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EMR Intercountry Workshop, December 2010 1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs
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EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

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Page 1: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20101 |

VP-IBD Surveillance Data, 2009VP-IBD Surveillance Data, 2009

Photo: Dr. Mary Agócs

Page 2: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20102 |

Page 3: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20103 |

VP-IBD and Rotavirus Global and Regional VP-IBD and Rotavirus Global and Regional Laboratory Network Structure, 2010Laboratory Network Structure, 2010

WHO Regional Reference Laboratories

WHO Global Reference Laboratories

Global:

IBD & Rota

IBD & Rota IBD & Rota

Rota

IBD

IBD & Rota

IBD & Rota

IBDRota

Rota

Rota

IBD Rota

IBD

Page 4: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20104 |

Countries in WHO VP-IBD Surveillance Network, by WHO Region and GAVI Eligibility, 2009

Countries in WHO VP-IBD Surveillance Network, by WHO Region and GAVI Eligibility, 2009

WHO Region

No. (%) GAVI- eligible countries

No. (%) GAVI-eligible reporting

countries

No.(%) sentinel sites

Total No.(%) reporting countries

AFR

35 (49) 19 (56) 28 (15) 21 (45) AMR 7 (10) 2 ( 6) 28 (15) 9 (19) EMR 6 (8) 4 (12) 101(53) 7 (15) EUR 8 (11) 1 ( 3) 3 (2) 1 ( 2) SEAR 8 (11) 4 (12) 8 (4) 4 ( 9)

WPR 8 (11) 4 (12) 24 (13) 5 (11)

TOTAL 72 (100) 34 (100) 192 (100) 47 (100)

34 / 47 reporting countries are GAVI-eligible= 72%

Page 5: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20105 |

Tier 1 VP-IBD Countries: Meningitis Surveillance

Tier 1 VP-IBD Countries: Meningitis Surveillance

Page 6: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20106 |

Tier 1: Meningitis Surveillance Data, 2008 Compared with 2009

Tier 1: Meningitis Surveillance Data, 2008 Compared with 2009

India, Philippines, and Viet Nam join the network in 2009

Year 2008 2009

WHO Region

No.(%) of countries reporting

No.(%) suspected meningitis

cases

No.(%) of countries reporting

No.(%) suspected meningitis

cases

% change in number of cases

from 2008 to 2009

AFR 22 (48) 8640 (39) 21 (45) 9634 (38) +12 AMR 8 (17) 3713 (17) 9 (19) 3743 (15) +1 EMR 9 (20) 7908 (36) 7 (15) 7787 (31) -2 EUR 1 (2) 130 (1) 1 (2) 103 (1) -21 SEAR 3 (6) 1104 (5) 4 (8) 2408 (9) +118 WPR 3 (6) 602 (3) 5 (11) 1765 (7) +193 TOTAL 46 (100) 22097 (100) 47 (100) 25440 (100) +15

Page 7: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

AMR

AFR

EMR

SEARWPR

Percent of suspected meningitis cases with probable bacterial meningitis, by country and WHO Region, 2009.

0 10 20 30 40 50 60 70 80 90 100

CameroonSwaziland

NamibiaNiger

TanzaniaMalawi

SenegalZimbabwe

BurundiGhana

ZambiaDRCTogo

EthiopiaUgandaBurkina

Côte d'IvoireRwandaGambia

KenyaEritrea

GuatemalaParaguayHonduras

VenezuelaBolivia

PanamaEcuadorMorocco

YemenPakistan

IraqAfghanistan

SyriaSudan

UkraineNepalIndia

BangladeshSri LankaMongolia

CambodiaViet Nam

% of meningitis with probable bacterial meningitis

EUR

22

52

49

922930

Page 8: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

Percent of probable bacterial meningitis with HI, Spn or NM identified, by country and WHO region, 2009

0 10 20 30 40 50 60 70 80 90 100

Gambia n=4BurkinaF n=29

Côte d'Ivoire n=37Tanzania n=17

DRC n=7Cameroon n=80Swaziland n=27

Niger n=151Namibia n=181

Senegal n=46Togo n=75

Uganda n=212Ethiopia n=218

Malawi n=468Kenya n=34

Zambia n=79Burundi n=10

Eritrea n=0Ghana n=9

Rwanda n=3Zimbabwe n=274

Panama n=50Paraguay n=53

Bolivia n=32Honduras n=26Guatema n=104Ecuador n=144

Venezuela n=248Sudan n=256

Morocco n=1624Iraq n=243

Pakistan n=620Afghanistan n=69

Syria n=205Yemen n=1100

Ukraine n=95Sri Lanka n=4

India n=82Nepal n=119

Banglad. n=302Mongolia n=18

Cambodia n=20Viet Nam n=327

% of probable bacterial meningitis

HI

Spn

NM

AMR

AFR

EMR

SEARWPR

EUR

Page 9: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 20109 |

% Probable Bacterial Meningitis Cases with HI, by Years of Hib Vaccine Introduction & WHO Region, 2009

(regional medians with country-specific ranges)

% Probable Bacterial Meningitis Cases with HI, by Years of Hib Vaccine Introduction & WHO Region, 2009

(regional medians with country-specific ranges)

Number of years of Hib vaccine introduction

<1 yr or Hib vaccine not in

use 1-4yrs 5+ yrs

WHO Region

No. countries with Hib

introduced

% of probable bacterial

meningitis cases with

HI

No. countries with Hib

introduced

% of probable bacterial

meningitis cases with HI

No. countries with Hib

introduced

% of probable bacterial

meningitis cases with HI

AFR* 6 14 (1-24) 7 1 (0-3) 8 0 (0-1) AMR** 0 0 1 0 8 3 (2-6) EMR 3 0 (0-4) 3 0 (0-1) 1 0 EUR 0 0 1 1 0 0 SEAR 3 6 (2-9) 1 100 0 0 WPR 3 4 (4-5)*** 2 0**** 0 0 OVERALL 15 5 15 0 17 1

*ND from Ghana

**ND from Brazil and El Salvador

***ND from the Philippines

****ND from PNG

Page 10: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

Data collected from WHO Regions and partners and WHO/IVB Database as of September 2010 .

Invasive Bacterial Diseases Surveillance Tier 2

Invasive Bacterial Diseases Surveillance Tier 2

Slide date: 16 September 2010

The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. ©WHO 2010. All rights reserved

16 Countries

VP-IBD Surveillance: Tier 2Meningitis-Sepsis-Pneumonia Surveillance

VP-IBD Surveillance: Tier 2Meningitis-Sepsis-Pneumonia Surveillance

Page 11: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201011 |

IBD Surveillance, Tier 2Meningitis-Sepsis-Pneumonia

IBD Surveillance, Tier 2Meningitis-Sepsis-Pneumonia

Numbers of reporting countries & children enrolled with pneumonia with % change from 2008 to 2009, by

WHO region

Numbers of reporting countries & children enrolled with pneumonia with % change from 2008 to 2009, by

WHO region

Year 2008 2009

WHO Region

No.(%) of reporting countries

No.(%) children enrolled with pneumonia

No.(%) of reporting countries

No.(%) children enrolled with pneumonia

% change in number of enrolled

from 2008 to 2009

AMR 7 (47) 11428 (72) 8 (50) 14546 (82) +27 EMR 4 (27) 1051 (7) 4 (25) 1634 (9) +55 SEAR 3 (20) 1198 (8) 3 (19) 4433 (25) +270 WPR 1 (7) 2286 (14) 1 (6) 1631(9) -29 TOTAL 15 (100) 15963 (100) 16 (100) 17811 (100) +12

SEAR: increased reporting from Bangladesh & Nepal

Page 12: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201012 |

Tier 2: Meningitis-Pneumonia-SepsisDetected Organisms, 2009

Tier 2: Meningitis-Pneumonia-SepsisDetected Organisms, 2009

WHO Region Haemophilus

influenzae Streptococcus pneumoniae

AMR 16 (37) 96 (60) EMR 2 ( 5) 19 (12) SEAR 25 (58) 31 (19)

WPR 0 13 ( 8)

OVERALL 43 (100) 159 (100)

Page 13: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

Percent distribution of Spn serotypes among cases of meningitis due to Spn, 2009

0 5 10 15 20 25

4 6B 9V14

18C19F23F

1 5 

7F3 

6A19A

2 8

9A9N

10A11A12A12F15B17F

2022F33F

4546

Sero

typ

e

% of Meningitis cases

AFR n=235 SEAR n=16

%serotypes in PCV-7, 10, and 13AFR: 48%, 80%, and 91%, SEAR: and 44%, 69%, and 75% ,

Spn. Serotype Data, Tier 1: MeningitisSpn. Serotype Data, Tier 1: Meningitis

Page 14: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201014 |

Rotavirus Surveillance, 2009Rotavirus Surveillance, 2009

Photo: Dr. Duncan Steele

Page 15: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201015 |

Rotavirus SurveillanceCountries Participating in the WHO Network and

Reporting Data for 2009

Rotavirus SurveillanceCountries Participating in the WHO Network and

Reporting Data for 2009

Data collected from WHO Regions.

Slide date: 2 August 2010Yes (55 Member States or 28% of Member States)

Page 16: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201016 |

IBD and Rotavirus Global and Regional IBD and Rotavirus Global and Regional Laboratory Network Structure, 2010Laboratory Network Structure, 2010

WHO Regional Reference Laboratories

WHO Global Reference Laboratories

Global:

IBD & Rota

IBD & Rota IBD & Rota

Rota

IBD

IBD & Rota

IBD & Rota

IBDRota

Rota

Rota

IBD Rota

IBD

Page 17: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201017 |

Countries in the WHO Rotavirus Surveillance Network, by WHO Region & GAVI Eligibility, 2009

Countries in the WHO Rotavirus Surveillance Network, by WHO Region & GAVI Eligibility, 2009

By GAVI eligibility WHO region

No.(%) of GAVI-eligible countries

No.(%) of GAVI-eligible countries

reporting

No.(%) hospital sentinel sites

Total No.(%) of reporting countries

AFR

35 (49) 12 (34) 18 (11) 12 (22) AMR 7 (10) 4 (57) 59 (34) 14 (25) EMR 6 (8) 4 (67) 68 (40) 13 (24) EUR 8 (11) 6 (75) 9 (5) 6 (11) SEAR 8 (11) 4 (50) 4 (2) 4 (7)

WPR 8 (11) 4 (50) 13 (8) 6 (11)

TOTAL 72 (100) 34 (47) 171 (100) 55 (100)

34 / 55 are GAVI-eligible= 62%

Page 18: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201018 |

Rotavirus Surveillance2008 Compared with 2009

Rotavirus Surveillance2008 Compared with 2009

Year 2008 2009

WHO Region

No. (%) of reporting countries

No. (%) of children enrolled

with acute diarrhoea

No. (%) of reporting countries

No. (%) of children enrolled

with acute diarrhoea

% change in number of

children enrolled from 2008 to

2009

AFR 8 (18) 3,838 (9) 12 (22) 5,071 (10) +32

AMR 9 (20) 13,761 (33) 14 (25) 16,427 (32) +19

EMR 13 (30) 14,640 (35) 13 (24) 14,477 (29) -1

EUR 5 (11) 4,801 (12) 6 (11) 6,330 (12) +32

SEAR 2 (4) 324 (1) 4 (7) 2,596 (5) +701

WPR 7 (16) 4,050 (10) 6 (11) 5,511 (11) +36

TOTAL 44 (100) 41,414 (100) 55 (100) 50,412 (100) +22

SEAR: Indonesia and Sri Lanka joined in 2009

NOTE: No data from the AMR countries of St. Vincent & Grenadines and Surinam.

Page 19: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201019 |

% positive for rotavirus among children enrolled with acute gastroenteritis who had stool specimens tested, by country and WHO region, 2009

0 10 20 30 40 50 60 70 80

DRCZimbabwe

GhanaTogo

KenyaTanzania

ZambiaSenegalUganda

Guinea BissauCameroon

EthiopiaGuyana

HondurasGuatemala

Bolivia Paraguay

ChileEl Salvador

SurinamVenezuelaColombiaPanama

NicaraguaEcuador

St.Vincent&GrenaIran

OmanAfghanistan

YemenLibyaSyria

IraqJordan

MoroccoEgypt

PakistanTunisiaSudan

UkraineTajikistan

GeorgiaArmenia

Republic ofAzerbaijanIndonesiaMyanmar

NepalSri LankaViet Nam

LaosFiji

MongoliaChina

Papua New Guinea

% positive for rotavirus

AMR

AFR

EMR

EUR

SEAR

WPR

Page 20: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201020 |

% Positive for Rotavirus, WHO Regional Medians and Ranges, 2009

% Positive for Rotavirus, WHO Regional Medians and Ranges, 2009

WHO region

No. (%) Reporting Countries

Median)%( Country-specific

Ranges)%(

AFR 12 (22)3515 – 59AMR 14 (25)25 0 – 52EMR 13 (24)4214 – 60EUR 6 (11)3712 – 52

SEAR 4 (7)3726 – 48WPR 6 (11)4724 – 68

TOTAL 55 (100)36 0 – 68

Countries using rotavirus vaccine: Bolivia, Colombia, Ecuador, El Salvador, Honduras, Nicaragua, Panama, Venezuela

Page 21: EMR Intercountry Workshop, December 2010 1 |1 | VP-IBD Surveillance Data, 2009 Photo: Dr. Mary Agócs.

EMR Intercountry Workshop, December 201021 |

Genotypes, 2009n=2,782Genotypes, 2009n=2,782

Global distribution of rotavirus serotypes n=21,256, 1993-2004

52.2%

11.5%2.8%

7.5%

2.3%

23.7% P[8], G1

P[4], G2

P[8], G3

P[8], G4

P[8], G9

Other

% distribution of rotavirus genotypes by country and WHO region, 2009

0% 20% 40% 60% 80% 100%

Kenya n=32

Uganda n=41

Tanzania n=31

Zambia n=40

Ethiopia n=30

Togo n=29

Zimbabwe n=30

Senegal n=70

Cameroon n=33

Guatemala n=213

El Salvador n=229

Nicaragua n=347

Sudan n=294

Azerbaijan n=86

Tajikistan n=55

Ukraine n=204

Moldova n=43

Indonesia n=195

Papua New Guinea n=12

Viet Nam n=735

% of total specimens typed

P[8], G1

P[4], G2

P[8], G3

P[8], G4

P[8], G9

uncommon

mixed

untypeable

AFR

AMR

EMR

EUR

SEAR

WPR

Countries using rotavirus vaccine: Nicaragua, El Salvador