1 Cisco Cloud Network Automation Provisioner Installation Guide, Release 2.1, Part: CCAMCP-CNAP-Install2-2.1 Installing Cisco Cloud Network Automation Provisioner Introduction The Cisco Cloud Architecture for Microsoft Cloud Platform (CCA for MCP) solution delivers IaaS, PaaS, and SaaS with integrated management software. The data center infrastructure is built with Cisco Application Centric Infrastructure (ACI) for the Data Center Fabric and Cisco UCS-based compute, Cisco Adaptive Security Appliance (ASA) firewall for security, and Cisco Aggregation Services Routers (Cisco ASR 9000 and Cisco ASR1000) data center edge routers. Additionally, Cisco virtualized network functions such as Cisco Cloud Services Router 1000V (CSR 1000V) are used to implement tenant services. Microsoft Hyper-V Hypervisor is used as the virtualizing layer for compute to run tenant workloads. The Management Stack is based on Microsoft Windows Azure Pack (WAP), which allows service providers to create plans and tenant administrators to subscribe to those plans. CCA for MCP enables service providers to host and offer sophisticated tenant network containers over a Cisco cloud infrastructure, enabling tenants to deploy multi-tier applications in the cloud. The provi- sioning of such containers is enabled by the use of the Cisco Advance Data Center Network Resource Provider in the Microsoft Windows Azure Pack Portals. Cisco Cloud Network Automation Provisioner (CNAP) software includes the Cisco Advance Data Center Resource Provider component, which exposes the Cisco infrastructure resources to the: • Service Provider Cloud Admin to publish plans that offer complex network containers • Tenant to use the subscriptions to instantiate the network containers and, using the VMClouds Resource Provider, deploy tenant workloads and attach to tenant Virtual networks A Microsoft WAP administrator can use Cisco CNAP for MCP Admin Portal to configure, manage, and administer Cisco Data Center Network resources. Cisco CNAP provides the capability to create tenant containers with sophisticated network services such as tenant edge routing, multiple security zones, fire- walling, NAT, MPLS VPN access, and Server Load Balancing. The administrator uses the portal to define and set up the available plans that will be visible in the Tenant Portal and that can be consumed by tenants. Tenants consume resources by using the Tenant Portal to subscribe to an available plan. This allows service providers to offer differentiated plans that provide more value to tenants and generate more revenue for service providers, with the convenience of automation to deploy sophisticated contain- ers for tenants. For more information, see: http://www.cisco.com/go/cloud.
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Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Electro Magnetic Fields and Implanted Medical Devices: MRI
compatibility
ESSCIRC 2010 Workshop 17 September
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Overview
• Introduction • MRI physics• Clinical value of MRI• Electro magnetic compatibility challenges.• Design “guidelines”• Regulatory requirements
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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IntroductionULTRAsponder project is an effort to avoid electromagnetic wavesas transmission medium.
Magnetic resonance imaging MRI is a harsh environment that challenge all implanted electronic circuits. Specially the Radiofrequency Communication.
The RF communication is a highly regulated environment, a disadvantage for medical devices. Unfortunately Electromagnetic Field density is not controlled yet.
But there are others treats for medical devices: exponentially growing remote data and energy transmission.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI physics• Magnetic resonance imaging device align proton spins with a strong
magnetic field. (0.1T to about 10T)Active magnetic shielding often used to limit the spatial magnetic field.
• The MR device brings ( a part of) the protons in resonance with a radio frequency field. (43 MHz per Tesla ~ kW )
Cage of Faraday to shield the RF.
• Magnetic gradients are needed to make a 3D measurement. (Current-~100 A) Gradients in x,y and z direction.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI physics
Without a magnetic field With a magnetic field
Excitation of the protons Detection of the NMR signal
1H
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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MRI physics.
• Static magnetic field– 0.3T to 3T commercial devices, up to 10T (research only).
(1T ~ 30.000 times earth magnetic field at the equator)• Superconducting magnet. (difficult to switch off)• Active shielding. (to limit the field outside the bore)
Permanent magnet 0.3T 1.2T open
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI physics
• Radio Frequency (RF) power– High RF power is needed to rotate hydrogen nuclei or
protons.– In the order of kW. (Like a microwave)– Power limited Specific Absorption Rate (SAR) by
repetition time of RF pulses– Depends on static magnetic field strength.– Frequency depends on static magnetic field strength
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI physicsSpatial encoding use additional magnetic fields which change along an axis.
-> Excitation only in one slice
The use of three so called gradient fields allow the excitation of arbitrary slices
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI physics
Gradient fields.
• Up to 100 mT/m. Power limited by to avoid peripheral nerve stimulation
• Noise due to gradient coil movement.• Induction of currents in conducting material.• Vibration in metal objects.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI physics
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90º 180º 90º
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RF
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Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Clinical value of MRI
• MRI is safe to use. No ionizing radiation.• Excellent soft tissue imaging.• A number of effects can be used to image.• Spectroscopy (tissue properties)
• More than half of the patients with implants need once MRI.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Clinical value of MRI
Increase.lack of adverse side effect.variety of applications.
Contraindication for active medical implantable devices under discussion! (Often no good alternative)
US MRI Procedures
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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MRI characteristics.
• Excellent Soft tissue imaging.• 3D images.• Multiple applications of the NMR effect.
– Magnetic resonance spectroscopy.– Functional MRI.– Interventional MRI.– Cardiac MRI (Multiple options for functional diagnosis).
• No adverse effects. (no radiation like x-ray)
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Heart (Sense)Balanced FFE, SENSE reduction Faktor 1.5
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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Heart (Flow)
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Head
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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Thorax
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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Electro magnetic compatibility challenges
• Static magnetic field: Force and torque.
• Gradients: Induction of voltages in conductors. dB/dt max ~
• RF Larmor frequency 42.58 MHz/Tesla8.5 MHz ( 0.2 T) to 127.7 MHz ( 3T) Power About 1KW
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Design “guidelines”• Static magnetic Avoid ferromagnetic material.
field Avoid “ferrite” materials in inductors
• Gradient fields: -Avoid inductive loops: wire loops thatmay form a conducting loop through the body fluid.-Structures with electrodes maystimulate nerves or muscles.-Eddy currents may Heat conducting shieldsand Vibrate conducting shields
• Gradient induced artifacts.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Design “guidelines”
Pacemaker artifact
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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Design “guidelines”
RF electro magnetic fields: electrical vector + magnetic vectorThe magnetic field rotates around the z axis. So the electrical field is in the z direction elongated conducting (insulated) structures function as antenna in the field. The received power may generate currents in the electrode tissue interface and generate local tissue heating.
• To spoil RF antenna properties it is important to keep structures relative short with respect to the wave length. ( 1/9 th of λair )
Epsilon r water is 81 c= 1/ SQRT(εμ) so λwater = 1/9 λair
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Design “guidelines”
• Temperature profile around an electrode during MRI
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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Design “guidelines”
• Transmission line properties apply for conducting structures.
• Perform in-vitro testing with the device in different positions.
• Perform Field simulations to evaluate worse case positions.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Initial Investigations: In-vitro
Phantom at opening of 1.5T MRI system
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
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Model of Human Body Human Body Mesh
Modeling EM fieldsFTDT simulation of the EM field distribution in a human.
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Heat transfer
SAR [dB] T [deg C]
Modeling EM fields
Medtronic Bakken Research Center Volkert Zeijlemaker Sept 17, 2010
ULTRAsponder projectWorkshop ESSCIRC 2010
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Regulatory requirements
• ISO IEC requirements are under construction. Technical specification is about to be distributed.
Requirements for the safety and compatibility of magnetic resonance imaging for patients with an active implantable medical device.
• This future standard requires evaluation of the medical device on most adverse effects from implantable devices during MRI
• Clinical evaluation may part of regulatory submission