www.durae.co.kr Durae’s Jeju Bio center was established in Jeju-do. Jeju-do is selected as the world natural heritage property by UNESCO and as the new 7wonders of nature. The bio center is working to discover, research and develop natural ingredients from plants growing in the natural environmental. HEAD OFFICE Dangjeong-ro 56, Gunpo-si, Gyeonggi-do, Republic of Korea. (435-832) Tel. +82-31-397-6066 Fax. +82-31-397-5322 E-mail. [email protected]JEJU BIO CENTER 104, Jeju Bio-Industry Development Center, Sanchundandong-gil 16, Jeju-City, Republic of Korea. (690-121) Tel. +82-64-723-6066 Fax. +82-64-723-6067 DURAE Corporation 2012. 10
16
Embed
Durae’s Jeju Bio centerprokcssmedia.blob.core.windows.net/sys-master-images/h51/...StaVectOr Slim active materials Main functions Change In Lean Body Mass Index 0.68 0.7 0.72 0.74
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
www.durae.co.kr
Durae’s Jeju Bio center was established in Jeju-do.Jeju-do is selected as the world natural heritage property by UNESCO and as the new 7wonders of nature. The bio center is working to discover, research and develop natural ingredients from plants growing in the natural environmental.
H e a D O f f i c e Dangjeong-ro 56, Gunpo-si, Gyeonggi-do, Republic of Korea. (435-832) Tel. +82-31-397-6066 Fax. +82-31-397-5322 E-mail. [email protected]
JeJu BiO center 104, Jeju Bio-Industry Development Center, Sanchundandong-gil 16, Jeju-City, Republic of Korea. (690-121) Tel. +82-64-723-6066 Fax. +82-64-723-6067
Durae corporation
2012. 10
Durae cOrPOratiOntruSt & cOnfiDence
Growing with customers by providinginnovative materials and technology.Durae always creates the new future with the customers. We will achieve a good and best company through theconstruction of the international business network onthe basis of the rising company, belief best company.
www.durae.co.kr
We continue to develop the innovative ingredients of cosmetics and personal care products to improve the beauty all around the world. Since established in 1997, we have rapidly grown every year. We concentrate on the development and supply what our customers want.
Growing with customers by providing innovative materials and technology.
DURAE Corporation
DURAE Corporation / 02
CreateNew Concept
New Material
Natural ext.
Collaborations
CustomerSuccess
InnovativeMaterials
Technology ReasonablePrice
DuraeCorporation
BestQuality
DURAETechnology
- Formulation Support- Optimization and combination of various useful ingredients- Development of innovative new base with better sensory effects
New DevelopMaterials for Cosmetics- Polymer Material- Skin Delivery Material- Synthetic / Purification
Exploring NewFunctional Ingredients
Networkingwith Professional
- New natural extracts- Plant Peptide- Certified biological efficacy- Self Production
- Compose to Technical in Network (International & Domestic)- Consulting
Create New Concept
CreateNew Concept
New Material
Natural ext.
Collaborations
CustomerSuccess
InnovativeMaterials
Technology ReasonablePrice
DuraeCorporation
BestQuality
DURAETechnology
- Formulation Support- Optimization and combination of various useful ingredients- Development of innovative new base with better sensory effects
New DevelopMaterials for Cosmetics- Polymer Material- Skin Delivery Material- Synthetic / Purification
Exploring NewFunctional Ingredients
Networkingwith Professional
- New natural extracts- Plant Peptide- Certified biological efficacy- Self Production
- Compose to Technical in Network (International & Domestic)- Consulting
Create New Concept
DURAE Corporation / 03
STAVECTOR (Stabilized Nanoencapsules)
StavectorCO-Q10
Anti Oxidant
Stavector Ursolic Acid
Health Skin
StavectorSlim
SlimingAnti Wrinkles
Stavector Retinol
Stavector Resveratrol
Whitening
Stavector Ellagic Acid
Stavector Licorice
Nanoemulsion
Stavector LSB20
Stavector BBS
Transdermal delivery system based on polyamidoamine dendrimer
Strengthen the hair root andpromote hair growth. Dandrop
Natural Extract
INCI NameTorreya Nucifera Seed Powder
Nelumbo Nucifera Seed Powder
Hibiscus Cannabinus Stem Powder
EffectsPhytoncide
Quench feeling, Body scrub
Exfoliation
ProductsJeju Bija Powder
Lotus Germ Powder
Kenaf Cellulose
Plant origin BIJA
Lotus Germ
Kenaf
Natural Powder
200n
mPolymerwall
ACTIVE
pH-TriggeredRelease inducing
group
ACTIVE
Stavector is easilypermeated into skin
The Particle Size 200nm
ACTIVE
The biopolymers are triggered
Skin pH 5.5
ACTIVE
Active Ingredientis released slowly
Release> >
DURAE Corporation / 05
1. Stavector is nanoencapsulation with the skin affinity biopolymer ; chitosan and cellulose acetate.2. It is encapsulated with biopolymer through polymer complexation process.3. Biopolymer is safe for the skin and enhance permeability in order to deliver high efficacy into the skin.
Nanoencapsulation
1. Controlled release guarantees the active ingredients are delivered to the skin in optimum level.2. Encapsulation and stabilization of the active ingredients ensure the long lasting effects.3. Nano-sized ingredients promote the enhanced penetration into the skin.4. Skin friendly biopolymer encapsulation does no harm to skin.5. The water base makes formulation and application easy.
Enhanced skin permeability
StaVectOr
Innovation for Young Looking SkinBy Stabilized Nanoencapsules
Newly developed Stavector is nanoencapulated and stabilized active ingredients series to ensure high efficiency and long lasting effects.
DURAE Corporation / 06
Garcinia Cambogia Extract
Phaseolus Vulgaris(Kidney Bean) Extract
Coleus Forskohlii Root Extract
Tetrahydropiperine(improving the skin penetration)
Lose Fat & Increase Lean Body Mass!Wanna be Slim?Specially encapsulated complexing of garcinia cambogia, coleus forskohlii, phaseolus vulgaris extract solution and tetrahydropiperine for cosmetic use.
1. Significant decrements in body weight 2. Decreasing cholesterol and fatty acids
Phaseolamin· Proteinaceous inhibitor of the enzyme alpha-amylase· Carbohydrate blocker· Amylase inhibitory activity
StaVectOr Slim
active materials
Main functions
Change In Lean Body Mass Index
0.68
0.7
0.72
0.74
0.76
0.78
0.8
0.82
0.84
0.86
Week 0 Week 3 Week 6 Week 9 Week 12
Lean
Bod
y M
ass
Inde
x
Placebo Forskolin
Initial
Final
200 30 40 50
Forskolin
Body Fat % (Signi�cant decrease in treated group, P≤0.05)
Polymer wall
SLIM
pH-TriggeredRelease inducing
group
-Garcinol- -Forskolin-
-Tetrahydropiperine-
DURAE Corporation / 07
Distribution of molecular weight of collagen and vegetable collagen
Keep Fresh skin and have Powerful Anti aging Effects
Plant PeptidePlant peptide is existed in the primary cell wall of plant cells.Keep Fresh skin and have Powerful Anti-aging Effects
Plant peptide thatexists in the first cell
wall of plant cells
A scaffold protein that ismassively produced during
the growth of a plant or whencell walls are damaged
Preserving skinstructure and elasticity
Preserves skin structure and elastic-ity by replenishing plant peptide that contains amino acids, glycine, pro-line, alanine, hydroxy proline which
are the most abundant collagen components in the human body.
Physiological Activity
Plant peptide which actsas an important natural
moisturizer for the skin contains more sugar than animal collagen,
and this highly functional substance provides durability to physiological
activities.
Safety
It safely breaks down when entering the skin since it is an amino acid which is a biological substance.
Plant peptide directly delivers amino acids of each plant to the skin which makes it better for skin absorption compared to animal collagen, and this provides protection for the skin from aging.
Moleculeof acidicpectin
Bonds of Ca betweenpectin moiecules
Molecule of hemicelluloseMicrofibril of cellulose
Moleculeof neutral
pectin
Moleculeof acidicpectin
Bonds of Ca betweenpectin moiecules
Molecule of hemicelluloseMicrofibril of cellulose
Moleculeof neutral
pectin
DURAE Corporation / 08
1. Melanin inhibition 2. Cytotoxicity(%)
4. Amino acid composition
0
20
40
60
80
100
10 20 5050 100Arbutin
Concentration (μg/ml)* Melanin Assay (%)
0
20
40
60
80
120
140
100
10 20 50 100Control
Concentration (μg/ml)* MTT Assay (%)
0
20
40
60
80
120
100
Green Tea GlycoproteinPro. Cont
0
20
40
60
80
100
10 20 5050 100Arbutin
Concentration (μg/ml)* Melanin Assay (%)
0
20
40
60
80
120
140
100
10 20 50 100Control
Concentration (μg/ml)* MTT Assay (%)
0
20
40
60
80
120
100
Green Tea GlycoproteinPro. Cont
0
20
40
60
80
100
10 20 5050 100Arbutin
Concentration (μg/ml)* Melanin Assay (%)
0
20
40
60
80
120
140
100
10 20 50 100Control
Concentration (μg/ml)* MTT Assay (%)
0
20
40
60
80
120
100
Green Tea GlycoproteinPro. Cont
3. Irritation relaxation(IL-1)(%)
Amino acid
Aspartic acid
Threonine
Serine
Glutamic acid
Glycine
Alanine
Valine
Cystine
Methionine
Isoleucine
Leucine
Tyrosine
Phenylalanine
Lysine
Histidine
Arginine
Proline
etc.
12.41
2.17
3.14
17.82
3.88
2.01
2.12
0.93
0.00
0.88
1.61
0.91
1.11
2.67
0.65
4.09
0.90
42.70
Green tea Glycoproteinnatural in Beauty
Double purpose-One-material
CharacteristicGreen tea glycoprotein is made from JAKSUL TEA which is first tender sprouts picked in late springwhen the nature brings back to life.
EffectsSkin brightening, Anti inflammatory
DURAE Corporation / 09
Amino acid composition
Amino acid
Aspartic acid
Glutamic acid
Serine
Glycine
Histidine
Arginine
Threonine
Alanine
Proline
Tyrosine
Valine
Methionine
Cystine2
Ileleucine
Leucine
Phenylalanine
Lysine
6.24
14.91
2.31
3.10
0.68
0.98
1.28
2.54
61.09
1.04
1.33
0.59
0.06
0.74
1.15
0.92
1.04
Anti oxidant activity (DPPH assay)
0
0.2
0.4
0.6
0.8
1ppm 5ppm 10ppm 1ppm 10ppm 100ppm50ppm
OD
515
Vitammin-C Betula bud glycoproteinControl
0
50
25
75
100
175
150
125
UVB 40mJ 1ppm 5ppm
% o
f Con
trol
Betula bud glycoprotein
Control
Anti aging activity (MMP-1 inhibition)0
0.2
0.4
0.6
0.8
1ppm 5ppm 10ppm 1ppm 10ppm 100ppm50ppm
OD
515
Vitammin-C Betula bud glycoproteinControl
0
50
25
75
100
175
150
125
UVB 40mJ 1ppm 5ppm
% o
f Con
trol
Betula bud glycoprotein
Control
CharacteristicBetula pendula believe that the name “birch” is derived from the word “protect”as the ancients is valued and protected the plant, considering it a gift from the gods. The birch tree has a long history of medicinal use in different countriesand cultures to cure skin diseased especially eczema, inflammations,rheumatism and urinary disorders.
EffectsAnti oxidant, Anti aging, Skin regeneration
Betula Bud Glycoprotein
DURAE Corporation / 10
Schnewhite
Seed Germination
INCI name: Lentinus Edodes ExtractCharacteristic : It is the whitest shiitake and comes out only in spring after long winter. Of a thousand shiitakes only a few ones becomes Schnewhite, so it is rather rare and has superior flavor and scent.Effects : Whitening, Immuno modulatory, Anti oxidant
Germination is the process by which plants, fungus andbacteria emerge from seeds and spores, and begin growth.When seeds began to germinate, the cell wall of seed andthe protoplast have hydrated.Protoplasts transform from the gel state to the sol state.Various enzymes become activated, and nutrition storedin the seed begins to change.
0
20
40
60
Schnewhite Kojic AcidShiitake
10ppm 100ppm 10ppm 100ppm 10ppm 100ppm
» Black Sesame (Sesamin)» Sorghum (Luteolin)» Black Rice (Ferulic acid)» Mungbean (Vitexin)
Anti oxident» Black Sesame (Sesamin)» Black Soybean (Daidzein)» Black Rice (Ferulic acid)
Anti aging» Sorghum (Luteolin)» Millet (p-Coumaric acid)» Milk thistle (Silymarin)
Whitening
HO
CH3
CH3
CH3
H3C
H3C
CH3
Optimum Active Ingredients
Seed Germination
» Black Sesame (Sesamin)» Sorghum (Luteolin)» Black Rice (Ferulic acid)» Mungbean (Vitexin)
Anti oxident» Black Sesame (Sesamin)» Black Soybean (Daidzein)» Black Rice (Ferulic acid)
Anti aging» Sorghum (Luteolin)» Millet (p-Coumaric acid)» Milk thistle (Silymarin)
Whitening
HO
CH3
CH3
CH3
H3C
H3C
CH3
Optimum Active Ingredients
Seed Germination
Inhibition of melanin synthesis (%)
extracts
-Ergosterol-
DURAE Corporation / 11
Skin Plant EssenceINCI name : Gynura Procumbens, Averrhoa Bilimbi, Jasminum Sambac and Carica Papaya. Characteristic: Traditional medicine comprises knowledge systems that developed over generations with in various societies before the era of modern medicine. Our products of research and development based on JAMU (Indonesian herbal medicine). Gynura procumbens : Main ingradients of skin plant essence. Indonesian Name is “Sambung = Persistence, Nvawa = Life” English Name is “Life sustainable Plant”Traditional medicine use: Inflammation, rheumatism, Skin diseases, Diabetes, Cancer medicationEffects : Anti oxidant, Anti aging, Whitening
Tremoist-2BINCI name : Tremella Fuciformis PolysaccharideCharacteristic: Tremoist-2B is an acidic hetero-polysaccharide extracted from the edible fruit bodies of the muchroom called Silver Ear in China. It is said that imperial Concubine Yang Kuei-fei, considered to be the most beautiful woman in Chinese history, used it for her facial care. It is a kind of plant-derived hyaluronic acid, because it contains much amount of glucuronic acid (about 20%) as hyaluronic acid does.Effects : Makes skin moist and smooth
Gynura Procumbens Leaf
160
140
120
100
80
60
40
20
0UV 1ppm10uM
RatinoicAcid
10ppm 50ppm
% o
f CTL
G. Procumbens
Control
O
O
CH2OH CH2OH CH2OH CH2OH CH2OH CH2OH
O
O
O
O
O
OOH
O
O
O
O
O
OHOAc
OH
COOHO
OHOH
OH
O O
O
OHOH
OH
COOHO
OHOH
O
OHOH
OH
O O
O
OH OAc OH OH OAc OHOH
10
8
6
4
2
05 10 15 20
amou
nt (m
icro
L)
Time(min)
Tremoist-2B
SodiumHyaluronate
Glycerin
Water
O
O
CH2OH CH2OH CH2OH CH2OH CH2OH CH2OH
O
O
O
O
O
OOH
O
O
O
O
O
OHOAc
OH
COOHO
OHOH
OH
O O
O
OHOH
OH
COOHO
OHOH
O
OHOH
OH
O O
O
OH OAc OH OH OAc OHOH
10
8
6
4
2
05 10 15 20
amou
nt (m
icro
L)
Time(min)
Tremoist-2B
SodiumHyaluronate
Glycerin
Water
MMP-1 expression inhibion assay DNA protection from UV damage
Amount of water inside
-Glucuronic acid-
Normal DNA Cell
DNA damage (tailing)
Damaged DNA Cell
Control
UV+ 10uM EGCG
UVB 30mJ
UV+ 50ppm G. Procumbens
DURAE Corporation / 12
SoapberryINCI name: Sapindus Trifoiatus Fruit ExtractCharacteristic : The soapberry has been used for centuries by Native Americans in India, and is still utilized for many purposes in Asia today. The shell of the soapberry fruit is very high in saponins, which acts as a surfactant that removes stains from skin.Effects : Mild detergent, Cleanser, Surfactant antimicrobialBiologically active constituents : Saponins
AloeINCI name : Aloe Barbadensis Leaf ExtractCharacteristic : Aloe vera (syn.A. barbadensis Mill.,A.vulgaris Lam.) is a species of Aloe, native to Northern Africa. Ancient times of Egyptians has been used externally to treat to various skin conditions such as cuts , burns and inflammation. Aloe is classed Liliopsida, well-known aloe is Aloe vera “ aloe” is ‘something bitter’ in Arabic, “vera” is ‘truth’ in Latin.Effects: Moisture, Anti bacterial
YambeanINCI name : Pachyrrhizus Erosus Root ExtractCharacteristic: Yambean is a component in the Indonesian traditional salad called “rujak”. It is eaten raw, sometimes with lemon juice and powdered chilli. Bengkoang consists of 86-90% water. It contains only trace amounts of protein and lipids. There are other compounds in bengkoang, such as adenine, choline, saponine and flavonoids.Effects : High moisture, UV absorption active material, Anti oxidant, Tyrosinase inhibitIon activity, Melanin synthesis Inhibition
HO
OH
O
O
6 10 3
1
4
2
1’2’
3’
4’
5’
6’
7 98
5
H
-Daidzein-
DURAE Corporation / 13
Kenaf celluloseINCI name: Hibiscus Cannabinus Stem PowderCharacteristic- Effective and mild exfoliation- Remove the rough skin layer leaving with a soft and supple skin.
Nano-scale interactions between PAMAM dendrimers and cellsA. The AFM images of the supported lipid bilayer without treatment.B. After exposure to generation 7 polyamidoamine (G7 PAMAM) dendrimer.
G2 PAMAM dendrimers are much more effective in skin permeationthan G4 Dendrimers were conjugated with fluorescein isothiocyanate (FITC)
Size effect of PAMAM dendrimers on skin permeation
Skin Delivery System : Dendrimer
Article!Effect of size, Surface Charge, and Hydrophobicity of Poly (amidoamine) Dendrimers on Their Skin PenetrationBiomacromolecules. 2012, 13, 2154-2162
Patent pending!Transdermal Delivery System based on PAMAM Dedrimer
Differentiated Active Delivery System!Well-controlled size (3 to 10nm)Ease of functionalization (conjugation with biofunctional molecules)High water solubility and Biocompatibility