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TABLE OF CONTENTSTHE LOBELIA NUMBER Page 3"THE MOST WONDERFUL REMEDY"LOBELIA FOR CALCULI Page 4LOBELIA USED HYPODERMICALLY Page 5LOBELIA USED HYPODERMICALLY Page 6MY EXPERIENCE WITH LOBELIA HYPO-

DERMICALLY Page 7

ASTHMA Page 8SHORTNESS OF BREATH Page 9LEG ULCERS Page 10ECZEMADIPTHERIABRONCHITISPERNICIOUS CONGESTIVE CHILL Page 11RECURRENT MIGRAINERIGID OS UTERUS Page 12A LIFE SAVED BY LOBELIA HYPODERMI-

CALLYPUERPERAL ECLAMPSIA Page 13AN EXPERIENCE WITH LOBELIA Page 14

EDITORIALSAN EARLY HYPODERMIC USE OF LOBE-

LIA Page 15LOBELIA HYPODERMICALLY ADMlNl-TERED, ITS MEDICAL INFLUENCE, AND

PHYSIOLOGICAL ACTION

DR. JENTZCHS INTRODUCTION OF ITSHYPODERMIC USEPHYSIOLOGICAL ACTION Page 16DR. BARTHOLOWS EXPERIMENTSBLOOD PRESSURE Page 18ADMINISTRATION Page 20DOSAGE Page 21ANTITOXIC INFLUENCEDIPTHERIA Page 24MEMBRANOUS CROUP Page 26

TONSILLITIS Page 27ASTHMAASTHMA WITH CYANOSIS Page 28BRONCHIAL ASTHMA Page 29BRONCHITIS Page 30PNEUMONIA Page 31PNEUMONIA IN CHILDREN Page 33WHOOPING COUGHPROTRACTED COUGH Page 34PULMONARY TUBERCULOSIS

ANGINA PECTORIS

OTHER HEART TROUBLES Page 3ACUTE HEART FAILUREASPHYXIA FROM ANESTHETICSSYNCOPE FROM APOPLEXY, CRANIALINJURY OR HEAT STROKE Page 3PARALYSIS Page 3SUN STROKETETANUS

CONVULSIONS Page 3ECLAMPSIA Page 4HYSTERICAL CONVULSIONS Page 4HYPODERMIC LOBELIA IN STRYCHNINEPOISONINGHICCOUGH Page 4PROFOUND TONIC SPASMVIOLENT INTESTINAL SPASMBRAIN STORMSPINAL MENINGITIS Page 4

CEREBROSPINAL MENINGITISEPILEPSYMALARIAMUSCULAR CRAMPSBILIOUS COLIC Page 4RENAL COLICOBSTINATE CONSTIPATIONGASTRITISSICK HEADACHE Page 4LOCOMOTOR ATAXIA

HYSTERIANERVOUS EXCITEMENTPTOMAINE POISONINGTOADSTOOL POISONING Page 4COMA FROM ACUTE ALCOHOLISMEDITORS POSTSCRIPT Page 4

Ellingwoods Therapeutist, Volume 9, #2, Page 2


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THE LOBELIA NUMBER.

The contributions we have had to ourequests to send us experiences in the use of

Lobelia hypodermically have been very large,nd endeavoring to get them into the fortyages of the January Journal, we had crowded

he matter to its very smallest compass, and

otwithstanding that, we had materialnough over, for ten or twelve pages more.This we have introduced into this February

umber with the regular matter here, but thewhole will make a very valuable collection ofacts.

The statements of the doctors are verynthusiastic. We have cut out a great many ofhe adjectives. Many of the experiences arenly isolated experiences, but the whole

hows us plainly the trend of the generalpinion, and it will be only a short time untilmore facts will be presented which will con-irm some of these and disprove others. This

will make our knowledge of this vitally im-ortant remedy very much more perfect.

Nearly every man who uses the reme-dy is surprised at the breadth of the field, andt the very prompt and satisfactory results hebtains, especially in acute or emergency cases.

t is certainly a reliable remedy and we mustll do all that we can to determine the factsoncerning it, and to establish its place beyond

doubt.

THE MOST WONDERFUL REMEDY"At the onset, I think now I am justified,

nd I believe that the future will prove posi-ively that I am justified for the immediateuture, in saying that there is no other one

emedy more wonderful than Lobelia inflata,used hypodermically. I make this statementdvisedly. I have been in the deep study of thection of this remedyin immediate touch

with the field of observers covering severalhousand menfor nearly ten years, and I canay to those who have paid no attention to it,hat if they enter the same field, it will open tohem the surprises of their entire professionalife.

I first considered the above statement

when I had it proven so conclusively to mthat a full hypodermic injection of Lobelia icertain cases, covered the precise field of ation in a given condition, that a dose of eacof strychnine, digitalis, atropine and carbonaof ammonium would have to be given for, we selected a remedy for each phase of thaemergency.

The truth of the statement above madhas been confirmed by the very large numbeof reports that have come in, from physicianliving at the most extreme points in the Unied States, with no knowledge of each othenor communication with each other, reporing in precisely the same lines, and makinalmost the same exact statements. This, witreference to the action of the remedy as aemergency remedy in apoplexy; in heat strok

in pernicious congestive chill; in variouforms of asphyxia, where two, three or all othe above remedies were indicatedthis oncovering the ground of all.

Especially convincing have been thstatements, fully confirmed, that this remedis a life-saver in a great variety of emergencies, where every possible commonly knowexpedient has been previously adopted, anthe patient given up to die, in many case

when it seemed more than true that the patient was even then into the throes of death.Dr. Jentszch's first experiment was i

diphtheria, and there are a very large numbeof reports that have repeated his experience ievery little detail, with the same results. Othe other hand, for quite a little time after thremedy was first taken up in this form, the reports of its action in diphtheria were conflicing. Now there is an agreement that it is a

equal remedy with antitoxin, and, where anttoxin fails, it should invariably be used, already saving very many lives. Other physicianuse it constantly in conjunction with antitoxin, believing that it prevents when so usethe anaphalaxis caused by antitoxin. anaphalaxis shows itself, this remedy is postively the remedy to save the patient's life.

These are only a few of the argumenthat convince me that it is the greatest sing

remedy known. If I am wrong, I am willing t



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cknowledge all arguments to the contrary.I have stated elsewhere in this publica-

ion that the mass of evidence has been muchreater than I expected. Not finding it possibleo get it into a single number of my journal, Iave scattered it along for two or threeumbers after the January issue and haveondensed in this volume the essential mat-

er from all the reports. But even this does notover all I have received. I have avoided aepetition of similar statements, when I hadatisfied myself of their weight and value asvidence. I have introduced one or two arti-les on the previous use of Lobelia by the old

method, in order to give the student of thisemedy a complete knowledge of the entireield of the remedy. All this to instigate,romote, and further the exact and careful

tudy of this most valuable remedy, conduc-ng to its establishment as quickly as possible,n its exact field.

Its invariable influence in producingrofound muscular relaxation and nerve se-

dation positively, without depression, butwith an increased vital force, places this reme-dy at once in a field by itself. We have no oth-r remedy nor combination of remedies thatan be relied upon to produce such a condi-

ion, to anything like the extent this remedywill.Concerning the form of the remedy

used, several manufacturers have paid con-iderable attention to getting out a non-alco-olic preparation, fully aseptic, one causing a

minimum of pain at the site of the injection,nd devoid of emetic properties. This haseen exceedingly hard to do, and no onelaims to approach such perfection but Lloyd

rothers of Cincinnati. Their preparation,which our editor named for them Subculoyd

obelia, has but little yet to be desired. It is anxcellent preparation and does not fail of re-ults. Other preparations produce good re-ults. Even the fluid extract has been used

with good results, but the Subculoyd has theminimum of undesirable results, and is in-

ariable in its influence.Dr. Bartholow's report referred to be-

ow was an important one, and I regret it

could not be published in full. He and ProJohn Uri Lloyd, in the early eighties, workein the early physiological and pharmaceuticobservations and studies of a large number oremedies, especially this one and Aconite anHydrastis. Their work practically introduceto the profession of America the problems ophysiological investigation of the action o

remedies, as was their work in the early separation of the vegetable alkaloids and resinoids. It was all pioneer work

LOBELIA FOR CALCULIIn 1878, I saw a married woman in New

Britain, Conn., who told me that she had stone in the urinary bladder that frequentlcame down in the urethra a little way, ancaused pain and stoppage of urine. I gave he

a couple of ounce packages of Lobelia herband told her the next time it did that way tmake a strong tea of the Lobelia; then to recline on her sofa with the nates a little up antake an enema of the Lobeliainter-rectumand vaginaand hold it then by pressure along as she could. At the second attempt thcalculus passed as big as a small plum stone.

I have caused a good many gall stoneto pass by using specific Lobelia. When th

pains come, about six to ten drops held in thstomach region by adding equal parts of deodorized tincture of opium. I got one stonabout one inch long and about one-half of ainch in diameter that had probably been preent in a man for over two years. It was coatewhite, and the efforts at extrusion caused thcoating to crack all over. The man has not haa repetition now in about ten years.

F. H. WILLIAMS, M. D. Bristol, Conn.



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The application of remedial agents toathological conditions is the part of the in-

ernist. These agents may be given by way ofmouth, hypodermically or endermically.

Nature indeed has been very kind iniving to us a sign whereby we may know to a

ertain degree of exactness the location of ourmany lesions, and as sciences are but the de-elopment of common sense in special direc-ions, we have the science of physical and spe-ific diagnosis, together with the microscopend X-ray as our instruments of instruction touide us.

There is one principle told in the longgos by Dr. J. M. Scudder, that the physicianhould know how a man stands, walks, sits,

alks, lies in bed; color of membranes, how heeels, sounds and smells.It is a well established fact that a great

deal of the above diagnostic points come to us,s it were, by intuition, attrition, or rather byhe rapid action of an educated nervous sys-em. The application of any drug to anyathological condition is like the solving of aeometrical problemyou must have yourngles, lines and distances right, or you can

ot solve your problem. Just so in therapeut-cs; if your diagnosis is wrong your remedy

will not relieve your patient, and if your diag-osis is right you get results.

For example, such remedies as Aconite,elladonna, Veratrum, Gelsemium, Rhus tox,r any other indicated remedy are as certain inheir action in relieving the sick as breadiven to the famishing will relieve hunger;ence great care should be taken in our diag-

osis, and time taken to examine our patients.I am beginning to realize a fact my fa-

her wrote me in a letter February 18, 1894,when he said, "It takes a whole life to prepare

ne to treat a sick baby or wife."And no less care should be taken in di-

gnosis for the proper application of this won-derful life-saving remedial agent, SubculoydLobelia. I am confident that it is the greatest

nown remedy in the profession today as an

mergency remedy, having a greater or wider

range, but yet of specific adaptation. It is great antispasmodic, a powerful antiseptic oantitoxin, a reliable alterative, a nerve sedative, certainly acting on the nerve centers anrespiratory centers, thus improving oxygention of the blood, and a most powerful resto

ative in collapse. With all the above princples in it, you will find that such an agent in great many severe diseases, may, at the criticmoment, save the life of your patients, as ha

been my experience.The antitoxin effect of Subculoyd Lobe

lia is something I do not understand, yet have watched it and it certainly has a widrange in this line. It is the first remedy to bthought of in the convulsions of childhood

giving from five to twenty drops and repeaing as needed. Not only is it the remedy foinfantile convulsions of all kinds, but thconvulsions of Angina Pectoris; in these casegiving thirty drops at a dose as in SpasmodAsthma and Croup of all kinds, and repeat thdose as needed.

I have used it in diphtheria with gratfying results, after having used antitoxin; anin Tetanus, had I a case, there is no remedy

would lay more stress on than Subculoyd Lobelia. Its antiseptic property and wonderfuantispasmodic action make it the remedy paexcellence in this terrible disease, and this, together with Subculoyd Gelsemium would cetainly be my sheet anchor in such conditions

This remedy has certainly had its triand wrought wonders in the recent spintroubles with horses in Kansas and Nebraskand will act just as effectually with spinal m

ningitis in the human.In pneumonia I find it of great valu

When the lungs are engorged, the breathing short and oppressed, the pulse is quick anrapid, and together with that anxious expresion of the countenance, I use Subculoyd Lo

belia, and repeat it every three to five or shours as needed. It will quiet the patien

bring down the pulse and favor better oxygenation of blood, in accordance with essen

tial principles.


LOBELIA USED HYPODERMICALLYE. E. GADD, M. D., DES MOINES, IOWA.


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This brings me to a case at Mercy Hos-ital in Des Moines that was operated on for

he largest umbilical hernia I ever saw. Somehree to five days after the operation the sur-eon and doctor in attendance said the patient

was going to die from asthma, as they couldot do anything for her; nothing seemed to doer any good. A doctor said to the doctor in at-

endance, Take this bottle up to the hospitalnd give her 25 or 30 drops hypodermically,nd I'll bet she will breathe better, and youtay there 45 minutes and give her the second

dose if she is not easier. The doctor did so,nd in a half hour the patient's breathingame down from more than forty to twenty-ne respirations per minute. In a night or soollowing she asked for some more of thatsleep medicine as she called it, which was

his life saving agent, Subculoyd Lobelia.There are so many-places that this rem-dy fits in in the emergencies of life that wehould acquaint ourselves with it far morehan any of us are doing today. I have not

used it in many of the offices in which it isapable of being used, yet the field compara-ively new is open to all for study and re-earch.

The case for which I write this article

articularly was a case of what I called pto-maine poisoning in a little girl eight years ofge, in February, 1913. I was called six miles inhe country to see this child, who was suffer-ng from some form of ptomaine poisoningr auto intoxication. The child had had a con-ulsion; the temperature was running 104,nd she was very delirious. I used the follow-ng remedies:

We gave enemas and administered the

ld-fashioned antibilious physic. Internally Iave Passiflora, drams 5; Gelsemium, drops5; Rhus tox, drops 8; water to make 4 ounces.ig., teaspoonful every 15 minutes to everyhree hours to control the nervous system.

Second prescription was Echinacea,rom four to five drops every two hours. Onhe 26th I called a nurse on the case, and theollowing is the report of case:

At the time of giving the first hypoder-

mic of Lobelia the tongue and mucous mem-

branes were parched and dry as in case otyphoid, and in a very short time after firhypodermic, say, about 10 minutes, thmucous membranes began to show moistursimply by the action of Lobelia on the centrnervous system. The nurse remained on thcase until March 11th, and the child made fine recovery, due to Subculoyd Lobelia.

NOTEThe hospital records, which the Doctfurnished with this paper, would be a valuable study foevery reader, but lack of space does not permit.

LOBELIA USED HYPODERMICALLYMARGARETHA WILKENLOH, M. D.,

CHICAGO.In the use of Lobelia hypodermically i

the treatment of children, the same rule applies as will apply with all specific remedieand their exact application. Other condition

being right, the same indications presentinalways calls for the same remedy.

The specific indications which are morconspicuous I have found as follows: The ciculation is feeble; there are cold extremitiethe tissues of the body are full, doughy, inelatic; a full, pallid, livid face, eyes dull, with dlated pupils; a full, broad, pale tongue or aelongated tongue with red edges, dry, rougswollen, perhaps with grayish white papilla

The whole mouth is dry from lack of secrtions from the mucous and salivary glandthe voice oppressed and halting from a lack oinnervation from the heart or lungs.

In many cases there is praecordial oppression; the patient complains of weighheaviness, tightness over the chest with sighing respiration. The pain is one of anguish ofear. It can be readily seen in the little oneface as the expression is almost characteristic.

This remedy is best given hypodermcally. I have used the subculoyd, though thspecific medicine may be given in hot wate

by the mouth, and in many cases the patienwill not vomit it. Large doses relax the whomuscular system, depress the circulation, lesen blood pressure, and lower the temperaturSmaller doses stimulate the vasomotonerves, aid the circulation through the improved heart action and induce an equalization of the circulation or a normal circulatio



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f the blood through the capillaries. It is atimulant to the entire sympathetic nervousystem, increasing innervation through its ac-ion upon the cerebrospinal centers. It antago-izes venous stagnation, which is no more or

ess than capillary stasis.If the stomach is loaded with unwhole-

ome food and the patient feels as if he could

omit, it relieves the stomach and produces aensation of comfort and rest.It is a powerful agent used hypodermi-

ally for the reduction of strangulated herniar where there is impaction of the feces, orrolonged chronic constipation. In whoopingough, or in scarlet fever, or measles whenhe eruption is slow to appear, or the urine isoaded with albumin, or where there is ure-

mic poisoning, which is shown by mental he-

etude; here the subculoyd hypodermicallycts as a diuretic, diaphoretic, and antispasmo-dic, as well as a stimulant. It will almost im-mediately improve the entire capillary circu-ation.

Where there is an excess of tempera-ure, it reduces this excess, promotes normalone, and if there is nervous excitability, its ac-ion on the cerebrospinal nervous system ishat of a profound sedative. In eruptive dis-

ases, it promotes the bringing out of theruption.I have used the remedy in a great many

ases of diphtheria, and have made the fol-owing observations: When the mucous

membranes of the mouth and nasal cavitiesre swollen, with a white, glistening ap-earance; where the tongue protrudes slowlynd to one side or the other, and seems tooarge for the mouth, or where the coat on the

membranes of the throat is of a dirty grayisholor, which is characteristic of straight

diphtheria cases, and where swallowing isery difficult, large doses of subculoyd Lobeliaypodermically are very important. Theyhould be given sufficiently often to restorehe secretions as soon as is consistent. Thenhey should be followed by smaller doses.

In respiratory troubles it is a special se-dative. Small doses often repeated, given with

lenty of water, improves the capillary circu-

lation. The skin becomes moist, the bowels oten move without an additional laxative, thtemperature declines, the kidneys act morfreely, in fact all secretion is stimulated, anthe disease comes to a safe and rapid termination.

If not seen until the disease has asumed a violent form, or until the symptom

of croupous pneumonia are conspicuouthen larger doses should be given, especially the bronchial tubes are loaded with mucus, there are whistling or sibilant rales, or on thother hand, the cough may be dry or whistlinand there may be rapid, shallow breathinwith an anxious expression, and a tendency tcyanosis, in full doses, I think, Lobelia is amost the only remedy. It stimulates secretionimproves the heart's action, and promote

retrograde metamorphosis through all thnormal excretory channels.Coughs that are due to the irritation o

the pneumogastric nerves are directly influenced by Lobelia. It relieves the pain induced by the cough, promotes normal expetoration and freedom of respiratory action.

In cerebrospinal meningitis thercomes a plainly marked time in which it is absolutely necessary to use Gelsemium and Ech

inacea. Here, especially with the latter remedywhen the face becomes ashen-pale and thpains in the muscles are extremely severand convulsions persist or are followed withgreater or less degree of paralysis, Lobelia is aimportant remedy. In some cases, full largdoses will be required and in other cases, especially in children, the smaller doses will be advisable. I believe that in some of my cases has actively promoted the restoration o

nerve force in previously paralyzed condtions.

MY EXPERIENCE WITH LOBELIAHYPODERMICALLY

D H. EDWARDS, M. D., WASHINGTON, PA

TETANUSI treated but one case of this dread di

ease with Lobelia. I was called in consultatiowith an Allopathic friend, who had diagnosethe case as beginning typhoid fever.



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In getting the history of the case, Iearned that the boy received an injury whilelaying football. During a charge against thepposite team, this boy struck his forehead

nto one of his opponents' mouth, the impactwas so severe that a tooth was broken off andodged into the scalp of the aggressor, andhere remained embedded until removed.

The tooth was extracted from its newurrounding and the wound dressed antisep-ically by the attending physician. The case

was lost sight of until the patient returned ofis own accord and presented a suppurating

wound with some cellulitis present in theurrounding tissue. The case was dressed andold to report the next day. This was two

weeks after the injury. The next day the pa-ient was worse.

The physician was called to see him,inding some of the symptoms of typhoidresent due to his septic condition. The tem-erature 103, pulse 90. That evening he took aonvulsion, and before morning had elevenonvulsions. The convulsions were of thelonic type, with severe episthotonos, andasted from three to five minutes.

After the third convulsion, which weubdued with chloroform, I suggested tetanus

nd started the Lobelia 30 minims every fif-een minutes, and oftener if he had a convul-ion. In all he received two ounces of Lobeliay noon the next day. We started the Lobeliabout 12 o'clock and by 4 o'clock the patient

was sweating profusely and had no more con-ulsions.

This case also received Anti Tetanic Se-um 5,000 units.

There was another consultation held

ater, after the convulsions ceased, with a sur-eon from Pittsburgh, Pa. He advised an im-

mediate operation and trephined for bloodlot or serum. The operation revealed neither.

The patient, however, recovered andas left the hospital.

In this case I think there is no doubtbout the diagnosis of tetanus, as the woundooked very angry with accumulation of pus,nd absolutely refused to heal until after the

onvulsions ceased, showing that the toxins

causing the convulsions also caused the suppuration. However, the Lobelia caused thconvulsions to cease, and may have antidotethe toxins also.

ASTHMAIn the treatment of asthma, I have e

tablished a reputation that extends to adjoin

ing states. I have cured so many that the fewhave not cured are lost track of.I received a letter some time ago from

Mr. S., who had gone to Florida for the relieof asthma. While there he met a patient omine whom I cured of a bad case of asthmThis patient advised Mr. S. to go to me and receive my injections for asthma. They had poitively cured him. Mr. S. asked me if it wapossible for him to get the treatment withou

coming such a distance. I wrote him that was impossible to treat him-successfully unless he was here, where I could give him aleast three injections a week.

Mrs. S. M., from W. Middletown, Paapplied for treatment for asthma, upon threcommendation of a friend of hers, whom treated and cured of a long standing case. Shcalled at the office with the usual train osymptoms. Examination revealed extrem

shortness of breath, with an abundance omucus rales throughout the tubes of botlungs, could not lie down at night on accounof the shortness of breath.

After the first injection, she reportefor next treatment and stated she was able tsleep all night with perfect ease. Gave her iall ten injections of thirty drops, giving themtwice weekly. The last time she was at the ofice, she was feeling well. I gave her a tho

ough examination, and found all the ralehad disappeared, and not a sign of shortnesof breath, even upon exertion. She is vermuch pleased with results.

I wish to state also this case received internally the following prescription:

Iodide Pot. ..............3iiSerpentaria ............3iiiSp. Lobelia ...........m.l 5Syrup Simp. and Aqua Dest.

q.s. ............oz. iv



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M Sig.One teaspoonful in water eve-y three hours.

This undoubtedly will assist in reliev-ng the asthmatic condition somewhat, but ifhis alone would accomplish a cure, why

would not all physicians cure their cases, aswe know they mostly rely upon potassium io-dide or some of its compounds in most every

ase of asthma. Hypodermic Lobelia is the keyo success.I have had one case out of 36 cases of

sthma that did not respond to repeated largedoses of hypodermic lobelia. It is a case of 25

ears standing in a woman of 30 years. I didot expect to cure this case with Lobelia, as sheas tuberculosis as a complication, if not thexciting cause. The physicians had to resort tonjections of morphine to relieve a spell, as

he called it.I started her at first on Lobelia, and sheesponded splendidly; in fact, she did notave an attack for several months, when, forome cause, it returned. I again started the in-ection regularly and controlled the attacksach time, but not as successfully as at first.

Thirty minims were used at this time. I nowncreased it to 45 and later to 60 minims. This

dosage never caused nausea, but caused relax-

tion and alleviation of the asthmatic attack.This case is still an asthmatic and will remain,think, as long as she lives. I wish to state thisase was also placed in the hospital and re-eived orificial treatment, which benefited herery much for a long time.

In summing up all the cases of asthma Iave treated with hypodermic Lobelia, I ar-ive at the conclusion that it is the best the

medical profession has access to at the present

ime. It will cure most cases of bronchial asth-ma and will alleviate reflex and cardiac asth-ma better and with less danger than mor-

hine. There are some cases, no doubt, inwhich morphine will act quicker, and I haveused thirty minims of Lobelia into which I

ut one-quarter of a grain of morphine withplendid results.

The dose varies with conditions. It isot poisonous, and may be given in large dos-

s. Thirty drops is my average dose. I may be

too strong on my dosage, but I am after relaxation.

SHORTNESS OF BREATHSome patients will call at the office an

say, Doctor, I am short of breath at times, omaybe, all the time complain of an oppressioin the chest. These cases are due to differen

causes. Sometimes it is the heart, sometimethe cause is in the bronchial tubes or lungsbut the physical symptoms are not pronounced. The patient still complains.

One case will illustrate. An elderly ma(about 78 years of age) was able to walk utown, but upon the least exertion had an oppression of chest. I examined him closely oseveral occasions and detected some loss ocompensation. I explained the matter to him

He took it all in, but acted as though he doubed the trouble was there.He always told me that his trouble wa

in his stomach, and I then tried to explaihow a deranged heart would cause a derangestomach. He did not care about that. All hwanted was, Can you relieve me? I made

bold statement, put him on Cactus anStrophanthus and, on the side, an injection oLobelia, every other day, until twelve inje

tions were given.He took very kindly to the injection

and made the remark the next visit, I thinyou have hit the spot, as I walked up towwithout the usual shortness of breath, anfeel better through the chest. Needless to saythe old gentleman recovered and remainwell to this day. I also wish to state that I hathis patient on Cactus, Crataegus anStrophanthus before the injections, off and o

for six months. Not until I gave the Lobelidid permanent results come.

A number of other cases I have treatelikewise, with good results. I wish to state few Lobelia axioms which I have found true:

Lobelia does not nauseate in doses from30 to 60 minims.

Lobelia causes no ulceration at the siof injection, with reasonable antiseptic precautions. I have never had one.

Lobelia will cure many cases if given



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hance.Lobelia will eliminate some cases of

drug addiction, if given time.

LEG ULCERSI have treated a few cases of ulcer of the

eg with daily injections of Lobelia. I think, byts antiseptic action, it destroys the formation

f pus, stimulates healthy granulations, there-y favors healing of any solution of continuityf tissue. The cases I have treated healed moreuickly than similar cases did, without the in-

ections of Lobelia.Lobelia locally forms one of the ingre-

dients of the Eclectic wash so highly recom-mended in these cases. I shall persist in usingt until I have fully tested its virtue. I am atresent treating a case who is getting nothing

nternally except the injections of Lobeliawith, of course, cleanliness of the parts locally.

shall report results of this case later.

ECZEMAI wish to report the case of a child one

ear of age, whom I treated for asthma. Thesthma responded nicely and with it went aad case of eczema of the cheeks, so frequentlyeen in infants during the teething period.

The skin peeled off nicely and beneath was aealthy skin with natural appearance. I haveot had an opportunity to treat another casef eczema of like character.

DIPTHERIAMr. P. came to the office complaining of

ore throat. Examination revealed very offen-ive odor, with swollen lymphatics, enlarged

onsils, with the characteristic gray membranewhich bled upon being removed. Tempera-ure 103, pulse 120. I sent the patient home

with instructions to go to bed, and that Iwould call later and administer antitoxin. I

ave 2,000 units, not, in my opinion, a suffi-ient quantity, but enough to keep down gos-ip of the community in regard to the treat-

ment used.The next morning the patient was no

etter, so I proceeded with hypodermic injec-

tions of Lobelia, thirty drops three times dailyWould have given it oftener if urgent symptoms had developed. The next day the mem

brane started to peel off and the patient madan uneventful recovery.

(2) Miss Jessie J., age 12, complained osore throat, with all the symptoms of thabove case. Anti -toxin, l,000 units, admini

tered (small dose), followed by injection of Lobelia three times daily. Patient recoverewithout complications whatever. Membrandisappeared on the third day, with all the other symptoms.

Three other cases of diphtheria I winot enumerate in detail, as the .symptomand treatment were the same as outlined ithe two cases cited above.

BRONCHITISI have treated a number of cases o

bronchitis with Lobelia, especially those casewith an abundance of mucous rales, and tendency to wheeze. I have had the patienreturn at the next visit and say that that injetion relieved them in a few minutes.

I had a patient in the office with bronchitis, accompanied with shortness obreath. After an examination I at once injecte

30 drops of Lobelia. I then started to prepare bottle of internal medicine and in about fivminutes she made the remark, Doctor, coulthat medicine be taking effect already ? asked why. She took several long breaths anremarked, I can breathe better than I have foa long time.

Lobelia surely is curative in these caseof bronchitis with shortness of breath, or oppression in the chest, with mucous rale

which can be heard with out even listeningsimply laying the hand on the chest will sufice to determine them. In cases of bronchitfollowing pneumonia, it will act as a stimulant as well as to relieve and cure annoyincough, with an abundance of rales.

In this field I am sure Lobelia will shinbetter than any other known remedy. It is pefectly harmless and has no bad after effect ado so many of the other drugs, as morphinheroin and codeine, so frequently prescribe



11/47

y the profession of today for this annoyingdisease.

PERNICIOUS CONGESTIVE CHILLA. W. BILLINGSLEY, M. D., ARKANSAS.

A girl of 13 years had always beenealthy, except for an occasional chill. At this

ime she had been chilling every other day formonth. Her parents thinking it was nothingut malaria, had given her a mild purgativend some quinine from time to time, and this

was all she had had for the chills.At 11 o'clock a. m., July 15, 1913, she

drank about a pint and a half of cold waternd a half hour later, which was the time ofer regular chill, she was taken with the mostiolent chill and soon became unconscious.

nstead of resorting to strychnine, atropine orlonoin, as I had usually done in such cases, Iave her 30 drops of subculoyd Lobelia and

wrapped her well in a blanket, wrung out ofot water to which pepper and ginger hadeen added. In half an hour she regained con-ciousness in part sufficiently to swallow andalk some.

I then went to the office to get somemore Lobelia, for I was anxious to try it thor-

ughly in this condition, as other treatments Iad tried in pernicious malarial affections

were not always satisfactory. I returned in 45minutes from the time the first dose was

iven, and found her again unconscious. Hermother said she had given her a large cupful

f cold water, which was contrary to my in-tructions. The girl soon complained of beingold again and sank into the stupor I founder on my return.

I then gave her 60 drops of the remedynd in half an hour she began to show much

warmth and commenced to sweat profusely.he then vomited the water and also herreakfast. There was at least half a gallon of

water.Her temperature was nearly 105 de-

rees. I prepared a mixture of Aconite andelladonna to combat the temperature, buthe would vomit it as fast as I would give it.

very time she swallowed anything, she

would vomit, and would even vomit wheshe had swallowed nothing.

The vomitus consisted of bilious mater for nearly half an hour. Of this she vomied at least a gallon, and then this was followe

by the vomiting of fecal matter, and I becamgreatly alarmed and was afraid that the Lobelia I had given her was the cause of the vo

miting, and I did not know then how easilycould check it.I again took her temperature and foun

it had fallen three degrees. I felt the pulse anfound it full, regular and soft. This gave mfresh courage. However, she continued vomiting feces for some time, when I concludeto give her morphine one-eighth of a grainand atropine 1/200 of a grain hypodermicallyand this, after half an hour, controlled the vo

miting.She then had only two degrees of feveand went to sleep. I injected a solution of tegrains of quinine into the gluteal region anpromised to see her the next day, or sooner, she be came worse. The next morning I founthe patient in an excellent condition. She waa little weak, but was feeling well the next dayShe has not been ill from any cause since.

I have made this report a little length

because I have not before seen a report fromthe use of Lobelia in pernicious malarial fever, neither have I had a patient vomit as thone did, either before or since that time.

I have used hypodermic Lobelia pehaps a hundred times and every time I havused it it was not until it seemed that deathcurtains were fast enfolding the patient.

RECURRENT MIGRAINEL. C. LAYCOCK, M. D., ALEXANDRIA OHIO

The mother of five children had beesubject for years to very severe at tacks of mgraine, occurring about every three to sweeks, which always kept her in bed five tseven days. She lives in a town five milefrom me, in which are four physicians, all owhom had treated her, as had several others.

I had treated her during the attacks, a



12/47

well as during the intervals, for more than aear, but with very little, if any, better resultshan the others. I was called to see her on thevening of October 10th last. Found her suf-ering with intense pain, radiating from theorehead up over the head to the base of therain and back of the neck, with frequent vo-

miting. Could keep nothing on the stomach. I

ave her three-eighths of a grain of morphiaypodermically, which relieved her a very lit-le, in about an hour. I was called again theext afternoon. She had now been in bed

hree days, was still suffering intensely, andaid she just couldn't endure the pain anyonger. I immediately gave her thirty dropsubculoyd Lobelia hypodermically. Not hav-ng time to stay and watch the effects, I did notee her again for a week. Asking then how she

ot along, as I had heard no more from her,he said, That last dose you gave me just act-d fine. I went to sleep in about two hours,nd got up the next morning free from head-che and not a bit sick at my stomach. Always,eretofore, I had to stay in bed a couple of daysfter the headache got better, and was veryick at my stomach, too.

These two cases have made me a strongdvocate of hypodermic Lobelia.

RIGID OS UTERUSMy experience with subculoyd Lobelia

s limited to these two cases, but its action inoth was highly satisfactory. My first case wasprimipara, 27 years of age. Labor was expect-

d about the 14th of last September, but shean over the time some ten days. I was calledt 9 p. m., Monday. Pains had commenced at 2. m., and were coming on every ten minutes.

xamination revealed a rather small pelvicavity, with os dilated about the size of a

dime.Progress was very slow. By noon, Tues-

day, the os was no larger than a nickel, and by2 o'clock Tuesday night it was dilated tobout the size of a 25-cent piece. During Mon-

day night and Tuesday-I had given her at in-ervals several doses of Caulophyllin, Macro-ys, -strychnine, quinine, but without any ef-

ect, so far as I could see, as at midnight Tues-

day the pains were very little, if any, strongeor more frequent than twenty-six hours, before, when I first saw her. By this time shhad become very nervous, restless and uneasy, with pulse at 100. the os still hard and rigiand dilated no larger than a quarter. I now dcided to try the Lobelia, and gave her thirtdrops of the subculoyd hypodermically. I

about twenty minutes, she remarked that shfelt a good deal better, and asked if I had giveher morphine. The pulse came down to 8with better strength and volume. Thnervous restlessness was entirely relievedand she would drop off to sleep between thpains, which soon became stronger and morfrequent.

By 4 o'clock Wednesday morning, fouhours after giving the drug, the os was full

dilated and the head was pressing against thpelvic rim.Though the pains were now strongl

expulsive, I realized that she could not be dlivered without help. So another physiciawas called who gave an anesthetic while I applied forceps, and together we worked as haras I ever worked in my life, alternately restinand helping each other (the nurse continuinthe anesthetic) for nearly two hours before w

succeeded in delivering the patient of a tweve-pound dead baby.I would have you notice that at the en

of thirty-six hours of labor, up to midnighTuesday, the os was still hard and rigid, andilated no larger than a 25-cent piece. Withifour hours after giving the subculoyd Lobelithe os was fully dilated, the pains strongly expulsive, and the patient much more comforable in every way. She made a good recovery.

A LIFE SAVED BY LOBELIAHYPODERMICALLY

DR. HARRISON, CHRISTOPHER, ILL.

During the month of April, 1914, whad here in Christopher, Ill., an epidemic oscarlet fever, which was the most severe have ever seen. I have in my practice treatemany cases of so-called scarlet fever, but all o

my cases were mild, never having lost a cas



13/47

When I would hear of children that had scar-et fever, that failed to get well, I would thinkt was because they failed to get the right treat-

ment.The epidemic that I have mentioned

bove knocked all of the conceit out of me.Only three families, however, were involved.The quarantine was well carried out and the

disease failed to spread. The contagious feverwas brought to us by a family moving hererom another town, where they had the mostevere epidemic of scarlet fever that this partf the country has ever known; ten to fifteenhildren dying every week, and for four orive weeks, so reports say.

Of the three families here that had thedisease, two of the children died. But it was tomy good luck that I failed to be called to treat

ither of the two that failed to get well. But Iad the care of one of the families, consistingf four children. All of the children took the

disease in a very bad form. Two of the child-en, the youngest, came very near dying, butecovered.

The youngest child, four years old, wasery sick. I will try to describe only the condi-ion of this one. All of the conditions com-

mon to scarlet fever were well marked. I

hought by the symptoms they were all gettingetter; temperature was very near normal,nd it seemed we were getting along excel-ently well.

Complications finally set in and becamehe factor in the case. Marked kidney affection

was now on. The heart showed marked weak-ess. The temperature fell to a little belowormal. General dropsy appeared, mostly of

he lower extremities, though the edema soon

ecame general over the body. Dyspnea, ordifficult breathing, was very bad. My little pa-ient could only breathe by being propped upn a rocking chair. Could not sleep, had noest for several days or nights.

One evening I called to see my patientnd I found all of the symptoms aggravated.

The pulsations of the wrist were scarcely per-eptible. At this time I gave up all hope. Ihought my patient could not live through

he night. Early the next morning, while at

the breakfast table, I received a call to comagain to see the sick child, as they thought shwas dying. I went to my office, taking with ma bottle of subculoyd Lobelia.

When I arrived where my patient wait appeared the child could not live an hour.could not feel any pulsations at the wrist. Thface and the lips were of a dusky hue. Breath

ing was difficult. As soon as possible I gave hypodermic of thirty drops of the medicine. Iabout forty minutes I gave thirty drops againIn one hour from the second injection I coulsee signs for the better. In two hours I gavanother hypodermic of twenty drops. By thtime I was sure the patient was a little better.

At 1 o'clock p. m. I found my patienmuch better. She was warm, pulsations at thwrist were weak, but plainly found. There wa

great improvement of the breathing. I gavanother injection of ten drops of the medcine. At 4 o'clock p. m. I found the patiensleeping, the only rest she had had since hesickness began. I called the next morning anfound my sick girl much better. She was nowon the bed, and resting well; had a goonight's rest. From this time on the child improved. Convalescence was a little slow. Itwo months, though, she had fully recovered

and is now a healthy and hearty child.(This corresponds with the cases indcated by several writers which makes this aagent which closes deaths door just before thpatient passes in. It is most wonderful thathere are so very many such cases reportedsnatched from death.ED.)

PUERPERAL ECLAMPSIAE. P. LENNER, M. D., HARRISON, OHIO.

I submit the following report of a casof eclampsia: Mrs. S., age 18, primipara. I wacalled about midnight and the child was borabout 5 a. m.

As the patient had not engaged me tattend her, I was unable to determine the condition of the urine previous to the confinement. Nothing unusual occurred during thprocess of delivery that would lead one to supect eclampsia.

I remained until 7 a. m. At 2 p. m. I wa



14/47

ummoned as quickly as possible to Mrs. S.,who was having spasms. I arrived in a shortime, to find that my patient of the early

morning had already had four convulsions,nd before I could get my overcoat off and geteady to examine her, she was in the throes ofnother.

I immediately gave her Gelsemium,

Veratrum, morphine and chloroform, andverything that I had ever heard of that waswithin reach, but got no results. The bladdernd bowels were evacuated, and the patient

was put in hot packs in a vain effort to pro-duce perspiration. She would have a convul-ion about every half hour, in spite of all weould do. Just as I was beginning to think thathe worst was over, and that we had control ofhe situation, she would have another con-

ulsion, so at 5 p. m. I asked for counsel, andhe nearest physician, six miles away, was sentor. It was an hour, at the least calculation, be-ore he could arrive, and during that time shead three more convulsions, more severehan the previous ones.

At last, as a final resort, I determined tory Lobelia. I did not have subculoyd Lobelia,ut did have plenty of the specific, and pro-eeded to administer one dram hypodermical-

y. In about ten minutes the patient was thor-ughly relaxed. She was not nauseated in theeast, but turned over and went to sleep andlept several hours. There was no recurrencef the spasms.

She had a sore arm, but she agreed thatsore arm was better than the convulsions.

When the consulting doctor arrived, the fightwas won, and it was too late for him to be ofny assistance, as the patient was sleeping

oundly.I am satisfied that Lobelia saved the life

f this patient.

AN EXPERIENCE WITH LOBELIAMARY L. GEISER, M. D., JOLIET, ILL.

The patient, my mother, aged nearly 70,lways delicate, with chronic bowel troubleobstipation, impaction, rectal stricture,tosis), December 5, at luncheon, ate sparingly

f stewed onions, an article of diet which she

long has eschewed on account of causincramping. Just twenty-four hours afterwarshe became affected with cramping throughout the abdomen. This continued all aftenoon and evening, with intervals of relienone of the ordinary measures, as soda, peppermint, and hot water producing any benefias very little flatus could be raised and non

passed, even with enemas.Next I tried strychnine and hyoscyamine, also without relief, excepting a hypnoteffect. And dryness of the mouth and markedepression supervened, with a pinched condtion of the features.

Having recently become interested iLobelia, I had procured a supply of the fluiextract in lieu of Lloyds, and now I felt wathe time to try it. I began with two drops in

little hot water. This was hardly swallowebefore the patient felt the stimulating effethrough her mouth and head like a nitritThis effect passed through the body alsThere also was some nausea, and as I did nowish my mother to start retching, I decided tgive only one drop thereafter. In half an houI administered one drop in warm water, anrepeated this every fifteen minutes for four ofive doses. The patient dropped into a quie

doze between each dose. After the second dosthe gas began to pass from the bowels, and shsuffered no more pain. She slept all nighcomplaining only of soreness the next morning.

The effect of the Lobelia was in everrespect restorative, the circulation improvedand vitality increased to its best for the patient. The remedy had proved at once a sedtive, a stimulant and a tonic, besides an ant

spasmodic. I understand its action in the casvery well, and agree heartily with the ideas othe Physiomedicalist, Dr. Alvin Curtis, londeceased, whose writings I have been readinand intend to develop its use in my practice tthe full extent of its applicability.

This was my first experience with thexcellent drug. The rapid action of the Lobeliseemed remarkable to me, its effect passing oso rapidly, leaving the patient definitely im

proved, and in part, restored, after each dose.



15/47

AN EARLY HYPODERMIC USE OFLOBELIA

S. W. MORELAND, M. D.

In 1882, shortly after I commenced to

ractice medicine, I was called to see a thir-een-year-old girl, suffering from severe con-ulsions. She had been having convulsionsor several hours. She was unconscious. Theonvulsions occurred every ten minutes. Theamily was anxious for something to be donet once to relieve the condition. The physicianttending had had but little experience. I filled

my syringe with a fluid preparation of LobeliaI don't remember what preparation it was)

nd injected it directly into her arm. This wasdone just at the close of a hard convulsion.There were no more convulsions. In tenminutes the patient relaxed. Slight vomiting

ccurred. Although there was a very sore armor a few days, the results were entirely satis-actory to the physician and family. The writeras used Lobelia hypodermically many timesince, but results, more than thirty years ago,

were all that could be desired from this reme-

dy.

LOBELIA HYPODERMICALLYADMlNlSTERED, ITS MEDICAL

INFLUENCE, AND PHYSIOLOGICALACTION

In the presentation to the profession o

a comprehensive consideration of Lobelia, am overwhelmed with the mass of facts thahave been presented to me, both from mown solicitation, and from matter referred tme by those whose opportunity for collectinfacts has been greater than that of mine. Suca mass is there that I have found it difficult tarrange the facts in order.

Notwithstanding this recent accumultion, the remedy is an old one. In fact, Lobeliwas one of the very first of the indigenouremedies of the United States to be broughconspicuously before the notice of the profesion. The Indians had used it and attracted atention to it. But Samuel Thompson becaminterested in it in 1796, he claims, from a dicovery he had made when a boy, to such aextent that he used it, usually with capsicumat least for a time, as almost his complete a

mamentarium.

DR. JENTZCHS INTRODUCTION OITS HYPODERMIC USE

It is passing strange that for more thaone hundred years, notwithstanding the pesistent use of the remedy by mouth and perectum, by the leading men in our school, anits advocacy by our most conspicuous teachers, no statement was published (at least to a

tract attention) of its use hypodermically. It



16/47

lmost exclusively with its hypodermic usehat the facts presented at this time were de-ermined.

This was brought about by an experi-nce had by Dr. Ernst Jentzsch of Chicago,

when his own child was in the throes of deathrom fulminating diphtheria. We quote hiswn words, from his first statement, except

hat he stated the suggestion came to him asn inspiration, and he reiterates the statementmade that the confidence with which he gavehe first dose was most remarkable. He said:My boy -was stricken with a fulminating casef naso-pharyngeal diphtheria. The serum an-itoxin was exhibited promptly, in sufficientlyarge doses, and repeated, and with no otheresult except that the child passed from an ac-ive sthenic condition, with dyspnea, into pas-

ive collapse and apnea. This I had witnessedefore, and knew it to be fatal with certainty. Iwas therefore in despair. I filled my hypoder-mic syringe with the pure specific medicineLobelia, and gave the child the entire doseubcutaneously. Strange to say, I gave it with aonfidence altogether out of proportion to mynowledge of its action, so used. However, theesult proved this to be justified, for the pa-ient responded immediately in a marvelous

manner.All the fatal symptoms gave way tohose of returning health, the patient passingrom a death struggle into a peaceful slumber,rom which he awoke after three hours,omewhat weak. Another dose was given,

which was followed by a still more pro-ounced reaction for the better. The patientrom that time continued to convalescence,nd, with the exception of a post-diphtheritic

haryngeal paralysis, made a rapid recovery.Later, the paralysis yielding to another dose ofhe same remedy.

He follows with a concise description ofis method of treating diphtheria. He says: Inny case where there is the least suspicion of

diphtheria I give a half drachm dose of thepecific medicine Lobelia hypodermically, andepeat in from two to twelve hours, once orftener, as indicated, until reaction sets-in,

which means a return to health.

Systemic remedies I give according tspecific indications.

By experience I have found the hypodermic injections best borne by the patienwhen injected anywhere on the trunk, abdominal parietes, the back and thighs.

PHYSIOLOGICAL ACTION

The above prompt results made sucan impression on Dr. Jentzsch that he immediately undertook a series of physiologic experiments to determine the action of Lobelso administered, upon all the vital functionand especially to determine whether the powerful depressant action shown with its emeteffect, when given by the stomach; its persisent irritation of the gastrointestinal tractwere present when administered hypoderm

cally. In giving it to healthy animals he noticed that the usual emesis was absent imany cases, but if present, usually with thfirst injection only, not subsequently. He observed but slight increased blood pressure; softening of the pulse, slowing of the respiration and moderate salivation, followed bquiet, with inclination to sleep if not diturbed, but alert and fully conscious whearoused. He then began the use of the remed

in line with these observations, and quicklobserved its powerful restorative effect, anthe fact that it was devoid of depressing influences of toxicity in anything like a reasonable dose; perfectly safe in its action and remarkably prompt when correctly indicated.

DR. BARTHOLOWS EXPERIMENTSThe first scientific experiments tha

were made to determine the precise physio

logical action of Lobelia were made at the rquest of Prof. Lloyd by Roberts Bartholow, MD., LL. D., Professor of Materia Medica in Jeferson Medical College, Philadelphia, ovethirty years ago. We have not room for thentire report, but the experiments were madwith hydrobromate of lobeline, and a numbeof very important observations were madAmong them that, in sufficient dose, this sais poisonous and will produce death in anmals. The following we quote from Dr. Ba



17/47

holows report taken from the Bulletin of theLloyd Library, number eleven, page 91:

Having ascertained that lobeline pos-esses the power to lessen the reflex action ofhe spinal centers, I have administered it inhose maladies characterized by irritability orxaltation of this function. In epilepsy it ap-ears to be a most promising remedy if right

onditions exist. It is the less useful, the moredecidedly the convulsive seizures approachhe epileptiform character; and it is more ef-ective, the nearer the cases are to the true orssential type. The bromides may be quite suc-essful in arresting convulsions due to coarseesions of the brain, although not acting onhe structural changes in any way. Lobeline

does not act favorably in such conditions."In nocturnal epilepsy, which, as is

ow well known, does not usually yield to theromides, and in the cases not arising from anbvious peripheral irritation or accompaniedy a defined aura, in the pale anemic andymphatic type of subject, the best results ob-ainable from this remedy may be expected.

As, however, definite conclusions can beormed only after sufficient length of time ob-ervations, the real value of the hydro-romate of lobeline must be ascertained by

omparative trials through several years.Now, it can be asserted merely that this reme-dy promises well.

More definite results can be givenrom the administration of lobeline in certain

neuroses of the respiratory organs, as asthma,whooping-cough, pseudoangina pectoris, inhe spasmodic cough of emphysema, theough of habit, renal and other reflex asthmas.omewhat more specific statements can be

made as respects its utility in all these cases.Dr. M. S. Aisbitt of Los Angeles gives us

theory concerning the action of Lobelia byhe mouth and hypodermically that may be

well worth thinking of. He believes that, in-roduced by the stomach, it acts upon theneumogastric nerves. Introduced hypoderm-

cally and absorbed, he thinks it acts more di-ectly upon the sympathetic nervous system. Iave not given this matter any thought yet,

ut I give it as a suggestion.

Lobelia acts directly upon the regulatincenters of the system; those of heat, of the ciculation, of nerve influences, both motor ansensory. It supports the heart; it improves thcirculation in its every feature; it over comeexcessive blood pressure, and restores perfetension in every form It is directly indicatein depression as well as in over-stimulation

It also controls hyperemiaevery form ocongestion. Whatever the cause of any gredepression, we cannot yet define the mavelous improvement observed from thagent. We hardly call it stimulation, and ythe improved condition is such as would utimately follow the action of the very besmost natural stimulants or tonics.

It is hard indeed to express the appaently contradictory influence exercised on th

above named depression, which has beeovercome in its most extreme form(in facin some cases where the skin was so cold anthe process of life so feeble as to cause one tthink that death had occurred, and yet the reaction appears very promptly) between thcondition and its influence in profound heastroke, as one doctor reports, where the temperature was 110 degrees, and others have reported from 106 degrees and up. Dr. Jentzsc

is enthusiastic about the action of this remedin heat stroke. It is useless to undertake to reconcile such an action in one unsupporteremedy. It is equally difficult to cause anyonwho has not used it to believe that it will accomplish these results.

Dr. Jentzsch, in reviewing for me at thtime (November 15th) his experiences sinchis last report, has confirmed the most of hprimary impressions. He does not hesitate t

say that emesis occurs so seldom that it cannobe counted as an objectionable factor. The local effects mentioned so frequently with thuse of various preparations during our firexperience with this agent hypodermically arstill seen with nearly all the preparations. Thsubculoyd preparation has probably in hhands the least unpleasant effects. In mocases, no pain is present. Most of the observers, it will be found, agree with this statemen

The specific medicine produces all th



18/47

ffects of the subculoyd with but very littlemesis, but its local effect is nearly always ob-ectionable. The general influence of the sub-uloyd is superior, probably, to other prepara-ions.

In no case has Jentzsch seen depression,ut always an increase of strength, a uniform-

y satisfactory development of functional

ower in every organ after its use.He advises the use of this remedy inhe abortion of many acute diseases. We

would expect this effect under two conditionst least; one in which the disease was causedy infection, and the other in which as arimary condition there was extreme conges-

ion. He believes that Lobelia is a corrector ofirculatory faults, and at the same time exer-ises an influence which increases the secre-

ions of every secretory organ, to excellent ad-antage. He thinks when irritation whichwould cause acute disease, which involveshe cerebrospinal system, that a hypodermic of

Lobelia will be found a most important reme-dy. He wrote a very interesting article on thisubject, which is found in ELLINGWOOD S

THERAPEUTIST for November, 1910.Dr. Powell of Ohio writes us that the

emedy produces a vasomotor relaxation,

with flushing of the capillaries. There is alow of warmth to the extremities, which areold and clammy. He has had emesis in butew cases. The action of the drug appears inrom five to ten minutes after the injection.

While in his diphtheria cases anti toxinad been given, he never fails to use Lobelianyhow. After close observation, he has seri-us doubts as to whether antitoxin is in anyarticular better than Lobelia. While the latter

emedy is positively devoid of danger, anddoes more than antidoting the poison, it pre-erves the strength, preserves nerve tone, isot only a preventive of diphtheritic paraly-is, but in many cases has promoted a cure ofhis condition, and has also cured mild formsf paralysis from other causes.

In many cases where antitoxin hasailed and the patient was given up to die, theatient has been saved by persistent use of Lo-

elia. This is the experience also of many oth-

er observers.A child of eleven was taken sick wit

diphtheria, December 15, 1913. She was treatewith antitoxin and made a good recovery. do not use antitoxin alone, but give the indcated remedies also, he says. On February 21914, she was again taken sick with diphtheia. This time she was treated with subculoy

Lobelia and got along better than the firtime, and said she would rather have me usthe Lobelia, even if it did have to be givetwice daily.

The diagnosis was made after a culturhad been taken from the childs throat, so wwere not mistaken in what was wrong thsecond time. That shows the antitoxin doenot confer a very long period:of immunity.

I think the use of immunizing dose

should not be depended on as much as theare, as the danger of anaphylaxis is alwaypresent.

With the Lobelia there is no such danger, as you cannot hurt the patient with it.

He thinks that the subculoyd is devoiof the emetic principle of the Lobelia, at leathat principle is eliminated to a very large exent.

He does not believe that Lobelia hypo

dermically in the real toxic sense is poisonouHe believes that it can be used in many casein almost unlimited quantity without harmas he has never seen any harm that he coulattribute to it. Others, however, think thacaution is necessary and that the remedy mu

be avoided in certain cases. It is no doubt ththis fact will be ultimately proven.

BLOOD PRESSURE

Dr. Zell L. Baldwin of KalamazoMichigan, made some observations at his sanitarium as to the increase of tension after iuse and to its influence upon blood pressurand did not come to any satisfactory conclusion. He used the sphygmograph in nearly 10cases, and any sharp, marked changes, excepin extreme cases, were not apparent. The improvement was uniform and steady, but rather slow in those cases in which the blood pres

sure was very low, but as yet we are not decid



19/47

d as to this point. The remedy is certainly aestorative to the nerve force at the centers ofnervation, acting directly upon the cardiacnd respiratory centers, restoring the inhibi-ory power of these centers, thus equalizinghe entire nervous and circulatory systems.

Many of the cases reported confirm this in-luence because of its direct effect upon the-

erebral circulation, mental conditions aremproved, unconsciousness or even coma aremmediately overcome.

In the first place the remedy has alwayseen supposed to be poisonous. Its violent in-luence upon the stomach and the depressionrom the vomiting is charged with the deathf patients during its early use, but recent ob-ervers have seldom been able to detect anyerious toxic influence. It is certainly not a de-

ressant when given hypodermically. Therere cases narrated in this report where therewas depression after its use, but that could

ave occurred from other causes.It is antispasmodic, but this effect is ac-

ompanied with strength rather than weak-ess. Dr. J. L. Ingram, at the Eclectic Medical

meeting of Missouri, stated that he believedhat the powerful stimulating effect in suffi-ient doses, where there is great depression,

rouses latent possibilities of the system tooncentrate its energies upon the life centers;lso, where the effect of this remedy was exer-ised, stimulating the medulla and vegetativeerve centers, respiration improves the heartction; also, spasmodic conditions in thehroat were overcome. In diphtheria and

diphtheritic croup the exudate is loosened andxpelled, and cyanosis is dissipated as thelood becomes oxygenated and the vital forces

eassert themselves.Dr. Alderson says that he notices its best

ffect in cases where the heart is generallyweak, and in these its total influence has beenhat of a stimulant and restorative, withoutny depressant effect. He says the pulseecomes stronger and fuller; all tendency toluttering and irregularity disappear and itstrength is restored. He has given it in as highs forty drop doses.

In an article read at the Wisconsin State

Eclectic Medical Society, published in the November, 1910, issue of ELLINGWOODTHERAPEUTIST, Dr. Jentzsch states concerning its influence: The remedy minimizes anlocal irritation, promotes immediate elimination, overcomes local blood stasis, stimulatin

both the venous capillaries and the arterierelaxes elastic tissues which are spasmodicall

contracted and promotes innervation. Thwide influence of this remedy under thesimportant conditions is certainly wonderfuand no one remedy seems to furnish all thactive elements essential so fully as this. Added to its active influence it is non poisonouand consequently harmless. The effect of single injection fully obtained will last aboutwelve hours, but the medicine may be repeated safely even when full influences ar

obtained at any time after three hours, thought best. The repetition to be determineby whether there is any progression or not ithe disease processes, as evidenced by the apparent symptoms.

The repetition of the remedy is demanded in the severer and; more malignancases, although a single dose is surprisingly eficient and permanent even in some malignant cases.

The injections are best given deep, either in the breast, abdomen, back or thighs, anhe thinks the patient should lay quietly aftetaking the injection for some little time tpermit the free, rapid absorption of the drugThe pronounced indication for Lobelia is toxemia with or without (but especially with) ciculatory disturbances. In these latter it is drectly indicated also, especially if there be irrtation of the cerebrospinal nervous system.

Dr. Jentzsch hesitates about claiminthat Lobelia is a stimulant, pure and simplas we understand the action of stimulantUnlike brandy or strychnine or digitalis, thimmediate and sharp, stimulating, or whipping-up effects do not appear in the same wato be lost when the effect of the medicine gone. The improvement on all conditions plainly marked, but the restoration is so nealy that of a full normal condition obtained i

a smooth and satisfactory manner, that h



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esitates about pronouncing it stimulation. Its more like an increase of vital force, whichemains to a large extent, in the improvedondition of all the functions after the remedyas had time to be fully eliminated. Dr. Bald-

win confirms all this from extensive observa-ions of tuberculosis cases.

From my own personal observations

nd from the conclusions I have drawn fromhe observations of others, I would say thatLobelia seems at once to supply a subtle butwholly sufficient force, power, or renewed vi-al influence, by which the nervous systemnd the essential vital force within the systemgain reassert themselves and obtain com-lete control of the functional action of everyrgan. From this influence, in a natural andufficient manner, a complete harmonious

peration of the whole combined forces is atnce resumed, in some cases, in an almosttartling manner. Other agents stimulate,rop up or temporarily increase the force andower of one or another function, while thisemedy with this peculiar power at once as-umes control of the whole, and succeedsgainst all the opposing influences as Generalheridan did, with his entire forces in retreatfter his celebrated twenty-mile ride at

Winchester.Concerning the anodyne influence ofhis remedy there is a difference of opinion.

That pain is relieved by its use is observed byll. Often it is relieved in a most satisfactorynd some times in a striking manner, but it is

usually cramp-like pains and pains that areelieved by taking off muscular tension. Lobe-a is a mild hypnotic and restores normalonditions, apparently, seeming to possess

oth sedative and stimulating properties. Ifhey be sthenic, the excitement is relieved, ifhey be asthenic the strength and normal ac-ion is restored.

As said, a direct narcotic influence canardly be attributed to it, and because of theact that it relieves nerve irritability imme-

diately, it has thus an active anodyne in-luence. It is certainly to be considered as im-ortant in all cases of extreme pain.

Concerning the fact that it induces nau-

sea or vomiting, in more than a thousand observations there are less than three percent othe cases reported in which there was annausea or inclination thereto. Dr. Palmer oDetroit, stands out conspicuously in his firexperiences, having an unusual number ocases of nausea and vomiting, some quitsevere, but there must have been some loc

conditions or some fault with the preparatiohe was administering or some coincidence ithe peculiar idiosyncrasies of the patient, as his alone in this report. Dr. Jentzsch, havinused several forms of Lobelia and yet has produced but little nausea, believes that less thatwo percent of the cases will be so affected, anthinks that the possibility of nausea need no

be considered in any case, as it is not frequenafter Lobelia, as it is after morphine and othe

commonly used remedies.

ADMINISTRATIONThe local irritation induced by the var

ous preparations that have been used, havmade its use very objectionable, especially ithe early cases, but the use of a non-alcoholpreparation seems to do away with this entirely. Fluid extracts have been used, but havinduced much irritation and pain. The effec

of specific Lobelia and subculoyd Lobelia aridentical, as far as their physiological anmedicinal action is concerned, and can be sused, there being more liability to local paifrom the alcohol of the specific medicine. Quite a number of writers have suggested that bthorough cleansing of the parts and instruments, by using any preparation very warmor by applying a hot compress locally immediately after the remedy is introduced, will d

away with the local pain.Dr. Niederkorn so suggests in a repo

in the Eclectic Medical Journal on cellular inflammation from the hypodermic use of specific medicine Lobelia. His belief was that thcondition is prevented by using the Lobelihot, in having the syringe and skin thoroughly sterilized, adding the remedy to an equaquantity of hot water. With these precautionhe had nothing but good results.

Dr. M. S. Aisbitt of Los Angeles, say



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In my use of Lobelia hypodermically I haveever used the subculoyd Lobelia or lobotox-

n. If I ever have a case in which I do notucceed with a good fluid extract, which Iave always used, I shall try the other prepa-ations.

A suggestion of Dr. Howes, in his Jour-al of Therapeutics and Dietetics, is that Lobe-

a promotes a flow of blood to the skin, caus-ng a recession of the eruptions of eruptiveevers, and increasing the warmth of the skin.

When the pulse wave is slow, and the heartction feeble, it is especially effective.

Dr. Jones, of Jonesville, Ind., thinks heas seen unpleasant results from Lobelia only

when there is albumin present in the urine,nd he had learned to avoid it in these cases.

DOSAGEI am confident that in certain cases thedosage has much to do with results. There areases in which ten minims will be all that isecessary, especially in children. In others,

wenty to thirty minims up to one dram, Re-axation should be studied with reference to

dosage separate or different from other condi-ions.

There are profound convulsive attacks

which end only in death. These can be treatedwith hypodermic Lobelia almost without re-

ard to how many half-dram, or dram doses,very half hour or hour are given, until relax-tion occurs. Then discontinue until again re-uired. This course seems to be justified by re-ults.

Dr. Thornton suggested at the Illinoistate meeting that in the dosage of Lobelia it

would be necessary to give a very much larger

uantity to men who use tobacco because ofhe fact that the alkaloids in the Lobelia wereimilar to those in tobacco, and tobacco users

were therefore inured to it. Dr. Hulick con-irmed this observation.

There are many cases of children inwhich from ten to fifteen drops twice a daywill be sufficient, but in aggravated cases or inhreatening cases no hesitation need be had iniving from fifteen to twenty minims and re-

eating the dose in from half an hour to an

hour, watching for results, and using the remedy again when its effects seem to be abatin

before a sufficient influence is obtained. Manof the observers have been reckless about thquantity used, using from one to two dramand repeating the dose in a short time, but none has reported any influence at all derogtory.

Dr. John Fearn used this remedy by thstomach for forty years, and his observationcan be compared with the good results witthose made from its hypodermic use. He believed the impression that is universal thaLobelia by the mouth always produces emesiis a most erroneous one. He used it in largdoses in many cases without producing thinfluence.

It was his common practice, thirty year

ago, to give hot Lobelia tea, especially witfirst confinements, to produce relaxation anfacilitate labor. (It certainly increases the forcof weak pains in many cases.) He has givesmall doses of powdered Lobelia for a lontime as a gastric stimulant and to increase thpower of circulation where there was no inflammation and where there was entire lacof digestive power, where the food lies tolong in the- stomach and ferments; where th

stomach is cold and there is much gas, owhere the stomach is very sensitive, and haproduced marked effects without nausea.

ANTITOXIC INFLUENCEThe question as to whether Lobelia d

rectly destroys toxins or exercises within thsystem a powerful antitoxin or antiseptic influence is one that is receiving a great deal oattention. The older writers depended upo

this remedy (sometimes alone) to cure syphlis, believing that it possesses a powerful aterative influence. Many of them became sconvinced of this as to make it impossible tchange their opinions. Dr. Jentzsch is confident that it exercises an antitoxic influence to marked degree. We must make very close observations when it is given for toxemias oany kind until we can positively determinwhether the general influence of the agent b

upon the nerve centers or upon the circula



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ion, upon the respiratory system, improvingxygenation of the blood, or upon the totallimination, or upon any or all of these, andow exercised.

Later, by active physiologic methods,we expect to be enabled to draw final conclu-ions concerning the total influence. Thisnowledge will be very important when de-

ermined. It is to be hoped that the present be-ef of some observers that its active antitoxicnfluence may be confirmed, as this will great-y broaden its application.

Dr. V. A. Baker, of Adrian, wrote oftenn the antiseptic action of this remedy after anxperience of sixty years by internal adminis-ration only. He asserts that the remedy over-omes a tendency to auto-toxemia, provingurative in many bad cases, and controlling

onvulsions so caused. He always used Lobe-a in the cure of syphilis in any stage.Dr. Homsher, of Denver, Colorado, be-

eves that Lobelia is locally and physiological-y an antiseptic, as it is also a powerful elimi-ative, stimulating every excretionary func-

ion in the body. He uses it a great deal in wa-er, with which he flushes the colon, findinghat it stimulates the peristaltic action of thentestinal canal, and also stimulates the excre-

ory glands of the canal. He uses it frequentlyor this purpose and has confidence that itwill exercise an important influence.

The objection is quite commonly madehat the alcohol in any preparation used isresent in sufficient quantity to induce thetimulating influence to a large extent that isbserved. There are two objections againsthis one is that the stimulating influence ofhe Lobelia is in no way similar to that of alco-

ol, and the other is that the stimulating ef-ect is widely observed by the action of prepa-ations that contain no alcohol. Still anotherbjection will be made that very many of thebservers have used other remedies in con-ection with Lobelia, which induced the in-luences attributed to Lobelia. Answering this

we can well say that to an observer, who ishoroughly familiar with the action of all theemedies used, there is no difficulty what ever

n distinguishing between the influences in-

duced by the other remedies and those induced by Lobelia, even when combinationare used, but we make no argument againthe fact that correct observations hypodermcally can only be made when Lobelia is usealone.

Dr. A. F. Stephens of St. Louis, one oour closest observers, makes the followin

important unique statement concerning thphysiologic action of this remedy in a recenletter to this editor:

I know that Lobelia, like every othething in Nature, has popularity as an attribute; that it contains within itself the principleof good and evil, so-called; that moving beween the positive and negative poles meaures the quality of its effects, which may beither beneficent or detrimental to life. H

who thinks Lobelia has no other than a bnign effect would better cultivate his power oobservation.

Lobelia, in moderate amount, will raisthe blood pressure when lowered, and withereby equalize the general circulation, thuaiding greatly the process of eliminationPushed beyond these limits it lowers th

blood pressure, weakens heart action and prohibits elimination and indirectly, if not direc

ly, causes death.In cases where the blood pressure increased above the normal Lobelia will lesen it, and in such conditions may be given imuch larger amounts without danger to life,

As to its so-called antiseptic propertieper se, or aside-from its action above outlinedI am not as yet prepared to say, as I havstudied the remedy for only thirty yearwhich is too short a time to pronounce a ve

dict upon so important a subject, especiallwhen no comparative blood analyses hav

been made. I am sure the remedy should nobe used indiscriminately. I believe it can bmade to produce fatal results.

Dr. H. D. Edwards, Washington, Pawrites as follows: I began using hypodermLobelia shortly after its introduction. I havfound in it a reliable remedy, not only for on

but for a number of ailments that we are con

fronted with in our daily routine. My exper



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nce is limited somewhat in regard to thisemedy, but nevertheless I have used about 75ottles as put out by Lloyd Brothers. I considerhat a sufficient quantity to arrive at some def-nite conclusion as regards what the remedy

will do in certain conditions. The above bot-les, I wish to state, hold approximately two

drams. The dosage administered was any-

where from fifteen to sixty minims. Nauseawas an unknown quantity, except in one case;hen only slight. The interval between dosesaried from fifteen minutes to half-an hour

n urgent cases, to daily injections. Some ofhe cases only received two injections of thirty

minims weekly.The diseases I have treated include the

ollowing: Diphtheria, asthma, tetanus,ronchitis, leg ulcers, and an other indefinite

ondition, a shortness of breath due to someunknown cause.Dr. Stevenson has used Lobelia by the

mouth first, and later hypodermically, in allor thirty-five years, and is in a position toompare the results. He thinks that in cases

where the local effect upon the stomach is noteadily induced, that much the same resultsan be obtained by giving it by the mouth thanan be secured by its action through the sto-

mach.J. B. Brewer, M. D., Jefferson, Wis., saysn a recent letter: My experience has provenhat we must not expect striking results invery case where we use this remedy, if weive it indiscriminately. It is like all otheremedies. It has a definite place, and it muste so given.

I believe that the remedy is a stimu-ant, especially in congestion. In those cases

where the hands, feet and the nose are cold,where there are large beads of sweat standing

ut on the forehead, or where the patienteems to be greatly prostrated. In such cases ashis, whatever the cause of the trouble, neith-r the doctor nor the patient will be disap-ointed."

We do not, in this consideration of Lo-elia, pay much attention to its influence tak-n by the mouth.

Because of its local effect upon the sto-

mach and intestinal tract it is a powerful dpressing emetic, and even in small dosewhen persisted in with children, it producean irritating cathartic effect, and unduly stimulates all the intestinal glandular organs. At time when emetics were common, this remedy was considered potent. It was used by thmouth when the tongue was heavily coated

especially at the base; when the entire systemwas sluggish, and glandular action was verdeficient. Its use, therefore, by this channhas been largely abandoned, and the remedy now being studied in line with the results oits hypodermic use. While an emetic of Lobelia is very prostrating, the patient soon recovers from a medium dose with a sense of we

being, and no untoward results are apt to bobserved.

H. H. Blankmeyer, M. D., Aransas PasTexas, combines Lobelia directly, as some others do, with morphine or H. M. C. He says: want to say just one thing concerning my observations I have made as to the action of thremedy when used as a menstruum instead owater in which to dissolve morphine or H. MC. They readily dissolve in it and when givewith morphine, the two together give us threlaxing effect of the Lobelia and the activ

anodyne influence of morphine, under cicumstances in which any depressing effect othe morphine is immediately antagonized bthe stimulating influence of the Lobelia, in iaction on the heart. At least, that is my way oreasoning, and my excuse for using this ofteninstead of water, in which to dissolve mophine or H. M. C.

Dr. Hunt, of Bregard, N. C., claims to ba past master in the use of H. M. C. He is als

skilled in the use of Lobelia. He believes thestwo remedies are highly synergistic. The dosemust be adjusted, however, for individucases. They can be well given together. Wheso given, however, he uses smaller doses.

Dr. Billingsley, of Newburg, Arkansasays he uses the remedy in renal colic, bilioucolic, puerperal eclampsia, pneumonia, strangulated hernia, and in spasmodic urethrastricture, when the catheter cannot be intro

duced; in heat stroke, snake bites, and in hy



24/47

eria. In another place we give a report fromhe doctor in the treatment of a case of perni-ious congestive chill which is very interest-ng and valuable. The doctor says there haseen several times when from groups of un-amed symptoms conditions appeared whicheemed to threaten death immediately, where

death was inevitable, where he would use Lo-

elia in full doses and get surprising results.He believes that Lobelia as an antitoxic reme-dy is superior to antitoxin.

The following is from Dr. T. D. Hol-ingsworth, Akron, Ohio.

My experience with Lobelia hypo-dermically has been almost entirely with theubculoyd Lobelia; have given a few hypo-

dermics of the specific medicine Lobelia andhere is no difference in the action of the pre-

arations so far as I can see, except the specificmedicine is painful even when diluted withterile water.

My experience with Lobotoxin is toomited to make any comparisons with thether preparations.

After several years of observation, Iwould say, the profession is looking upon thisemedy more sanely, with less excitement,nd conclude that from the whole, it is a most

aluable auxiliary to our methods of treatingdiphtheria; that it antagonizes more perfectly,erhaps, than any other one remedy, all theonditions which result from the develop-

ment of the specific toxins, and from themixed infections which are apt to follow. Inmost cases it antagonizes these toxins promp-ly and satisfactorily, but in an occasional casehere seems to be a necessity for a more activentiseptic remedy.

A very few deny any benefit whatevern diphtheria; others have not patience to car-y out the use of the remedy, and still othersave been unable to observe satisfactory re-ults, because, I think, of improper use of theemedy, or because of its local influence,

which at first, with the alcoholic liquid, was aery great objection to its use."

Dr. J. E. G. Waddington, of Detroit, wasot favorably impressed at first, either by the

tatements made concerning Lobelia, nor by

the results he obtained, but later having treaed a fairly large number of cases

Ellingwood9-2

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