Top Banner
Drugs in pregnancy and lactation By Mariam Talal Yusor Jaffar Sherin Raad
30
Welcome message from author
This document is posted to help you gain knowledge. Please leave a comment to let me know what you think about it! Share it to your friends and learn new things together.
Transcript
Page 1: Drugs in pregnency

Drugs in pregnancy and lactation

By

Mariam Talal

Yusor Jaffar

Sherin Raad

Page 2: Drugs in pregnency

By

Mariam Talal

Yusor Jafar

Sherin Raad

Page 3: Drugs in pregnency

Pharmacokinetics in pregnancy• Absorption• Albumin and albumin binding capacity• Metabolism • Excretion• Most drugs are expected to have shorter

half life during late pregnancy• During labor, the drug concentration may

increase rather than decrease

Page 4: Drugs in pregnency
Page 5: Drugs in pregnency

Role of the placenta

Page 6: Drugs in pregnency

• Drug transfer is greater during late gestation because

• Pathological processes can affect uteroplacental blood flow

• Certain drugs can also induce or inhibit placental enzymes

Page 7: Drugs in pregnency

Drug effects on the fetus• Chronic drug exposure rather than single-

dose therapy may influence fetal cell growth

• Drug may act as teratogenic agent in many ways

• Cardiac output is greater in fetus than adult

• Blood-brain permeability is greater in the fetus

Page 8: Drugs in pregnency

• Mitochondrial number increase in in the fetal brain and heart

• Total body water and plasma protein• Autonomic receptors• Human fetal liver microsomes• Excretion of most drug is slower in fetus

Page 9: Drugs in pregnency

Fetal drug therapy

• Specific fetal tissues may be more selective in drug uptake

• Drug administration can occur by:

I. Passive transplacental route

II. Direct intra-amniotic intramuscular injection

Page 10: Drugs in pregnency
Page 11: Drugs in pregnency

Drug effects on the fetusThe effect of a teratogen is depend on:

I. The dose reaching the developing embryo or fetus

II. Gestational age

III. Duration of exposure

IV. The genotype of the mother and the fetus

V. Effect of other agents

VI. Difficulty to prove a drug effect

Page 12: Drugs in pregnency
Page 13: Drugs in pregnency
Page 14: Drugs in pregnency

Drugs Commonly Prescribed in Pregnancy and Breast-feeding

Page 15: Drugs in pregnency

Antianxiety drugdiazepam … FDA = D

Page 16: Drugs in pregnency

Antibiotics

Page 17: Drugs in pregnency

Anticoagulants

Page 18: Drugs in pregnency

Anticonvulsants

Page 19: Drugs in pregnency

Antihypertensives

Page 20: Drugs in pregnency

Chemotherapy drugsFDA=D,X

Page 21: Drugs in pregnency

Mood-stabilizing drug

Page 22: Drugs in pregnency

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Page 23: Drugs in pregnency

Oral antihyperglycemic drugs

Page 24: Drugs in pregnency

Sex hormones

Page 25: Drugs in pregnency

Skin treatments

Page 26: Drugs in pregnency

Thyroid drugs

Page 27: Drugs in pregnency

Vaccines (live virus)

Page 28: Drugs in pregnency

Others

Page 29: Drugs in pregnency
Page 30: Drugs in pregnency