Effects of Electronic Cigarette Constituents on the Human Lung: A … · Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400 . number.
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Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial Min-Ae Song1, 2, Sarah A. Reisinger1, Jo L. Freudenheim3, Theodore M. Brasky1, Ewy A. Mathé1,4, Joseph P. McElroy, Quentin A. Nickerson1, Daniel Y. Weng1, Mark D. Wewers6, Peter G. Shields1* 1 Comprehensive Cancer Center, The Ohio State University and James Cancer Hospital, Columbus, OH 2 Division of Environmental Health Science, College of Public Health, The Ohio State University, Columbus, OH 3 Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 4 Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, OH 5 Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 6 Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Ohio State University, Columbus, OH
*Address for Correspondence: Peter G. Shields, MD Comprehensive Cancer Center The Ohio State University Wexner Medical Center 460 W. 10th Avenue, 9th Floor, Suite D920, Columbus, OH 43210-1240 Phone: 614-688-6563 Email: [email protected] Running title: Effects of Electronic Cigarette on the Human Lung
Conflict of Interest: PGS has served as an expert witness and consultant in tobacco company litigation on behalf of plaintiffs. The other authors declare that they have no potential conflicts of interest.
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Table 1. Inflammatory cell counts and cytokines in bronchoalveolar lavage fluids: Randomized trial of never smokers Clinical Trials Control (n=14) E-cig use (n=13) Control (n=14) E-cig use (n=13)
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400
Published OnlineFirst October 16, 2019.Cancer Prev Res Min-Ae Song, Sarah A. Reisinger, Jo L. Freudenheim, et al. Lung: A Pilot Clinical TrialEffects of Electronic Cigarette Constituents on the Human
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Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 16, 2019; DOI: 10.1158/1940-6207.CAPR-19-0400