Electrolytes and Metabolic Emergencies Edward Omron MD, MPH Pulmonary Service
May 07, 2015
Electrolytes and Metabolic Emergencies
Edward Omron MD, MPH
Pulmonary Service
ObjectivesObjectives• Review causes and clinical manifestations of
severe electrolyte disturbances
• Outline emergent management of electrolyte disturbances
• Recognize and treat acute adrenal insufficiency, thyroid storm and myxedema coma
• Describe management of severe hyperglycemic syndromes
• Review causes and clinical manifestations of severe electrolyte disturbances
• Outline emergent management of electrolyte disturbances
• Recognize and treat acute adrenal insufficiency, thyroid storm and myxedema coma
• Describe management of severe hyperglycemic syndromes
Principles of Electrolyte Disturbances
Principles of Electrolyte Disturbances
• Implies an underlying disease process
• Treat the electrolyte change, but seek the cause
• Clinical manifestations usually not specific to a particular electrolyte change, e.g., seizures, arrhythmias
• Implies an underlying disease process
• Treat the electrolyte change, but seek the cause
• Clinical manifestations usually not specific to a particular electrolyte change, e.g., seizures, arrhythmias
Principles of Electrolyte Disturbances
Principles of Electrolyte Disturbances
• Clinical manifestations determine urgency of treatment, not laboratory values
• Speed and magnitude of correction dependent on clinical circumstances
• Frequent reassessment of electrolytes required
• Clinical manifestations determine urgency of treatment, not laboratory values
• Speed and magnitude of correction dependent on clinical circumstances
• Frequent reassessment of electrolytes required
HypokalemiaHypokalemia
• K < 3.5 mmol/L
• Etiology – alkalosis, diuresis, dka, ngs, n/v, hypomagnesemia
• Manifestations – life threatening arrhythmias
• Deficit poorly estimated by serum levels
• K < 3.5 mmol/L
• Etiology – alkalosis, diuresis, dka, ngs, n/v, hypomagnesemia
• Manifestations – life threatening arrhythmias
• Deficit poorly estimated by serum levels
Which one of the following ECG changes is least likely to occur with hypokalemia?
• ST-T segment depression
• T wave inversion
• AV Blocks (2nd and 3rd degree)
• PVC’s
• U waves
• QT prolongation
HypokalemiaHypokalemia• Treat aggressively in severe metabolic
acidosis
• Correct hypomagnesemia
• ECG monitoring with emergent administration
• Allowable maximum iv dose per hour controversial– Life threatening arrhythmias: 10 mmols/ 20 minutes
– KCL 20 mmols/hr Central IV or 20 mmol/ PO q1 hour
– KCL 10 mmols/hr peripheral IV (Inefficient)
• Treat aggressively in severe metabolic acidosis
• Correct hypomagnesemia
• ECG monitoring with emergent administration
• Allowable maximum iv dose per hour controversial– Life threatening arrhythmias: 10 mmols/ 20 minutes
– KCL 20 mmols/hr Central IV or 20 mmol/ PO q1 hour
– KCL 10 mmols/hr peripheral IV (Inefficient)
HyperkalemiaHyperkalemia
• K>5.5 mmol/dL
• Etiology – renal failure, acidemia, cell death, drugs(ACE/Succinylcholine)
• Manifestations – arrhythmias: peaked t waves,
QRS widening, sine wave.
• K>5.5 mmol/dL
• Etiology – renal failure, acidemia, cell death, drugs(ACE/Succinylcholine)
• Manifestations – arrhythmias: peaked t waves,
QRS widening, sine wave.
Hyperkalemia – TreatmentHyperkalemia – Treatment
• Urgency of treatment- clinical manifestations
• Stop intake
• Give calcium for cardiac toxicity
• Shift K+ into cell – glucose + insulin, NaHCO3, inhaled 2-agonist (high dose)
• Remove from body – diuretics, sodium polystyrene sulfonate, dialysis
• Urgency of treatment- clinical manifestations
• Stop intake
• Give calcium for cardiac toxicity
• Shift K+ into cell – glucose + insulin, NaHCO3, inhaled 2-agonist (high dose)
• Remove from body – diuretics, sodium polystyrene sulfonate, dialysis
HyponatremiaHyponatremia
• Na < 135 mmol/L• Hypo-osmolar hyponatremia
– Euvolemic (SIADH,Hypothyroidism)– Hypovolemic (Diuretics, Adrenal Insuff.)
– Hypervolemic (CHF, Cirrhosis, NS)• Normo- or hyperosmolar hyponatremia
• Pseudohyponatremia• Manifestations – neurologic (brain edema)
• Na < 135 mmol/L• Hypo-osmolar hyponatremia
– Euvolemic (SIADH,Hypothyroidism)– Hypovolemic (Diuretics, Adrenal Insuff.)
– Hypervolemic (CHF, Cirrhosis, NS)• Normo- or hyperosmolar hyponatremia
• Pseudohyponatremia• Manifestations – neurologic (brain edema)
65 yo wm POD 2 TURP presents lethargic to ICU
• HR =90, BP = 120/80, RR = 15• Na = 114, K =3.8, Cl = 78, HCO3 = 20, Cre = 1.2
– Free Water Restriction– Isotonic Saline– Hypertonic Saline– Furosemide– Ringers Lactate
• (infusate Na - serum Na)/ (TBW+1)
• NS(154 mmol/L)– (154 - 114) / (42L + 1) = Delta 0.9 mmol
• Hypertonic Saline– (514 - 114) / (42+1) = Delta 9.3 mmol– Given over 24 hours (40 cc/hr)– Correct 0.5 mmol/hr until Na > 120 mmol/L
Delta Plasma Na from 1 liter of fluid
Hyponatremia – TreatmentHyponatremia – Treatment• Hypovolemic Na – give normal saline,
rule out adrenal insufficiency
• Hypervolemic Na – increase free H2O loss
• Euvolemic hyponatremia
– Restrict free water intake
– Increase free water loss
– Normal or hypertonic saline
• Correct slowly due to possibility of demyelinating syndromes
• Hypovolemic Na – give normal saline, rule out adrenal insufficiency
• Hypervolemic Na – increase free H2O loss
• Euvolemic hyponatremia
– Restrict free water intake
– Increase free water loss
– Normal or hypertonic saline
• Correct slowly due to possibility of demyelinating syndromes
HypernatremiaHypernatremia• Na > 145 mmol/L
• Causes: diarrhea, vomiting, diuresis, thirst, diabetes insipidus
• Manifestations- neurologic
• Na = 160 mmol, 70 kg male
– 1 L D5W changes Na by 4 mmol/L
– H2O deficit (L) = [ 0.6 wt (kg) ]
[ observed Na/140 - 1 ] = 6 Liter Free H2O
Urine Osmolality > 500 mOsmol/kg extrarenal or osmotic diuresis, < 300 mOsmol/kg diabetes insipidus
• Na > 145 mmol/L
• Causes: diarrhea, vomiting, diuresis, thirst, diabetes insipidus
• Manifestations- neurologic
• Na = 160 mmol, 70 kg male
– 1 L D5W changes Na by 4 mmol/L
– H2O deficit (L) = [ 0.6 wt (kg) ]
[ observed Na/140 - 1 ] = 6 Liter Free H2O
Urine Osmolality > 500 mOsmol/kg extrarenal or osmotic diuresis, < 300 mOsmol/kg diabetes insipidus
Hypernatremia – TreatmentHypernatremia – Treatment• Provide intravascular volume
replacement
• Consider giving one-half of free H2O deficit initially
• Reduce Na cautiously: 0.5-1.0 mmol/L/hr
• Secondary neurologic syndromes with rapid correction
• Provide intravascular volume replacement
• Consider giving one-half of free H2O deficit initially
• Reduce Na cautiously: 0.5-1.0 mmol/L/hr
• Secondary neurologic syndromes with rapid correction
Other Electrolyte DeficitsCa, PO4, Mg
Other Electrolyte DeficitsCa, PO4, Mg
• May produce serious but nonspecific cardiac, neuromuscular, respiratory, and other effects
• All are primarily intracellular ions, so deficits difficult to estimate
• Titrate replacement against clinical findings
• May produce serious but nonspecific cardiac, neuromuscular, respiratory, and other effects
• All are primarily intracellular ions, so deficits difficult to estimate
• Titrate replacement against clinical findings
Other Electrolyte DisordersOther Electrolyte Disorders
• Hypocalcemia
– Calcium chloride or gluconate
– Bolus + continuous infusion
– Albumin correction is useless
• Hypercalcemia
– Rehydration with normal saline
– Loop diuretics
• Hypocalcemia
– Calcium chloride or gluconate
– Bolus + continuous infusion
– Albumin correction is useless
• Hypercalcemia
– Rehydration with normal saline
– Loop diuretics
Other Electrolyte DisordersOther Electrolyte Disorders
• Hypophosphatemia
– PO4 < 2.5 mg/dL
– Replacement iv for level < 1 mg/dL
• Hypomagnesemia
– Emergent administration over 5–10 mins– Less urgent administration over
10–60 mins
• Hypophosphatemia
– PO4 < 2.5 mg/dL
– Replacement iv for level < 1 mg/dL
• Hypomagnesemia
– Emergent administration over 5–10 mins– Less urgent administration over
10–60 mins
What is most likely to present in a patient with severe magnesium deficiency?
• Respiratory Depression
• Bradycardia
• Tetany
• Hypotension
• Loss of patellar reflex
• 35 yo with fever, hypotension, and syncope– 2 months of fatigue, weight loss– BP 70/40, HR 110, temp 103, RR 18– Na = 128, K = 5.6, Cl = 102, HCO3 = 16– Glucose = 60, BUN = 28, Creat = 1.2– Bolus 3L NS, BP 80/50 Dopamine started
1. Norepinephrine and decrease dopamine 2. Dexamethasone 4 mg IV 3. Infuse 1 liter hetastarch 4. Thyroxine IV and hydrocortisone 100 mg IV
Acute Adrenal InsufficiencyAcute Adrenal Insufficiency
• Nonspecific manifestations– Abdominal pain, nausea, emesis– Orthostatic/refractory hypotension
• Laboratory findings– Hyponatremia, hyperkalemia– Hypoglycemia– metabolic acidosis– Hypereosinophillia
• Nonspecific manifestations– Abdominal pain, nausea, emesis– Orthostatic/refractory hypotension
• Laboratory findings– Hyponatremia, hyperkalemia– Hypoglycemia– metabolic acidosis– Hypereosinophillia
Acute Adrenal InsufficiencyAcute Adrenal Insufficiency
• Baseline blood samples
• Volume and glucose infusion
• Dexamethasone or hydrocortisone
• ACTH stimulation test if needed
• Treat precipitating conditions
• Baseline blood samples
• Volume and glucose infusion
• Dexamethasone or hydrocortisone
• ACTH stimulation test if needed
• Treat precipitating conditions
Hyperglycemic SyndromesHyperglycemic Syndromes
• Diabetic ketoacidosis (DKA)
• Hyperglycemic hyperosmolar state (HHS)
• Manifestations – dehydration, polyuria/polydipsia, altered mental status, BP, nausea, emesis, abdominal pain
• Diabetic ketoacidosis (DKA)
• Hyperglycemic hyperosmolar state (HHS)
• Manifestations – dehydration, polyuria/polydipsia, altered mental status, BP, nausea, emesis, abdominal pain
Hyperglycemic Syndromes – Laboratory
Hyperglycemic Syndromes – Laboratory
• Hyperglycemia/hyperosmolality
• Ketonemia/ketonuria (DKA)
• Increased anion gap metabolic acidosis (DKA)
• Electrolyte changes (K, PO4, Na)
• Hyperglycemia/hyperosmolality
• Ketonemia/ketonuria (DKA)
• Increased anion gap metabolic acidosis (DKA)
• Electrolyte changes (K, PO4, Na)
Hyperglycemic Syndromes – Treatment
Hyperglycemic Syndromes – Treatment
• Identify and treat precipitating factors
• Restore fluid/electrolyte balance
• Insulin – iv bolus and infusion
• Add glucose to infusion when glucose <250-300 mg/dL (13.9-16.7 mmol/L)
• Treat electrolyte changes (K, PO4)
• NaHCO3 rarely needed
• Lactated Ringers preferred crystalloid
• Identify and treat precipitating factors
• Restore fluid/electrolyte balance
• Insulin – iv bolus and infusion
• Add glucose to infusion when glucose <250-300 mg/dL (13.9-16.7 mmol/L)
• Treat electrolyte changes (K, PO4)
• NaHCO3 rarely needed
• Lactated Ringers preferred crystalloid
• 28 yo with schizophrenia, acute delirium– HR 120, T 101.6, BP 96/50– bibasilar rales, 2/6 systolic murmur– ECG with atrial fibrillation– WBC 10,000, CK 150, (-) LP, UA, and head
CT
1. Dantrolene 2. Haloperidol 3. Antibiotics 4. Propylthiouracil, propranol
Thyroid StormThyroid Storm• Exaggerated manifestations of
hyperthyroidism
• Supportive measures
• Specific measures
– Propylthiouracil or methimazole
– Propranolol
– Potassium or sodium iodide
– Dexamethasone, sodium ipodate
• Exaggerated manifestations of hyperthyroidism
• Supportive measures
• Specific measures
– Propylthiouracil or methimazole
– Propranolol
– Potassium or sodium iodide
– Dexamethasone, sodium ipodate
• 56 yo obese female minimally responsive– HR 64, RR 10, BP 160/100, T 96.5– Distant heart sounds, 3+ LE non-pitting edema– CXR: bilateral effusions/ cardiomegaly– Na = 130, Hb = 10.2, CK = 500, WBC =13000– (-) head ct and lumbar puncture
– 1. Intravenous thyroxine, hydrocortisone– 2. TTE– 3. Neurology consult– 4. flumazenil
Myxedema ComaMyxedema Coma
• Manifestations of severe hypo-thyroidism
• Supportive measures – airway, fluids, glucose, warming
• Treat precipitating cause
• Hydrocortisone
• L-thyroxine
• Manifestations of severe hypo-thyroidism
• Supportive measures – airway, fluids, glucose, warming
• Treat precipitating cause
• Hydrocortisone
• L-thyroxine