154 | Page International Standard Serial Number (ISSN): 2319-8141 Full Text Available On www.ijupbs.com International Journal of Universal Pharmacy and Bio Sciences 6(1): January-February 2017 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES IMPACT FACTOR 2.96*** ICV 6.16*** Pharmaceutical Sciences RESEARCH ARTICLE …………!!! ENHANCEMENT OF DISSOLUTION RATE OF CILNIDIPINE USING LIQUISOLID TECHNIQUE Shalaka P. Rasal *1 Sheetal B. Gondkar 1 Nikhil P. Mahalpure 1 Ravindra B. Saudagar 2 1 Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy Anjaneri, Nashik, Maharashtra, India. 2 Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy Anjaneri, Nashik, Maharashtra, India. KEYWORDS: Dissolution rate, Carrier and Coating material,Liquisolid technique, Cilnidipine. For Correspondence: Shalaka P. Rasal* Address: Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy Anjaneri, Nashik, Maharashtra, India. . ABSTRACT The purpose of this study was to improve the dissolution rate of a poorly soluble drug, Cilnidipine using Liquisolid technique. Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Polyethylene glycol was selected as the solvent. Avicel PH 102 and Aerosil 200 were used as carrier, coating material respectively for preparing the tablets. The formulation were then evaluated for their flow properties such as bulk density, tapped density, compressibility index, angle of repose and Hausner’s ratio. DSC and PXRD analysis were performed to know whether there is any interaction between drug and excipients and also to study the changes in drug crystallinity. The dissolution study revealed the optimized formulation have higher drug release rates than that of plain drug, marketed and conventional tablets. Among the different formulations prepared, LS-7 with Lf value of 1.22 and R value of 12.5, was chosen as the best formulation based on higher percentage drug release 85.68%. The study has produced encouraging results and it was concluded that Liquisolid technology can be used as an efficient method in improving the solubility and dissolution characteristics of poorly soluble drugs.
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154 | P a g e International Standard Serial Number (ISSN): 2319-8141
Full Text Available On www.ijupbs.com
International Journal of Universal Pharmacy and Bio Sciences 6(1): January-February 2017
INTERNATIONAL JOURNAL OF UNIVERSAL
PHARMACY AND BIO SCIENCES IMPACT FACTOR 2.96***
ICV 6.16***
Pharmaceutical Sciences RESEARCH ARTICLE …………!!!
ENHANCEMENT OF DISSOLUTION RATE OF CILNIDIPINE USING
LIQUISOLID TECHNIQUE Shalaka P. Rasal
*1Sheetal B. Gondkar
1 Nikhil P. Mahalpure
1 Ravindra B. Saudagar
2
1Department of Pharmaceutics, Ravindra Gambhirrao Sapkal College of Pharmacy Anjaneri,
Nashik, Maharashtra, India. 2
Department of Pharmaceutical Chemistry, Ravindra Gambhirrao Sapkal College of Pharmacy
Anjaneri, Nashik, Maharashtra, India.
KEYWORDS:
Dissolution rate, Carrier
and Coating
material,Liquisolid
technique, Cilnidipine.
For Correspondence:
Shalaka P. Rasal*
Address:
Department of
Pharmaceutics, Ravindra
Gambhirrao Sapkal
College of Pharmacy
Anjaneri, Nashik,
Maharashtra, India.
.
ABSTRACT
The purpose of this study was to improve the dissolution rate of a poorly
soluble drug, Cilnidipine using Liquisolid technique. Different LS
compacts were prepared using a mathematical model to calculate the
required quantities of powder and liquid ingredients to produce
acceptably flowable and compressible admixture. Polyethylene glycol
was selected as the solvent. Avicel PH 102 and Aerosil 200 were used as
carrier, coating material respectively for preparing the tablets. The
formulation were then evaluated for their flow properties such as bulk
density, tapped density, compressibility index, angle of repose and
Hausner’s ratio. DSC and PXRD analysis were performed to know
whether there is any interaction between drug and excipients and also to
study the changes in drug crystallinity. The dissolution study revealed the
optimized formulation have higher drug release rates than that of plain
drug, marketed and conventional tablets. Among the different
formulations prepared, LS-7 with Lf value of 1.22 and R value of 12.5,
was chosen as the best formulation based on higher percentage drug
release 85.68%. The study has produced encouraging results and it was
concluded that Liquisolid technology can be used as an efficient method
in improving the solubility and dissolution characteristics of poorly
soluble drugs.
155 | P a g e International Standard Serial Number (ISSN): 2319-8141
Full Text Available On www.ijupbs.com
INTRODUCTION:
The poor dissolution rate of water insoluble drug is still a substantial problem confronting the
pharmaceutical industry. The numbers of new and, beneficial chemical entities do not reach the
public merely because of their poor oral bioavailability due to inadequate dissolution.
Liquisolid System
The technique of ‘liquisolid compacts’ is a new and promising addition towards such a novel aim.
The term ‘liquid medication’ implies oily liquid drugs and solutions or suspensions of water
insoluble solid drugs carried in suitable non-volatile solvent systems termed the liquid vehicles.
Due to significantly increased wetting properties and surface area of drug available for dissolution,
liquisolid compacts of water-insoluble substances may be expected to display enhanced drug