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Page 1: EDITORIAL STAFF - University of Minnesota
Page 2: EDITORIAL STAFF - University of Minnesota

EDITORIAL STAFF W. ALBERT SULLIVAN, JR., M.D.Editor

EIVIND HOFF, JR.Executive Editor

ADMINISTRATIVE SPONSORS

Minnesota Medical Foundation

KARL W. ANDERSON, M.D.President

MALVIN E. HERZVice-President

ROBERT A. ULSTROM, M.D.Secretary-Treasurer

EIVIND O. HOFF, JR.Executive Director

Board of TrusteesJOHN F. ALDEN, M.D.RAy AMBERGHOWARD A. ANDERSEN, M.D.T. RICHARD ANDERSONEARL E. BAKKENMRS. FRANK W. BOWMANH. MEAD CAVERT, M.D.CARL E. CHRISTENSON, M.D.HERMAN E. DRILL, M.D.PAUL DWAN, M.D.PHILIP L. ECKMAN, M.D.BERTIN C. GAMBLEM. MELVIN GOLDFINE, M.D.BERNARD HALPER, M.D.WILLIAM HARTFIEL, M.D.O. M. HEIBERG, M.D.JOHN M. HOLLERNROBERT B. HOWARD, M.D.L. G. IDSTROM, M.D.DENNIS J. KANE, M.D.JAMES E. KELLEYYORK E. LANGTONLEWIS W. LEHRSAMUEL MASLONCHARLES A. NEUMEISTER, M.D.RUSSELL O. SATHER, M.D.HAROLD G. SCHEIE, M.D.VERNON D. E. SMITH, M.D.HAROLD VAN EVERYRICHARD L. VARCO, M.D.CECIL J. WATSON, M.D.

University of Minnesota Medical SchoolMALCOLM Moos, President

University of MinnesotaROBERT B. HOWARD, M.D., Dean

College of Medical SciencesH. MEAD CAVERT, M.D., AssociatfJ DeanROBERT A. ULSTROM, M.D., Associate DeanROBERT J. MCCOLLISTER, M.D., Assistant DeaROBERT O. MULHAUSEN, M.D., Assistant Dean

University of Minnesota HospitalsJOHN H. WESTERMAN, Director

Minnesota Medical Alumni· AssociationKENNETH P. MANlCK, M.D., PresidentLEONARD ARLING, M.D., Vice-PrfJsidentGEORGE W. JANDA, M.D., Vice-Prf/sidentEMERSON E. HOPPES, M.D., SecretaryHENRY W. QUIST, M.D., Treasurer

Page 3: EDITORIAL STAFF - University of Minnesota

UNIVERSITY OF MINNESOTA

Medical BulletinOfJicial Publi<:ation of

UNIVERSITY OF MINNESOTA HOSPITALSMINNESOTA MEDICAL FOUNDATION

MINNESOTA MEDICAL ALUMNI ASSOCIATIONCircuUltion this issue: 6,200 24 Pages

VOLUME XXXIX

ALUMNI SURVEY

The Class of 1937

;vlEDICAL SCIENCE

April 1968

CONTENTS

NUMBER 8

....... 194

An Experimental Summer Program forFreshman Medical Students

THEODORE M. COLE, M.D., THOMAS P. ANDERSON, M.D.,and NANCY CREWE, Ph.D. .212

Neuropathological Aspects ofChediak-Higashi Disease

Joo Ho SUNG, M.D. and EMANUEL M. STADLAN, M.D. 215

MEDICAL SCHOOL NEWS

DR. JOHN J. SCIARRA Named Head ofObstetrics and Gynecology

ALUMNI DEATHS AND MEMORIALS

.218

220

Published monthly from September through June at Minneapolis, Minn. No ad­vertising accepted. Second class postage paid at Minneapolis, Minn. Address allcommunications to The Editor, University of Minnesota Medical Bulletin, 1342Mayo Bldg., University of Minnesota, Minneapolis, Minn..55455.

Page 4: EDITORIAL STAFF - University of Minnesota

The Class of 1937 (MB)When thirty-nine members of the Class of 1937

(MB's) attended the Medical Alumni HomecomingReunion last year, Lloyd Sherman spoke for theclass. So it has always been. No one seems to re­member electing a class president, and "LloydSherman has usually spoken for the Class", accord­ing to one alumnus.

When the editors asked the Class of '37 to speakfor itself regarding their medical teachers, there wasa generous tribute to the faculty. The remarks ofeach man are printed in italic type at the end of hisnews capsule. *

One hundred eight survive and 14 are deceasedfrom the 122-member class. All but a fete are stillgoing strong in practice after 30 years. Here aresome other statistics which turned up:

• 31 of the 108 surviving graduates are in generalpractice.

• 50 of the 108 survivors are practicing in Minne­sota.

11

f.lumni

• Fifteen are practicing in California (next highest).

• Eight have sons or daughters in the field ofMedicine.

• Three have sons graduating from the MedicalSchool this year. (David Gaviser, Leon Harris, andWilliam Hollinshead).

• One classmemher has ten children.

• Fifteen did not an.swer the survey.

*Question: Which teacher influenced you the most in Medical School?

194

Page 5: EDITORIAL STAFF - University of Minnesota

Carl W. Ahl* is director of the medical clinic of Phelps DodgeCorp., a copper mining operation in Douglas, Ariz. His indus­trial and general practice has covered 18 years. During WorldWar II, he was in the Air Force. Carl lives at 2001 10th St.,Douglas, with his wife, Myrtle (Crosby, Minn.). They have fourchildren, including Norman, a junior at UCLA Medical School,and Carolvn, a dietetic intern at the Universitv of California."Dr. J. Arthur Myers-he seemed sincerely interested in me asa student and person . . . an interesting teacher and thoughtfulperson . .. strengthened the image of the good physician."

John H. Aldes* is an orthopedic surgeon and director of theservice at Cedars of Lebanon-Sinai Medical Center, Los An­geles, Calif. He trained at Yale and Cincinnati U. and servedin World War II. John holds a "Phvsician's Award" which waspresented him in 1960 by Pres. Eiseilhower, and has been activein Universitv of Minnesota alumni circles. His wife, Hannah, isdeceased. J~hn lives at 908 Bel Air Rd., Los Angeles.

George W. Anderson* practices OB-GYN at Providence, R. I.Lying-In Hospital, and lives at 1 Magee St. in that city. Heteaches at Tufts University and served in the Army duringWorld War II.

Wallace D. Armstrong* is professor and head of the MedicalSchool's Department of Biochemistry, having received the Ph.D.from the University in 1933. His crusty shell, twinkling eyes,and Irish humor are fondlv recalled bv a host of Minnesotaalumni. Wallace and his wife, Marv, live at 12 Orlin Ave. SE.One of his two daughters, Wally admits, is a law student. Wal­lace is an occasional golfer and Civil War buff. He holds anhonorarv doctorate from Stockholm University, three awardsfor rese~rch in calcified tissues, and is considered an internation­al authority on fluorides. "E. T. Bell, J. C. Litzenberg, and C. J.Watson-for their high moral values and strict application andprecision of medical knowledge."

James B. Arey is a professor of pathology at Temple Univer­sity and is full time at its pediatric unit, St. Christopher's Hospi­tal for Children. He has spent 19 years on this assignment, andlives at 215 Avon Rd., Narberth, Pa. The Arevs (Harriet) havethree children. "Dr. E. T. Bell." .

Florian H. Baumgartner has been a GP in Albany, Minn. for.30 vears, and is 7th district councilor for the Minnesota StateMedical Association. He and his wife, Kathleen, have 10 child-

• Member, Minnesota Medical Foundation

Page 6: EDITORIAL STAFF - University of Minnesota

THE MEDICAL BULLETI!'

F. H. Baumgartner Philip Beckjord John AIdes

ren, among them Gerald F., a dentist at Park Rapids, Minn."Dr. E. T. Bell, Dr. Ray Bieter, Dr. Cecil Watson, Dr. O. H.Wangensteen, and especially Dr. Clarence M. Jackson, a truegentleman and scholar."

Arnetta Becker is married to Schuyler P. Brown (Med. '41).She doesn't practice but likes boating and sailing. The Brownslive in St. Petersburg, Fla. (11340 7th St. K) and Schuyler prac­tices at the Bay Pines V.A. Hospital. They have five children,the youngest in the 9th grade "maybe to wind up in medicine.""Dr. Irvine McQuarrie."

Philip R. Beckjord* started as a GP in Willmar, Minn., be­came an Armv medical officer in 1940, remained until his re­tirement in 19"60, and today is professor and chairman of PublicHealth Administration at Tulane University, New Orleans, La.He and his wife, Margaret, have four children. Phil receivedthe M.P.H. degree from Minnesota in 1949, and a doctoratefrom Johns Hopkins in 1957. "Dr. Owen Wangensteen-I wasone of his surgical interns."

Louis A. Benesh* is in general practice with two associatesin Elk River, Minn. He lives on RR. 2 with his wife, Marcella.Their son, George, is a senior in vet medicine at the Universityof Minnesota. Louis likes hunting and fishing. "Dr. E. T. Bell­taught pathology with relation to clinical medicine."

Anthony S. Berlin* was a GP for 20 years in Minnesota be­fore 1957 when he relocated in Anaheim, Calif. "A busy officepractice," he reports, "with weekends off for travel, visitors,and deep sea fishing." Tony and his wife, Mildred, live at 2200S. Redwood Dr., Anaheim. They have three children, one anRN.

*Member, Minnesota Medical Foundation

196

Page 7: EDITORIAL STAFF - University of Minnesota

THE MEDICAL BULLETIN

Abe E. Berman is a pediatrician in Sacramento, Calif., hislocation for 28 years. Abe trained at Minneapolis General Hos­pital and spent five years in the Army. He now lives at 4637Cabana Way, with his wife, Pearl. They have two children.

Albert A. Bodaski's address is 6802 N. 19th St., Phoenix,Arizona.

James W. Bratholdt* has spent 27 years in general practicein Watertown, Minn. His associates at the Watertown MedicalClinic are David Philp, and David Smith (Med. '62). Jim ison the school board, is a Mason, and likes to play bridge. Heand his wife, Norma, have two sons and two daughters. "Dr.E. T. Bell-for his teaching in basic pathology."

Carl G. Caspers* says he "enjoys his orthopedic surgerypractice in Minneapolis very much" and "proposes to continueuntil the 'grim reaper' serves me notice." He's lasted 25 yearsso far, including 1941-45 spent in the Army. Carl likes athleticsand lives at 4635 Casco Ave., Edina, with his wife, Bernadette.Thev have six children.

Byron B. Cochrane* has practiced ophthalmology about 20vears in St. Paul. After Army service in the War, he trained atMiller Hospital 1945-49. The Cochranes (wife: Audrey Lidren)live at 2230 Goodrich Ave., St. Paul. Among their five childrenis a son, Dennis, who will enter the Medical School this fall.

Ephraim B. Cohen* is an internist with 20 years practice inMinneapolis, now in association with Solomon Zak (Med. '57).Bud served nearly seven years in the Army, and is married toLillian Kay, a Canadian. Thev live at 4013 Basswood Rd., havetwo daughters in college, ,ind Bud teaches at the MedicalSchool. He is very interested in diabetes detection and is holderof the "Physicia~ of the Year" award given by the Mayor ofMinneapolis a few years ago for work with handicapped people."Dean E. P. Lyon-a man of exceptional personal insight andinfinite patience."

Rear Admiral John S. Cowan* is a career Naval officer with27 years of service. He is Fleet Medical Officer of the U.S.Pacific Fleet, presently headquartered in Honolulu. John is alsoa certified internist, and lives at 28 Makalapa Dr. with his wife,Catherine. A daughter is a student at the University of Pennsyl­vania Medical School, and a son is in pre-med. They have oneother child.

*Member, Minnesota Medical Foundation

197

Page 8: EDITORIAL STAFF - University of Minnesota

THE MEDICAL BULLETIN

Luther F. Davis operates the 4-man Davis Clinic, a generalpractice group, in Wadena, Minn., where he has been practic­ing since 1938 except for four years in the Army. He enjoys"central Minnesota with its seasons and seasonal activities."Miriam, his wife, is from Grand Rapids, Minn. They have sevenchildren, including a med. tech and two in college studyingpharmacy.

Theodore S. Drachman, after many vears of fulltime servicein the field of public health, is now public health consultant andwriter of suspense fiction. He took up his pen in earnest a coupleof years ago, has three books published, and two more under­way. Ted lives on Eagle St. in Philmont, N.Y. with his wife,Grace. They have two children. "Dr. A. T. Rasmussen-he wasthe 'high priest' of the comprehensive examinations whichobsessed everyone for the whole four years. I was a transfer tothe sec01ul year and had to pass the first year camps which madeit all the worse."

Ed Flink R. Adm. J. S. Cowan T. S. Drachman

Arnold H. Dysterheft* is a 27-year veteran of general prac­tice in McNary, Ariz. and is current president of the ArizonaState Medical Association. He is presently part of a group prac­tice at the McNary Hospital. He and his wife, Mildred, haveone child. "Dr. Cecil ]. Watson."

Raymond L. Eck* has been a GP for 22 years in Lewistown,Mont. He is active in Shrine work and likes coin collecting.Ray and Hazel Eck live at 201 Elm St. They have two sons anda daughter. Ray served in Alaska and Europe in World War II."Dr. William A. O'Brien-for his humility and goodness."

*Member, Minnesota Medical Foundation

198

Page 9: EDITORIAL STAFF - University of Minnesota

THE MEDICAL BULLETIN

Sidney M. Falk* says he's now convinced "solo" is the "onlyway to fly," so he's presently practicing ophthalmology alonein El Monte, Calif. Sid lives at 911 Hampton Rd. in nearbyArcadia. He spent five years in the Pacific during the war. Heand his wife, Marcia, have two teenage sons.

Jules Feinstein has been an internist for 23 years in Min­neapolis, where he has been chief of medicine at Mt. Sinai Hos­pital, and lives at 3901 Cedar Lake Rd. He and his wife, Jay,have two children. Jules was in the Air Force 1942-44, andnow relaxes with golf and painting ("more ... in the future!")."Dean E. P. Lyon."

William E. Fitzsimons has spent 30 years as a solo GP inBrainerd, Minn. His interest in family practice is abiding, and heis among that city's greatest sports fans. (Editor's note: I re­member receiving my first high school basketball physical examfrom W.E.F.) Bill lives at 1706 Linden La. with his wife, Enid.They are both skilled golfers and parents of two children.

Edmund B. Flink,* a native Minnesotan, has been professorand chairman of the Department of Medicine at West VirginiaUniversity Medical School for the last eight years. He lives at303 Sylvan PI., Morgantown, with his wife, Marian, (R.N.,Minn. '37). They have four children. Eddie received the Ph.D.in Medicine from Minnesota in 194.5. He was on the facultv atMinnesota many years before joining the "Minnesota colony" inWest Virginia. "Dr. E. T. Bell-he kept an intere.st in our classand in me personally during my entire training."

Carl Fosmark just returned from a two-month big game huntin Africa (see photo). He is now back to his general practice atMadison, Wis. His special interest is aviation medicine, arisingperhaps, from three years Air Force duty during World WarII. He and his wife,Lucille, live at 602 S. Thornton Ave. Thevhave one child. "All-they all helped, I had no favorites." .

Donald B. Frane* practices general medicine in north Min­neapolis with E. Robert Schwartz (Med. '36) and Richard E.Streu (Med. '60). Don spent two years in the Army in Burmaduring the War, and has been in north Minneapolis 1.5 years,and always a GP. He lives at 43.56 Xerxes Ave. N. He and hiswife, Evelyn, have a married daughter and a son studyingengineering at the University.

Nils A. Franzen* is in solo general practice in Detroit, Mich.His home address is 1.5360 Oakfield, where he lives with his

*Member, Minnesota Medical Foundation

199

Page 10: EDITORIAL STAFF - University of Minnesota

THE :\IEDICAL BULLETIN

wife, Burnetta. Nils enjoys travel, and looks forward to retire­ment "in Florida or Arizona."

Harold C. Freedman*does general practice witha four-man group in Shaf­ter, Calif., an associationof 22 years, preceded byfive years in the Air Force.His ~vife, Opal, is from Al­bert Lea. Thev have twodaughters. HU1:old is deep­ly interested in sportsmedicine, and "takes careof all local athletic teams.""Dr. Oteen Wangensteen­from him I learned the'scientific method,' andDr. Hobart Reimann-hetaught me to be a thera­peutic skeptic."

David Gaviser has prac- Carl Fosmark

ticed general surgery for22 years in Minneapolis, and is on the Medical School's clinicalfacult~,. He received the M.S. in surgery from Minnesota andwas in military service. Dave and Minette Gaviser will watchone of their t\VO children, James, graduate from the MedicalSchool next June. They live at 2431 Cedar Lane, Minneapolis."Dr. O. H. Wangensteen."

Elmer K. George has spent 30 years as a GP in Missoula,Mont., except for Pacific service during World War II. He liveson \v. Greenough Dr. with his wife, Leenora. They have sevenchildren, among them a dietitian and an R.T. Elmer loveshunting and fishing and is an amateur carpenter. "Dr. E. T.Bell-he teas my best teacher of clinical medicine."

Lloyd C. Gilman* is a general surgeon at the LakelandClinic, Willmar, Minn., where he has spent 25 years. But thisMarch he was to start a Urology residency at St. Paul-RamseyHospital. He and his wife have three children. Lloyd servedwith the Army in Europe during World War II.

Martin N. Gordon's address is 9629 Brighton, Beverly Hills,Calif.

*Member, Minnesota Medical Foundation

200

Page 11: EDITORIAL STAFF - University of Minnesota

THE MEDICAL BULLETIN

Harald M. Graning has been a U.S.P.H.S. career medicalofficer for 30 years, and is presently assistant Surgeon General.He likes fishing, and lives at 707 Arundel Place, Annapolis, Md.His wife, Thelma, is from Minneapolis. They have three child­ren. Harold obtained the M.P.H. degree from Johns Hopkinsin 1941. "Dr. Irvine McQuarrie-for his unusual breadth of in­terest. Also Drs. Wangensteen and Watson."

Russel B. Grant* is director of surgery at Hackensack, N.].Hospital and lives at 241 Fairmont Rd. in nearby Ridgewood.He received his surgical training at Mayo, and served five yearswith the Army during the War. Russ and Eleanor Grant havea son and daughter. "Dr. Wangensteen and Dr. Bell."

James A. Graves' address is 2118 Wilkes Ave., Biloxi, Miss.

Edwin W. Hakala is a partner in the Richmond, Va. Ortho­pedic Clinic. He has been there 10 years, and teaches at theMedical College of Virginia. Ed spent 20 years in the Army, re­tiring to private practice in 1958. He likes skiing and golf, livesat 4509 Croatan Rd. with his wife, Margaret. A son was a 1967graduate of the Medical College of Virginia.

Harry A. Hanson is believed to reside in Rochester, N.Y.

Leon D. Harris* is in general practice in Richfield, Minn.,and lives in another Minneapolis suburb, Burnsville, at 13400Colfax Ave. S. His wife, Marian, is from Dawson, Minn. Theirson, James D., will graduate from the Medical School this June.Leon was in the service during World War II.

Erling T. Hauge practices OB-GYN with a five-man groupat the Oakdale Medical Building, Minneapolis, and lives at 219Ardmore Dr. He has been in private practice since completingAir Force duty in World War II. Erling's wife, Em, is a formerUniversitv R.N. Thev have two children.. .

Lyle J. Hay is director of medical education at MetropolitanMedical Center (St. Barnabas Hospital) in Minneapolis, and aclinical professor of surgery at the Medical School. He receivedthe Ph.D. in surgery from Minnesota in 1949 after World WarII service. Lyle lives at 1517 E. River Road, Minneapolis, withhis wife, Midge. They have five children. Lyle is past presidentof the Minnesota Division, American Cancer Societv, and theMinnesota Surgical Society. "Dr. Owen H. Wange~een."

Robert T. Hewitt* is chief deputy director of the CaliforniaDepartment of Mental Health. He has been in administrative

*Member, Minnesota Medical Foundation

201

Page 12: EDITORIAL STAFF - University of Minnesota

THE MEDICAL BULLETIN

medicine seven years, and obtained the M.P.H. degree fromJohns Hopkins. Bob was with the U.S.P.H.s. during World War III, now lives at 2037 Oxford St., Sacramento, Calif. He and .his wife, Joan, have three children, one a lawyer. "Dr. E. T. .Bell-an excellent teacher, scholar, and gentleman with con- 1...tagious enthusiasm and 5illCerity." .

William H. Hollinshead practices internal medicine in St.Paul and teaches in the Medical School's program at St. Paul­Ramsey Hospital. He reports he and his wife, Mary, have been"tied up with raising and educating our four children", one ofwhom is William H. Hollinshead III, who will graduate in Junefrom the Medical School. The family home is at 693 GoodrichAve. Bill is 1968 president of the Ramsey County Medical So­ciety. "I?,r. C. ]. Watson-a very astute clinician and excellentteacher.

Harald Graning Douglas Hursh Lloyd Gilman

Emil G. Holmstrom* has had eight years in "semi-retire­ment" as part of a group practice limited to office gynecology inLos Angeles. He is former professor and head of OB-GYN atthe University of Utah, now enjoys gardening and travel. Heand his wife, Peg, keep busy with various projects and havetwo sons. Home is at 235 La Vereda Rd., Pasadena. Emilteaches at Kaiser Foundation Hospital. "Dr. ]. L. McKelvey­he encouraged me to take graduate training and to enter teach­ing."

Fred C. Holzapfel, always a GP, and has spent the last 12years in practice at 5001 Olson Highway, Golden Valley, Minn.He served in the Navy in the War, and has two children."Dr. lackson-I worked with him in Anatomy for ]if years."

Bernard J. Hughes' address is Doctors Park, St. Cloud, Minn.

'Member, Minnesota Medical Foundation

202

Page 13: EDITORIAL STAFF - University of Minnesota

R. J. Kamish

THE MEDICAL BULLETIN

M. Douglas Hursh* is now practicing ophthalmology withthe Wheaton, Ill. Eye Clinic, and lives at 1314 Santa Rosa inthat city. Previously he was a career medical missionary withMrs. Hursh in Nigeria, founding the 140-bed Kana Eye Hospitalthere. The Hurshes have two sons and two daughters. "Dr.O. H. Wangensteen-we respected him for character, ability, andreputation."

Karl E. Johnson* spent five years with the Marines duringWorld War II and has since spent 22 years practicing in Duluth,Minn. He lives at 127 S. 43rd Ave. E. with his wife, Catharine.They have two sons-both planning medical careers-and adaughter in pre-law. "Dr. E. T. Bell-his tremendous mind, abil­ity to teach, kindliness, and thorough knowledge of his sub;ect."

Orville H. Jones is a solo GP in Mankato, Minn. and liveson Rte. 1. He has been there since graduation. His wife, Louise,was a nurse at Rochester, Minn. They have six children and sixgrandchildren. Orville is a backer of the American Field Serviceprogram, and likes to collect antiques.

Robert J. Kamish* is assistant director, American College ofSurgeons, and a veteran of 30 years service with the U.S. ArmyMedical Corps. His last assignment beforeretiring was Health Director, Panama CanalZone. He is now responsible for planningthe clinical programs of A.C.S., and liveswith his wife, Margaret, at 835 WesterfieldDr., Wilmette, Ill. 60091. A son, Pat, grad­uates from Dentistrv school this vear.. .

Harry D. Kaplan lives at 57 MontagueSt., Brooklyn, N.Y. and is engaged in re­search and teaching in neurosurgery at theNew Jersey College of Medicine. Single, hespent 1941-46 in the Armv, and enjoysphotography and sports cars."'Dr. A. T. Ras­mussen and Dr. William Peyton."

Irvine M. Karon was a GP until spending 3Jf years of seaduty with the Navy in World War II. Then he trained fordermatology, and has now practiced as a specialist in St. Paul,Minn. since 1949. He teaches in the clinical program at theUniversitv and lives with wife Ruth and familv at 1795 Pine­hurst Av~., St. Paul. Their oldest son is on the University facultyin Library Science.

*Member. Minnesota Medical Foundation

203

Page 14: EDITORIAL STAFF - University of Minnesota

THE :\lEDICAL BULLETIK

Henry H. Kavitt is a radiologist with the Permanente Clinicin Portland, Ore. He lives at 3650 SW Bridlemile La., and"enjoys the Pacific Northwest." Henry and his wife, Margaret,have two daughters. Henry trained at Minnesota and was inthe Army 1941-46. "Dr. Leo Rigler."

Thomas J. Kenyon was a pathologist, served in the Ann~'

during the War, but has practiced internal medicine for thelast 20 ~'ears. He practices in St. Paul and lives at 230 S. Mis­sissippi River Blvd. "Dr. E. T. Bell."

Lewis A. Knutson has been a GP in Spring Grove, Minn.since 1945. During World War II he served with the ArmyMedical Corps in Venezuela and Europe. Lew's wife, Ruth,was from Belgrade, Minn. They have three children.

Sheldon KoH's address is 53.53 Balboa Blvd., Encino, Calif.

Arnold J. Kremen* is a private surgeon in Minneapolis andclinical professor at the Medical School, where he obtained thePh.D. in surgery in 1946. He was in the Army 1942-45, nowpractices principally at Mt. Sinai Hospital. Arnold lives at 4817Morgan Ave. S., Minneapolis, with his wife, Virginia. They havethree children. "Dr. O. H. Wangensteen."

Bernard G. Lannin* is a surgeon in St. Paul, Minn. and clini­cal associate professor at the Medical School. He is also attend­ing physician for numerous Twin Cities athletic teams, includ­ing University squads. Barne~' obtained the Ph.D. in surgeryfrom Minnesota in 1944. He lives with his wife, Noreen, at 2148Lower St. Dennis Rd., St. Paul. They have two daughters. "Dr.E. T. Bell."

D. John Lauer* is medical director of the International Tele­phone and Telegraph Corp., New York City, and has practicedoccupational medicine for 25 years. He obtained a degree inthis field from the University of Pittsburgh in 1950, after servingin the Navy 1940-45. When not "traveling a lot" on business,John lives at 717 Orienta Ave., Mamaroneck, N.Y. with his wife,Helene, who was from Waseca, Minn. Thev have seven child­ren. "Dr. William A. O'Brien-he stimulated an interest in pre­ventive medicine."

William V. Leary's address is 3208 Locke La., Houston, Tex.

William L. Lehman is a pathologist at the Portland MedicalCenter, and lives on Rte. 1, Box 310, Clackamas, Ore. He hasbeen there 20 years and formerly taught at the University of

*Member, Minnesota Medical Foundation

204

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THE MEDICAL BULLETIN

Oregon. Bill's wife, Josephine, is from Maryland. They havefour teenagers. Bill was in the Navy in World War II, is currentpresident of the Northwestern Medical Association, an outdoor­medical fellowship. "Dr. E. T. Bell."

Robert S. Leighton's address is V.A. Hospital, Seattle, Wash.

Robert C. Lofgren has been a dermatologist in Salinas, Calif.for 13 years. He served with the Navv Medical Corps startingin 1942. Bob and his wife, Virginia, have three sons and likegolf and ham radio. They live at 304 W. Alisal St.

Dwight L. Martin* counts 20 years of internal medicinepractice in St. Paul, and lives at 2220 Bayard Ave. He and hiswife, Evelyn, have two sons, both teachers. Dwight teaches atMiller and St. Paul-Ramsey hospitals. "Dr.William A. O'Brien-he loved his studentsand ,;espected patients as human individ­uals.

Donovan L. McCain's* address is 545W. 7th St., St. Paul, Minn.

Frank F. McKean* has been a solo GPin Allison, Ia. for 27 vears. He is marriedto Charlotte Ohnstad ~nd lives at 508 ElmSt. Thev have two sons in the Twin Cities."Dean E. P. Lyon-his explanation of theusual doctor's day in a speech at Macalesterinfluenced me to go to M ed school." Dwight Martin

Charlotte Meller is a staff psychiatrist with the county Men­tal Health Service in Sacramento, Calif., and lives in nearbyAuburn, (P.O. Box 823). She trained at St. Peter State Hospitaland Minneapolis General, and is now married to Mr. Charles E.Biddle, an Ohioan. They have two children. Charlotte likes toswim, read, and paint, :md will "continue to practice until re­tirement." "Dr. ]. Arthur Myers . .. of T.B. fame-he was friend­ly, quiet, and easy to talk to."

Robert L. Meller* practices neurology and psychiatry inMinneapolis with an associate, and is a clinical professor atthe Medical School. Bob served in the Army during World WarII. He and his wife, June, live at 4614 Moorland Ave., Edina.They have a daughter and two sons. "J. C. McKinley. He in­fluenced me to go into neurology and psychiatry."

Jules O. Meyer is assistant medical director of NorthwesternMutual Life Insurance Co. in Milwaukee, Wis., a post he took

*Member, Minnesota Medical Foundation

205

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Arthur Moss

THE ~IEDlCAL BULLETIl\:

fairly recently after 16 years in the Army Medical Corps. For­merly in practice in Grand Rapids, Minn., he now lives at 1124E. Hermitage Rd., Milwaukee, with his wife, 110. They haveone daughter. "Dr. George E. Fahr."

Robert W. Merrill* moved to Des Moines, la. this vear topractice physiatry at Younker Memorial Rehabilitation Center.He completed a fellowship 1965-67 at the University of Min­nesota, after 26 years of general practice in Morris, Minn. Bobnow lives at 1144 Americana Ct. He and his wife, Mabel, havea son and daughter. "Dr. ]. C. Litzenberg-persistent teachingof conservative management of obstetrics."

Daniel J. Moos' address is 609 Medical Arts Bldg., Min­neapolis, Minn.

Arthur J. Moss is professor and head of the Department ofPediatrics at UCLA School of Medicine. He trained at Minne­sota before War service, then settled inCalifornia in 1946, gradually moving intofull time pediatrics and cardiology atUCLA. He became head of the departmentin October, 1967. Art lives at 2701 ForresterDr. with his wife, Alice Litman, of St. Paul.They have two daughters and one son. "Dr.Irvine H. McQuarrie."

Leslie A. Moren* is a general practi­tioner with the Elko, Nev. Clinic, a multi­specialty group he joined in 1946 after Wardutv. Les lives at 777 Court St. with hiswife, Laurena. Thev have four children."Dr. Cecil]. Watson."

James E. Murphy has been a GP for 26 years in Las Vegas,Nev. He is associated with the North Las Vegas Medical Cen­ter, and lives at 1413 N. 30th, with his wife, Katherine. Thevhave four children. Jim served in the Army 1941-46. "Can't say~too many good ones tchen I teas a student."

Donald R. Nichols is head of a Section of Infectious Diseasesat the Mayo Clinic, Rochester, Minn., and professor of clinicalmedicine in the Mayo Graduate School. Don and Mary Nicholshave six children and live at 1068 Plummer La. Don has spenthis entire career at the Mayo Clinic. ·'Dr. C. ]. Watson-his aca­demic competence and research ability stimulated me to exploresimilar interests."

'Member, Minnesota Medical Foundation

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Walter R. Nickel is a solo dermatologist in San Diego, Calif.,his location for 22 years. He teaches at USC and lives at 730Silvergate Ave. Walt and Mona Nickel have five sons, includingone, an intern at John Hopkins. Walt spent 1941-45 in theArmy, then took his master's at Minnesota. "Dr. Henry Michel­son-by far the most accomplished lecturer we had."

Duane C. Olson* is in general practice in Minneapolis withDr. Kenneth Hodges (Med. '54), and lives at 7440 W. ShoreDrive, Edina. He and his wife, Lvndis, have three children,including Dr. Charles Olson (Mel '65), an Air Force flightsurgeon.

Eldon C. Olson* likes to travel, owns several quarter horses,and has practiced general medicine in No. Hollywood, Calif. forthe last 21 years. He was in the Navy Medical Corps from 1937to 1946, and now lives at 4654 Placidia Ave. He and his wife,Dorothy, have two married sons. "Dr. ]. A. Myers-for dedica­tion to his work and compassion for his patients."

William A. Owens has been in general practice at the Monte­video, Minn. Clinic for 28 years, except for World War II dutyin Africa and Europe. He and his wife, Hildegarde, have twosons and two daughters. "Dr. William A. O'Brien-because of hisdown-to-earth methods and philosophy."

E. Irvine Parson has been a general surgeon in Duluth,Minn. for 25 years. He studied bronchoesophagology at TempleU., and served in the Army in Europe during World War II.Dr. Parson resides at 510 Kenilworth Ave. with his wife, Jeanne.They have four children.

Harry L. Plotke* is an "ardent golfer" and has practicedophthalmology 19 years in St. Paul, Minn. He lives at 1120 St.Dennis Court, teaches at the Medical School, and is past presi­dent of the Minn. Academy of Ophthalmology and Otolaryngol­ogy. He was in the Army during World War II. Harry and hiswife, Lea, have a son and daughter. "Dr. Cecil]. Watson-en­;oyed his classes and clinics. He imbued me tcith enthusiasmfor diagnosis and the Art of medicine."

Elmer C. Paulson* has been a radiologist in St. Paul since1953 and practices with the St. Paul Radiology P.A. He teachesat the Medical School, where he took his residency 1948-51.Elmer was in the Air Force 1942-46, now lives at 2294 StanfordCt., St. Paul, with his wife, Ethel. They have four children.

Lowell John Peterson received the M.S. in surgery from Min­nesota in 1949, and has since practiced in Reno, Nev. He served

*Member, Minnesota Medical Foundation

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in the Army in the Pacific 1942-46, now lives at 345 JuniperHill Road. He"and his wife, Jeanne, have no children. "Dr. OwenWangensteen.

John T. Pewters* practices family medicine with three medi­cal alumni partners in Minneapolis (Sherman Child '52, JohnHiatt '59, Roger Christgau '64). Jack has always been a GP, andis presently speaker of the House of Delegates, Minnesota StateMedical Association, as well as A.M.A. delegate. He lives at2015 Queen Ave. S., Minneapolis, with his wife, Mary. Theyhave two daughters and three grandchildren. Jack was in theAir Force 1942-46.

Lewis J. Roberts' address is 3620 Central Ave., Minneapolis,Minn.

Maurice C. Rousseau has been a GP at the Brown Clinic,'Natertown, S.D. for 30 years, except for World War II service.He lives with his wife, Rose, at 1273 Crestview. They have foursons including a Navy doctor. Maurice says his father, a physi­cian, was his greatest influence in entering Medicine.

Leslie G. Seebach retired in 1963 after 25 vears' service withthe U.S. Navy Medical Corps. He came out a Captain, withextensive combat experience during World War II. Les lives at325 Plum St., Red Wing, Minn., with his wife, Marjorie. Theyhave six childten, two at the University. Les says he's "enjoy­ing retirement, gets to travel a lot, and spends quite a bit oftime at the University these days." "Dr. George Fahr, Dr. ]. A.Myers, and Dr. Cecil ]. Watson-for their fine clinical teachingand encouragement of the highest standards of medical prac­tice."

Leon Seley* is a GP and allergist practicing alone in Sunny­vale, Calif. He lives at 857 Seale Ave. in nearby Palo Alto, andis an ll-year "native" of California. His wife, Florence, is aspeech therapist. They have two children. "Dr. Moses Barronand Dr. O. H. Wangensteen."

Charles H. Scheifley's address is 101 S. Washington, ParkRidge, Ill.

Anthony A. Schmitz' address is Mankato Clinic, Mankato,Minn.

James T. Shelden* is a radiologist with the \Vatson Clinic,Lakeland, Fla., a 22-year association. He lives at 2231 JonilaAve. with his wife, Alfreda. They have three children. Jimtrained at Mayo 1938-42, spent 1942-46 in the Army.

*Member, 'Minnesota Medical Foundation

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Robert B. TudorGordon StromSidney Yugend

Lloyd F. Sherman* practices proctology in Minneapolis andteaches at the Medical Schoo!. His associates are Bob Tenner(Med. '36) and Jerry Schottler (Med. '60). Lloyd trained atTemple University, and served with the Marines in the Pacificin World War II. He likes water skiing and lives at 3004 Tonka­ha Dr., Wayzata, Minn. with his wife, Ruth. They have fourchildren. "Dr. C. D. Creevy and Dr. Richard L. Va rca-by beingcompletely informed on their sllb;ect material."

Michael W. Silver* has been a solo internist and pathologistin Paterson, N.J. since he completed five years of Air Force dutyin World War II. He lives at 334 Park Ave. and hopes to "retireand become a gentleman farmer," where he can pursue hisfavorite hobby, horseback riding. Mike and his wife, Muriel,have one married daughter.

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*Member, Minnesota Medical Foundation

Donald E. Stewart is a general surgeon with the Northwest­ern Clinic, Crookston, Minn. He has been there 19 years follow­ing five years in the Army and training at the University ofMinnesota. Don has been a leader in Minnesota Cancer Societywork and lives at 518 N. Ash St. with his wife, Phyliss. Theyhave four daughters and one son.

Bernard Street* is "very happy in general practice in North­field, Minn., an unusually attractive location within convenientdistance of the Twin Cities." He's been there 22 years andserved nearly five years in the Armed Forces during World WarII. His profession'll associate is David C. Halvorson (Med. '58).Bernie lives at 307 Elm. He and his wife, Mary, have four child­ren. "Dr. Thomas Kinsella-I learned from him that it was pos­.sible to do good smgertj withollt raising hell in the operatingroom."

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THE "-I E DIe ALB U L LET I 1\'

Gordon W. Strom* is a urologist with 25 years experience,18 of them in downtown Minneapolis, with offices in the South­dale Medical Bldg. He lives at 95 Woodland Circle, Edina, andteaches at the V.A. Hospital. A son, Erik, is a sophomore in theMedical School. Gordon and his wife, Barbara, have two otherchildren, and like skiing, hunting, and raising garden vegetables.

Rodney F. Sturley* lives at 330 Woodlawn Ave., St. Paul,practices OB-GYN, and teaches at the Medical School. Heserved 3)~ years in the South Pacific during World War II. Rodand Jane Sturley have four daughters, the oldest a nursing grad­uate of the University. "We're all skiers and have a great lovefor Colorado," he writes. "Prof. ]. L. McKelvey-1 lcas one ofhis first fellows."

Hendrik J. Svien has been a neurosurgeon at the Mayo Clinicsince 1942, except for Navy service in the War. He teaches inthe Mayo Graduate School and leads his family on skiing andgolf outings. The Svien household is at 827 Eighth St. SW,Rochester. Hendrik and his wife, Nancy, have three children."Dr. Andrew Rasmussen."

Gordon H. Tesch* is a GP and senior member of the ElkRiver, Minn. Clinic. He has spent 30 years there, has beencounty coroner 28 years, likes boating as a hobby, and has beeninterested in diabetes research. He is married to Harriet Paschkeof Blue Earth, and lives at 231 Nile Place. Thev have threechildren. "All-they all had their merits." .

Benedict Trach* has been solo in general practice in Min­neapolis for twenty years. He was in the Air Force during WorldV\'ar II and is married to Dorothy Bennett of Minneapolis. Theyhave two children and live at 4700 W. Lake St. "Dr. O. H.Wangensteen-for his surgical research and training."

Robert B. Tudor* studied pediatrics after World War IIAlmy service at Duke and Johns Hopkins, and has practicedsince 1949 at the Quain & Ramstad Clinic, Bismarck, N.D. Hiswife, June, is from Glenwood, Minn. They are avid sports fans,and Bob is an active Republican. He is a councilor of the N.D.State Medical Association. The Tudors have three children.

James L. Vadheim has been a general surgeon in Tacoma,Wash. since receiving the M.S. from Mayo in 1942. He playstennis or squash daily and lives with his wife, Jeanne (Prince­ton, Minn.), at 1908 N. Puget Sound. They have three grown

• Member, Minnesota Medical Foundation

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THE MEDICAL BULLETIN

children, Jim is 1968 president of the North Pacific SurgicalAssociation. "Dr. E. T. Bell-his clinical pathology conferenceswill never be forgotten."

Francis M. Walsh* has practiced ophthalmology for 29years, including 20 in Minneapolis, where he got an M.S. fromthe University of Minnesota. He spent two years in the AleutianIslands with the Army during World War II, now lives withhis wife, Hazel, at 4200 W. 44th St., Minneapolis. They havethree sons. "George Fahr-for his sincerity, showmanship, andknowledge of his subject."

William V. Walsh* practices with a group of psychiatristsin Lexington, Ky. He has been there 13 years, and also teachesat the University of Kentucky Medical School. Bill was in theArmy during the War, is now married to Maxine Whitcomb ofMinneapolis. They have three children and live at 3345 Lans-

downe Dr. Lexington. "Dr. C. ]. Wat­son- for his ability as a teacher andclinician."

B. Henry Williams' address is1225 4th St. NW, Washington, D.C.

Frederic F. Wippermann* hasbeen an ophthalmologist for 24 years,and is on the clinical faculty at theMedical School. He practices in Min­neapolis with a partner, Robert Rock­nem (Med. '46). Fred served in theNavy during the war. He is marriedto Sylvia Striegl of Minneapolis. Twoof their four children are deceased.Fred started skiing last year, now

loves it. This spring he's on a South American trip for the Inter­national Eye Foundation. "Dr. E. T. Bell-insight, humor, profes­sor, and man."

William W. Wood's address is 3409 Worth Hill Dr., FortWorth, Tex.

Sidney F. Yugend has been a GP in Indianola, la. since leav­ing military service in 1946. He was a medical officer in theCanal Zone, now lives at 1004 N. "c" St. with his wife, Harriet.They have four children, including a daughter in pre-med atNebraska. "Dr. Owen Wangensteen-I was greatly impressedwith his great knowledge, ability, and kindness. I still recallwhen he gave me my oral exam in surgery."

*Member, Minnesota Medical Foundation

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The following members of theJack I. Chalek

William O. ClarkeGordon M. Erskine

John Albert HardimanElwyn R. Hudec

Linus F. LeitschuhArnold Irvin Manson

Class of 1937 are deceased.Robert A. MavesRobert F. MearsAlexander J. Ross

Ben SommersA. Carlyle Tingdale

Clifford T. WaddEdwin J. Welte

Rehabilitation

An Experimental Summer Programfor Freshmen Medical Students*

Theodore M. Cole, M.D.t

Thomas P. Anderson, M.D.t

Nancy Crewe, Ph.D.§

9-or the past two years, the Department of Physical Medi­cine and Rehabilitation has been experimenting with a summerfellowship program for medical students following their Fresh­man year at the Medical School. The following is a report on theplanning, implementation and evaluation of this program.

PLANl'ING

Five key steps in planning the program include: (1) Thesetting of obiectives departed from the traditional generalizationof "knowing" or "understanding." The objectives are now drawnin terms of student behavior. Eleven units of behavior were iden­tified which required the student to use accepted principles,

"'From a report to University of Minnesota Hospitals on April 5, 1968t Assistant Professor, Department of Physical :Medicine and Rehabilitation, Uni­

versity of Minnesota Hospitals:j::Associate Clinical Professor, Kenny Rehabilitation Institute§Research Psychologist. Kenny Rehabilitation Institute

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THE jVIEDICAL BULLETIN

approaches and techniques of rehabilitation. It is thus easier todevelop curriculum content, student motivation, teaching effi­ciency, evaluation and feedback for the student, by which hecan match his perfOimance to the standards. (2) The oraniza­tion of curriculum flowed easily and directly from these objec­tives. (3) Staff included not only physicians but also membersof the allied health fields who could make special contributions(4) Students were selected on the basis of interview and voca­tional preference. (5) Communication between staff and stu­dents was promoted enabling the handling of problems as theyarose.

IMPLEMENTATION

The I2-week summer fellowship was divided into five periodsas follows: ( 1) One week of classroom orientation includedclinical application of some aspects of anatomy and physiology,orientation to problems in evaluation and management of chron­ic illness and representative case presentations. (2) Two weeksof clinical orientation to the types of patients and activities thestudent would be dealing with during the remainder of thesummer was essential to give him a desirable set for the nextperiod. (3) Two weeks of intensive learning period followed.The students learned to participate in a limited number of clini­cal activities such as history taking, manual muscle testing, jointexamination, portions of the neurological examination, gait anal­ysis, plethysmography, some rehabilitation techniques, prescrip­tion writing for physical therapy and occupational therapy, andprosthetics and orthotics. (4) Six weeks of clinical assignmentscame next. The best aspect of this period was the ratio of onestudent to one staff physician. As the student became more pro­ficient, he was given greater responsibility in carrying out exami­nations, progressing from the role of observer to recorder toassistant and finally to performing the activity, either with orwithout supervision. (3) One week was allowed for the termpaper. The student selected his own subject with approval ofthe directors. Coaching in scientific and medical writing was pro­vided by a professional editor. Not only was student responseto this assignment enthusiastic, but the papers were of con­sistently high quality.

One morning every week was devoted to student seminars.The quality of the seminars was greatly improved when atten­tion was paid to method of presentation as well as content.

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EVALUATION

The program was evaluated through collection of both de­scriptive data and data relating to the obfectives of the program.Discussion, questionnaires, rating scales, examinations, and agroup interview were employed. Descriptive infOlmation in­cluded the students' comments about each lecture and theirweekly assessment of activities. They reported spending anaverage of more than four hours per day in direct interactionwith the supervising physician. Each student kept a daily recordof his activities during the clinical period, noting whether heobserved, assisted with or performed an examination or activity,thereby indicating to his new physician-instructor areas in whichadditional experience was most needed.

To determine whether the obfectives of the program weremet, skills, interest and attitudes were assessed. Ability to diag­nose the loss of self-care capabilities, to perceive social problems,and to plan management accordingly, was evaluated with a testcase given at the beginning and again at the end of the summer.Every student improved and the group change was statisticallySignificant (p< .01). Weekly, each supervising physician ratedhis student's competence in performing selected physical exami­nations. Although everyone asserted that improvement resulted,the rating instrument was not sensitive enough to detect change.The semantic differential scale technique used at the beginningand the end of the summer to assess students attitudes towardtypes of patients, conditions of practice and certain medicalspecialties showed that the responses to chronic illness and toteam practice of medicine became significantly more favorable.

In retrospect, the fellowship program was consonant withfive recommendations of the Medical School's Educational PolicyCommittee: (l) Experimentation in nelt: methods of teaching,(2) Evaluation of methods, (3) Development of better studentattitudes, (4) Early exposure of the student to the patient andto clinical medicine, and (5) Closer relationship between studentand faculty.

In view of the evaluations and student and faculty enthusi­asm, this experimental educational program will be continuedin 1968 and further refined.

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Neurology

NeUfopathological Aspects ofChediak-Higashi Disease*

Joo Ho Sung, M.D.tEmanuel M. Stadlan, M.D.t

Chediak-Higashi disease is a rare heredofamilial illnessaffecting infants and children primarily. It is probably trans­mitted as an autosomal recessive trait, and is characterizedclinically by defective pigmentation, photosensitivity, and in­creased susceptibility to infections. The diagnosis is readily es­tablished by observation of unique giant granulations in leuko­cytes. The affected children eventually develop widespreadlymphohistiocytic infiltrations in various organs or tissues whichmay simulate a lymphoid malignancy.

In recent years, similar illnesses occurring in Aleutian minksand Hereford cattle have been identified. Genetic, ultrastruc­tural, and immunological studies have been undertaken by avariety of investigators, particularly from the University of Min­nesota. There have been only a few pathological reports, anddescriptions of the nervous system alterations are scanty andincomplete. During the past five years our laboratory of Neuro­pathology has had the opportunity to examine the nervous sys­tem of three children with well-documented Chediak-Higashidisease. These patients, one male and two females, were 3, 2J~,

and 11:14 years old, respectively, at the time of death. The twoolder children were siblings. An additional patient, a 17-year-oldfemale was also studied pathologically at Columbia Universityin New York. These four patients are the basis of this report.

Essentially two kinds of changes were found in the nervoussystem: cellular infiltrations and cytoplasmic inclusions. Theformer, limited to the three older patients, consisted of wide­spread, though mild, leptomeningeal and perivascular lympho­histiocytic infiltrations. The cellular infiltration and microglial

*From a report to the Staff Meeting of University of Minnesota Hospitals onMarch 1, 1968

t Associate Professor, Division of Neurology

=1:Assistant Professor, Division of Neurolog)

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THE c.IEDICAL BULLETIN

reaction in the brains and spinal cords of the two older patientsand in the brain of the third patient resembled meningoen­cephalomyelitis of viral origin. The peripheral nerves of the twoolder patients contained severe lymphohistiocytic infiltrations.The peripheral nerves of the remaining two younger patientswere not available for examination. SimilarlY, severe, diffusecellular infiltrations involved the entire para-aortic sympatheticchains of the eleven-year-old. The sympathetic ganglia were notexamined in the remaining patients. These pathological changescorrelate well with the clinically evident peripheral neuropathyand with the dysautonomic symptoms. These pathologicalchanges in the peripheral and autonomic nervous systems havenot been described preViously. Although the cellular infiltrationsare more apparent on routine pathological examination and havea bearing on the clinical symptoms, they appear to be secondaryto recurrent infections. Moreover, these symptoms and changeswere not present in the youngest patient.

Cytoplasmic inclusions, on the other hand, were commonto all patients. These occurred in nerve cells, astrocytes, choroidplexus lining cells, Schwann cells, histiocytes and epithelium ofrenal tubules. The inclusions varied not only from one cell typeto another but also to some extent from one cell to another inthe same cell line. Though the giant granules of leukocytes werefirst recognized in 1943, the inclusions within histiocytes andabnormal melanin granules of the skin were not observed until1958. The inclusions in nerve cells, renal tubular epitheliumand other cells were onl:' first recognized in 1962 in our oldestpatient. Not until 1966, after examination of the brains of theremaining three patients, did the consistent occurrence and sig­nificance of the neuronal inclusions become apparent.

The inclusions within nerve cells in many respects resemblelipofuscin granules. The inclusions become more prominent withincreasing age, accumulate within nerve cells, and vary fromone nerve cell group to another, as do lipofuscin granules. Theneurones harboring the inclusions are otherwise unaltered. Thevarious staining reactions and autofluorescence of the inclusionsare essentially identical to those of lipofuscin granules. However,the inclusions differ from lipofUScin granules by virtue of theirlarge size, marked irregularity in size and shape, and tendencyto clump or fuse to form discrete masses. Another remarkablealteration is in the pigment granules of the neurones of thesubstantia nigra. These are unusually coarse, irregular in size,and tend to clump, forming discrete masses.

Electron microscopic observations of the neurones of the 11­year-old suggest that the inclusions are formed by remarkable

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THE "'-I ED I CAL B U L LET I 1\

enlargement, fusion or agglomeration of dense bodies remInIS­cent of lysosomes and secondary lysosomes or residual bodieswhich resemble lipofuscin granules in some respects.

Similar light and electron microscopic observations havebeen made in Aleutian minks. Here again, there are cytoplasmicinclusions within nerve cells. The resemblance between the in­clusions and lipofuscin granules in natural dark minks parallelsthat described in humans.

Whatever the basic defect in Chediak-Higashi disease maybe, it appears to become manifest in lysosomes and relatedstructures. This has led some investigators to suggest that alysosomal abnormality may be a primary defect in this disease.However, a number of lysosomal enzymes of leucocytes of thepatients and minks with the disease have been found to beunaltered. Some investigators have further suggested that theremay be a gene-induced alteration somewhere along a granule­forming pathway common to all granule-forming cells; perhapsan alteration in granule membranes in the disease. However,since lysosomal enzymes appear to be normal and no abnormali­ties are recognizable in various structures such as Golgi andendoplasmic reticulum, one should still consider the possibilitythat the lysosomal abnormality may be secondary to some othergenetically-induced abnormality.

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jvledicol SCHool /Yews

Dr. John J. Sciarra AppointedHead of OB-GYN at Medical School

Dr. John J. Sciarra has been appointed Professor and Headof the Department of Obstetrics and Gynecelogy at the Univer·sitv of Minnesota Medical School, effective Julv 1, 1968. Dr.Sciarra, assistant professor of obstetrics and gYI~ecelogy at theCollege of Physicians and Surgeons of Columbia University, willsucceed John L. McKelvey, M.D., C.M. who retired in 1967after 29 veal's as chief of OB-GYN. Dr. Konald A. Prem hasbeen acting head in the interim period.

Dr. Sciarra, 36, has been associated with Columbia Univer­sitv and the Columbia-Presbvterian Medical Center in New YorkCity since 1953. He currentiy holds an appointment as AssistantAttending Obstetrician and Gynecologist at the PresbyterianHospital and Assistant Visiting Gynecologist at the Francis Dela­field Hospital.

A native of Connecticut, Dr. Sciarra received his B.S. degreefrom Yale College in 1953 and his M.D. degree from ColumbiaP. and S. in 1957. Following an internship in Surgery at theYale New Haven Medical Center he returned to the Columbia­Presbyterian Medical Center in 19.58 to begin his reSidency inObstetrics and Gynecology at the Sloane Hospital for 'Vomen.

In 1960 Dr. Sciarra received a fellowship from the JosiahMacy, Jr. Foundation for postgraduate study in reproductivephysiology and worked for three years in the Department ofAnatomy at Columbia University, receiving the Ph.D. degreefrom the Facultv of Pure Science, Columbia Universitv, in 1963.At the completion of his residency Dr. Sciarra was awarded aSpecial Fellowship from the Institute of Child Health and Hu­man Development, National Institutes of Health. He was namedAssistant Professor of Obstetrics and G~'necelogy at ColumbiaUniversitv in 1965.

Dr. Sciarra's research interests relate to the biology of theplacenta and the hormones produced by this organ. In 1965 hereceived the Carl G. Hartman Award of the American FertilitySociety for his immunohistochemical studies on the localizationof protein hormones within the human placenta. His present re­search is concerned with the assa~' of placental hormones innormal and abnormal pregnancy and with the evaluation ofplacental function. Dr. Sciarra's clinical interests are in the fieldsof g~'necologic endocrinology, fertilit~·, and infertility.

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THE MEDICAL BULLETIN

Dennis W. Watson, Ph.D., pro­fessor and head of the Departmentof Microbiology at the MedicalSchool, has been elected presidentof the American Society for Micro­biology.

tbtiversitll .Hospitals ;NewsForty-one new interns will be assigned to University of Min­

nesota Hospitals starting July 1st following completion of the1968 National Intern Matching Program. This will be one lessthan in 1967, according to John H. Westerman, director of theHospitals.

Eight members of the Medical School's Class of 1968 willbe included. They are Kent B. Crosslev, Robert I. Hustrulid,Margaret Rick, a~d Ronald Soltis (Med{cine); Richard S. Greg­ory and Michael D. Weiner (Surgery); and Ronald E. Black­more and Paul M. Blum (Pediatrics).

Other new interns will be products of 27 U.S. medicalschools and two foreign schools (Argentina and Japan).

Hospitals in the state of Minnesota requested a total of 269interns under the 1968 NIMP and received a total of 141­eight fewer than in 1967. Of the 141 internships, 114 werefilled by University, Hennepin County General, and St. PauI­Ramsey Hospitals.

With an all time high census mark of 722 patients included,University of Minnesota Hospitals posted an average dailycensus of 672 patients during the month of February, 1968.Monthly average for the year has been 616.

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AluMni Dell/Its• 1919

Dr. Thomas O. Young, Duluth, Minn. Died February 2, 1968at the age of 74 years. He was a native Minnesotan and a Du­luth resident for 43 years. Dr. Young trained in surgery at theMayo Graduate School of Medicine, and was founder and firstpresident of the Duluth Surgical Society.

• 1921Dr. Peter C. Engelhart, Minneapolis, Minn. Died December

30, 1967. He was 71 years old.

• 1922Dr. Eleanor Bohnsack Crim, Seattle, Wash. Died January 30,

1968 at age 72 years. She was former health officer in Fargo,N.D. and had served as a medical missionarv in India.

• 1924Dr. William D. Brown, Sr., Minneapolis, Minn. Died March

20, 1968 at the age of 65. He was in general practice in Min­neapolis for more than 40 years until his retirement in 1967.Dr. Brown was a graduate of Minneapolis Central High Schooland a staffmember at Fairview Hospital. He was honored bythe National Association for the Advancement of Colored Peoplein 1965.

MEMORIAL GIFTSThe Minnesota Medical Foundation acknowledges with

gratitude recent contributions made in memory of:

Alice W. Adler Mrs. Harlan S. MillerGladys Bartsch Dr. Morse J. ShapiroFred Boehlke Rosemary ShielyRuth Eckhoff Mrs. Helen Sterns

Mrs. Ralph Jacobson James Q. TaylorDennis M. Koza Dr. William E. TaylorMaurice Mandel Wesley D. Vars

Walter H. Mashek Lisle C. Vickerman

Memorial gifts are a thoughtful means of honoring thememory of a relative, friend, or colleague. Gifts maybe designated for specific purposes. The Minnesota Medi­cal Foundation acknowledge all gifts to both donor andnext of kin.

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Continuation Medical EducationPOSTGRADUATE COURSES FOR PHYSICIANS

University of Minnesota Medical School

The following postgraduate medical courses have beenscheduled for the months ahead. Note the dates and make yourplans now to attend. For information, write Director, Continua­tion Medical Education, 1350 Mayo, University of Minnesota,Minneapolis, Minn. 55455. Telephone: (A.C. 612) 373-8024.

April 19 - May 1May 23 - 25May 23 - 25Sept. 17 - 19Oct. 17 - 19Oct. 21 - 25Nov. 13 -15Nov. 21- 23

1968

· OphthalmologySurgery

· Anesthesiology· .. Pediatrics

· . Dermatology...... Radiology (Nuclear Medicine)

· .Ophthalmology (Refraction)· . Orthopedic Surgery (Scoliosis)

Jan. 16 - 18Jan. 23 - 25Feb. 6 - 8Feb. 13 - 15Feb. 17-19Apr. 21 - 25Apr. 19Apr. 28 - 30May 22 - 24May 22 - 24

1969

· Otolaryngology.... Obstetrics

· . Psychiatry............... Pediatric Neurology

......... Internal Medicine· .. Proctology· .. Trauma

(tentative) . Ophthalmology (General)· .. Surgery

............... Anesthesiology

MINNESOTA MEDICAL FOUNDATION1342 Mayo Bldg., Minneapolis, Minn. 55455

List me as a supporter of the MINNESOTA MEDICAL FOUNDATION in thefollOWing category: (Membership dues are for one year)

o Sustaining ($100.00) 0 Annual ($25.00) ·0 Resident ($3.00)

Dues are tax-deductible. Membership underwrites cost of the UNIVERSITY OF

MINNESOTA MEDICAL BULLETIN.

Name - _(Please Print)

o Dues accompany this application.

Address ~ _

Medical School Class of_~ _o Please bill me.

Zipp- _

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New Head of OB-GYN

Dr. John J. Sciarra is appointedas head of the department of

Obstetrics and Gynecology.

See page 218

Second Class Postage Paidat Minneapolis, Minnesota