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epidermis
dermis
Subcutaneousfat tissue
Dermatohistopathology
(clinicopathological correlation)Ji tork
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Stratum corneum
(horny layer)
Stratum granulosum(granular layer)
Stratum spinosum
(spinous layer)
Stratum basale
(basal layer)
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Langerhans cell ?
Melanocyte
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Langerhans cell
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Melanocyte
Fibroblast
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melanin stain
Pityriasis versicolor Normal skin
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Fibroblast
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Elastic fibres
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Eccrine sweat gland Adipose tissue
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Eccrine sweat glandsecretory part
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Eccrine sweat glandduct of Eccrine sweat gland
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Duct of Eccrine sweat gland
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Dermis
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Apocrine sweat gland
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Sebaceous gland
holocrine secretion
(Pilosebaceal unit)
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Vein
Lymfatic vessel
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Nerve and vessels
Pil b l i
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Pars
bulbaris
isthmus
infundibulum
Papilla
Hair follicle:
inner root
sheath
outer rootsheath
basement
membrane
fibrous
sheath
matrix
Pilosebaceal unit
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Arrector muscle - m. arrector pili
Sebaceous gland
Hair shaft (telogen)
Pilosebaceal unit
Hair follicle
H i h f l
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Hair shaft - - anagen
Hair shaft - telogen
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Hair shaft - telogen
Hair shaft - - anagen
Arrector muscle
Hair bulge
hair stem cells
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Vater-Paccini
Lamellated corpuscleSpecialized nerve receptor
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Meissner corpuscle
specialized nerve receptor
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hyperkeratosis
acanthosis
fibrotisation
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Lichen sclerosus et atrophicus
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vVacuolar degeneration
parakeratosis
papilomatosis
acanthosis
Coarse keratohyaline granules
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Verruca vulgarisVulgar wart
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Verruca plantaris
plantar wart
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Ku oko - clavus
Plantar wart verruca plantaris
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Plantar wart verruca plantaris
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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Exocytosis
Spongiosis
Intercellular bridges
(desmosomes)
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Eczema:
-Exocytosis
-Spongiosis
-Exsudate
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Dyshidrotic vesicles
Acute eczema
weeping
Acute dyshidrotic eczema
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y
Spongiosis, exocytosis, exsudate (crust)chronic eczema
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p g , y , ( )
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multilocular intraepidermal vesicle
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Intracellular oedema
balooning
Multinucleated cells
blister
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acantholysis
Pemphigus vulgaris direct Nikolsky sign
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Pemphigus vulgaris direct Nikolsky sign
Pemphigus vulgaris indirect Nikolsky sign
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Pemphigus vulgaris indirect Nikolsky sign
Pemphigus vulgaris
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Pemphigus vulgaris
direct immunofluorescence
Intercellular positivity
IgG
C3 complement
Dermatitis herpetiformis Duhring
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Dermatitis herpetiformis Duhring
microabscess
with neutrophils
Dermatitis herpetiformis Duhring
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direct immunofluorescence
grainy IgA
in papillae
Linear IgA dermatosis
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a g a
direct immunofluorescence
linear IgA at basement membrane
Auspitz signPsoriasis vulgaris
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Psoriasis vulgaris
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Microabscess with neutrophils (Munro)
Spongiform pustule (Kogoj)
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PsoriasisMicroabscess with neutrophils (Munro)
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Psoriasis pustulosa
Psoriasis pustulosa
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Impetiginisation of eczema
( d i f ti )
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(secondary infection)
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Seborrhoeic keratosis (senile wart, verruca senilis)pigmented type
(dif.dg. melanoma)
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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Bowen disease (m. Bowen)
Squamous cell carcinoma in situ
psoriasiform
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Basal cell carcinoma
superficial, multicentric type
Basal cell carcinoma
-
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Basal cell carcinoma
nodular type
sal cell carcinoma
vasive sclerosing (sclerodermiform)
-
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vasive sclerosing (sclerodermiform)
type
Basal cell carcinoma
Sclerosing (sclerodermiform) type
-
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Sclerosing (sclerodermiform) type
Basal cell carcinoma ulcus terebrans type
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asa ce ca c o a u cus te eb a s type
Basal cell carcinoma ulcus
rodens
type
Melanocytic nevus - junctional
-
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Flat - macule
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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Melanocytic nevus - compound
Maculo-papular
-
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Melanocytic nevus
intradermal
Papules,nodules
Superficial spreading
-
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melanoma (SSM)
60%
S fi i l di l (SSM)
-
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Secondary regression
Superficial spreading melanoma (SSM)
60%
Superficial spreading melanoma (SSM)
-
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Secondary regression
Superficial spreading melanoma (SSM)
60%
S d d lSecondary regression
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Secondary nodular
superficial spreading melanoma
(SN SSM)
satelite amelanotic
metastases
exulceration
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Amelanotic nodular melanoma
Melanoma
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Melanoma
Cellular and nuclear atypia
Atypical mitosis
-
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Fat tissue
Breslow 1,0 mm (stage IA) 5-year survival = 95-98%
-
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10-year survival = to 95%Breslow > 4 mm (IIB no ulceration) - 5-year survival = 63%
(IIB with ulceration) - 5-year survival = 45%
Stage T N M 5-year survivalTab. 29.2.2./2 Staging of melanomu TNM classification (tumor, noduli lymphatici, metastasis) ( AJCC 2002)
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0 Tis N 0 M 0 100
I A T 1 a N 0 M 0 >95
I B T 1b
T 2a
N 0
N 0
M 0
M 0
89-91
II A T 2b
T 3a
N 0
N 0
M 0
M 0
77-79
II B T 3bT 4a N 0N 0 M 0M 0 63-67
II C T 4b N 0 M 0 45
III A T 1a 4a N 1a 2a M 0 63-69
III B T 1a
4aT 1b 4b
N 1b,2b,2cN 1a,2a,2c
M 0M 0
46-5330-50
III C PT1b 4b
jakkoliv T
N 1b,2b, 2c
N 3
M 0
M 0
24-29
IVjakkoliv T jakkoliv N jakkoliv M
7-19
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7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
93/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
95/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
97/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
98/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
99/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
103/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
105/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
106/111
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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pidatpityriasis versicolorklinika
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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ku oko klinika
ekzm puch vymnit
psoriasishistologiefoto mikroskopickho sklka
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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Auspitz signPsoriasis vulgaris
-
7/30/2019 engl dermatohistologie zkladn pro mediky tork rev
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