333.Otolaryngol Head Neck Surg. 1999; 125: 330-333.
Hall D., Littlefield, P., Birkmire-Peters, D. and Holtel, M. Hall D., Littlefield, P., Birkmire-Peters, D. and Holtel, M. Radiofrequency ablation versus electrocautery in Radiofrequency ablation versus electrocautery in Tonsillectomy. Otolaryngol Head Neck Surg. 2004;130:300-5.Tonsillectomy. Otolaryngol Head Neck Surg. 2004;130:300-5.
Isaacson, G. Inside-Out Complete Tonsillectomy: Extended Isaacson, G. Inside-Out Complete Tonsillectomy: Extended Intracapsular Tonsillectomy for Severe Sore Throat. Ann Otol Intracapsular Tonsillectomy for Severe Sore Throat. Ann Otol Rhinol Laryngol 2005; 114: 757-761.Rhinol Laryngol 2005; 114: 757-761.
Johnson, L., Elluru, R., Myer C. Complications of Johnson, L., Elluru, R., Myer C. Complications of Adenotonsillectomy. Laryngoscope 2002; 112: 35–36.Adenotonsillectomy. Laryngoscope 2002; 112: 35–36.
Koltai, P., Solares, A., Mascha, E., Xu, M. Intracapsular Koltai, P., Solares, A., Mascha, E., Xu, M. Intracapsular Partial Tonsillectomy for Tonsillar Hypertrophy in Children. Partial Tonsillectomy for Tonsillar Hypertrophy in Children. Laryngoscope 2002; 112: 17–19.Laryngoscope 2002; 112: 17–19.
Selected BibliographySelected Bibliography Lee, K., Bent J., Dolitsky, J., Hinchcliffe, A., Mansfield, E., Lee, K., Bent J., Dolitsky, J., Hinchcliffe, A., Mansfield, E.,
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Maddern, B. Electrosurgery for Tonsillectomy. Laryngoscope Maddern, B. Electrosurgery for Tonsillectomy. Laryngoscope 2002; 112: 11–13.2002; 112: 11–13.
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Potts, K., Augenstein, A., Goldman, J. A Parallel Group Potts, K., Augenstein, A., Goldman, J. A Parallel Group Analysis of Tonsillectomy Using the Harmonic Scalpel vs Analysis of Tonsillectomy Using the Harmonic Scalpel vs Electrocautery. Arch Otolaryngol Head Neck Surg. 2005; 131: Electrocautery. Arch Otolaryngol Head Neck Surg. 2005; 131: 49-51.49-51.
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Sorin, A., Bent, J., April, M., Ward, R. Complications of Sorin, A., Bent, J., April, M., Ward, R. Complications of Microdebrider-Assisted Powered Intracapsular Tonsillectomy Microdebrider-Assisted Powered Intracapsular Tonsillectomy and Adenoidectomy. Laryngoscope 2004; 114: 297–300.and Adenoidectomy. Laryngoscope 2004; 114: 297–300.
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Windfuhr, J., Deck J., Remmert, S. Hemorrhage Following Windfuhr, J., Deck J., Remmert, S. Hemorrhage Following Coblation Tonsillectomy. Ann Otol Rhinol Laryngol 2005; Coblation Tonsillectomy. Ann Otol Rhinol Laryngol 2005; 114: 749-56.114: 749-56.