1 Drugs in Sport Associate Professor Peter Brukner Centre for Sports Medicine Research and Education Ancient civilisations Greeks (mushrooms) Romans (herbs) Egyptians (hooves) Norway (Berserkers -mushrooms) Nineteenth century caffeine alcohol nitroglycerine opium strychnine
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Drugs in Sporthms.health.uq.edu.au/sportsmedicine/hmst7002/Drugs/files/Drugs.pdf · rapid loss of weight ⇒ dangerous excrete or dilute illegal substances Peptide hormones and analogues
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Drugs in Sport
Associate Professor Peter Brukner
Centre for Sports Medicine Researchand Education
Ancient civilisations Greeks (mushrooms) Romans (herbs) Egyptians (hooves) Norway (Berserkers
-mushrooms)
Nineteenth century caffeine alcohol nitroglycerine opium strychnine
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Anabolic steroids 1927 - Fred Koch bull testicles World War II 1952 Olympics (Russians)
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Blood doping Finnish distance runners 1970s
Growth hormoneErthropoietin
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Drugs in sportDefinition of doping
Doping is the deliberate orinadvertant (accidental)use by athletes of bannedsubstances or methods thatmay enhance performance
Anabolic steroids:females menstrual irregularities deepening of voice male pattern baldness hirsutism alterered libido enlarged clitoris
Anabolic steroids:side effectsAdolescents acneν ⇑ facial and body hairν premature closure of epiphyseal
growth platesν male pattern baldnessν deepening of voice
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Anabolic steroid and healthrisk behaviours 1 million users in USA spend more than $100 million 4-11% of male adolescents 0.5-2.9% of female
adolescents
Anabolic steroidsAddicted in same way as other drugs ⇒ roid rages severe mood liability aggressive or violent behaviour disinhibition impaired judgement anxiety, panic paranoid delusions
Withdrawal from the drug may also produce acutesymptomatology similar to that seen during alcoholand opioid withdrawal
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Anabolic steroidsWhere are they obtained?
doctors gymnasiums mail order
Anabolic steroids cyclical pyramid stacking different steroids for different
needs
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Beta 2 agonists All Beta 2 agonists are banned except
inhalants containing the ingredientssalbutamol and terbutaline e.g.Ventolin, Bricanyl, Respolin
Diuretics rapid loss of weight⇒ dangerous
excrete or dilute illegalsubstances
Peptide hormones andanalogues
Human growth hormone (HGH),human chorionic gonadotrophin(HCG), corticotrophin (ACTH),erythropoeitin (EPO)
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Human Growth Hormone(HGH)
produced by pituitary gland essential for normal growth treatment of dwarfism from cadavers since 1985 recombinant HGH
Insulin-like growthfactors (IGFs)Previously known assomatomedins
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Erythropoietin naturally occurring hormone secreted by kidney stimulates bone marrow increased red blood cell production synthetic EPO available treatment of anaemia of chronic renal
failure
Eythropoietin Marked increase in haematocrit
increased oxygen carrying capacityof the blood
increase in viscosity of bloodespecially if associated withdehydration
potentially fatal
Prohibited methods1. Enhancement of oxygen transfer
- Blood doping- Modified haemoglobin products
2. Pharmacological, chemical and physicalmanipulation
3. Gene doping
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Blood doping withdraw blood 6 weeks prior allow time for blood count to
return to normal reinfuse blood day or two before
competition
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Pharmacological, chemical andphysical manipulation
administration of diuretics catheterization sample substitution inhibition of renal excretion
alcohol cannabinoids local anaesthetic glucocorticosteroids beta blockers
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Corticosteroids Corticosteroids are permitted under the
following conditions: creams, ointments, eye drops, inhalants
e.g. Becotide, local injections
Beta blockers Beta blockers will only be tested
for in sports where they are likelyto enhance performance e.g.archery, shooting, bobsleigh,diving, luge, modern pentathlon,ski jumping
Drugs in sportWhat drugs are tested for in acompetition test? anabolic steroids stimulants diuretics narcotic analgesics (ex codeine) peptide hormones masking agents
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Drugs in sportWhat drugs are tested for in anout-of-competition test? anabolic steroids diuretics masking agents
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Why athletes take drugs1. Belief that their competitors are taking drugs2. Do anything possible to succeed3. Pressure from coaches, parents & peers4. Pressure from authorities5. Lack of access to legal methods to enhance
performance6. Community attitudes and expectations regarding
success and performance7. Financial rewards8. Influence of media in facilitating expectations and