Effect of growth hormone on aging connective tissue in muscle
and tendon: gene expression, morphology, and function following
immobilization and rehabilitation A. P. Boesen, K. Dideriksen, C.
Coupp, S. P. Magnusson, P. Schjerling, M. Boesen, P. Aagaard, M.
Kjaer, and H. Langberg
Effect of growth hormone on aging connective tissue in muscle
and tendon:gene expression, morphology, and function following
immobilization and rehabilitationA. P. Boesen, K. Dideriksen, C.
Coupp, S. P. Magnusson, P. Schjerling, M. Boesen, P. Aagaard, M.
Kjaer, and H. Langberg
Presented by Juni Royntan TampubolonGuided by dr. Vera Sp.PD.,
K.Ger.
KSM ILMU PENYAKIT DALAMRUMAH SAKIT IMMANUELBANDUNG - 2015
BackgroundPhysical activity is with aging inactivity loss in
skeletal strengthElderly >> prone comorbidity and
hospitalization accelerate loss of skeletal muscle mass and
strength detrimental for the functional capacity and the risk for
fall injuriesRecent studies inactivity has no major morphological
effect on tendon size it self but rather seems to decrease tendon
biomechanical properties and reduce collagen synthesis
The growth hormon(GH)/IGF-1 collagen turnover + inhibit muscle
protein degradation potential importance during immobilizationAging
gradual loss of the GH/IGF-I axis change body composition with body
fat & loss muscle massit is unknown whether loss in
musculotendinous tissue during inactivity can counteracted by GH
and whether GH accelerate rehabilitation in aging individuals.
BackgroundMethods
Study designStatistics analysisUsing two-way repeated-measures
ANOVA Post hoc test65-80- yrBMI 18-30
Result
Result
Result
Result
Result
Result
ConclusionIn elderly humans, GH seems to have a matrix
stabilizing effect during inactivity and rehabilitation by
stimulating collagen expression in the musculotendinous tissue and
increasing tendon CSA.