Figure 1 www.elepharm.com ELE-BOTULITOXIN Supplement Facts: Botulinum A Toxin(50IU\100IU\200IU) Packing: 1 vial/box www.elepharm.com ELE-BOTULITOXIN MECHANISM OF ACTION Argireline works by inhibiting the release of neurotransmitters released by the brain that tell these facial muscles to tense. As a result, neurotransmitters are note released efficiently and facial contractions are weakened and muscles relaxed, thus inhibiting the formation of wrinkles and fine lines. COSMETIC BENEFITS/INDICATIONS Similar as botulinum toxin, this anti-wrinkle peptide, attenuates wrinkles and expression lines, reducing the depth and makes the face become smoother. ELE-ARGIRELINE Supplement Facts: Argireline(50mg\100mg\200mg) Packing: 1 vial/box ELE-ARGIRELINE Storage: Store at a temperature of -5 to -20ºC. Do not use after the expiry date. Storage: Store below 25ºC and at a cool,dark place within 2 months;Recommended to protect from light at 2-8ºC long-time storage if more than 60days. MECHANISM AND INDICATION ELE-BOTULITOXIN is an acetylcholine release inhibitor and a neuromuscular blocking agent indicated for: - Temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugators and/or procerus muscle activity in adult patients. - Temporary improvement in the appearance of moderate to severe lateral canthal lines associated with orbicularis oculi activity in adult patients. DOSAGE AND ADMINISTRATION Dilution Instructions for ELE-BOTULITOXIN Vials (50 Units, 100 Units and 200 Units) * Preservative-free 0.9% sodium chloride injection, USP In treating adult patients for one or more indications with ELE-BOTULITOXIN, the maximum cumulative dose should generally not exceed 360 Units, in a 3 month interval. Diluent* Add to 50 Unit Vial 1.25 mL Resulting Dose Units per 0.1 mL 4 Units Diluent* Add to 100 Unit Vial 2.5 mL Resulting Dose Units per 0.1 mL 4 Units Diluent* Add to 200 Unit Vial 5.0 mL Resulting Dose Units per 0.1 mL 4 Units Injection Sites and Dosage Injection Sites Injection Dosage 0.1 mL (4 Units) by intramuscular injection into each of 5 sites, 2 in each corrugators muscle and 1 in the procerus muscle for a total dose of 20 Units. 0.1 mL (4 Units) into each of 3 sites per side (6 total injection points) in the lateral orbicularis oculi muscle, for a total of 24 Units. Glabellar Lines Lateral Canthal Lines DOSAGE AND ADMINISTRATION Diluent* Add to 50 mg Vial 1.25 mL Resulting Dose 4mg/0.1mL Resulting Dose 4mg/0.1mL Resulting Dose 4mg/0.1mL Diluent* Add to 100 mg Vial 2.5 mL Diluent* Add to 200 mg Vial 5.0 mL * Preservative-free 0.9% sodium chloride injection, USP Mark areas of masseteric prominence on clenching as Figure 1. Use a 30-gauge needle to inject along the inferior border of the masseter. The needle tip was used to palpate the mandible and then retracted 1 to 2 mm prior to injection, thus avoiding the superficial facial musculature. 25 I.U. of Botox/ 25 mg of ARGIRELINE (5 I.U./0.1 ml or 5mg/0.1ml ) was injected per side at previously marked sites. One week after initial injection, reexamine and ask patient to clench their jaws again. Evaluate symptoms of masseter paralysis. If no difficulties chewing resulted, but persistent masseteric prominence was present on clenching, then inject an additional 25 I.U. of Botox/ 25 mg of ARGIRELINE per side. Inject up to 3 times at 1-week intervals. Often injection was requested superiorly, toward the zygomatic arch, for further narrowing. Injection Sites and Dosage Injection Sites Injection Dosage 0.1 mL (4 mg) by intramuscular injection into each of 5 sites, 2 in each corrugators muscle and 1 in the procerus muscle for a total dose of 20 mg . 0.1 mL (4 mg) into each of 3 sites per side (6 total injection points) in the lateral orbicularis oculi muscle, for a total of 24 mg . Glabellar Lines Lateral Canthal Lines LECITHIN INJECTION Supplement Facts: Phosphatidylcholine 250mg+ sodium deoxycholate 237.5mg /5ml Packing: 5 vials/box Shelf life: 36 months. ELE-LIPOLYSIS INJECTION Supplement Facts: Phosphatidylcholine 250mg/5ml Packing: 5 ampoules/box Shelf life: 36 months. DOSAGE AND ADMINISTRATION The technique is effective for the stubborn fat of the double chin, abdomen, waist and hip, etc. The injection should be injected into the fat deposit following a multi-injection pattern according to the shape of the fat deposit. The amounts of LECITHIN (ELE-LIPOLYSIS) injected into each fat deposit ranged between 5 ml and 30 ml per application according to the individual needs of the patient. For the detailed injection parts and dosages, please see the table here below. Storage: ELE-LIPOLYSIS store below 25℃, LECITHIN store under refrigeration (4℃~9℃). Store in the original carton in order to protect from light. ELE L-CARNITINE INJECTION Supplement Facts: L-Carnitine 2g/5ml Packing: 5 ampoules/box Shelf life: 36 months. ELE L-CARNITINE INJECTION Supplement Facts: L-Carnitine 1g/5ml Packing: 5 ampoules/box Shelf life: 36 months. DOSAGE AND ADMINISTRATION L-Carnitine Injection is a weight loss treatment that helps the body turn fat into energy. Some sportsmen use this L-Carnitine to enhance their performance and tone up their muscles. L-Carnitine injection is recommended at 1 g every 2 days or 2 g every 4 days for best result. However, you may reduce the dosage with the advice of doctor. The L-Carnitine is taken intravenously either by normal injection or using a butterfly needle or subcutaneous injection. After taking this L-Carnitine, you can carry out exercise around 15-20 minutes daily. Storage: Store below 25℃. Store in the original carton in order to protect from light. LECITHIN INJECTION Supplement Facts: Phosphatidylcholine 250mg+sodium deoxycholate 237.5mg /5ml L-Carnitine 2g/5ml Packing: 5 vials+5 ampoules/box Shelf life: 36 months. DOSAGE AND ADMINISTRATION Extract L-Carnitine injection completely with a syringe, and inject into the Lecithin Injection vial, shake well for subcutaneous injection. The injection was injected into the fat deposit following a multi-injection pattern according to the shape of the fat deposit. The detailed injection parts and dosages are shown in the following table. Storage: Store under refrigeration (4℃~9℃). Store in the original carton in order to protect from light. Use immediately after mixed. Injection site Facial fat Depth: 3 - 4mm, quantity: 0.1-0.2 ml, point distance: 1-2.5 cm Depth: 6-13mm, quantity: 0.1-0.2ml. point distance: l-2.5cm Depth: 6-13mm, quantity: 0.1-0.2ml. point distance: l-2.5cm, at least 10 points, 30 points is advised Body fat Abdominal fat Dosage and injection method Injection parts Dosage per administration Abdomen/waist/hip Inject 0.7~0.8ml on a spot and move to next half an inch or a centimeter distant. Other parts such as armpit, upper arm, back and thigh Adjust (mostly less than abdomen/waist/hip) injection quantity according to the obesity degree of the part to be injected. For those areas with small fat deposits were infiltrated at only one central point, whereas in larger areas, the injections were at equidistant points of approximately 1 cm. At each application site, 0.2ml was injected, totaling 0.2 to 5.0ml (10-250mg) per session Face (double chin) Injection parts Dosage per administration Abdomen/waist/hip Inject 0.4~0.5ml on a spot and move to next half an inch or a centimeter distant Other parts such as armpit, upper arm, back and thigh Adjust (mostly less than abdomen/waist/hip) injection quantity according to the obesity degree of the part to be injected. Face (double chin) For those areas with small fat deposits were infiltrated at only one central point whereas in larger areas, the injections were at equidistant points of approximately 1 cm. At each application site, 0.2ml was injected, totaling 0.2 to 5.0ml per session.