Journal of Mechanical Engineering Vol 18(1), 39-51, 2021 ___________________ ISSN 1823-5514, eISSN 2550-164X Received for review: 2020-03-20 © 2021 Faculty of Mechanical Engineering, Accepted for publication: 2020-12-10 Universiti Teknologi MARA (UiTM), Malaysia. Published: 2021-01-15 Electrospinning, Preparation and Characterization of Polyvinylidene Fluoride / Pectin Electrospun Loaded with Benzalkonium Chloride as a Drug Reservoirs Mohd Syahir Anwar Hamzah, Celine Ng, Jumadi Abdul Sukor Faculty on Engineering Technology, Universiti Tun Hussein Onn Malaysia, Pagoh Higher Education Hub, 84600 Pagoh, Johor, Malaysia. Kamarul Syazwan Mohd Ali Abdul Muaz Food Enterprise, 20-A, Pusat Perniagaan Benut, Jalan Pontian, 82100 Benut, Johor, Malaysia. Nadirul Hasraf Mat Nayan * Oases Integrated Group (OIG), Universiti Tun Hussein Onn Malaysia, 86400 Parit Raja, Johor, Malaysia. *[email protected] ABSTRACT Porous nanofiber electrospun of polyvinylidene fluoride (PVDF)/pectin was successfully developed using electrospinning method containing benzalkonium chloride (BAC) as a drug model for the controlled drug delivery system assessment. The electrospun was tested for its mechanical, morphological, and wettability properties. Scanning electron microscope (SEM) micrograph demonstrated that the smooth surfaces of nanofibers morphology had achieved up to 2 wt% pectin inclusion with optimum fiber diameter, 143 ± 1.4 nm. The optimized scaffold PVDF/Pectin showed that the reduction of mechanical integrity and optimum value of tensile strength, modulus strength, and elongation at break were 5.98 ± 0.17 MPa, 16.82 ± 0.10 MPa, and 79.3 ± 1.3% MPa. Water contact angle analysis and degree of swelling suggested that inclusion of pectin had enhanced the wettability properties of hydrophobic PVDF electrospun with highest swelling capacity achieved of 78.9 ± 1.7%. The in vitro drug release tests using BAC, which was released from the hybrid electrospun nanofibers, achieved prolonged release profile due to elimination of the uncontrollable initial burst release.
Electrospinning, Preparation and Characterization of Polyvinylidene Fluoride / Pectin Electrospun Loaded with Benzalkonium Chloride as a Drug Reservoirs
Jun 17, 2023
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